Reference/ChemSpider 17215925
type: UnificationXref
id: 17215925
db: ChemSpider

Reference/BioCyc CPD-535
type: UnificationXref
id: CPD-535
db: BioCyc

Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

Reference/PubChem-compound 923
type: UnificationXref
id: 923
db: PubChem-compound

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Transport14524
type: Transport
participant stoichiometry: Compound/PW C000077/Stoichiometry/1.0
right: D-Glucose
spontaneous: true
left: D-Glucose
name: D-Glucose (→) Transport: Homo sapiens to Homo sapiens, Intestine
conversion direction: REVERSIBLE

Sorbitol dehydrogenase
type: Complex
component stoichiometry: Protein/485 Cytosol/Stoichiometry/4.0
cellular location: Cytosol
component: Sorbitol dehydrogenase

Transport14525
type: Transport
participant stoichiometry: Compound/PW C000077 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000077/Stoichiometry/1.0
right: D-Glucose
spontaneous: false
left: D-Glucose
name: D-Glucose (→) Transport: Homo sapiens, Blood Vessel to Homo sapiens, Liver, Hepatocyte, Cytosol
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C00794
type: UnificationXref
id: C00794
db: KEGG Compound

Compound/PW C113289 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Fructose-3-phosphate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 439153
type: UnificationXref
id: 439153
db: PubChem-compound

TransportCatalysis94
type: Catalysis
controller: Sodium/glucose cotransporter 1
controlled: Transport121
control type: ACTIVATION

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Unknown
type: ProteinReference
organism: BiologicalState26

Transport121
type: Transport
participant stoichiometry: Compound/PW C000458/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000077/Stoichiometry/1.0
right: D-Glucose
right: Sodium
spontaneous: false
left: D-Glucose
left: Sodium
name: D-Glucose (→), Sodium (→) Transport: Homo sapiens, Intestine to Homo sapiens, Intestine, Epithelial Cell
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 439709
type: UnificationXref
id: 439709
db: PubChem-compound

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

ChemicalStructure/PW C000458
type: ChemicalStructure
structure format: SMILES
structure data: [Na+]

Compound/PW C000143 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Reference/PubChem-compound 5962
type: UnificationXref
id: 5962
db: PubChem-compound

Reference/CAS 53188-23-1
type: UnificationXref
id: 53188-23-1
db: CAS

Reference/CAS 14066-19-4
type: UnificationXref
id: 14066-19-4
db: CAS

Sorbitol
type: SmallMoleculeReference
xref: Reference/PubChem-compound 5780
xref: Reference/HMDB HMDB0000247
xref: Reference/ChEBI CHEBI 17924
xref: Reference/ChemSpider 5576
xref: Reference/CAS 50-70-4
xref: Reference/KEGG Compound C00794
chemical formula: C6H14O6
molecular weight: 182.07904
structure: ChemicalStructure/PW C000168

Reference/ChEBI CHEBI 15846
type: UnificationXref
id: CHEBI:15846
db: ChEBI

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

Reference/HMDB HMDB0000660
type: UnificationXref
id: HMDB0000660
db: HMDB

Fructose-3-phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Fructose-3-phosphate

Reference/ChemSpider 5747
type: UnificationXref
id: 5747
db: ChemSpider

Reference/CELL TYPE ONTOLOGY CL 0000182
type: UnificationXref
id: CL:0000182
db: CELL TYPE ONTOLOGY

Reference/CAS 53-59-8
type: UnificationXref
id: 53-59-8
db: CAS

Reference/BRENDA TISSUE ONTOLOGY BTO 0000759
type: UnificationXref
id: BTO:0000759
db: BRENDA TISSUE ONTOLOGY

Very long-chain acyl-CoA synthetase
type: ProteinReference
xref: Reference/UniProt O14975

NADH
type: SmallMolecule
cellular location: Cytosol
entity reference: NADH

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

Reference/ChEBI CHEBI 16474
type: UnificationXref
id: CHEBI:16474
db: ChEBI

Reference/BioCyc LYS
type: UnificationXref
id: LYS
db: BioCyc

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Fructosamine-3-kinase
type: Protein
cellular location: Cytosol
entity reference: Fructosamine-3-kinase

Reference/CAS 2280-44-6
type: UnificationXref
id: 2280-44-6
db: CAS

Reference/BioCyc ALPHA-GLUCOSE-16-BISPHOSPHATE
type: UnificationXref
id: ALPHA-GLUCOSE-16-BISPHOSPHATE
db: BioCyc

Reaction218144
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000077 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000168 Cytosol/Stoichiometry/1.0
right: Sorbitol
right: NADP
spontaneous: false
left: D-Glucose
left: Hydrogen Ion
left: NADPH
name: D-Glucose + Hydrogen Ion + NADPH ↔ NADP + Sorbitol
conversion direction: REVERSIBLE

Reference/ChEBI CHEBI 16908
type: UnificationXref
id: CHEBI:16908
db: ChEBI

Reference/PubChem-compound 130872
type: UnificationXref
id: 130872
db: PubChem-compound

ReactionCatalysis207515
type: Catalysis
controller: Aldose reductase
controlled: Reaction218144
control type: ACTIVATION

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

Schiff Base
type: SmallMoleculeReference
xref: Reference/PubChem-compound 86573619
chemical formula: C19H24N6O3
molecular weight: 384.19098
structure: ChemicalStructure/PW C113301

Schiff Base
type: SmallMolecule
entity reference: Schiff Base

ChemicalStructure/PW C113289
type: ChemicalStructure
structure format: SMILES
structure data: OCC(O)C(O)C(OP(O)(O)=O)C(=O)CO

NADPH
type: SmallMoleculeReference
xref: Reference/CAS 53-57-6
xref: Reference/HMDB HMDB0000221
xref: Reference/PubChem-compound 22833512
xref: Reference/BioCyc NADPH
xref: Reference/ChemSpider 17215925
xref: Reference/KEGG Compound C00005
xref: Reference/ChEBI CHEBI 16474
chemical formula: C21H30N7O17P3
molecular weight: 745.0911
structure: ChemicalStructure/PW C000146

NADP
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00006
xref: Reference/CAS 53-59-8
xref: Reference/BioCyc NAD(P)
xref: Reference/HMDB HMDB0000217
xref: Reference/ChEBI CHEBI 18009
xref: Reference/PubChem-compound 5886
xref: Reference/ChemSpider 5675
chemical formula: C21H28N7O17P3
molecular weight: 743.07544
structure: ChemicalStructure/PW C000143

Compound/PW C043261/Stoichiometry/1.0
type: Stoichiometry
physical entity: Fructoselysine
stoichiometric coefficient: 1.0

Solute carrier family 2, facilitated glucose transporter member 2
type: ProteinReference
xref: Reference/UniProt P11168

Reference/BioCyc NADPH
type: UnificationXref
id: NADPH
db: BioCyc

Compound/PW C000414 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Compound/PW C000146 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

Unknown
type: Protein
cellular location: Cytosol
entity reference: Unknown

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Reference/UniProt P13866
type: UnificationXref
id: P13866
db: UniProt

Reference/UniProt Q00796
type: UnificationXref
id: Q00796
db: UniProt

Compound/PW C001144 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

Compound/PW C000168 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sorbitol
stoichiometric coefficient: 1.0

Reference/CAS 50-70-4
type: UnificationXref
id: 50-70-4
db: CAS

Reference/CAS 58-68-4
type: UnificationXref
id: 58-68-4
db: CAS

Reference/ChemSpider 2913859
type: UnificationXref
id: 2913859
db: ChemSpider

Reference/UniProt P15121
type: UnificationXref
id: P15121
db: UniProt

ChemicalStructure/PW C113299
type: ChemicalStructure
structure format: SMILES
structure data: OCC(O)C(O)CC(=O)C=O

Reference/CAS 56-87-1
type: UnificationXref
id: 56-87-1
db: CAS

Reference/HMDB HMDB0000217
type: UnificationXref
id: HMDB0000217
db: HMDB

Compound/PW C113299/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-Deoxyglucosone
stoichiometric coefficient: 1.0

D-Glucose
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000122
xref: Reference/PubChem-compound 5793
xref: Reference/CAS 2280-44-6
xref: Reference/ChemSpider 5589
xref: Reference/ChEBI CHEBI 4167
xref: Reference/BioCyc GLC
xref: Reference/KEGG Compound C00031
chemical formula: C6H12O6
molecular weight: 180.06339
structure: ChemicalStructure/PW C000077

ChemicalStructure/PW C043261
type: ChemicalStructure
structure format: SMILES
structure data: NC(CCCCNC1OC(CO)C(O)C(O)C1=O)C(O)=O

L-Lysine
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Lysine

Reference/PathWhiz PW127074
type: UnificationXref
id: PW127074
db: PathWhiz

D-Fructose
type: SmallMoleculeReference
xref: Reference/BioCyc CPD-535
xref: Reference/ChEBI CHEBI 28645
xref: Reference/ChemSpider 388775
xref: Reference/PubChem-compound 439709
xref: Reference/KEGG Compound C02336
xref: Reference/HMDB HMDB0000660
xref: Reference/CAS 53188-23-1
chemical formula: C6H12O6
molecular weight: 180.06339
structure: ChemicalStructure/PW C000517

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

Compound/PW C000077 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Glucose
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00006
type: UnificationXref
id: C00006
db: KEGG Compound

Hydrogen Ion
type: SmallMolecule
cellular location: Cytosol
entity reference: Hydrogen Ion

Reference/ChEBI CHEBI 18009
type: UnificationXref
id: CHEBI:18009
db: ChEBI

Reference/BioCyc GLC
type: UnificationXref
id: GLC
db: BioCyc

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Sodium/glucose cotransporter 1
type: Protein
entity reference: Sodium/glucose cotransporter 1

Reference/KEGG Compound C01330
type: UnificationXref
id: C01330
db: KEGG Compound

Compound/PW C000721 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00005
type: UnificationXref
id: C00005
db: KEGG Compound

Reference/KEGG Compound C00004
type: UnificationXref
id: C00004
db: KEGG Compound

Compound/PW C113301 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Schiff Base
stoichiometric coefficient: 1.0

NADPH
type: SmallMolecule
cellular location: Cytosol
entity reference: NADPH

Reference/KEGG Compound C00003
type: UnificationXref
id: C00003
db: KEGG Compound

Liver
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000759

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

ChemicalStructure/PW C000143
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000221
type: UnificationXref
id: HMDB0000221
db: HMDB

Reference/HMDB HMDB0000588
type: UnificationXref
id: HMDB0000588
db: HMDB

ChemicalStructure/PW C000146
type: ChemicalStructure
structure format: SMILES

Reference/CAS 53-57-6
type: UnificationXref
id: 53-57-6
db: CAS

TransportCatalysis142
type: Catalysis
controller: Solute carrier family 2, facilitated glucose transporter member 2
controlled: Transport187
control type: ACTIVATION

TransportCatalysis5349
type: Catalysis
controller: Very long-chain acyl-CoA synthetase
controlled: Transport14535
control type: ACTIVATION

Compound/PW C040034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Reference/ChemSpider 388775
type: UnificationXref
id: 388775
db: ChemSpider

Reference/ChEBI CHEBI 17924
type: UnificationXref
id: CHEBI:17924
db: ChEBI

NAD
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15846
xref: Reference/HMDB HMDB0000902
xref: Reference/CAS 53-84-9
xref: Reference/KEGG Compound C00003
xref: Reference/PubChem-compound 5893
xref: Reference/BioCyc NAD
xref: Reference/ChemSpider 5682
chemical formula: C21H27N7O14P2
molecular weight: 663.10913
structure: ChemicalStructure/PW C000721

Metabolism and Physiological Effects of 3-Deoxyglucosone
type: Pathway
pathway order: PathwayTransport/2511460
pathway order: PathwayEnzymeReaction/2511462
pathway order: PathwayEnzymeReaction/2511461
pathway order: PathwayEnzymeReaction/2511464
pathway order: PathwayTransport/2511455
pathway order: PathwayEnzymeReaction/2511519
pathway order: PathwayTransport/2511520
pathway order: PathwaySubPathway/118406
pathway order: PathwaySubPathway/118405
pathway order: PathwayTransport/2511457
pathway order: PathwayEnzymeReaction/2511507
pathway order: PathwayEnzymeReaction/2511518
pathway order: PathwayTransport/2511456
pathway order: PathwayEnzymeReaction/2511517
pathway component: Transport121
pathway component: Transport187
pathway component: TransportCatalysis142
pathway component: TransportCatalysis5349
pathway component: ReactionCatalysis332
pathway component: 2.3.1.85
pathway component: ReactionCatalysis207515
pathway component: Reaction218894
pathway component: Reaction218893
pathway component: Transport14524
pathway component: Transport14535
pathway component: Reaction218888
pathway component: ReactionCatalysis208359
pathway component: Transport14525
pathway component: ReactionCatalysis208345
pathway component: ReactionCatalysis208353
pathway component: Reaction218144
pathway component: 2.7.1.171
pathway component: Apoptosis
pathway component: Neurotoxicity
pathway component: TransportCatalysis94
pathway component: 1.1.1.14
pathway component: TransportCatalysis5340
xref: Reference/SMPDB SMP0125516
xref: Reference/PathWhiz PW127074
organism: Homo sapiens

Reference/HMDB HMDB0000902
type: UnificationXref
id: HMDB0000902
db: HMDB

Fructosamine-3-kinase
type: ProteinReference
xref: Reference/UniProt Q9H479
organism: BiologicalState26

Sorbitol dehydrogenase
type: ProteinReference
xref: Reference/UniProt Q00796
organism: BiologicalState26

Reference/BioCyc NAD(P)
type: UnificationXref
id: NAD(P)
db: BioCyc

NADH
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001487
xref: Reference/CAS 58-68-4
xref: Reference/PubChem-compound 439153
xref: Reference/BioCyc NADH
xref: Reference/ChemSpider 388299
xref: Reference/KEGG Compound C00004
xref: Reference/ChEBI CHEBI 16908
chemical formula: C21H29N7O14P2
molecular weight: 665.12476
structure: ChemicalStructure/PW C001144

D-Glucose
type: SmallMolecule
entity reference: D-Glucose

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Hepatocyte
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000182

TransportCatalysis5340
type: Catalysis
controller: Solute carrier family 2, facilitated glucose transporter member 2
controlled: Transport14525
control type: ACTIVATION

Alkaline phosphatase, tissue-nonspecific isozyme
type: Protein
cellular location: Cytosol
entity reference: Alkaline phosphatase, tissue-nonspecific isozyme

Transport187
type: Transport
participant stoichiometry: Compound/PW C000077/Stoichiometry/1.0
right: D-Glucose
spontaneous: false
left: D-Glucose
name: D-Glucose (→) Transport: Homo sapiens, Intestine, Epithelial Cell to Homo sapiens, Blood Vessel
conversion direction: LEFT_TO_RIGHT

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

ChemicalStructure/PW C000118
type: ChemicalStructure
structure format: SMILES
structure data: NCCCC[C@H](N)C(O)=O

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Reference/CAS 53-84-9
type: UnificationXref
id: 53-84-9
db: CAS

Reference/HMDB HMDB0000122
type: UnificationXref
id: HMDB0000122
db: HMDB

SubPathwayInteraction118405
type: Interaction
name: SubPathway118405Reaction
name: SubPathwayReaction
participant: 3-Deoxyglucosone

Adenosine triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine triphosphate

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

Reference/HMDB HMDB0000247
type: UnificationXref
id: HMDB0000247
db: HMDB

Protein/485 Cytosol/Stoichiometry/4.0
type: Stoichiometry
physical entity: Sorbitol dehydrogenase
stoichiometric coefficient: 4.0

SubPathwayInteraction118406
type: Interaction
name: SubPathway118406Reaction
name: SubPathwayReaction
participant: 3-Deoxyglucosone

3-Deoxyglucosone
type: SmallMolecule
cellular location: Cytosol
entity reference: 3-Deoxyglucosone

Reference/ChEBI CHEBI 29101
type: UnificationXref
id: CHEBI:29101
db: ChEBI

NADP
type: SmallMolecule
cellular location: Cytosol
entity reference: NADP

BiologicalState26
type: BioSource
cell type: Hepatocyte
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Liver, Hepatocyte
tissue: Liver

ChemicalStructure/PW C000721
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C02336
type: UnificationXref
id: C02336
db: KEGG Compound

Reference/KEGG Compound C00031
type: UnificationXref
id: C00031
db: KEGG Compound

Schiff Base
type: SmallMolecule
cellular location: Cytosol
entity reference: Schiff Base

Reference/ChemSpider 899
type: UnificationXref
id: 899
db: ChemSpider

Sodium
type: SmallMolecule
entity reference: Sodium

Reference/ChemSpider 5682
type: UnificationXref
id: 5682
db: ChemSpider

Compound/PW C000517 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Fructose
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001144
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0245856
type: UnificationXref
id: HMDB0245856
db: HMDB

Reference/ChEBI CHEBI 28645
type: UnificationXref
id: CHEBI:28645
db: ChEBI

2.7.1.171
type: BiochemicalReaction
participant stoichiometry: Compound/PW C113289 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000517 Cytosol/Stoichiometry/1.0
right: Fructose-3-phosphate
right: Adenosine diphosphate
right: Hydrogen Ion
spontaneous: false
EC number: 2.7.1.171
left: D-Fructose
left: Adenosine triphosphate
name: Adenosine triphosphate + D-Fructose → Adenosine diphosphate + Fructose-3-phosphate + Hydrogen Ion
conversion direction: LEFT_TO_RIGHT

D-Glucose
type: SmallMolecule
cellular location: Cytosol
entity reference: D-Glucose

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

Reference/PubChem-compound 86573619
type: UnificationXref
id: 86573619
db: PubChem-compound

Reference/ChemSpider 5675
type: UnificationXref
id: 5675
db: ChemSpider

Reaction218888
type: BiochemicalReaction
participant stoichiometry: Compound/PW C113289 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C113299 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000775 Cytosol/Stoichiometry/1.0
right: Hydrogen phosphate
right: 3-Deoxyglucosone
spontaneous: false
left: Fructose-3-phosphate
name: Fructose-3-phosphate → 3-Deoxyglucosone + Hydrogen phosphate
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C00047
type: UnificationXref
id: C00047
db: KEGG Compound

ReactionCatalysis208345
type: Catalysis
controller: Fructosamine-3-kinase
controlled: 2.7.1.171
control type: ACTIVATION

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C113301
type: ChemicalStructure
structure format: SMILES

Adenosine diphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine diphosphate

Apoptosis
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway118405
pathway component: SubPathwayInteraction118405
name: SubPathway

Neurotoxicity
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway118406
pathway component: SubPathwayInteraction118406
name: SubPathway

Reference/CAS 17341-25-2
type: UnificationXref
id: 17341-25-2
db: CAS

D-Fructose
type: SmallMolecule
cellular location: Cytosol
entity reference: D-Fructose

Reference/ChEBI CHEBI 18019
type: UnificationXref
id: CHEBI:18019
db: ChEBI

Sorbitol dehydrogenase
type: Protein
cellular location: Cytosol
entity reference: Sorbitol dehydrogenase

ReactionCatalysis332
type: Catalysis
controller: Sorbitol dehydrogenase
controlled: 1.1.1.14
control type: ACTIVATION

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Reference/ChemSpider 5589
type: UnificationXref
id: 5589
db: ChemSpider

Sodium/glucose cotransporter 1
type: ProteinReference
xref: Reference/UniProt P13866

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

2.3.1.85
type: BiochemicalReaction
participant stoichiometry: Compound/PW C043261 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C113299 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000118 Cytosol/Stoichiometry/1.0
right: 3-Deoxyglucosone
right: L-Lysine
spontaneous: false
EC number: 2.3.1.85
left: Fructoselysine
name: Fructoselysine → 3-Deoxyglucosone + L-Lysine
conversion direction: LEFT_TO_RIGHT

Reaction218894
type: BiochemicalReaction
participant stoichiometry: Compound/PW C113301/Stoichiometry/1.0
participant stoichiometry: Compound/PW C043261/Stoichiometry/1.0
right: Fructoselysine
spontaneous: false
left: Schiff Base
name: Schiff Base → Fructoselysine
conversion direction: LEFT_TO_RIGHT

Reaction218893
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000118 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000077 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C113301 Cytosol/Stoichiometry/1.0
right: Schiff Base
right: Water
spontaneous: false
left: D-Glucose
left: L-Lysine
name: D-Glucose + L-Lysine ↔ Schiff Base + Water
conversion direction: REVERSIBLE

Reference/ChemSpider 388299
type: UnificationXref
id: 388299
db: ChemSpider

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Compound/PW C001034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001487
type: UnificationXref
id: HMDB0001487
db: HMDB

Reference/UniProt O14975
type: UnificationXref
id: O14975
db: UniProt

Water
type: SmallMolecule
cellular location: Cytosol
entity reference: Water

NAD
type: SmallMolecule
cellular location: Cytosol
entity reference: NAD

Compound/PW C113299 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-Deoxyglucosone
stoichiometric coefficient: 1.0

Compound/PW C000458/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 1.0

Reference/UniProt Q9H479
type: UnificationXref
id: Q9H479
db: UniProt

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Compound/PW C000077/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Glucose
stoichiometric coefficient: 1.0

Hydrogen phosphate
type: SmallMoleculeReference
xref: Reference/ChemSpider 2913859
xref: Reference/BioCyc ALPHA-GLUCOSE-16-BISPHOSPHATE
xref: Reference/HMDB HMDB0000973
xref: Reference/KEGG Compound C01293
xref: Reference/CAS 14066-19-4
xref: Reference/ChEBI CHEBI 43474
xref: Reference/PubChem-compound 3681305
chemical formula: H3O4P
molecular weight: 97.9769
structure: ChemicalStructure/PW C000775

Reference/ChemSpider 5576
type: UnificationXref
id: 5576
db: ChemSpider

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

ChemicalStructure/PW C000168
type: ChemicalStructure
structure format: SMILES
structure data: OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO

Compound/PW C001420 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Reference/PubChem-compound 720
type: UnificationXref
id: 720
db: PubChem-compound

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Hydrogen phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Hydrogen phosphate

Reference/UniProt P11168
type: UnificationXref
id: P11168
db: UniProt

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

Reference/PubChem-compound 5893
type: UnificationXref
id: 5893
db: PubChem-compound

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

3-Deoxyglucosone
type: SmallMolecule
entity reference: 3-Deoxyglucosone
name: SubPathwayInput

Reference/HMDB HMDB0000973
type: UnificationXref
id: HMDB0000973
db: HMDB

Reference/KEGG Compound C01293
type: UnificationXref
id: C01293
db: KEGG Compound

1.1.1.14
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000721 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000168 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000517 Cytosol/Stoichiometry/1.0
right: D-Fructose
right: NADH
spontaneous: false
EC number: 1.1.1.14
left: NAD
left: Sorbitol
name: NAD + Sorbitol ↔ D-Fructose + NADH
conversion direction: REVERSIBLE

Reference/SMPDB SMP0125516
type: UnificationXref
id: SMP0125516
db: SMPDB

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Fructoselysine
type: SmallMolecule
entity reference: Fructoselysine

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

L-Lysine
type: SmallMoleculeReference
xref: Reference/BioCyc LYS
xref: Reference/ChEBI CHEBI 18019
xref: Reference/ChemSpider 5747
xref: Reference/CAS 56-87-1
xref: Reference/HMDB HMDB0000182
xref: Reference/PubChem-compound 5962
xref: Reference/KEGG Compound C00047
chemical formula: C6H14N2O2
molecular weight: 146.10553
structure: ChemicalStructure/PW C000118

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 5886
type: UnificationXref
id: 5886
db: PubChem-compound

Fructoselysine
type: SmallMolecule
cellular location: Cytosol
entity reference: Fructoselysine

ChemicalStructure/PW C000775
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=O

Fructose-3-phosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 130872
chemical formula: C6H13O9P
molecular weight: 260.02972
structure: ChemicalStructure/PW C113289

Reference/ChEBI CHEBI 4167
type: UnificationXref
id: CHEBI:4167
db: ChEBI

Very long-chain acyl-CoA synthetase
type: Protein
entity reference: Very long-chain acyl-CoA synthetase

Reference/HMDB HMDB0000182
type: UnificationXref
id: HMDB0000182
db: HMDB

Aldose reductase
type: Protein
cellular location: Cytosol
entity reference: Aldose reductase

Reference/PubChem-compound 5793
type: UnificationXref
id: 5793
db: PubChem-compound

Reference/UniProt P05186
type: UnificationXref
id: P05186
db: UniProt

Aldose reductase
type: ProteinReference
xref: Reference/UniProt P15121
organism: BiologicalState26

Sorbitol
type: SmallMolecule
cellular location: Cytosol
entity reference: Sorbitol

ReactionCatalysis208359
type: Catalysis
controller: Unknown
controlled: 2.3.1.85
control type: ACTIVATION

ChemicalStructure/PW C000077
type: ChemicalStructure
structure format: SMILES

Compound/PW C043261 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Fructoselysine
stoichiometric coefficient: 1.0

Reference/PubChem-compound 22833512
type: UnificationXref
id: 22833512
db: PubChem-compound

Compound/PW C000118 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Lysine
stoichiometric coefficient: 1.0

ReactionCatalysis208353
type: Catalysis
controller: Alkaline phosphatase, tissue-nonspecific isozyme
controlled: Reaction218888
control type: ACTIVATION

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

3-Deoxyglucosone
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0245856
chemical formula: C6H10O5
molecular weight: 162.05283
structure: ChemicalStructure/PW C113299

Alkaline phosphatase, tissue-nonspecific isozyme
type: ProteinReference
xref: Reference/UniProt P05186
organism: BiologicalState26

Fructoselysine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 720
chemical formula: C12H22N2O7
molecular weight: 306.1427
structure: ChemicalStructure/PW C043261

Reference/BioCyc NADH
type: UnificationXref
id: NADH
db: BioCyc

Compound/PW C113301/Stoichiometry/1.0
type: Stoichiometry
physical entity: Schiff Base
stoichiometric coefficient: 1.0

Reference/BioCyc NAD
type: UnificationXref
id: NAD
db: BioCyc

Reference/PubChem-compound 5780
type: UnificationXref
id: 5780
db: PubChem-compound

Sodium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000588
xref: Reference/PubChem-compound 923
xref: Reference/KEGG Compound C01330
xref: Reference/ChEBI CHEBI 29101
xref: Reference/ChemSpider 899
xref: Reference/CAS 17341-25-2
chemical formula: Na
molecular weight: 22.989769
structure: ChemicalStructure/PW C000458

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Transport14535
type: Transport
participant stoichiometry: Compound/PW C113299 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C113299/Stoichiometry/1.0
right: 3-Deoxyglucosone
spontaneous: false
left: 3-Deoxyglucosone
name: 3-Deoxyglucosone (→) Transport: Homo sapiens, Liver, Hepatocyte, Cytosol to Homo sapiens, Blood Vessel
conversion direction: LEFT_TO_RIGHT

Solute carrier family 2, facilitated glucose transporter member 2
type: Protein
entity reference: Solute carrier family 2, facilitated glucose transporter member 2

ChemicalStructure/PW C000517
type: ChemicalStructure
structure format: SMILES
structure data: OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O

Compound/PW C000775 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen phosphate
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 43474
type: UnificationXref
id: CHEBI:43474
db: ChEBI

Reference/PubChem-compound 3681305
type: UnificationXref
id: 3681305
db: PubChem-compound