Organophosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 9477

Myosin light chain kinase, smooth muscle
type: ProteinReference
xref: Reference/UniProt Q15746
organism: Homo sapiens

Compound/PW C000714 Synapse/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetylcholine
stoichiometric coefficient: 1.0

Acetic acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15366
xref: Reference/BioCyc ACET
xref: Reference/CAS 64-19-7
xref: Reference/KEGG Compound C00033
xref: Reference/ChemSpider 171
xref: Reference/HMDB HMDB0000042
xref: Reference/PubChem-compound 176
chemical formula: C2H4O2
molecular weight: 60.02113
structure: ChemicalStructure/PW C000029

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Interaction4155
type: MolecularInteraction
interaction type: direct_interaction
name: Atropine inhibits Muscarinic acetylcholine receptor M3
participant: Muscarinic acetylcholine receptor M3
participant: Atropine

ReactionCatalysis207644
type: Catalysis
controller: Acetylcholinesterase
controlled: Reaction218289
control type: ACTIVATION

L type Calcium channel
type: Complex
component stoichiometry: Protein/2712 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/2720 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/2706 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Voltage-dependent P/Q-type calcium channel subunit alpha-1A
component: Voltage-dependent L-type calcium channel subunit beta-1
component: Voltage-dependent calcium channel subunit alpha-2/delta-2

direct_interaction
type: InteractionVocabulary

Reference/HMDB HMDB0000895
type: UnificationXref
id: HMDB0000895
db: HMDB

Reference/CAS 64-19-7
type: UnificationXref
id: 64-19-7
db: CAS

Reference/GENE ONTOLOGY GO 0070382
type: UnificationXref
id: GO:0070382
db: GENE ONTOLOGY

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Reference/HMDB HMDB0000097
type: UnificationXref
id: HMDB0000097
db: HMDB

Serine/threonine-protein phosphatase PP1-beta catalytic subunit
type: Protein
cellular location: Cytosol
entity reference: Serine/threonine-protein phosphatase PP1-beta catalytic subunit

Voltage-dependent P/Q-type calcium channel subunit alpha-1A
type: Protein
cellular location: Cytosol
entity reference: Voltage-dependent P/Q-type calcium channel subunit alpha-1A

Acetylcholine
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15355
xref: Reference/CAS 51-84-3
xref: Reference/HMDB HMDB0000895
xref: Reference/ChemSpider 182
xref: Reference/KEGG Compound C01996
xref: Reference/BioCyc ACETYLCHOLINE
xref: Reference/PubChem-compound 187
chemical formula: C7H16NO2
molecular weight: 146.1181
structure: ChemicalStructure/PW C000714

Calcium
type: SmallMolecule
cellular location: Cytosol
entity reference: Calcium

ChemicalStructure/PW C097005
type: ChemicalStructure
structure format: SMILES

Compound/PW C001420 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/GENE ONTOLOGY GO 0016529
type: UnificationXref
id: GO:0016529
db: GENE ONTOLOGY

Voltage-dependent calcium channel subunit alpha-2/delta-2
type: Protein
cellular location: Cytosol
entity reference: Voltage-dependent calcium channel subunit alpha-2/delta-2

Reference/HMDB HMDB0014712
type: UnificationXref
id: HMDB0014712
db: HMDB

Reference/SMPDB SMP0125413
type: UnificationXref
id: SMP0125413
db: SMPDB

L type Calcium channel
type: Complex
component stoichiometry: Protein/2720/Stoichiometry/1.0
component stoichiometry: Protein/2706/Stoichiometry/2.0
component stoichiometry: Protein/2712/Stoichiometry/1.0
component: Voltage-dependent calcium channel subunit alpha-2/delta-2
component: Voltage-dependent L-type calcium channel subunit beta-1
component: Voltage-dependent P/Q-type calcium channel subunit alpha-1A

Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Reference/CELL TYPE ONTOLOGY CL 0000187
type: UnificationXref
id: CL:0000187
db: CELL TYPE ONTOLOGY

Protein/2720 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Voltage-dependent L-type calcium channel subunit beta-1
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16595
type: UnificationXref
id: CHEBI:16595
db: ChEBI

Interaction3528
type: MolecularInteraction
interaction type: direct_interaction
name: Gq protein signaling cascade activates Phospholipase C
participant: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
participant: Guanine nucleotide-binding protein G(q) subunit alpha

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Sarcoplasmic Reticulum
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0016529

Reference/UniProt Q9NQ66
type: UnificationXref
id: Q9NQ66
db: UniProt

Reference/PathWhiz PW126961
type: UnificationXref
id: PW126961
db: PathWhiz

Reference/UniProt P20309
type: UnificationXref
id: P20309
db: UniProt

Atropine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0014712
xref: Reference/KEGG Compound C01479
xref: Reference/CAS 51-55-8
xref: Reference/ChEBI CHEBI 16684
xref: Reference/ChemSpider 10194105
chemical formula: C17H23NO3
molecular weight: 289.1678
structure: ChemicalStructure/PW C009065

Reference/BRENDA TISSUE ONTOLOGY BTO 0000887
type: UnificationXref
id: BTO:0000887
db: BRENDA TISSUE ONTOLOGY

Reference/CAS 85166-31-0
type: UnificationXref
id: 85166-31-0
db: CAS

Muscarinic acetylcholine receptor M3
type: Protein
cellular location: Cell Membrane
entity reference: Muscarinic acetylcholine receptor M3

Reference/BioCyc ACETYLCHOLINE
type: UnificationXref
id: ACETYLCHOLINE
db: BioCyc

Compound/Generic369 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Diacylglycerol
stoichiometric coefficient: 1.0

Protein kinase C alpha type
type: ProteinReference
xref: Reference/UniProt P17252
organism: Homo sapiens

TransportCatalysis4984
type: Catalysis
controller: Inositol 1,4,5-trisphosphate receptor type 1
controlled: Transport14002
control type: ACTIVATION

Interaction242
type: MolecularInteraction
interaction type: direct_interaction
name: Inositol 1,4,5-trisphosphate activates Inositol 1,4,5-trisphosphate receptor type 1
participant: Inositol 1,4,5-trisphosphate
participant: Inositol 1,4,5-trisphosphate receptor type 1

Inositol 1,4,5-trisphosphate receptor type 1
type: Protein
entity reference: Inositol 1,4,5-trisphosphate receptor type 1

Interaction3995
type: MolecularInteraction
interaction type: direct_interaction
name: Muscarinic acetylcholine receptor M3 activates Gq protein signaling cascade
participant: Muscarinic acetylcholine receptor M3
participant: Guanine nucleotide-binding protein G(q) subunit alpha

Compound/PW C097005 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphatidylinositol 4,5-bisphosphate
stoichiometric coefficient: 1.0

Protein/1597 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calmodulin-1
stoichiometric coefficient: 1.0

Interaction3990
type: MolecularInteraction
interaction type: direct_interaction
name: Protein kinase C activates L type Calcium channel
participant: Protein kinase C alpha type
participant: L type Calcium channel

Protein/2712/Stoichiometry/1.0
type: Stoichiometry
physical entity: Voltage-dependent P/Q-type calcium channel subunit alpha-1A
stoichiometric coefficient: 1.0

Compound/PW C009065 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Atropine
stoichiometric coefficient: 1.0

SubPathwayInteraction118211
type: Interaction
name: SubPathwayReaction
name: SubPathway118211Reaction
participant: Myosin light chain 3

Reference/ChemSpider 10194105
type: UnificationXref
id: 10194105
db: ChemSpider

SubPathwayInteraction118212
type: Interaction
name: SubPathwayReaction
name: SubPathway118212Reaction
participant: Myosin light chain 3

Reference/UniProt P62140
type: UnificationXref
id: P62140
db: UniProt

Reference/ChemSpider 266
type: UnificationXref
id: 266
db: ChemSpider

Vesicular acetylcholine transporter
type: Protein
entity reference: Vesicular acetylcholine transporter

Compound/PW C000714 Exocytic Vesicle/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetylcholine
stoichiometric coefficient: 1.0

ReactionCatalysis207193
type: Catalysis
controller: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
controlled: 3.1.4.11
control type: ACTIVATION

Protein/2712 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Voltage-dependent P/Q-type calcium channel subunit alpha-1A
stoichiometric coefficient: 1.0

Reference/UniProt P17252
type: UnificationXref
id: P17252
db: UniProt

Atropine Action Pathway
type: Pathway
pathway order: PathwayTransport/2510270
pathway order: PathwayTransport/2510251
pathway order: PathwayTransport/2510271
pathway order: PathwayTransport/2510250
pathway order: PathwayInteraction/509
pathway order: PathwayEnzymeReaction/2510273
pathway order: PathwayInteraction/2849
pathway order: PathwayInteraction/2828
pathway order: PathwayEnzymeReaction/2510246
pathway order: PathwayEnzymeReaction/2510247
pathway order: PathwayEnzymeReaction/2510269
pathway order: PathwayEnzymeReaction/2510248
pathway order: PathwayInteraction/3528
pathway order: PathwayEnzymeReaction/2510249
pathway order: PathwaySubPathway/118211
pathway order: PathwayInteraction/3995
pathway order: PathwaySubPathway/118212
pathway order: PathwayInteraction/242
pathway order: PathwayTransport/2531439
pathway order: PathwayInteraction/3990
pathway order: PathwayInteraction/4155
pathway order: PathwayInteraction/4572
pathway component: TransportCatalysis2234
pathway component: 3.1.4.11
pathway component: Interaction4155
pathway component: ReactionCatalysis207644
pathway component: Interaction4572
pathway component: ReactionCatalysis203360
pathway component: Interaction3528
pathway component: Transport14421
pathway component: Transport14002
pathway component: Transport14422
pathway component: Transport15554
pathway component: Transport11095
pathway component: ReactionCatalysis507
pathway component: Muscle Contraction
pathway component: TransportCatalysis5283
pathway component: Muscle Relaxation
pathway component: Reaction213775
pathway component: 3.1.3.16
pathway component: 2.3.1.6
pathway component: TransportCatalysis4984
pathway component: Interaction242
pathway component: ReactionCatalysis203359
pathway component: Interaction3995
pathway component: Reaction218289
pathway component: Interaction3990
pathway component: Reaction213774
pathway component: Interaction509
pathway component: Interaction2849
pathway component: ReactionCatalysis207193
pathway component: Interaction2828
xref: Reference/SMPDB SMP0125413
xref: Reference/PathWhiz PW126961
organism: Homo sapiens

Voltage-dependent L-type calcium channel subunit beta-1
type: Protein
cellular location: Cytosol
entity reference: Voltage-dependent L-type calcium channel subunit beta-1

Inositol 1,4,5-trisphosphate receptor type 1
type: Complex
component stoichiometry: Protein/2126 Cytosol/Stoichiometry/4.0
cellular location: Cytosol
component: Inositol 1,4,5-trisphosphate receptor type 1

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Calmodulin-1
type: ProteinReference
xref: Reference/UniProt P0DP23
organism: Homo sapiens

Compound/PW C001155 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Inositol 1,4,5-trisphosphate
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00114
type: UnificationXref
id: C00114
db: KEGG Compound

Choline O-acetyltransferase
type: ProteinReference
xref: Reference/UniProt P28329
organism: BiologicalState1060

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
type: Protein
cellular location: Cytosol
entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1

Protein/2126 Cytosol/Stoichiometry/4.0
type: Stoichiometry
physical entity: Inositol 1,4,5-trisphosphate receptor type 1
stoichiometric coefficient: 4.0

Compound/PW C000353 Sarcoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Reference/GENE ONTOLOGY GO 0005886
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

ReactionCatalysis507
type: Catalysis
controller: Choline O-acetyltransferase
controlled: 2.3.1.6
control type: ACTIVATION

Reference/UniProt P28329
type: UnificationXref
id: P28329
db: UniProt

Reference/BioCyc inositol 1,4,5-trisphosphate
type: UnificationXref
id: inositol_1,4,5-trisphosphate
db: BioCyc

BiologicalState71
type: BioSource
cell type: Neuron
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Neuron

ChemicalStructure/PW C009065
type: ChemicalStructure
structure format: SMILES

Reference/BRENDA TISSUE ONTOLOGY BTO 0001832
type: UnificationXref
id: BTO:0001832
db: BRENDA TISSUE ONTOLOGY

Compound/PW C000714 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetylcholine
stoichiometric coefficient: 1.0

Voltage-dependent calcium channel subunit alpha-2/delta-2
type: Protein
entity reference: Voltage-dependent calcium channel subunit alpha-2/delta-2

Choline
type: SmallMolecule
cellular location: Cytosol
entity reference: Choline

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/UniProt Q9NY47
type: UnificationXref
id: Q9NY47
db: UniProt

Reference/ChemSpider 388562
type: UnificationXref
id: 388562
db: ChemSpider

Reference/HMDB HMDB0000464
type: UnificationXref
id: HMDB0000464
db: HMDB

Myocyte
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000187

Reference/UniProt P50148
type: UnificationXref
id: P50148
db: UniProt

Reference/PubChem-compound 24742074
type: UnificationXref
id: 24742074
db: PubChem-compound

Guanine nucleotide-binding protein G(q) subunit alpha
type: Protein
cellular location: Cytoplasm
entity reference: Guanine nucleotide-binding protein G(q) subunit alpha

Muscle
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000887

Reference/CELL TYPE ONTOLOGY CL 0000540
type: UnificationXref
id: CL:0000540
db: CELL TYPE ONTOLOGY

Neuron
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000540

Muscarinic acetylcholine receptor M3
type: ProteinReference
xref: Reference/UniProt P20309
organism: BiologicalState1050

Voltage-dependent P/Q-type calcium channel subunit alpha-1A
type: Protein
entity reference: Voltage-dependent P/Q-type calcium channel subunit alpha-1A

Serine/threonine-protein phosphatase PP1-beta catalytic subunit
type: ProteinReference
xref: Reference/UniProt P62140
organism: Homo sapiens

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Phosphatidylinositol 4,5-bisphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Phosphatidylinositol 4,5-bisphosphate

Reference/CAS 14127-61-8
type: UnificationXref
id: 14127-61-8
db: CAS

ChemicalStructure/PW C000353
type: ChemicalStructure
structure format: SMILES
structure data: [Ca++]

Muscle Contraction
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway118211
pathway component: SubPathwayInteraction118211
name: SubPathway

Muscle Relaxation
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway118212
pathway component: SubPathwayInteraction118212
name: SubPathway

BiologicalState933
type: BioSource
cell type: Myocyte
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Muscle, Myocyte
tissue: Muscle

Calcium
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Calcium

Reference/BioCyc CPD-563
type: UnificationXref
id: CPD-563
db: BioCyc

Reference/UniProt Q16572
type: UnificationXref
id: Q16572
db: UniProt

Reference/UniProt P0DP23
type: UnificationXref
id: P0DP23
db: UniProt

Voltage-dependent L-type calcium channel subunit beta-1
type: Protein
entity reference: Voltage-dependent L-type calcium channel subunit beta-1

Phosphatidylinositol 4,5-bisphosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 24742074
chemical formula: C47H80O19P3
molecular weight: 1041.4507
structure: ChemicalStructure/PW C097005

Calmodulin-1
type: Protein
cellular location: Cytosol
entity reference: Calmodulin-1

Reference/KEGG Compound C01479
type: UnificationXref
id: C01479
db: KEGG Compound

Reference/CAS 51-55-8
type: UnificationXref
id: 51-55-8
db: CAS

Protein kinase C alpha type
type: Protein
cellular location: Cytosol
entity reference: Protein kinase C alpha type

Acetylcholinesterase
type: ProteinReference
xref: Reference/UniProt P22303
organism: BiologicalState1060

Inositol 1,4,5-trisphosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001498
xref: Reference/PubChem-compound 439456
xref: Reference/CAS 85166-31-0
xref: Reference/BioCyc inositol 1,4,5-trisphosphate
xref: Reference/KEGG Compound C01245
xref: Reference/ChEBI CHEBI 16595
xref: Reference/ChemSpider 388562
chemical formula: C6H15O15P3
molecular weight: 419.96237
structure: ChemicalStructure/PW C001155

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Reference/BioCyc ACET
type: UnificationXref
id: ACET
db: BioCyc

Reference/ChEBI CHEBI 29108
type: UnificationXref
id: CHEBI:29108
db: ChEBI

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

Compound/PW C000065 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Choline
stoichiometric coefficient: 1.0

Choline
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15354
xref: Reference/ChemSpider 299
xref: Reference/BioCyc CPD-563
xref: Reference/PubChem-compound 305
xref: Reference/CAS 62-49-7
xref: Reference/HMDB HMDB0000097
xref: Reference/KEGG Compound C00114
chemical formula: C5H14NO
molecular weight: 104.10754
structure: ChemicalStructure/PW C000065

Compound/PW C000029 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetic acid
stoichiometric coefficient: 1.0

Acetylcholine
type: SmallMolecule
cellular location: Synapse
entity reference: Acetylcholine

Reference/UniProt Q14643
type: UnificationXref
id: Q14643
db: UniProt

Inositol 1,4,5-trisphosphate receptor type 1
type: ProteinReference
xref: Reference/UniProt Q14643

Reference/KEGG Compound C00033
type: UnificationXref
id: C00033
db: KEGG Compound

Reference/UniProt P08590
type: UnificationXref
id: P08590
db: UniProt

Reference/KEGG Compound C01245
type: UnificationXref
id: C01245
db: KEGG Compound

Transport14002
type: Transport
participant stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353 Sarcoplasmic Reticulum/Stoichiometry/1.0
right: Calcium
spontaneous: false
left: Calcium
name: Calcium (→) Transport: Homo sapiens, Cell, Sarcoplasmic Reticulum to Homo sapiens, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Reference/UniProt P22303
type: UnificationXref
id: P22303
db: UniProt

Inositol 1,4,5-trisphosphate receptor type 1
type: Complex
component stoichiometry: Protein/2126/Stoichiometry/4.0
component: Inositol 1,4,5-trisphosphate receptor type 1

Acetylcholine
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Acetylcholine

Transport11095
type: Transport
participant stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
right: Calcium
spontaneous: false
left: Calcium
name: Calcium (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Protein/2706 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Voltage-dependent calcium channel subunit alpha-2/delta-2
stoichiometric coefficient: 2.0

Eye
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000439

Acetylcholinesterase
type: Protein
cellular location: Extracellular Space
entity reference: Acetylcholinesterase

Diacylglycerol
type: SmallMolecule
cellular location: Cytosol
entity reference: Diacylglycerol

2.3.1.6
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000065 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000714 Cytosol/Stoichiometry/1.0
right: Acetylcholine
spontaneous: false
EC number: 2.3.1.6
left: Choline
name: Choline → Acetylcholine
conversion direction: LEFT_TO_RIGHT

BiologicalState1050
type: BioSource
cell type: Myocyte
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Eye, Myocyte
tissue: Eye

Compound/PW C000353 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Diacylglycerol
type: SmallMoleculeReference

Acetylcholine
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Acetylcholine

ChemicalStructure/PW C001155
type: ChemicalStructure
structure format: SMILES

Reference/UniProt Q02641
type: UnificationXref
id: Q02641
db: UniProt

Muscarinic acetylcholine receptor M3
type: Protein
cellular location: Extracellular Space
entity reference: Muscarinic acetylcholine receptor M3

ChemicalStructure/PW C000065
type: ChemicalStructure
structure format: SMILES
structure data: C[N+](C)(C)CCO

Interaction509
type: MolecularInteraction
interaction type: direct_interaction
name: Diacylglycerol activates Protein kinase C
participant: Diacylglycerol
participant: Protein kinase C alpha type

Protein/2126/Stoichiometry/4.0
type: Stoichiometry
physical entity: Inositol 1,4,5-trisphosphate receptor type 1
stoichiometric coefficient: 4.0

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

Compound/PW C000714 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetylcholine
stoichiometric coefficient: 1.0

Reference/UniProt Q15746
type: UnificationXref
id: Q15746
db: UniProt

Reference/CAS 51-84-3
type: UnificationXref
id: 51-84-3
db: CAS

BiologicalState1060
type: BioSource
cell type: Neuron
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Sympathetic Nervous System, Neuron
tissue: Sympathetic Nervous System

Vesicular acetylcholine transporter
type: ProteinReference
xref: Reference/UniProt Q16572

BoundComplex/506 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium_Calmodulin (Homo sapiens)
stoichiometric coefficient: 1.0

Inositol 1,4,5-trisphosphate receptor type 1
type: Protein
cellular location: Cytosol
entity reference: Inositol 1,4,5-trisphosphate receptor type 1

Reference/PubChem-compound 305
type: UnificationXref
id: 305
db: PubChem-compound

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

ChemicalStructure/PW C000029
type: ChemicalStructure
structure format: SMILES
structure data: CC(O)=O

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Interaction4572
type: MolecularInteraction
interaction type: direct_interaction
name: Organophosphate inhibits Acetylcholinesterase
participant: Organophosphate
participant: Acetylcholinesterase

Reference/PubChem-compound 439456
type: UnificationXref
id: 439456
db: PubChem-compound

Transport15554
type: Transport
participant stoichiometry: Compound/PW C009065/Stoichiometry/1.0
participant stoichiometry: Compound/PW C009065 Extracellular Space/Stoichiometry/1.0
right: Atropine
spontaneous: false
left: Atropine
name: Atropine (→) Transport: Homo sapiens, Blood Vessel to Homo sapiens, Muscle, Myocyte, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Exocytic Vesicle
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0070382

Sympathetic Nervous System
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0001832

Water
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Water

Voltage-dependent calcium channel subunit alpha-2/delta-2
type: ProteinReference
xref: Reference/UniProt Q9NY47

Reaction213775
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
participant stoichiometry: BoundComplex/506 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/1597 Cytosol/Stoichiometry/1.0
right: Calcium_Calmodulin (Homo sapiens)
spontaneous: false
left: Calcium
left: Calmodulin-1
name: Calcium + Calmodulin → Calcium + Calmodulin (Homo sapiens)
conversion direction: LEFT_TO_RIGHT

3.1.3.16
type: BiochemicalReaction
participant stoichiometry: Protein/3041 Cytosol/Stoichiometry/1.0
right: Myosin light chain 3
spontaneous: false
EC number: 3.1.3.16
left: Myosin light chain 3
name: Myosin LC-P → Myosin light chain 3
conversion direction: LEFT_TO_RIGHT

Protein/3041 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Myosin light chain 3
stoichiometric coefficient: 1.0

Voltage-dependent P/Q-type calcium channel subunit alpha-1A
type: ProteinReference
xref: Reference/UniProt O00555

Muscarinic acetylcholine receptor M3
type: Protein
cellular location: Cytoplasm
entity reference: Muscarinic acetylcholine receptor M3

Guanine nucleotide-binding protein G(q) subunit alpha
type: ProteinReference
xref: Reference/UniProt P50148
organism: Homo sapiens

ChemicalStructure/PW C000714
type: ChemicalStructure
structure format: SMILES
structure data: CC(=O)OCC[N+](C)(C)C

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
type: ProteinReference
xref: Reference/UniProt Q9NQ66
organism: Homo sapiens

Reaction213774
type: BiochemicalReaction
participant stoichiometry: Protein/3041 Cytosol/Stoichiometry/1.0
right: Myosin light chain 3
spontaneous: false
left: Myosin light chain 3
name: Myosin light chain 3 → Myosin LC-P
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0001498
type: UnificationXref
id: HMDB0001498
db: HMDB

Myosin light chain kinase, smooth muscle
type: Protein
cellular location: Cytosol
entity reference: Myosin light chain kinase, smooth muscle

Organophosphate
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Organophosphate

Acetylcholine
type: SmallMolecule
cellular location: Exocytic Vesicle
entity reference: Acetylcholine

Interaction2828
type: MolecularInteraction
interaction type: direct_interaction
name: Acetylcholine activates Muscarinic acetylcholine receptor M3
participant: Acetylcholine
participant: Muscarinic acetylcholine receptor M3

Reference/HMDB HMDB0000042
type: UnificationXref
id: HMDB0000042
db: HMDB

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/ChEBI CHEBI 15366
type: UnificationXref
id: CHEBI:15366
db: ChEBI

Voltage-dependent L-type calcium channel subunit beta-1
type: ProteinReference
xref: Reference/UniProt Q02641

Guanine nucleotide-binding protein G(q) subunit alpha
type: Protein
cellular location: Cytosol
entity reference: Guanine nucleotide-binding protein G(q) subunit alpha

Reference/KEGG Compound C00076
type: UnificationXref
id: C00076
db: KEGG Compound

3.1.4.11
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001155 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C097005 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/Generic369 Cytosol/Stoichiometry/1.0
right: Diacylglycerol
right: Inositol 1,4,5-trisphosphate
spontaneous: false
EC number: 3.1.4.11
left: Phosphatidylinositol 4,5-bisphosphate
name: Phosphatidylinositol 4,5-bisphosphate → Diacylglycerol + Inositol 1,4,5-trisphosphate
conversion direction: LEFT_TO_RIGHT

ReactionCatalysis203360
type: Catalysis
controller: Serine/threonine-protein phosphatase PP1-beta catalytic subunit
controlled: 3.1.3.16
control type: ACTIVATION

Reference/BioCyc CA+2
type: UnificationXref
id: CA%2b2
db: BioCyc

Reference/ChemSpider 299
type: UnificationXref
id: 299
db: ChemSpider

Protein/2720/Stoichiometry/1.0
type: Stoichiometry
physical entity: Voltage-dependent L-type calcium channel subunit beta-1
stoichiometric coefficient: 1.0

Calcium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000464
xref: Reference/BioCyc CA+2
xref: Reference/ChemSpider 266
xref: Reference/ChEBI CHEBI 29108
xref: Reference/CAS 14127-61-8
xref: Reference/KEGG Compound C00076
xref: Reference/PubChem-compound 271
chemical formula: Ca
molecular weight: 39.96259
structure: ChemicalStructure/PW C000353

Reference/ChemSpider 171
type: UnificationXref
id: 171
db: ChemSpider

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Atropine
type: SmallMolecule
entity reference: Atropine

TransportCatalysis5283
type: Catalysis
controller: Vesicular acetylcholine transporter
controlled: Transport14421
control type: ACTIVATION

Reference/UniProt O00555
type: UnificationXref
id: O00555
db: UniProt

Cell Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005886

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reaction218289
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000065 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000029 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000714 Extracellular Space/Stoichiometry/1.0
right: Acetic acid
right: Choline
spontaneous: false
left: Acetylcholine
left: Water
name: Acetylcholine + Water ↔ Acetic acid + Choline
conversion direction: REVERSIBLE

Reference/PubChem-compound 271
type: UnificationXref
id: 271
db: PubChem-compound

Choline O-acetyltransferase
type: Protein
cellular location: Cytosol
entity reference: Choline O-acetyltransferase

Interaction2849
type: MolecularInteraction
interaction type: direct_interaction
name: Calcium + Calmodulin (Homo sapiens) activates Myosin light chain kinase, smooth muscle
participant: Myosin light chain kinase, smooth muscle
participant: Calcium_Calmodulin (Homo sapiens)

Myosin light chain 3
type: Protein
cellular location: Cytosol
entity reference: Myosin light chain 3
name: SubPathwayInput

Acetylcholine
type: SmallMolecule
cellular location: Cytosol
entity reference: Acetylcholine

TransportCatalysis2234
type: Catalysis
controller: L type Calcium channel
controlled: Transport11095
control type: ACTIVATION

Reference/PubChem-compound 9477
type: UnificationXref
id: 9477
db: PubChem-compound

Reference/PubChem-compound 187
type: UnificationXref
id: 187
db: PubChem-compound

Transport14421
type: Transport
participant stoichiometry: Compound/PW C000714 Exocytic Vesicle/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000714 Cytosol/Stoichiometry/1.0
right: Acetylcholine
spontaneous: false
left: Acetylcholine
name: Acetylcholine (→) Transport: Homo sapiens, Sympathetic Nervous System, Neuron, Cytosol to Homo sapiens, Sympathetic Nervous System, Neuron, Exocytic Vesicle
conversion direction: LEFT_TO_RIGHT

Myosin light chain 3
type: ProteinReference
xref: Reference/UniProt P08590
organism: Homo sapiens

Transport14422
type: Transport
participant stoichiometry: Compound/PW C000714 Synapse/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000714 Exocytic Vesicle/Stoichiometry/1.0
right: Acetylcholine
spontaneous: true
left: Acetylcholine
name: Acetylcholine (→) Transport: Homo sapiens, Sympathetic Nervous System, Neuron, Exocytic Vesicle to Homo sapiens, Sympathetic Nervous System, Neuron, Synapse
conversion direction: REVERSIBLE

Acetic acid
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Acetic acid

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Protein/2706/Stoichiometry/2.0
type: Stoichiometry
physical entity: Voltage-dependent calcium channel subunit alpha-2/delta-2
stoichiometric coefficient: 2.0

Reference/GENE ONTOLOGY GO 0045202
type: UnificationXref
id: GO:0045202
db: GENE ONTOLOGY

Reference/ChEBI CHEBI 15355
type: UnificationXref
id: CHEBI:15355
db: ChEBI

Reference/ChEBI CHEBI 15354
type: UnificationXref
id: CHEBI:15354
db: ChEBI

Compound/PW C009065/Stoichiometry/1.0
type: Stoichiometry
physical entity: Atropine
stoichiometric coefficient: 1.0

Atropine
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Atropine

ReactionCatalysis203359
type: Catalysis
controller: Myosin light chain kinase, smooth muscle
controlled: Reaction213774
control type: ACTIVATION

Compound/PW C000065 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Choline
stoichiometric coefficient: 1.0

Reference/CAS 62-49-7
type: UnificationXref
id: 62-49-7
db: CAS

Reference/KEGG Compound C01996
type: UnificationXref
id: C01996
db: KEGG Compound

Reference/ChEBI CHEBI 16684
type: UnificationXref
id: CHEBI:16684
db: ChEBI

Reference/PubChem-compound 176
type: UnificationXref
id: 176
db: PubChem-compound

Calcium
type: SmallMolecule
cellular location: Sarcoplasmic Reticulum
entity reference: Calcium

Choline
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Choline

Inositol 1,4,5-trisphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Inositol 1,4,5-trisphosphate

Calcium_Calmodulin (Homo sapiens)
type: Complex
component stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/1597 Cytosol/Stoichiometry/1.0
cellular location: Cytosol
component: Calcium
component: Calmodulin-1

Reference/BRENDA TISSUE ONTOLOGY BTO 0000439
type: UnificationXref
id: BTO:0000439
db: BRENDA TISSUE ONTOLOGY

Reference/ChemSpider 182
type: UnificationXref
id: 182
db: ChemSpider

Synapse
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0045202