Excretion
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway118482
pathway component: SubPathwayInteraction118482
name: SubPathway

Reference/ChemSpider 17215925
type: UnificationXref
id: 17215925
db: ChemSpider

Endoplasmic Reticulum Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005789

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Reference/ChEBI CHEBI 58210
type: UnificationXref
id: CHEBI:58210
db: ChEBI

Reference/BioCyc UDP
type: UnificationXref
id: UDP
db: BioCyc

Reference/CAS 30516-87-1
type: UnificationXref
id: 30516-87-1
db: CAS

Compound/PW C113307 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 5’glucuronyl zidovudine
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

ChemicalStructure/PW C104784
type: ChemicalStructure
structure format: SMILES

Cytochrome P450 3A4
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: Cytochrome P450 3A4

Reference/SMPDB SMP0125559
type: UnificationXref
id: SMP0125559
db: SMPDB

Reference/CAS 2616-64-0
type: UnificationXref
id: 2616-64-0
db: CAS

Cytochrome P450 3A4
type: ProteinReference
xref: Reference/UniProt P08684
organism: BiologicalState973

NADPH
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: NADPH

Compound/PW C104784 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: FMN
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000935
type: UnificationXref
id: HMDB0000935
db: HMDB

Compound/PW C108887 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3'-Amino-3'-deoxythymidine
stoichiometric coefficient: 1.0

Reference/ChemSpider 5675
type: UnificationXref
id: 5675
db: ChemSpider

Solute carrier family 22 member 7
type: ProteinReference
xref: Reference/UniProt Q9Y694

Reference/KEGG Compound C00167
type: UnificationXref
id: C00167
db: KEGG Compound

Canalicular multispecific organic anion transporter 2
type: ProteinReference
xref: Reference/UniProt O15438

Reference/UniProt O15438
type: UnificationXref
id: O15438
db: UniProt

Uridine diphosphate glucuronic acid
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Uridine diphosphate glucuronic acid

Reference/UniProt P16662
type: UnificationXref
id: P16662
db: UniProt

Reference/PubChem-compound 108074
type: UnificationXref
id: 108074
db: PubChem-compound

Compound/PW C000146 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

Uridine 5'-diphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 17659
xref: Reference/PubChem-compound 6031
xref: Reference/CAS 58-98-0
xref: Reference/HMDB HMDB0000295
xref: Reference/KEGG Compound C00015
xref: Reference/ChemSpider 5809
xref: Reference/BioCyc UDP
chemical formula: C9H14N2O12P2
molecular weight: 404.0022
structure: ChemicalStructure/PW C000201

Compound/PW C113307 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: 5’glucuronyl zidovudine
stoichiometric coefficient: 1.0

Zidovudine Metabolism
type: Pathway
pathway order: PathwayEnzymeReaction/2512007
pathway order: PathwaySubPathway/118482
pathway order: PathwayEnzymeReaction/2512006
pathway order: PathwayEnzymeReaction/2512009
pathway order: PathwayTransport/2512012
pathway order: PathwayTransport/2512221
pathway order: PathwayTransport/2512011
pathway order: PathwayTransport/2512005
pathway order: PathwayTransport/2512004
pathway order: PathwayTransport/2512013
pathway component: 2.4.1.17
pathway component: Excretion
pathway component: TransportCatalysis5389
pathway component: Transport14568
pathway component: ReactionCatalysis202450
pathway component: Transport14567
pathway component: Reaction218986
pathway component: ReactionCatalysis208445
pathway component: TransportCatalysis5390
pathway component: Transport14574
pathway component: TransportCatalysis5391
pathway component: ReactionCatalysis208441
pathway component: Transport14565
pathway component: Transport14573
pathway component: Transport14572
pathway component: TransportCatalysis5385
pathway component: Reaction212806
pathway component: TransportCatalysis5384
xref: Reference/SMPDB SMP0125559
xref: Reference/PathWhiz PW127122
organism: Homo sapiens

3'-Amino-3'-deoxythymidine
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: 3'-Amino-3'-deoxythymidine

Reference/CELL TYPE ONTOLOGY CL 0000182
type: UnificationXref
id: CL:0000182
db: CELL TYPE ONTOLOGY

Zidovudine
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Zidovudine

Reference/CAS 53-59-8
type: UnificationXref
id: 53-59-8
db: CAS

Reference/BRENDA TISSUE ONTOLOGY BTO 0000759
type: UnificationXref
id: BTO:0000759
db: BRENDA TISSUE ONTOLOGY

TransportCatalysis5389
type: Catalysis
controller: Canalicular multispecific organic anion transporter 2
controlled: Transport14572
control type: ACTIVATION

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

Reference/ChEBI CHEBI 17200
type: UnificationXref
id: CHEBI:17200
db: ChEBI

ReactionCatalysis202450
type: Catalysis
controller: Cytochrome P450 3A4
controlled: Reaction212806
control type: ACTIVATION

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

ChemicalStructure/PW C113307
type: ChemicalStructure
structure format: SMILES

Compound/PW C001065 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 1.0

Compound/PW C001420 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

ChemicalStructure/PW C113306
type: ChemicalStructure
structure format: SMILES

Hydrogen Ion
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Hydrogen Ion

Reference/ChEBI CHEBI 16474
type: UnificationXref
id: CHEBI:16474
db: ChEBI

Reference/ChemSpider 952
type: UnificationXref
id: 952
db: ChemSpider

Water
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Water

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Oxygen
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001377
xref: Reference/ChemSpider 952
xref: Reference/KEGG Compound C00007
xref: Reference/ChEBI CHEBI 15379
xref: Reference/PubChem-compound 977
xref: Reference/BioCyc CPD-6641
xref: Reference/CAS 7782-44-7
chemical formula: O2
molecular weight: 31.98983
structure: ChemicalStructure/PW C001065

Reference/GENE ONTOLOGY GO 0005789
type: UnificationXref
id: GO:0005789
db: GENE ONTOLOGY

Reference/KEGG Compound C00061
type: UnificationXref
id: C00061
db: KEGG Compound

TransportCatalysis5385
type: Catalysis
controller: Solute carrier family 22 member 7
controlled: Transport14568
control type: ACTIVATION

ChemicalStructure/PW C108887
type: ChemicalStructure
structure format: SMILES

Compound/PW C113307/Stoichiometry/1.0
type: Stoichiometry
physical entity: 5’glucuronyl zidovudine
stoichiometric coefficient: 1.0

FMNH2
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 16048
xref: Reference/BioCyc FMNH2
xref: Reference/KEGG Compound C01847
xref: Reference/PubChem-compound 445395
xref: Reference/CAS 5666-16-0
xref: Reference/ChemSpider 393046
xref: Reference/HMDB HMDB0001142
chemical formula: C17H23N4O9P
molecular weight: 458.12027
structure: ChemicalStructure/PW C000891

TransportCatalysis5384
type: Catalysis
controller: Canalicular multispecific organic anion transporter 2
controlled: Transport14567
control type: ACTIVATION

Reference/ChemSpider 16522
type: UnificationXref
id: 16522
db: ChemSpider

Reference/PubChem-compound 44229199
type: UnificationXref
id: 44229199
db: PubChem-compound

Reference/UniProt Q9Y694
type: UnificationXref
id: Q9Y694
db: UniProt

Reference/BioCyc UDP-GLUCURONATE
type: UnificationXref
id: UDP-GLUCURONATE
db: BioCyc

Reference/PubChem-compound 6031
type: UnificationXref
id: 6031
db: PubChem-compound

Reference/PubChem-compound 445395
type: UnificationXref
id: 445395
db: PubChem-compound

5’glucuronyl zidovudine
type: SmallMolecule
entity reference: 5’glucuronyl zidovudine
name: SubPathwayInput

3’-amino-3’-deoxythimidine glucuronide
type: SmallMolecule
entity reference: 3’-amino-3’-deoxythimidine glucuronide
name: SubPathwayInput

BiologicalState973
type: BioSource
cell type: Hepatocyte
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Liver, Hepatocyte
tissue: Liver

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

Reference/CAS 7782-44-7
type: UnificationXref
id: 7782-44-7
db: CAS

ReactionCatalysis208445
type: Catalysis
controller: UDP-glucuronosyltransferase 2B7
controlled: Reaction218986
control type: ACTIVATION

Reference/HMDB HMDB0001377
type: UnificationXref
id: HMDB0001377
db: HMDB

TransportCatalysis5390
type: Catalysis
controller: Canalicular multispecific organic anion transporter 2
controlled: Transport14573
control type: ACTIVATION

Transport14574
type: Transport
participant stoichiometry: Compound/PW C008998/Stoichiometry/1.0
participant stoichiometry: Compound/PW C008998 Cytosol/Stoichiometry/1.0
right: Zidovudine
spontaneous: false
left: Zidovudine
name: Zidovudine (→) Transport: Homo sapiens, Liver, Hepatocyte, Cytosol to Homo sapiens, Blood Vessel
conversion direction: LEFT_TO_RIGHT

TransportCatalysis5391
type: Catalysis
controller: Canalicular multispecific organic anion transporter 2
controlled: Transport14574
control type: ACTIVATION

ReactionCatalysis208441
type: Catalysis
controller: UDP-glucuronosyltransferase 2B7
controlled: 2.4.1.17
control type: ACTIVATION

ChemicalStructure/PW C000201
type: ChemicalStructure
structure format: SMILES

Transport14573
type: Transport
participant stoichiometry: Compound/PW C113306 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C113306/Stoichiometry/1.0
right: 3’-amino-3’-deoxythimidine glucuronide
spontaneous: false
left: 3’-amino-3’-deoxythimidine glucuronide
name: 3’-amino-3’-deoxythimidine glucuronide (→) Transport: Homo sapiens, Liver, Hepatocyte, Cytosol to Homo sapiens, Blood Vessel
conversion direction: LEFT_TO_RIGHT

Compound/PW C000746 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Uridine diphosphate glucuronic acid
stoichiometric coefficient: 1.0

Transport14572
type: Transport
participant stoichiometry: Compound/PW C113307 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C113307/Stoichiometry/1.0
right: 5’glucuronyl zidovudine
spontaneous: false
left: 5’glucuronyl zidovudine
name: 5’glucuronyl zidovudine (→) Transport: Homo sapiens, Liver, Hepatocyte, Cytosol to Homo sapiens, Blood Vessel
conversion direction: LEFT_TO_RIGHT

NADPH
type: SmallMoleculeReference
xref: Reference/CAS 53-57-6
xref: Reference/HMDB HMDB0000221
xref: Reference/PubChem-compound 22833512
xref: Reference/BioCyc NADPH
xref: Reference/ChemSpider 17215925
xref: Reference/KEGG Compound C00005
xref: Reference/ChEBI CHEBI 16474
chemical formula: C21H30N7O17P3
molecular weight: 745.0911
structure: ChemicalStructure/PW C000146

Reference/CAS 5666-16-0
type: UnificationXref
id: 5666-16-0
db: CAS

NADP
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00006
xref: Reference/CAS 53-59-8
xref: Reference/BioCyc NAD(P)
xref: Reference/HMDB HMDB0000217
xref: Reference/ChEBI CHEBI 18009
xref: Reference/PubChem-compound 5886
xref: Reference/ChemSpider 5675
chemical formula: C21H28N7O17P3
molecular weight: 743.07544
structure: ChemicalStructure/PW C000143

Compound/PW C008998 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Zidovudine
stoichiometric coefficient: 1.0

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Reference/ChemSpider 32555
type: UnificationXref
id: 32555
db: ChemSpider

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Uridine diphosphate glucuronic acid
type: SmallMoleculeReference
xref: Reference/BioCyc UDP-GLUCURONATE
xref: Reference/CAS 2616-64-0
xref: Reference/PubChem-compound 17473
xref: Reference/HMDB HMDB0000935
xref: Reference/ChEBI CHEBI 17200
xref: Reference/ChemSpider 16522
xref: Reference/KEGG Compound C00167
chemical formula: C15H22N2O18P2
molecular weight: 580.0343
structure: ChemicalStructure/PW C000746

Reference/BioCyc NADPH
type: UnificationXref
id: NADPH
db: BioCyc

Zidovudine
type: SmallMolecule
cellular location: Cytosol
entity reference: Zidovudine

Reference/KEGG Compound C01847
type: UnificationXref
id: C01847
db: KEGG Compound

Compound/PW C113306 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3’-amino-3’-deoxythimidine glucuronide
stoichiometric coefficient: 1.0

Reference/CAS 58-98-0
type: UnificationXref
id: 58-98-0
db: CAS

5’glucuronyl zidovudine
type: SmallMolecule
cellular location: Cytosol
entity reference: 5’glucuronyl zidovudine

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

SubPathwayInteraction118482
type: Interaction
name: SubPathway118482Reaction
name: SubPathwayReaction
participant: Zidovudine
participant: 5’glucuronyl zidovudine
participant: 3’-amino-3’-deoxythimidine glucuronide

Reference/BioCyc CPD-6641
type: UnificationXref
id: CPD-6641
db: BioCyc

Reference/ChEBI CHEBI 10110
type: UnificationXref
id: CHEBI:10110
db: ChEBI

Transport14568
type: Transport
participant stoichiometry: Compound/PW C008998/Stoichiometry/1.0
participant stoichiometry: Compound/PW C008998 Cytosol/Stoichiometry/1.0
right: Zidovudine
spontaneous: false
left: Zidovudine
name: Zidovudine (→) Transport: Homo sapiens, Blood Vessel to Homo sapiens, Liver, Hepatocyte, Cytosol
conversion direction: LEFT_TO_RIGHT

Compound/PW C040034 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Compound/PW C000891 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: FMNH2
stoichiometric coefficient: 1.0

Transport14567
type: Transport
participant stoichiometry: Compound/PW C008998/Stoichiometry/1.0
right: Zidovudine
spontaneous: false
left: Zidovudine
name: Zidovudine (→) Transport: Homo sapiens, Intestine to Homo sapiens, Blood Vessel
conversion direction: LEFT_TO_RIGHT

3’-amino-3’-deoxythimidine glucuronide
type: SmallMoleculeReference
chemical formula: C16H21N5O10
molecular weight: 443.12885
structure: ChemicalStructure/PW C113306

5’glucuronyl zidovudine
type: SmallMoleculeReference
chemical formula: C16H21N5O10
molecular weight: 443.12885
structure: ChemicalStructure/PW C113307

ChemicalStructure/PW C000891
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

Compound/PW C000201 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Uridine 5'-diphosphate
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001065
type: ChemicalStructure
structure format: SMILES
structure data: O=O

Transport14565
type: Transport
participant stoichiometry: Compound/PW C008998/Stoichiometry/1.0
right: Zidovudine
spontaneous: false
left: Zidovudine
name: Zidovudine (→) Transport: Homo sapiens to Homo sapiens, Intestine
conversion direction: LEFT_TO_RIGHT

Solute carrier family 22 member 7
type: Protein
entity reference: Solute carrier family 22 member 7

FMN
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: FMN

UDP-glucuronosyltransferase 2B7
type: ProteinReference
xref: Reference/UniProt P16662
organism: BiologicalState973

Reference/HMDB HMDB0000217
type: UnificationXref
id: HMDB0000217
db: HMDB

Zidovudine
type: SmallMoleculeReference
xref: Reference/CAS 30516-87-1
xref: Reference/ChemSpider 32555
xref: Reference/KEGG Compound C07210
xref: Reference/HMDB HMDB0014638
xref: Reference/PubChem-compound 35370
xref: Reference/ChEBI CHEBI 10110
chemical formula: C10H13N5O4
molecular weight: 267.09674
structure: ChemicalStructure/PW C008998

Canalicular multispecific organic anion transporter 2
type: Protein
entity reference: Canalicular multispecific organic anion transporter 2

Compound/PW C008998 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Zidovudine
stoichiometric coefficient: 1.0

3'-Amino-3'-deoxythymidine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 108074
chemical formula: C10H15N3O4
molecular weight: 241.10626
structure: ChemicalStructure/PW C108887

Reference/HMDB HMDB0000295
type: UnificationXref
id: HMDB0000295
db: HMDB

Reference/HMDB HMDB0001142
type: UnificationXref
id: HMDB0001142
db: HMDB

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Reference/ChemSpider 5809
type: UnificationXref
id: 5809
db: ChemSpider

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/KEGG Compound C00007
type: UnificationXref
id: C00007
db: KEGG Compound

Reference/ChEBI CHEBI 15379
type: UnificationXref
id: CHEBI:15379
db: ChEBI

Oxygen
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Oxygen

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Reference/KEGG Compound C00006
type: UnificationXref
id: C00006
db: KEGG Compound

Reference/UniProt P08684
type: UnificationXref
id: P08684
db: UniProt

FMN
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00061
xref: Reference/ChEBI CHEBI 58210
xref: Reference/PubChem-compound 44229199
chemical formula: C17H18N4O9P
molecular weight: 453.0828
structure: ChemicalStructure/PW C104784

Reference/ChEBI CHEBI 18009
type: UnificationXref
id: CHEBI:18009
db: ChEBI

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/PubChem-compound 5886
type: UnificationXref
id: 5886
db: PubChem-compound

Reference/KEGG Compound C00005
type: UnificationXref
id: C00005
db: KEGG Compound

Liver
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000759

ChemicalStructure/PW C000143
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000221
type: UnificationXref
id: HMDB0000221
db: HMDB

ChemicalStructure/PW C000146
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 17473
type: UnificationXref
id: 17473
db: PubChem-compound

Compound/PW C113306/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3’-amino-3’-deoxythimidine glucuronide
stoichiometric coefficient: 1.0

Reference/PathWhiz PW127122
type: UnificationXref
id: PW127122
db: PathWhiz

UDP-glucuronosyltransferase 2B7
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: UDP-glucuronosyltransferase 2B7

Reference/CAS 53-57-6
type: UnificationXref
id: 53-57-6
db: CAS

2.4.1.17
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000201 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000746 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C008998 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C113307 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: 5’glucuronyl zidovudine
right: Uridine 5'-diphosphate
right: Hydrogen Ion
spontaneous: false
EC number: 2.4.1.17
left: Uridine diphosphate glucuronic acid
left: Zidovudine
name: Uridine diphosphate glucuronic acid + Zidovudine → 5’glucuronyl zidovudine + Hydrogen Ion + Uridine 5'-diphosphate
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0014638
type: UnificationXref
id: HMDB0014638
db: HMDB

FMNH2
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: FMNH2

3’-amino-3’-deoxythimidine glucuronide
type: SmallMolecule
cellular location: Cytosol
entity reference: 3’-amino-3’-deoxythimidine glucuronide

Reference/KEGG Compound C00015
type: UnificationXref
id: C00015
db: KEGG Compound

ChemicalStructure/PW C000746
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc FMNH2
type: UnificationXref
id: FMNH2
db: BioCyc

Reference/PubChem-compound 22833512
type: UnificationXref
id: 22833512
db: PubChem-compound

Reference/KEGG Compound C07210
type: UnificationXref
id: C07210
db: KEGG Compound

Zidovudine
type: SmallMolecule
entity reference: Zidovudine
name: SubPathwayInput

Reference/BioCyc NAD(P)
type: UnificationXref
id: NAD(P)
db: BioCyc

ChemicalStructure/PW C008998
type: ChemicalStructure
structure format: SMILES
structure data: CC1=CN([C@H]2C[C@H](N=[N+]=[N-])[C@@H](CO)O2)C(=O)NC1=O

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Uridine 5'-diphosphate
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Uridine 5'-diphosphate

Reference/ChemSpider 393046
type: UnificationXref
id: 393046
db: ChemSpider

Reference/PubChem-compound 35370
type: UnificationXref
id: 35370
db: PubChem-compound

Hepatocyte
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000182

NADP
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: NADP

Compound/PW C000143 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16048
type: UnificationXref
id: CHEBI:16048
db: ChEBI

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

3’-amino-3’-deoxythimidine glucuronide
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: 3’-amino-3’-deoxythimidine glucuronide

Reference/ChEBI CHEBI 17659
type: UnificationXref
id: CHEBI:17659
db: ChEBI

Reference/PubChem-compound 977
type: UnificationXref
id: 977
db: PubChem-compound

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Compound/PW C008998/Stoichiometry/1.0
type: Stoichiometry
physical entity: Zidovudine
stoichiometric coefficient: 1.0

Reaction218986
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000201 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000746 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C108887 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C113306 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: 3’-amino-3’-deoxythimidine glucuronide
right: Uridine 5'-diphosphate
right: Hydrogen Ion
spontaneous: false
left: 3'-Amino-3'-deoxythymidine
left: Uridine diphosphate glucuronic acid
name: 3'-Amino-3'-deoxythymidine + Uridine diphosphate glucuronic acid → 3’-amino-3’-deoxythimidine glucuronide + Hydrogen Ion + Uridine 5'-diphosphate
conversion direction: LEFT_TO_RIGHT

5’glucuronyl zidovudine
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: 5’glucuronyl zidovudine

Reaction212806
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000146 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C008998 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C104784 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C108887 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000891 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Water
right: 3'-Amino-3'-deoxythymidine
right: FMN
right: Hydrogen Ion
right: NADP
spontaneous: false
left: Oxygen
left: Zidovudine
left: NADPH
left: FMNH2
name: FMNH2 + NADPH + Oxygen + Zidovudine → 3'-Amino-3'-deoxythymidine + FMN + Hydrogen Ion + NADP + Water
conversion direction: LEFT_TO_RIGHT

Compound/PW C113306 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3’-amino-3’-deoxythimidine glucuronide
stoichiometric coefficient: 1.0