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Polymerase acidic protein Polymerase basic protein 2 Polymerase basic protein 2 Polymerase acidic protein RNA polymerase Multidrug resistance- associated protein 4 Hemagglutinin Neuraminidase Matrix protein 2 Nucleoprotein Non-structural protein 1 Nuclear export protein RNA-directed RNA polymerase catalytic subunit Polymerase basic protein 2 Polymerase acidic protein RNA polymerase Baloxavir Baloxavir Baloxavir marboxil H2O Manganese Calcium Manganese Influenza A virus (A/Korea/426/1968(H2N2)) RNA Influenza A virus (A/Korea/426/1968(H2N2)) RNA Influenza A virus (A/Korea/426/1968(H2N2)) RNA Influenza A virus (A/Korea/426/1968(H2N2)) RNA Influenza A virus (A/Korea/426/1968(H2N2)) mRNA Influenza A virus (A/Korea/426/1968(H2N2)) mRNA Manganese Endocytosis Viral RNA Viral mRNA RNA replication Rimantadine inhibits matrix protein 2 on the influeza virus, which is responsible for the uncoating of the virus. The inhibition of the synthesis of mRNA prevents the translation of mRNA into required viral proteins Translation Viral RNA and viral proteins are unable to be assembled or released due to the inhibition of mRNA synthesis Assembly Budding & Release Respiratory Epithelial Cell Cytosol Nucleus Baloxavir inhibits polymerase acidic protein which is part of RNA polymerase and blocks the initiation of mRNA synthesis Hydrolysis Transcription Baloxavir marboxil is hydrolyzed into baloxavir by esterases in the gastrointestinal lumen, intestinal epithelium, liver and blood
PA PB2 PB2 PA PB1 ABCC4 HA NA M NP NS NS PB1 PB2 PA PB1 Baloxavir Baloxavir Baloxavir marboxil Water Influenza A virus (A/Korea/426/1968(H2N2)) RNA Influenza A virus (A/Korea/426/1968(H2N2)) RNA Influenza A virus (A/Korea/426/1968(H2N2)) RNA Influenza A virus (A/Korea/426/1968(H2N2)) RNA Influenza A virus (A/Korea/426/1968(H2N2)) mRNA Influenza A virus (A/Korea/426/1968(H2N2)) mRNA
PA PB2 PB2 PA PB1 ABCC4 HA NA M NP NS NS PB1 PB2 PA PB1 Balox Balox Bal mar H2O Mn2+ Ca2+ Mn2+ I A v A I A v A I A v A I A v A I A v A I A v A Mn2+ Endocytosis Viral RNA Viral mRNA RNA replication Rimantadine inhibits matrix protein 2 on the influeza virus, which is responsible for the uncoating of the virus. The inhibition of the synthesis of mRNA prevents the translation of mRNA into required viral proteins Translation Viral RNA and viral proteins are unable to be assembled or released due to the inhibition of mRNA synthesis Assembly Budding & Release Respiratory Epithelial Cell Cytosol Nucleus Baloxavir inhibits polymerase acidic protein which is part of RNA polymerase and blocks the initiation of mRNA synthesis Hydrolysis Transcription Baloxavir marboxil is hydrolyzed into baloxavir by esterases in the gastrointestinal lumen, intestinal epithelium, liver and blood
PA PB2 PB2 PA PB1 ABCC4 HA NA M NP NS NS PB1 PB2 PA PB1 Balox Balox Bal mar H2O I A v A I A v A I A v A I A v A I A v A I A v A