PathWhiz

Pathway Description

Penciclovir Action Pathway

Homo sapiens

Drug Action Pathway

Penciclovir is a topical nucleoside polymerase inhibitor used in the treatment of various herpes simplex virus (HSV) infections. Penciclovir has in vitro activity against herpes simplex virus types 1 (HSV-1) and 2 (HSV-2). In cells infected with HSV-1 or HSV-2, viral thymidine kinase phosphorylates penciclovir to a monophosphate form. The monophosphate form of the drug is then converted to penciclovir triphosphate by cellular kinases. Penciclovir triphosphate inhibits the activity of DNA polymerase by competing with its substrate dGTP. Less Viral DNA is transported into the nucleus, therefore, less viral DNA is integrated into the host DNA. Less viral proteins produced, fewer viruses can form.

References

Penciclovir Pathway References

https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/020629s019lbl.pdf

Pubmed: 17016423

Pubmed: 16033961

Pubmed: 19895215

Pubmed: 19228073

Pubmed: 11752352

Pubmed: 12709344

Pubmed: 17488477

Pubmed: 29126136

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