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Acetyl-CoA acetyltransferase, cytosolic Mevalonate kinase Phosphomevalonate kinase Diphosphomevalonate decarboxylase Isopentenyl- diphosphate Delta-isomerase 1 Farnesyl pyrophosphate synthase Geranylgeranyl pyrophosphate synthase Farnesyl pyrophosphate synthase Geranylgeranyl pyrophosphate synthase Squalene synthase Squalene monooxygenase Lanosterol synthase Delta(24)- sterol reductase Lanosterol 14-alpha demethylase Lamin-B receptor Delta(24)- sterol reductase Methylsterol monooxygenase 1 Sterol-4- alpha- carboxylate 3- dehydrogenase, decarboxylating 3-keto-steroid reductase 3-beta- hydroxysteroid- Delta(8),Delta(7)- isomerase Delta(24)- sterol reductase Delta(24)- sterol reductase 3-beta- hydroxysteroid- Delta(8),Delta(7)- isomerase 3-beta- hydroxysteroid- Delta(8),Delta(7)- isomerase Lathosterol oxidase Delta(24)- sterol reductase Delta(24)- sterol reductase 3-hydroxy-3- methylglutaryl- coenzyme A reductase Sterol O- acyltransferase 1 Lysosomal acid lipase/cholesteryl ester hydrolase Acetoacetyl-CoA Acetyl-CoA Cholesterol CoA H2O 3-Hydroxy-3-methylglutaryl-CoA CoA Mevalonic acid ATP Mevalonic acid-5P ADP ATP ADP (R)-5-Diphosphomevalonic acid ATP ADP Pi Isopentenyl pyrophosphate CO2 Dimethylallylpyrophosphate Geranyl-PP PPi Farnesyl pyrophosphate PPi NADPH Squalene NADP PPi O2 NADPH (S)-2,3-Epoxysqualene H2O NADP Lanosterol NADPH 24,25-Dihydrolanosterol NADP O2 NADPH 4,4-Dimethylcholesta- 8,14,24-trienol Formic acid NADP H2O NADPH 4,4-Dimethyl-5a-cholesta- 8,24-dien-3-b-ol NADP NADPH 4,4-Dimethyl-5a-cholesta-8- en-3b-ol NADP NADPH O2 4a-Methylzymosterol-4- carboxylic acid NADP H2O NADP 3-Keto-4-methylzymosterol NADPH CO2 NADPH 4a-Methylzymosterol NADP Zymosterol intermediate 2 5a-Cholesta-7,24-dien-3b-ol NADPH 5a-Cholest-8-en-3b-ol NADP NADPH Lathosterol NADP 7-Dehydrodesmosterol 7-Dehydrocholesterol NADPH NADP Desmosterol NADPH O2 NADP H2O NADPH NADP NADPH NADP Vitamin D3 8-Dehydrocholesterol NADPH NADP CoA Fatty acid Cholesterol Ester H2O Fatty acid H2O Magnesium Magnesium Magnesium Magnesium Magnesium Magnesium FAD FAD Heme FAD Iron FAD FAD Iron FAD FAD Butyrate Metabolism Pyruvate Metabolism Valine, Leucine, and Isoleucine Degradation Tryptophan Metabolism Pyruvate Metabolism Fatty Acid Metabolism Steroidogenesis Bile Acid Biosynthesis Endoplasmic Reticulum Peroxisome Peroxisome Intracellular Space Extracellular Space Endoplasmic Reticulum Lysosome hv Spontaneous isomeration