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Non-structural protein 2 Fusion glycoprotein F1 Fusion glycoprotein F2 Fusion glycoprotein F2 Major surface glycoprotein G Small hydrophobic protein Nucleoprotein RNA-directed RNA polymerase L Phosphoprotein Matrix protein Protein M2-1 Protein M2-2 Non-structural protein 1 Phosphoprotein Fusion glycoprotein F1 RNA-directed RNA polymerase L Palivizumab Palivizumab Magnesium Magnesium Respiratory syncytial virus RNA Respiratory syncytial virus RNA Respiratory syncytial virus RNA Respiratory syncytial virus RNA Ribosome Transcription RNA Replication Translation Golgi Apparatus Blood Vessel The human respiratory syncytial virus (RSV) is prevented entering the host cell, and therefore, the viral RNA is not released into the host cell Endoplasmic Reticulum Viral RNA is translated into proteins required for viral RNA replication and viral cell synthesis Viral mRNA is replicated by viral RNA-directed RNA polymerase Viral RNA and viral proteins are transported via the golgi apparatus to the plasma membrane, where particle budding occurs Palivizumab binds to fusion glycoprotein F which inhibits the binding and uptake of the virus into the host cell Respiratory syncytial virus Infected Cell Endocytosis Due to the inhibition of host cell binding and uptake, viral propagation and infection is unable to occur
Melanosome 1B F F F G SH N L P M M2-1 M2-2 1C P F L Palivizumab Palivizumab Respiratory syncytial virus RNA Respiratory syncytial virus RNA Respiratory syncytial virus RNA Respiratory syncytial virus RNA
1B F F F G SH N L P M M2-1 M2-2 1C P F L Paliv Paliv Mg2+ Mg2+ R s v R R s v R R s v R R s v R Ribosome Transcription RNA Replication Translation Golgi Apparatus Blood Vessel The human respiratory syncytial virus (RSV) is prevented entering the host cell, and therefore, the viral RNA is not released into the host cell Endoplasmic Reticulum Viral RNA is translated into proteins required for viral RNA replication and viral cell synthesis Viral mRNA is replicated by viral RNA-directed RNA polymerase Viral RNA and viral proteins are transported via the golgi apparatus to the plasma membrane, where particle budding occurs Palivizumab binds to fusion glycoprotein F which inhibits the binding and uptake of the virus into the host cell Respiratory syncytial virus Infected Cell Endocytosis Due to the inhibition of host cell binding and uptake, viral propagation and infection is unable to occur
Melanosome 1B F F F G SH N L P M M2-1 M2-2 1C P F L Paliv Paliv R s v R R s v R R s v R R s v R