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Solute carrier family 22 member 1 Nevirapine transporter 12- Hydroxynevirapine metabolite mitochondrial transporter 4- Carboxynevirapine mitochondrial transporter 4- Carboxynevirapine transporter 3- Hydroxynevirapine glucuronide transporter 8- Hydroxynevirapine glucuronide transporter 2- Hydroxynevirapine glucuronide transporter 12- Hydroxynevirapine glucuronide transporter Cytochrome P450 2C9 UDP- glucuronosyltransferase 1-9 Cytochrome P450 3A4 UDP- glucuronosyltransferase 1-9 Cytochrome P450 3A4 UDP- glucuronosyltransferase 1-9 Cytochrome P450 2B6 UDP- glucuronosyltransferase 1-9 Cytochrome P450 2B6 Cytochrome P450 3A4 Alcohol dehydrogenase class-3 Aldehyde dehydrogenase, mitochondrial 2- Hydroxynevirapine glucuronide 3- Hydroxynevirapine glucuronide 8- Hydroxynevirapine glucuronide 12- Hydroxynevirapine glucuronide 4- Carboxynevirapine Nevirapine Nevirapine Nevirapine Nevirapine Nevirapine 12- Hydroxynevirapine 12- Hydroxynevirapine 12- Hydroxynevirapine metabolite 12- Hydroxynevirapine metabolite 4- Carboxynevirapine 4- Carboxynevirapine 3- Hydroxynevirapine glucuronide 8- Hydroxynevirapine glucuronide 2- Hydroxynevirapine glucuronide 12- Hydroxynevirapine glucuronide O2 FMNH2 H2O Flavin Mononucleotide H+ Uridine diphosphate glucuronic acid H+ Uridine 5'-diphosphate O2 FMNH2 2- Hydroxynevirapine H2O H+ Flavin Mononucleotide Uridine diphosphate glucuronic acid Uridine 5'-diphosphate H+ FMNH2 O2 8- Hydroxynevirapine H2O H+ Flavin Mononucleotide Uridine diphosphate glucuronic acid Uridine 5'-diphosphate H+ FMNH2 O2 3- Hydroxynevirapine Flavin Mononucleotide H2O H+ Uridine diphosphate glucuronic acid Uridine 5'-diphosphate H+ FMNH2 O2 3- Hydroxynevirapine Flavin Mononucleotide H2O H+ O2 FMNH2 12- Hydroxynevirapine H2O Flavin Mononucleotide H+ NAD NADH H+ H2O NAD NADH H+ Heme Heme Heme Heme Heme Heme Zinc Excretion Endoplasmic Reticulum Cytosol Intestinal Epithelial Cell Hepatocyte
Endoplasmic Reticulum SLC22A1 Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown CYP2C9 UGT1A9 CYP3A4 UGT1A9 CYP3A4 UGT1A9 CYP2B6 UGT1A9 CYP2B6 CYP3A4 ADH5 ALDH2 2- Hydroxynevirapine glucuronide 3- Hydroxynevirapine glucuronide 8- Hydroxynevirapine glucuronide 12- Hydroxynevirapine glucuronide 4- Carboxynevirapine Nevirapine Nevirapine Nevirapine Nevirapine Nevirapine 12- Hydroxynevirapine 12- Hydroxynevirapine 12- Hydroxynevirapine metabolite 12- Hydroxynevirapine metabolite 4- Carboxynevirapine 4- Carboxynevirapine 3- Hydroxynevirapine glucuronide 8- Hydroxynevirapine glucuronide 2- Hydroxynevirapine glucuronide 12- Hydroxynevirapine glucuronide Oxygen FMNH2 Water Flavin Mononucleotide Hydrogen Ion Uridine diphosphate glucuronic acid Hydrogen Ion Uridine 5'-diphosphate Oxygen FMNH2 2- Hydroxynevirapine Water Hydrogen Ion Flavin Mononucleotide Uridine diphosphate glucuronic acid Uridine 5'-diphosphate Hydrogen Ion FMNH2 Oxygen 8- Hydroxynevirapine Water Hydrogen Ion Flavin Mononucleotide Uridine diphosphate glucuronic acid Uridine 5'-diphosphate Hydrogen Ion FMNH2 Oxygen 3- Hydroxynevirapine Flavin Mononucleotide Water Hydrogen Ion Uridine diphosphate glucuronic acid Uridine 5'-diphosphate Hydrogen Ion FMNH2 Oxygen 3- Hydroxynevirapine Flavin Mononucleotide Water Hydrogen Ion Oxygen FMNH2 12- Hydroxynevirapine Water Flavin Mononucleotide Hydrogen Ion NAD NADH Hydrogen Ion Water NAD NADH Hydrogen Ion Excretion
SLC22A1 CYP2C9 UGT1A9 CYP3A4 UGT1A9 CYP3A4 UGT1A9 CYP2B6 UGT1A9 CYP2B6 CYP3A4 ADH5 ALDH2 2hng 3HnpGlu 8HnG 12HG 4-Cnevp Nevi Nevi Nevi Nevi Nevi 12-Hnvp 12-Hnvp 12-Hy m 12-Hy m 4-Cnevp 4-Cnevp 3HnpGlu 8HnG 2hng 12HG O2 FMNH2 H2O FlvnMnt H+ UDPGlcA H+ UDP O2 FMNH2 2HN H2O H+ FlvnMnt UDPGlcA UDP H+ FMNH2 O2 8Hn H2O H+ FlvnMnt UDPGlcA UDP H+ FMNH2 O2 3-HNevp FlvnMnt H2O H+ UDPGlcA UDP H+ FMNH2 O2 3-HNevp FlvnMnt H2O H+ O2 FMNH2 12-Hnvp H2O FlvnMnt H+ NAD NADH H+ H2O NAD NADH H+ Heme Heme Heme Heme Heme Heme Zinc Excre Endoplasmic Reticulum Cytosol Intestinal Epithelial Cell Hepatocyte
Endoplasmic Reticulum SLC22A1 CYP2C9 UGT1A9 CYP3A4 UGT1A9 CYP3A4 UGT1A9 CYP2B6 UGT1A9 CYP2B6 CYP3A4 ADH5 ALDH2 2hng 3HnpGlu 8HnG 12HG 4-Cnevp Nevi Nevi Nevi Nevi Nevi 12-Hnvp 12-Hnvp 12-Hy m 12-Hy m 4-Cnevp 4-Cnevp 3HnpGlu 8HnG 2hng 12HG O2 FMNH2 H2O FlvnMnt H+ UDPGlcA H+ UDP O2 FMNH2 2HN H2O H+ FlvnMnt UDPGlcA UDP H+ FMNH2 O2 8Hn H2O H+ FlvnMnt UDPGlcA UDP H+ FMNH2 O2 3-HNevp FlvnMnt H2O H+ UDPGlcA UDP H+ FMNH2 O2 3-HNevp FlvnMnt H2O H+ O2 FMNH2 12-Hnvp H2O FlvnMnt H+ NAD NADH H+ H2O NAD NADH H+ Excre