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Solute carrier family 22 member 7 Canalicular multispecific organic anion transporter 2 Canalicular multispecific organic anion transporter 2 Canalicular multispecific organic anion transporter 2 Canalicular multispecific organic anion transporter 2 Canalicular multispecific organic anion transporter 2 Canalicular multispecific organic anion transporter 2 UDP- glucuronosyltransferase 1-9 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 UDP- glucuronosyltransferase 2B7 Buprenorphine Norbuprenorphine Buprenorphine glucuronide Norbuprenorphine glucuronide Hydroxynorbuprenorphine Hydroxybuprenorphine Buprenorphine Buprenorphine Norbuprenorphine Norbuprenorphine glucuronide Buprenorphine glucuronide Hydroxynorbuprenorphine Hydroxybuprenorphine Uridine diphosphate glucuronic acid Uridine 5'-diphosphate H+ O2 FMNH2 H+ H2O Flavin Mononucleotide Cyclopropanecarboxaldehyde O2 FMNH2 Flavin Mononucleotide H2O H+ O2 FMNH2 Flavin Mononucleotide H+ H2O Uridine diphosphate glucuronic acid Uridine 5'-diphosphate H+ Excretion Excretion Heme Heme Heme Heme Cytosol Hepatocyte Endoplasmic Reticulum IV administration
Endoplasmic Reticulum SLC22A7 ABCC3 ABCC3 ABCC3 ABCC3 ABCC3 ABCC3 UGT1A9 CYP3A4 CYP3A4 CYP3A4 CYP3A4 UGT2B7 Buprenorphine Norbuprenorphine Buprenorphine glucuronide Norbuprenorphine glucuronide Hydroxynorbuprenorphine Hydroxybuprenorphine Buprenorphine Buprenorphine Norbuprenorphine Norbuprenorphine glucuronide Buprenorphine glucuronide Hydroxynorbuprenorphine Hydroxybuprenorphine Uridine diphosphate glucuronic acid Uridine 5'-diphosphate Hydrogen Ion Oxygen FMNH2 Hydrogen Ion Water Flavin Mononucleotide Cyclopropanecarboxaldehyde Oxygen FMNH2 Flavin Mononucleotide Water Hydrogen Ion Oxygen FMNH2 Flavin Mononucleotide Hydrogen Ion Water Uridine diphosphate glucuronic acid Uridine 5'-diphosphate Hydrogen Ion Excretion Excretion
SLC22A7 ABCC3 ABCC3 ABCC3 ABCC3 ABCC3 ABCC3 UGT1A9 CYP3A4 CYP3A4 CYP3A4 CYP3A4 UGT2B7 Bupreno Norbu Bup glu Nor glu Hydro Hydro Bupreno Bupreno Norbu Nor glu Bup glu Hydro Hydro UDPGlcA UDP H+ O2 FMNH2 H+ H2O FlvnMnt Cyclo O2 FMNH2 FlvnMnt H2O H+ O2 FMNH2 FlvnMnt H+ H2O UDPGlcA UDP H+ Excre Excre Heme Heme Heme Heme Cytosol Hepatocyte Endoplasmic Reticulum IV administration
Endoplasmic Reticulum SLC22A7 ABCC3 ABCC3 ABCC3 ABCC3 ABCC3 ABCC3 UGT1A9 CYP3A4 CYP3A4 CYP3A4 CYP3A4 UGT2B7 Bupreno Norbu Bup glu Nor glu Hydro Hydro Bupreno Bupreno Norbu Nor glu Bup glu Hydro Hydro UDPGlcA UDP H+ O2 FMNH2 H+ H2O FlvnMnt Cyclo O2 FMNH2 FlvnMnt H2O H+ O2 FMNH2 FlvnMnt H+ H2O UDPGlcA UDP H+ Excre Excre