Loader
Loading Pathway...
Solute carrier family 22 member 1 Canalicular multispecific organic anion transporter 2 (S)-Nicotine delta-1',5'- iminium ion transporter 2'- Hydroxynicotine transporter Nicotine glucuronide transporter Nornicotine transporter 4- (Methylnitrosamino)- 1-(3- pyridyl)-1- butanol trransporter N- Methylnicotinium transporter Nicotine-1'- N-oxide transporter Cotinine transporter Norcotinine transporter Hydroxycotinine transporter Cotinine glucuronide transporter Cotinine N-oxide transporter 4- (Methylnitrosamino)- 1-(3- pyridyl)-1- butanone transporter Cytochrome P450 2A6 Dimethylaniline monooxygenase [N-oxide- forming] 3 Cytochrome P450 2A6 UDP- glucuronosyltransferase 1-4 Cytochrome P450 2A6 Unknown Unknown Unknown Cytochrome P450 2A6 Cytochrome P450 2A6 Aldehyde oxidase Cytochrome P450 2A6 UDP- glucuronosyltransferase 1-4 Cytochrome P450 1A2 N- Methylnicotinium Cotinine Nicotine Nicotine-1'- N-oxide Nicotine glucuronide Nornicotine Norcotinine Cotinine N-oxide Cotinine glucuronide Hydroxycotinine 2'- Hydroxynicotine 4- (Methylnitrosamino)- 1-(3- pyridyl)-1- butanone 4- (Methylnitrosamino)- 1-(3- pyridyl)-1- butanol (S)-Nicotine delta-1',5'- iminium ion Nicotine Nicotine Nicotine (S)-Nicotine delta-1',5'- iminium ion 2'- Hydroxynicotine Nicotine glucuronide Nornicotine 4- (Methylnitrosamino)- 1-(3- pyridyl)-1- butanol N- Methylnicotinium Nicotine-1'- N-oxide Cotinine Norcotinine Hydroxycotinine Cotinine glucuronide Cotinine N-oxide 4- (Methylnitrosamino)- 1-(3- pyridyl)-1- butanone O2 FMNH2 H2O Flavin Mononucleotide H+ O2 NADPH H+ H2O NADP Uridine diphosphate glucuronic acid Uridine 5'-diphosphate H+ Nicotine imine H+ O2 NADH H2O Formaldehyde NAD H2O O2 H2O2 H+ O2 NADPH H+ H2O NADP Uridine diphosphate glucuronic acid Uridine 5'-diphosphate Heme FAD Heme Heme Heme Heme Heme Excretion Heme FAD Molybdopterin 2Fe-2S Cytosol Hepatocyte Endoplasmic Reticulum
Endoplasmic Reticulum SLC22A1 ABCC3 Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown CYP2A6 FMO3 CYP2A6 UGT1A4 CYP2A6 Unknown Unknown Unknown CYP2A6 CYP2A6 AOX1 CYP2A6 UGT1A4 CYP1A2 N- Methylnicotinium Cotinine Nicotine Nicotine-1'- N-oxide Nicotine glucuronide Nornicotine Norcotinine Cotinine N-oxide Cotinine glucuronide Hydroxycotinine 2'- Hydroxynicotine 4- (Methylnitrosamino)- 1-(3- pyridyl)-1- butanone 4- (Methylnitrosamino)- 1-(3- pyridyl)-1- butanol (S)-Nicotine delta-1',5'- iminium ion Nicotine Nicotine Nicotine (S)-Nicotine delta-1',5'- iminium ion 2'- Hydroxynicotine Nicotine glucuronide Nornicotine 4- (Methylnitrosamino)- 1-(3- pyridyl)-1- butanol N- Methylnicotinium Nicotine-1'- N-oxide Cotinine Norcotinine Hydroxycotinine Cotinine glucuronide Cotinine N-oxide 4- (Methylnitrosamino)- 1-(3- pyridyl)-1- butanone Oxygen FMNH2 Water Flavin Mononucleotide Hydrogen Ion Oxygen NADPH Hydrogen Ion Water NADP Uridine diphosphate glucuronic acid Uridine 5'-diphosphate Hydrogen Ion Nicotine imine Hydrogen Ion Oxygen NADH Water Formaldehyde NAD Water Oxygen Hydrogen peroxide Hydrogen Ion Oxygen NADPH Hydrogen Ion Water NADP Uridine diphosphate glucuronic acid Uridine 5'-diphosphate Excretion
SLC22A1 ABCC3 CYP2A6 FMO3 CYP2A6 UGT1A4 CYP2A6 CYP2A6 CYP2A6 AOX1 CYP2A6 UGT1A4 CYP1A2 NM Cotinin Nicot Nc-1-NO NictGlu Nornico Norctin CotnN-O CotGluA HCotin 2H 4-M-1-3 Nnal S-N d-1 Nicot Nicot Nicot S-N d-1 2H NictGlu Nornico Nnal NM Nc-1-NO Cotinin Norctin HCotin CotGluA CotnN-O 4-M-1-3 O2 FMNH2 H2O FlvnMnt H+ O2 NADPH H+ H2O NADP UDPGlcA UDP H+ Nicotim H+ O2 NADH H2O Formol NAD H2O O2 H2O2 H+ O2 NADPH H+ H2O NADP UDPGlcA UDP Heme FAD Heme Heme Heme Heme Heme Excre Heme FAD mlyBdpn 2Fe2S Cytosol Hepatocyte Endoplasmic Reticulum
Endoplasmic Reticulum SLC22A1 ABCC3 CYP2A6 FMO3 CYP2A6 UGT1A4 CYP2A6 CYP2A6 CYP2A6 AOX1 CYP2A6 UGT1A4 CYP1A2 NM Cotinin Nicot Nc-1-NO NictGlu Nornico Norctin CotnN-O CotGluA HCotin 2H 4-M-1-3 Nnal S-N d-1 Nicot Nicot Nicot S-N d-1 2H NictGlu Nornico Nnal NM Nc-1-NO Cotinin Norctin HCotin CotGluA CotnN-O 4-M-1-3 O2 FMNH2 H2O FlvnMnt H+ O2 NADPH H+ H2O NADP UDPGlcA UDP H+ Nicotim H+ O2 NADH H2O Formol NAD H2O O2 H2O2 H+ O2 NADPH H+ H2O NADP UDPGlcA UDP Excre