TransportCatalysis5367
type: Catalysis
controller: Solute carrier family 22 member 9
controlled: Transport14550
control type: ACTIVATION

TransportCatalysis5368
type: Catalysis
controller: Solute carrier family 22 member 9
controlled: Transport14551
control type: ACTIVATION

Aryl hydrocarbon receptor
type: ProteinReference
xref: Reference/UniProt P35869
organism: BiologicalState1169

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Compound/PW C000935 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: N'-Formylkynurenine
stoichiometric coefficient: 1.0

direct_interaction
type: InteractionVocabulary

Transport11253
type: Transport
participant stoichiometry: Compound/PW C000741/Stoichiometry/1.0
right: L-Tryptophan
spontaneous: false
left: L-Tryptophan
name: L-Tryptophan (→) Transport: Homo sapiens to Homo sapiens, Intestine
conversion direction: LEFT_TO_RIGHT

Indoleamine 2,3-dioxygenase 1
type: Protein
cellular location: Cytoplasm
entity reference: Indoleamine 2,3-dioxygenase 1

Reference/UniProt Q07837
type: UnificationXref
id: Q07837
db: UniProt

Histone H4
type: ProteinReference
xref: Reference/UniProt P62805

SubPathwayInteraction118439
type: Interaction
name: SubPathway118439Reaction
name: SubPathwayReaction
participant: Interleukin-10

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Protein/4648/Stoichiometry/1.0
type: Stoichiometry
physical entity: Histone acetyltransferase type B catalytic subunit
stoichiometric coefficient: 1.0

TransportCatalysis5364
type: Catalysis
controller: Neutral amino acid transporter A
controlled: Transport14547
control type: ACTIVATION

Protein/1808 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Nuclear factor NF-kappa-B p105 subunit
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00328
type: UnificationXref
id: C00328
db: KEGG Compound

Reference/PubChem-compound 910
type: UnificationXref
id: 910
db: PubChem-compound

BoundComplex/583/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Kynurenine_Aryl hydrocarbon receptor (Homo sapiens)
stoichiometric coefficient: 1.0

Compound/PW C001065 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 1.0

Transport14513
type: Transport
participant stoichiometry: Protein/428 Nucleus/Stoichiometry/1.0
participant stoichiometry: Protein/428 Cytoplasm/Stoichiometry/1.0
right: Indoleamine 2,3-dioxygenase 1
spontaneous: true
left: Indoleamine 2,3-dioxygenase 1
name: Indoleamine 2,3-dioxygenase 1 (→) Transport: Homo sapiens, Blood Vessel, Macrophage, Nucleus to Homo sapiens, Blood Vessel, Macrophage, Cytoplasm
conversion direction: REVERSIBLE

Histone acetyltransferase type B catalytic subunit
type: Protein
entity reference: Histone acetyltransferase type B catalytic subunit

Transport14512
type: Transport
participant stoichiometry: BoundComplex/583 Nucleus/Stoichiometry/1.0
participant stoichiometry: BoundComplex/583 Cytoplasm/Stoichiometry/1.0
right: L-Kynurenine_Aryl hydrocarbon receptor (Homo sapiens)
spontaneous: false
left: L-Kynurenine_Aryl hydrocarbon receptor (Homo sapiens)
name: L-Kynurenine + Aryl hydrocarbon receptor (Homo sapiens) (→) Transport: Homo sapiens, Blood Vessel, Macrophage, Cytoplasm to Homo sapiens, Blood Vessel, Macrophage, Nucleus
conversion direction: LEFT_TO_RIGHT

Transport14514
type: Transport
participant stoichiometry: Protein/20827 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Protein/20827 Nucleus/Stoichiometry/1.0
right: Interleukin-10
spontaneous: true
left: Interleukin-10
name: Interleukin-10 (→) Transport: Homo sapiens, Blood Vessel, Macrophage, Nucleus to Homo sapiens, Blood Vessel, Macrophage, Cytoplasm
conversion direction: REVERSIBLE

1.13.11.52
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000741 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000935 Cytosol/Stoichiometry/1.0
right: N'-Formylkynurenine
spontaneous: false
EC number: 1.13.11.52
left: Oxygen
left: L-Tryptophan
name: L-Tryptophan + Oxygen → N'-Formylkynurenine
conversion direction: LEFT_TO_RIGHT

Reference/UniProt P01579
type: UnificationXref
id: P01579
db: UniProt

Reference/PathWhiz PW127041
type: UnificationXref
id: PW127041
db: PathWhiz

Interleukin-10
type: ProteinReference
xref: Reference/UniProt P22301
organism: BiologicalState1169

Reference/CELL TYPE ONTOLOGY CL 0000182
type: UnificationXref
id: CL:0000182
db: CELL TYPE ONTOLOGY

Reference/BRENDA TISSUE ONTOLOGY BTO 0000759
type: UnificationXref
id: BTO:0000759
db: BRENDA TISSUE ONTOLOGY

Reaction218817
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000538 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Protein/14361 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: BoundComplex/583 Cytoplasm/Stoichiometry/1.0
right: L-Kynurenine_Aryl hydrocarbon receptor (Homo sapiens)
spontaneous: false
left: L-Kynurenine
left: Aryl hydrocarbon receptor
name: Aryl hydrocarbon receptor + L-Kynurenine → L-Kynurenine + Aryl hydrocarbon receptor (Homo sapiens)
conversion direction: LEFT_TO_RIGHT

Reference/UniProt Q9NVP2
type: UnificationXref
id: Q9NVP2
db: UniProt

Reference/ChemSpider 952
type: UnificationXref
id: 952
db: ChemSpider

Compound/PW C000092 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Formic acid
stoichiometric coefficient: 1.0

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Reference/ChemSpider 278
type: UnificationXref
id: 278
db: ChemSpider

Importin-4
type: Protein
entity reference: Importin-4

Aryl hydrocarbon receptor
type: Protein
cellular location: Cytoplasm
entity reference: Aryl hydrocarbon receptor

L-Kynurenine_Aryl hydrocarbon receptor (Homo sapiens)
type: Complex
component stoichiometry: Compound/PW C000538 Nucleus/Stoichiometry/1.0
component stoichiometry: Protein/14361 Nucleus/Stoichiometry/1.0
cellular location: Nucleus
component: Aryl hydrocarbon receptor
component: L-Kynurenine

N'-Formylkynurenine
type: SmallMoleculeReference
xref: Reference/ChemSpider 886
xref: Reference/HMDB HMDB0001200
xref: Reference/KEGG Compound C02406
xref: Reference/PubChem-compound 910
xref: Reference/ChEBI CHEBI 18377
xref: Reference/BioCyc N-FORMYLKYNURENINE
xref: Reference/CAS 1022-31-7
chemical formula: C11H12N2O4
molecular weight: 236.07971
structure: ChemicalStructure/PW C000935

Reference/SMPDB SMP0125524
type: UnificationXref
id: SMP0125524
db: SMPDB

Reference/UniProt Q9Y294
type: UnificationXref
id: Q9Y294
db: UniProt

Reference/KEGG Compound C02406
type: UnificationXref
id: C02406
db: KEGG Compound

L-Kynurenine
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Kynurenine

Reference/HMDB HMDB0000684
type: UnificationXref
id: HMDB0000684
db: HMDB

Reference/CAS 73-22-3
type: UnificationXref
id: 73-22-3
db: CAS

SubPathwayInteraction118446
type: Interaction
name: SubPathwayReaction
name: SubPathway118446Reaction
participant: L-Kynurenine_Aryl hydrocarbon receptor (Homo sapiens)

SubPathwayInteraction118447
type: Interaction
name: SubPathway118447Reaction
name: SubPathwayReaction
participant: L-Kynurenine

Reference/UniProt Q8IVM8
type: UnificationXref
id: Q8IVM8
db: UniProt

L-Kynurenine
type: SmallMolecule
cellular location: Nucleus
entity reference: L-Kynurenine

ReactionCatalysis1353
type: Catalysis
controller: Kynurenine formamidase
controlled: 3.5.1.9
control type: ACTIVATION

L-Kynurenine_Aryl hydrocarbon receptor (Homo sapiens)
type: Complex
component stoichiometry: Compound/PW C000538 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/14361 Cytoplasm/Stoichiometry/1.0
cellular location: Cytoplasm
component: L-Kynurenine
component: Aryl hydrocarbon receptor

Protein/8259/Stoichiometry/1.0
type: Stoichiometry
physical entity: Chromatin assembly factor 1 subunit B
stoichiometric coefficient: 1.0

Protein/8867/Stoichiometry/1.0
type: Stoichiometry
physical entity: Histone H4
stoichiometric coefficient: 1.0

L-Kynurenine_Aryl hydrocarbon receptor (Homo sapiens)
type: Complex
component stoichiometry: Compound/PW C000538 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/14361 Cytosol/Stoichiometry/1.0
cellular location: Cytosol
component: L-Kynurenine
component: Aryl hydrocarbon receptor

TransportCatalysis5328
type: Catalysis
controller: Histone H3.1 complex
controlled: Transport14512
control type: ACTIVATION

Compound/PW C000741/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Tryptophan
stoichiometric coefficient: 1.0

L-Tryptophan
type: SmallMoleculeReference
xref: Reference/CAS 73-22-3
xref: Reference/KEGG Compound C00078
xref: Reference/ChEBI CHEBI 16828
xref: Reference/PubChem-compound 6305
xref: Reference/BioCyc TRP
xref: Reference/HMDB HMDB0000929
xref: Reference/ChemSpider 6066
chemical formula: C11H12N2O2
molecular weight: 204.08987
structure: ChemicalStructure/PW C000741

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Reference/BioCyc CPD-6641
type: UnificationXref
id: CPD-6641
db: BioCyc

L-Kynurenine
type: SmallMolecule
entity reference: L-Kynurenine
name: SubPathwayInput

Compound/PW C000741 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Tryptophan
stoichiometric coefficient: 1.0

Neutral amino acid transporter A
type: Protein
entity reference: Neutral amino acid transporter A

Protein/14361 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Aryl hydrocarbon receptor
stoichiometric coefficient: 1.0

Protein/8261/Stoichiometry/1.0
type: Stoichiometry
physical entity: Nuclear autoantigenic sperm protein
stoichiometric coefficient: 1.0

3.5.1.9
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000092 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000538 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000935 Cytosol/Stoichiometry/1.0
right: Formic acid
right: L-Kynurenine
spontaneous: false
EC number: 3.5.1.9
left: N'-Formylkynurenine
left: Water
name: N'-Formylkynurenine + Water → Formic acid + L-Kynurenine
conversion direction: LEFT_TO_RIGHT

ReactionCatalysis2059
type: Catalysis
controller: Indoleamine 2,3-dioxygenase 1
controlled: 1.13.11.52
control type: ACTIVATION

Reference/PathWhiz PW127083
type: UnificationXref
id: PW127083
db: PathWhiz

Reference/UniProt P62805
type: UnificationXref
id: P62805
db: UniProt

Reference/KEGG Compound C00007
type: UnificationXref
id: C00007
db: KEGG Compound

Compound/PW C000538 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Kynurenine
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/UniProt Q09028
type: UnificationXref
id: Q09028
db: UniProt

ChemicalStructure/PW C000935
type: ChemicalStructure
structure format: SMILES
structure data: NC(CC(=O)C1=CC=CC=C1NC=O)C(O)=O

Protein/8258/Stoichiometry/1.0
type: Stoichiometry
physical entity: Histone chaperone ASF1B
stoichiometric coefficient: 1.0

Liver
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000759

Nuclear factor NF-kappa-B p105 subunit
type: ProteinReference
xref: Reference/UniProt P19838
organism: BiologicalState1169

Reference/GENE ONTOLOGY GO 0005634
type: UnificationXref
id: GO:0005634
db: GENE ONTOLOGY

Renal Impairment
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway118446
pathway component: SubPathwayInteraction118446
name: SubPathway

Muscle Atrophy
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway118447
pathway component: SubPathwayInteraction118447
name: SubPathway

Histone acetyltransferase type B catalytic subunit
type: ProteinReference
xref: Reference/UniProt O14929

Neutral and basic amino acid transport protein rBAT
type: Protein
entity reference: Neutral and basic amino acid transport protein rBAT

Reference/PubChem-compound 161166
type: UnificationXref
id: 161166
db: PubChem-compound

B(0,+)-type amino acid transporter 1
type: Protein
entity reference: B(0,+)-type amino acid transporter 1

Histone chaperone ASF1B
type: Protein
entity reference: Histone chaperone ASF1B

Histone chaperone ASF1A
type: Protein
entity reference: Histone chaperone ASF1A

Reference/HMDB HMDB0001200
type: UnificationXref
id: HMDB0001200
db: HMDB

Blood Vessel
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0001102

Indoleamine 2,3-dioxygenase 1
type: Protein
cellular location: Nucleus
entity reference: Indoleamine 2,3-dioxygenase 1

Chromatin assembly factor 1 subunit B
type: Protein
entity reference: Chromatin assembly factor 1 subunit B

Reference/UniProt Q8TEX9
type: UnificationXref
id: Q8TEX9
db: UniProt

Reference/ChEBI CHEBI 16946
type: UnificationXref
id: CHEBI:16946
db: ChEBI

Reference/ChEBI CHEBI 16828
type: UnificationXref
id: CHEBI:16828
db: ChEBI

BiologicalState51
type: BioSource
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Blood Vessel
tissue: Blood Vessel

Hepatocyte
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000182

Protein/14361/Stoichiometry/1.0
type: Stoichiometry
physical entity: Aryl hydrocarbon receptor
stoichiometric coefficient: 1.0

Kynurenine Uremic Toxin Pathway
type: Pathway
pathway order: PathwayTransport/2511590
pathway order: PathwayTransport/2511660
pathway order: PathwayTransport/2511591
pathway order: PathwayEnzymeReaction/2511558
pathway order: PathwayTransport/2511658
pathway order: PathwayTransport/2511619
pathway order: PathwayTransport/2511618
pathway order: PathwayTransport/2511620
pathway order: PathwaySubPathway/118446
pathway order: PathwayInteraction/1289
pathway order: PathwayInteraction/4212
pathway order: PathwayInteraction/4211
pathway order: PathwayEnzymeReaction/2511659
pathway order: PathwaySubPathway/118439
pathway order: PathwayEnzymeReaction/2511559
pathway order: PathwayTransport/2511589
pathway order: PathwayEnzymeReaction/2511617
pathway order: PathwaySubPathway/118447
pathway component: Reaction218835
pathway component: TransportCatalysis5328
pathway component: TransportCatalysis5367
pathway component: Reaction218817
pathway component: TransportCatalysis5368
pathway component: Interaction1289
pathway component: Interaction4212
pathway component: Interaction4211
pathway component: Transport14547
pathway component: Transport11253
pathway component: Transport14540
pathway component: 3.5.1.9
pathway component: TransportCatalysis5364
pathway component: ReactionCatalysis2059
pathway component: Anti-inflammatory pathway
pathway component: Transport14513
pathway component: Transport14512
pathway component: Transport14514
pathway component: 1.13.11.52
pathway component: Transport14551
pathway component: Transport14550
pathway component: TransportCatalysis5355
pathway component: Renal Impairment
pathway component: Muscle Atrophy
pathway component: ReactionCatalysis1353
xref: Reference/PathWhiz PW127083
xref: Reference/SMPDB SMP0125524
organism: Homo sapiens

Aryl hydrocarbon receptor
type: Protein
cellular location: Nucleus
entity reference: Aryl hydrocarbon receptor

Importin-4
type: ProteinReference
xref: Reference/UniProt Q8TEX9

L-Tryptophan
type: SmallMolecule
entity reference: L-Tryptophan

Interferon gamma
type: Protein
cellular location: Cytoplasm
entity reference: Interferon gamma

Reference/UniProt P68431
type: UnificationXref
id: P68431
db: UniProt

Reference/ChemSpider 6066
type: UnificationXref
id: 6066
db: ChemSpider

Histone-binding protein RBBP4
type: Protein
entity reference: Histone-binding protein RBBP4

Protein/428 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Indoleamine 2,3-dioxygenase 1
stoichiometric coefficient: 1.0

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

Nuclear autoantigenic sperm protein
type: Protein
entity reference: Nuclear autoantigenic sperm protein

Solute carrier family 22 member 9
type: ProteinReference
xref: Reference/UniProt Q8IVM8

Histone H3.1
type: Protein
entity reference: Histone H3.1

TransportCatalysis5355
type: Catalysis
controller: Neutral and basic amino acid transport protein rBAT/B(0,+)-type amino acid transporter 1
controlled: Transport14540
control type: ACTIVATION

Histone H3.1 complex
type: Complex
component stoichiometry: Protein/8259/Stoichiometry/1.0
component stoichiometry: Protein/8867/Stoichiometry/1.0
component stoichiometry: Protein/8257/Stoichiometry/1.0
component stoichiometry: Protein/8263/Stoichiometry/1.0
component stoichiometry: Protein/8260/Stoichiometry/1.0
component stoichiometry: Protein/4648/Stoichiometry/1.0
component stoichiometry: Protein/3684/Stoichiometry/1.0
component stoichiometry: Protein/8261/Stoichiometry/1.0
component stoichiometry: Protein/8258/Stoichiometry/1.0
component stoichiometry: Protein/8146/Stoichiometry/1.0
component: Histone chaperone ASF1B
component: Histone chaperone ASF1A
component: Histone-binding protein RBBP4
component: Histone H4
component: Importin-4
component: Chromatin assembly factor 1 subunit B
component: Nuclear autoantigenic sperm protein
component: Histone H3.1
component: Histone acetyltransferase type B catalytic subunit
component: Chromatin assembly factor 1 subunit A

Protein/14361 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Aryl hydrocarbon receptor
stoichiometric coefficient: 1.0

Chromatin assembly factor 1 subunit A
type: Protein
entity reference: Chromatin assembly factor 1 subunit A

Reference/CAS 1022-31-7
type: UnificationXref
id: 1022-31-7
db: CAS

Protein/14361 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Aryl hydrocarbon receptor
stoichiometric coefficient: 1.0

BiologicalState26
type: BioSource
cell type: Hepatocyte
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Liver, Hepatocyte
tissue: Liver

L-Kynurenine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: L-Kynurenine

Indoleamine 2,3-dioxygenase 1
type: ProteinReference
xref: Reference/UniProt P14902
organism: BiologicalState1169

Reference/PubChem-compound 6305
type: UnificationXref
id: 6305
db: PubChem-compound

Interaction1289
type: MolecularInteraction
interaction type: direct_interaction
name: Interferon gamma activates Indoleamine 2,3-dioxygenase 1
participant: Indoleamine 2,3-dioxygenase 1
participant: Interferon gamma

Reference/HMDB HMDB0000929
type: UnificationXref
id: HMDB0000929
db: HMDB

BoundComplex/583 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Kynurenine_Aryl hydrocarbon receptor (Homo sapiens)
stoichiometric coefficient: 1.0

Formic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Formic acid

L-Tryptophan
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Tryptophan

Reference/UniProt P43007
type: UnificationXref
id: P43007
db: UniProt

Reference/CELL TYPE ONTOLOGY CL 0000235
type: UnificationXref
id: CL:0000235
db: CELL TYPE ONTOLOGY

Reference/UniProt P22301
type: UnificationXref
id: P22301
db: UniProt

Compound/PW C000538 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Kynurenine
stoichiometric coefficient: 1.0

BoundComplex/583 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Kynurenine_Aryl hydrocarbon receptor (Homo sapiens)
stoichiometric coefficient: 1.0

Neutral and basic amino acid transport protein rBAT/B(0,+)-type amino acid transporter 1
type: Complex
component: Neutral and basic amino acid transport protein rBAT
component: B(0,+)-type amino acid transporter 1

Neutral amino acid transporter A
type: ProteinReference
xref: Reference/UniProt P43007

N'-Formylkynurenine
type: SmallMolecule
cellular location: Cytosol
entity reference: N'-Formylkynurenine

Reference/ChemSpider 886
type: UnificationXref
id: 886
db: ChemSpider

Reference/BRENDA TISSUE ONTOLOGY BTO 0001102
type: UnificationXref
id: BTO:0001102
db: BRENDA TISSUE ONTOLOGY

ChemicalStructure/PW C000741
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CC1=CNC2=C1C=CC=C2)C(O)=O

Reference/PubChem-compound 18971002
type: UnificationXref
id: 18971002
db: PubChem-compound

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

BiologicalState1169
type: BioSource
cell type: Macrophage
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Blood Vessel, Macrophage
tissue: Blood Vessel

Reference/BioCyc TRP
type: UnificationXref
id: TRP
db: BioCyc

Protein/20827 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Interleukin-10
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000142
type: UnificationXref
id: HMDB0000142
db: HMDB

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

Reference/ChEBI CHEBI 18377
type: UnificationXref
id: CHEBI:18377
db: ChEBI

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reference/UniProt P49321
type: UnificationXref
id: P49321
db: UniProt

Interaction4212
type: MolecularInteraction
interaction type: direct_interaction
name: L-Kynurenine + Aryl hydrocarbon receptor (Homo sapiens) activates Interleukin-10
participant: Interleukin-10
participant: L-Kynurenine_Aryl hydrocarbon receptor (Homo sapiens)

Reference/KEGG Compound C00058
type: UnificationXref
id: C00058
db: KEGG Compound

Interaction4211
type: MolecularInteraction
interaction type: direct_interaction
name: L-Kynurenine + Aryl hydrocarbon receptor (Homo sapiens) + Nuclear factor NF-kappa-B p105 subunit (Homo sapiens) activates Indoleamine 2,3-dioxygenase 1
participant: L-Kynurenine_Aryl hydrocarbon receptor (Homo sapiens)_Nuclear factor NF-kappa-B p105 subunit (Homo sapiens)
participant: Indoleamine 2,3-dioxygenase 1

Oxygen
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001377
xref: Reference/ChemSpider 952
xref: Reference/KEGG Compound C00007
xref: Reference/ChEBI CHEBI 15379
xref: Reference/PubChem-compound 977
xref: Reference/BioCyc CPD-6641
xref: Reference/CAS 7782-44-7
chemical formula: O2
molecular weight: 31.98983
structure: ChemicalStructure/PW C001065

Formic acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 30751
xref: Reference/ChemSpider 278
xref: Reference/PubChem-compound 18971002
xref: Reference/BioCyc FORMATE
xref: Reference/CAS 64-18-6
xref: Reference/KEGG Compound C00058
xref: Reference/HMDB HMDB0000142
chemical formula: CH2O2
molecular weight: 46.005478
structure: ChemicalStructure/PW C000092

Reference/BioCyc FORMATE
type: UnificationXref
id: FORMATE
db: BioCyc

Protein/428 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Indoleamine 2,3-dioxygenase 1
stoichiometric coefficient: 1.0

Water
type: SmallMolecule
cellular location: Cytosol
entity reference: Water

L-Kynurenine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000684
xref: Reference/KEGG Compound C00328
xref: Reference/ChemSpider 141580
xref: Reference/ChEBI CHEBI 16946
xref: Reference/PubChem-compound 161166
xref: Reference/CAS 2922-83-0
xref: Reference/BioCyc L-KYNURENINE
chemical formula: C10H12N2O3
molecular weight: 208.0848
structure: ChemicalStructure/PW C000538

B(0,+)-type amino acid transporter 1
type: ProteinReference
xref: Reference/UniProt P82251

Reference/UniProt P35869
type: UnificationXref
id: P35869
db: UniProt

Reference/SMPDB SMP0125485
type: UnificationXref
id: SMP0125485
db: SMPDB

L-Kynurenine_Aryl hydrocarbon receptor (Homo sapiens)_Nuclear factor NF-kappa-B p105 subunit (Homo sapiens)
type: Complex
component stoichiometry: Compound/PW C000538 Nucleus/Stoichiometry/1.0
component stoichiometry: Protein/14361 Nucleus/Stoichiometry/1.0
component stoichiometry: Protein/1808 Nucleus/Stoichiometry/1.0
cellular location: Nucleus
component: Aryl hydrocarbon receptor
component: Nuclear factor NF-kappa-B p105 subunit
component: L-Kynurenine

Neutral and basic amino acid transport protein rBAT
type: ProteinReference
xref: Reference/UniProt Q07837

Reference/UniProt P19838
type: UnificationXref
id: P19838
db: UniProt

Nuclear factor NF-kappa-B p105 subunit
type: Protein
cellular location: Nucleus
entity reference: Nuclear factor NF-kappa-B p105 subunit

Reference/UniProt P82251
type: UnificationXref
id: P82251
db: UniProt

Histone H3.1
type: ProteinReference
xref: Reference/UniProt P68431

Nuclear autoantigenic sperm protein
type: ProteinReference
xref: Reference/UniProt P49321

Kynurenine formamidase
type: Protein
cellular location: Cytosol
entity reference: Kynurenine formamidase

Chromatin assembly factor 1 subunit A
type: ProteinReference
xref: Reference/UniProt Q13111

Reference/CAS 7782-44-7
type: UnificationXref
id: 7782-44-7
db: CAS

Reference/HMDB HMDB0001377
type: UnificationXref
id: HMDB0001377
db: HMDB

Histone chaperone ASF1A
type: ProteinReference
xref: Reference/UniProt Q9Y294

Histone chaperone ASF1B
type: ProteinReference
xref: Reference/UniProt Q9NVP2

Chromatin assembly factor 1 subunit B
type: ProteinReference
xref: Reference/UniProt Q13112

Compound/PW C000538/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Kynurenine
stoichiometric coefficient: 1.0

Histone H4
type: Protein
entity reference: Histone H4

Compound/PW C001420 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Reference/UniProt Q13112
type: UnificationXref
id: Q13112
db: UniProt

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/UniProt Q13111
type: UnificationXref
id: Q13111
db: UniProt

Reaction218835
type: BiochemicalReaction
participant stoichiometry: BoundComplex/587 Nucleus/Stoichiometry/1.0
participant stoichiometry: BoundComplex/583 Nucleus/Stoichiometry/1.0
participant stoichiometry: Protein/1808 Nucleus/Stoichiometry/1.0
right: L-Kynurenine_Aryl hydrocarbon receptor (Homo sapiens)_Nuclear factor NF-kappa-B p105 subunit (Homo sapiens)
spontaneous: false
left: Nuclear factor NF-kappa-B p105 subunit
left: L-Kynurenine_Aryl hydrocarbon receptor (Homo sapiens)
name: L-Kynurenine + Aryl hydrocarbon receptor (Homo sapiens) + Nuclear factor NF-kappa-B p105 subunit → L-Kynurenine + Aryl hydrocarbon receptor (Homo sapiens) + Nuclear factor NF-kappa-B p105 subunit (Homo sapiens)
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C00078
type: UnificationXref
id: C00078
db: KEGG Compound

Reference/BioCyc L-KYNURENINE
type: UnificationXref
id: L-KYNURENINE
db: BioCyc

Histone-binding protein RBBP4
type: ProteinReference
xref: Reference/UniProt Q09028

ChemicalStructure/PW C001065
type: ChemicalStructure
structure format: SMILES
structure data: O=O

L-Kynurenine_Aryl hydrocarbon receptor (Homo sapiens)
type: Complex
component stoichiometry: Protein/14361/Stoichiometry/1.0
component stoichiometry: Compound/PW C000538/Stoichiometry/1.0
component: Aryl hydrocarbon receptor
component: L-Kynurenine
name: SubPathwayInput

Reference/ChEBI CHEBI 30751
type: UnificationXref
id: CHEBI:30751
db: ChEBI

Indoleamine 2,3-dioxygenase 1
type: Protein
cellular location: Cytosol
entity reference: Indoleamine 2,3-dioxygenase 1

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Reference/CAS 2922-83-0
type: UnificationXref
id: 2922-83-0
db: CAS

Protein/8146/Stoichiometry/1.0
type: Stoichiometry
physical entity: Histone-binding protein RBBP4
stoichiometric coefficient: 1.0

Reference/UniProt Q63HM1
type: UnificationXref
id: Q63HM1
db: UniProt

ChemicalStructure/PW C000092
type: ChemicalStructure
structure format: SMILES
structure data: OC=O

Interferon gamma
type: ProteinReference
xref: Reference/UniProt P01579
organism: BiologicalState1169

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/ChEBI CHEBI 15379
type: UnificationXref
id: CHEBI:15379
db: ChEBI

Protein/3684/Stoichiometry/1.0
type: Stoichiometry
physical entity: Importin-4
stoichiometric coefficient: 1.0

BoundComplex/583 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Kynurenine_Aryl hydrocarbon receptor (Homo sapiens)
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000538
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CC(=O)C1=CC=CC=C1N)C(O)=O

Macrophage
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000235

Oxygen
type: SmallMolecule
cellular location: Cytosol
entity reference: Oxygen

Compound/PW C000538 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Kynurenine
stoichiometric coefficient: 1.0

Protein/8263/Stoichiometry/1.0
type: Stoichiometry
physical entity: Chromatin assembly factor 1 subunit A
stoichiometric coefficient: 1.0

Transport14551
type: Transport
participant stoichiometry: BoundComplex/583/Stoichiometry/1.0
participant stoichiometry: BoundComplex/583 Cytosol/Stoichiometry/1.0
right: L-Kynurenine_Aryl hydrocarbon receptor (Homo sapiens)
spontaneous: false
left: L-Kynurenine_Aryl hydrocarbon receptor (Homo sapiens)
name: L-Kynurenine + Aryl hydrocarbon receptor (Homo sapiens) (→) Transport: Homo sapiens, Liver, Hepatocyte, Cytosol to Homo sapiens, Blood Vessel
conversion direction: LEFT_TO_RIGHT

Transport14550
type: Transport
participant stoichiometry: Compound/PW C000538 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000538/Stoichiometry/1.0
right: L-Kynurenine
spontaneous: false
left: L-Kynurenine
name: L-Kynurenine (→) Transport: Homo sapiens, Liver, Hepatocyte, Cytosol to Homo sapiens, Blood Vessel
conversion direction: LEFT_TO_RIGHT

Interleukin-10
type: Protein
cellular location: Cytoplasm
entity reference: Interleukin-10
name: SubPathwayInput

Protein/20827 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Interleukin-10
stoichiometric coefficient: 1.0

Kynurenine formamidase
type: ProteinReference
xref: Reference/UniProt Q63HM1
organism: BiologicalState26

Reference/CAS 64-18-6
type: UnificationXref
id: 64-18-6
db: CAS

Reference/BioCyc N-FORMYLKYNURENINE
type: UnificationXref
id: N-FORMYLKYNURENINE
db: BioCyc

Transport14547
type: Transport
participant stoichiometry: Compound/PW C000741 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000741/Stoichiometry/1.0
right: L-Tryptophan
spontaneous: false
left: L-Tryptophan
name: L-Tryptophan (→) Transport: Homo sapiens, Blood Vessel to Homo sapiens, Liver, Hepatocyte, Cytosol
conversion direction: LEFT_TO_RIGHT

Aryl hydrocarbon receptor
type: Protein
entity reference: Aryl hydrocarbon receptor

Protein/8257/Stoichiometry/1.0
type: Stoichiometry
physical entity: Histone chaperone ASF1A
stoichiometric coefficient: 1.0

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Transport14540
type: Transport
participant stoichiometry: Compound/PW C000741/Stoichiometry/1.0
right: L-Tryptophan
spontaneous: false
left: L-Tryptophan
name: L-Tryptophan (→) Transport: Homo sapiens, Intestine to Homo sapiens, Blood Vessel
conversion direction: LEFT_TO_RIGHT

Nucleus
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005634

Solute carrier family 22 member 9
type: Protein
entity reference: Solute carrier family 22 member 9

Reference/ChemSpider 141580
type: UnificationXref
id: 141580
db: ChemSpider

Reference/PubChem-compound 977
type: UnificationXref
id: 977
db: PubChem-compound

BoundComplex/587 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Kynurenine_Aryl hydrocarbon receptor (Homo sapiens)_Nuclear factor NF-kappa-B p105 subunit (Homo sapiens)
stoichiometric coefficient: 1.0

Aryl hydrocarbon receptor
type: Protein
cellular location: Cytosol
entity reference: Aryl hydrocarbon receptor

Anti-inflammatory pathway
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway118439
pathway component: SubPathwayInteraction118439
xref: Reference/SMPDB SMP0125485
xref: Reference/PathWhiz PW127041
name: SubPathway

Reference/UniProt P14902
type: UnificationXref
id: P14902
db: UniProt

Protein/8260/Stoichiometry/1.0
type: Stoichiometry
physical entity: Histone H3.1
stoichiometric coefficient: 1.0

Reference/UniProt O14929
type: UnificationXref
id: O14929
db: UniProt

Interleukin-10
type: Protein
cellular location: Nucleus
entity reference: Interleukin-10