Loxoprofen
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Loxoprofen

Reference/CAS 57576-52-0
type: UnificationXref
id: 57576-52-0
db: CAS

Reference/BioCyc PROSTAGLANDIN-H2
type: UnificationXref
id: PROSTAGLANDIN-H2
db: BioCyc

Arachidonic acid
type: SmallMoleculeReference
xref: Reference/CAS 506-32-1
xref: Reference/BioCyc ARACHIDONIC ACID
xref: Reference/ChEBI CHEBI 15843
xref: Reference/KEGG Compound C00219
xref: Reference/HMDB HMDB0001043
xref: Reference/ChemSpider 392692
xref: Reference/PubChem-compound 444899
chemical formula: C20H32O2
molecular weight: 304.24023
structure: ChemicalStructure/PW C000821

Reference/ChEBI CHEBI 15843
type: UnificationXref
id: CHEBI:15843
db: ChEBI

Thromboxane A2
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Thromboxane A2

Reference/PubChem-compound 445049
type: UnificationXref
id: 445049
db: PubChem-compound

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Reference/PubChem-compound 5280360
type: UnificationXref
id: 5280360
db: PubChem-compound

Prostaglandin E2
type: SmallMoleculeReference
xref: Reference/CAS 363-24-6
xref: Reference/ChemSpider 4444059
xref: Reference/KEGG Compound C00584
xref: Reference/BioCyc 5Z13E-15S-1115-DIHYDROXY-9-OXOPROS
xref: Reference/PubChem-compound 5280360
xref: Reference/ChEBI CHEBI 15551
xref: Reference/HMDB HMDB0001220
chemical formula: C20H32O5
molecular weight: 352.22498
structure: ChemicalStructure/PW C000949

Compound/PW C113477 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Loxoprofen trans-OH metabolite
stoichiometric coefficient: 1.0

Compound/PW C022674 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Loxoprofen
stoichiometric coefficient: 1.0

direct_interaction
type: InteractionVocabulary

Thromboxane A2
type: SmallMoleculeReference
xref: Reference/CAS 57576-52-0
xref: Reference/PubChem-compound 5280497
xref: Reference/ChemSpider 4444137
xref: Reference/BioCyc ALPHA11-ALPHA-EPOXY-15-HYDROXYTHROMBA
xref: Reference/ChEBI CHEBI 15627
xref: Reference/KEGG Compound C02198
xref: Reference/HMDB HMDB0001452
chemical formula: C20H32O5
molecular weight: 352.22498
structure: ChemicalStructure/PW C001121

Cytosolic phospholipase A2
type: Protein
cellular location: Cytosol
entity reference: Cytosolic phospholipase A2

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Carbonyl reductase [NADPH] 1
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: Carbonyl reductase [NADPH] 1

Prostaglandin G/H synthase 1
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: Prostaglandin G/H synthase 1

Reaction212945
type: BiochemicalReaction
participant stoichiometry: Compound/Generic41 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001814 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001068 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/Generic40 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Prostaglandin G2
right: Reduced acceptor
spontaneous: false
left: Water
left: Acceptor
left: Prostaglandin H2
name: Acceptor + Prostaglandin H2 + Water ← Prostaglandin G2 + Reduced acceptor
conversion direction: RIGHT_TO_LEFT

Reaction219339
type: BiochemicalReaction
participant stoichiometry: Compound/PW C113477 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C022674 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Loxoprofen trans-OH metabolite
spontaneous: false
left: Loxoprofen
name: Loxoprofen → Loxoprofen trans-OH metabolite
conversion direction: LEFT_TO_RIGHT

Reference/UniProt Q4U2R8
type: UnificationXref
id: Q4U2R8
db: UniProt

Reference/PubChem-compound 5282411
type: UnificationXref
id: 5282411
db: PubChem-compound

Reference/UniProt P24557
type: UnificationXref
id: P24557
db: UniProt

Reference/CAS 68767-14-6
type: UnificationXref
id: 68767-14-6
db: CAS

Compound/Generic617 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phospholipids
stoichiometric coefficient: 1.0

Reference/CELL TYPE ONTOLOGY CL 0000182
type: UnificationXref
id: CL:0000182
db: CELL TYPE ONTOLOGY

Reference/ChemSpider 4444137
type: UnificationXref
id: 4444137
db: ChemSpider

Reference/BRENDA TISSUE ONTOLOGY BTO 0000759
type: UnificationXref
id: BTO:0000759
db: BRENDA TISSUE ONTOLOGY

Reference/KEGG Compound C00219
type: UnificationXref
id: C00219
db: KEGG Compound

Solute carrier family 22 member 6
type: Protein
entity reference: Solute carrier family 22 member 6

Reaction213363
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000821 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/Generic617 Cytosol/Stoichiometry/1.0
right: Arachidonic acid
spontaneous: false
left: Phospholipids
name: Phospholipids → Arachidonic acid
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C02198
type: UnificationXref
id: C02198
db: KEGG Compound

Reference/ChEBI CHEBI 15022
type: UnificationXref
id: CHEBI:15022
db: ChEBI

Reference/ChemSpider 952
type: UnificationXref
id: 952
db: ChemSpider

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

5.3.99.5
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001068 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001121 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Thromboxane A2
spontaneous: false
EC number: 5.3.99.5
left: Prostaglandin H2
name: Prostaglandin H2 → Thromboxane A2
conversion direction: LEFT_TO_RIGHT

Reference/UniProt P35354
type: UnificationXref
id: P35354
db: UniProt

Reference/UniProt P16152
type: UnificationXref
id: P16152
db: UniProt

Reference/UniProt Q16647
type: UnificationXref
id: Q16647
db: UniProt

Compound/PW C000949 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Prostaglandin E2
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00584
type: UnificationXref
id: C00584
db: KEGG Compound

Loxoprofen
type: SmallMolecule
entity reference: Loxoprofen

Compound/PW C001121 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Thromboxane A2
stoichiometric coefficient: 1.0

Reference/UniProt O14684
type: UnificationXref
id: O14684
db: UniProt

Reference/KEGG Compound C01312
type: UnificationXref
id: C01312
db: KEGG Compound

Reference/ChEBI CHEBI 76204
type: UnificationXref
id: CHEBI:76204
db: ChEBI

Reference/CAS 363-24-6
type: UnificationXref
id: 363-24-6
db: CAS

Reference/PubChem-compound 5280497
type: UnificationXref
id: 5280497
db: PubChem-compound

Acceptor
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Acceptor

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Prostaglandin E synthase
type: Complex
component stoichiometry: Protein/76 Cytoplasm/Stoichiometry/3.0
cellular location: Cytoplasm
component: Prostaglandin E synthase

Reference/BioCyc CPD-6641
type: UnificationXref
id: CPD-6641
db: BioCyc

Phospholipids
type: SmallMoleculeReference

Compound/PW C001065 Endoplasmic Reticulum Membrane/Stoichiometry/2.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 2.0

Prostaglandin E2
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Prostaglandin E2

Thromboxane-A synthase
type: ProteinReference
xref: Reference/UniProt P24557
organism: Homo sapiens

Reference/CAS 42935-17-1
type: UnificationXref
id: 42935-17-1
db: CAS

Prostaglandin E synthase
type: Protein
cellular location: Cytoplasm
entity reference: Prostaglandin E synthase

ReactionCatalysis188
type: Catalysis
controller: Prostaglandin E synthase
controlled: 5.3.99.3
control type: ACTIVATION

Reference/KEGG Compound C00007
type: UnificationXref
id: C00007
db: KEGG Compound

Oxygen
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Oxygen

Compound/Generic41 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acceptor
stoichiometric coefficient: 1.0

ReactionCatalysis187
type: Catalysis
controller: Prostacyclin synthase
controlled: 5.3.99.4
control type: ACTIVATION

Prostaglandin G/H synthase 2
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: Prostaglandin G/H synthase 2

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Protein/76 Cytoplasm/Stoichiometry/3.0
type: Stoichiometry
physical entity: Prostaglandin E synthase
stoichiometric coefficient: 3.0

Prostaglandin G/H synthase 1
type: ProteinReference
xref: Reference/UniProt P23219
organism: Homo sapiens

Prostaglandin G/H synthase 2
type: ProteinReference
xref: Reference/UniProt P35354
organism: Homo sapiens

Liver
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000759

Loxoprofen trans-OH metabolite
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Loxoprofen trans-OH metabolite

Transport15247
type: Transport
participant stoichiometry: Compound/PW C113477/Stoichiometry/1.0
participant stoichiometry: Compound/PW C113477 Cytosol/Stoichiometry/1.0
right: Loxoprofen trans-OH metabolite
spontaneous: false
left: Loxoprofen trans-OH metabolite
name: Loxoprofen trans-OH metabolite (→) Transport: Homo sapiens, Blood Vessel to Homo sapiens, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Transport15246
type: Transport
participant stoichiometry: Compound/PW C113477/Stoichiometry/1.0
participant stoichiometry: Compound/PW C113477 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Loxoprofen trans-OH metabolite
spontaneous: false
left: Loxoprofen trans-OH metabolite
name: Loxoprofen trans-OH metabolite (→) Transport: Homo sapiens, Liver, Hepatocyte, Endoplasmic Reticulum Membrane to Homo sapiens, Blood Vessel
conversion direction: LEFT_TO_RIGHT

ReactionCatalysis208781
type: Catalysis
controller: Carbonyl reductase [NADPH] 1
controlled: Reaction219339
control type: ACTIVATION

ReactionCatalysis738
type: Catalysis
controller: Prostaglandin G/H synthase 2
controlled: 1.14.99.1
control type: ACTIVATION

Arachidonic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Arachidonic acid

Compound/PW C113477/Stoichiometry/1.0
type: Stoichiometry
physical entity: Loxoprofen trans-OH metabolite
stoichiometric coefficient: 1.0

Protein/914 Endoplasmic Reticulum Membrane/Stoichiometry/2.0
type: Stoichiometry
physical entity: Prostaglandin G/H synthase 1
stoichiometric coefficient: 2.0

Reference/ChemSpider 4444059
type: UnificationXref
id: 4444059
db: ChemSpider

ReactionCatalysis73
type: Catalysis
controller: Prostaglandin G/H synthase 1
controlled: 1.14.99.1
control type: ACTIVATION

Reference/PubChem-compound 444899
type: UnificationXref
id: 444899
db: PubChem-compound

Prostaglandin G2
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0003235
xref: Reference/PubChem-compound 5280883
xref: Reference/ChEBI CHEBI 27647
xref: Reference/CAS 51982-36-6
xref: Reference/KEGG Compound C05956
xref: Reference/ChemSpider 4444406
chemical formula: C20H32O6
molecular weight: 368.21988
structure: ChemicalStructure/PW C001814

ReactionCatalysis77
type: Catalysis
controller: Thromboxane-A synthase
controlled: 5.3.99.5
control type: ACTIVATION

Reference/UniProt P23219
type: UnificationXref
id: P23219
db: UniProt

Loxoprofen trans-OH metabolite
type: SmallMolecule
entity reference: Loxoprofen trans-OH metabolite

Hepatocyte
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000182

Reference/ChemSpider 8213221
type: UnificationXref
id: 8213221
db: ChemSpider

Reference/ChemSpider 392800
type: UnificationXref
id: 392800
db: ChemSpider

Compound/PW C001068 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Prostaglandin H2
stoichiometric coefficient: 1.0

Solute carrier family 22 member 6
type: ProteinReference
xref: Reference/UniProt Q4U2R8

Prostaglandin I2
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15552
xref: Reference/ChemSpider 4445566
xref: Reference/HMDB HMDB0001335
xref: Reference/BioCyc 5Z13E-15S-69-ALPHA-EPOXY-11-ALPHA
xref: Reference/PubChem-compound 5282411
xref: Reference/CAS 35121-78-9
xref: Reference/KEGG Compound C01312
chemical formula: C20H32O5
molecular weight: 352.22498
structure: ChemicalStructure/PW C001028

Reference/KEGG Compound C05956
type: UnificationXref
id: C05956
db: KEGG Compound

Reference/SMPDB SMP0126099
type: UnificationXref
id: SMP0126099
db: SMPDB

Loxoprofen trans-OH metabolite
type: SmallMolecule
cellular location: Cytosol
entity reference: Loxoprofen trans-OH metabolite

Phospholipids
type: SmallMolecule
cellular location: Cytosol
entity reference: Phospholipids

Reference/HMDB HMDB0001335
type: UnificationXref
id: HMDB0001335
db: HMDB

Arachidonic acid
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Arachidonic acid

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

Compound/PW C001814 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Prostaglandin G2
stoichiometric coefficient: 1.0

Reference/BioCyc ALPHA11-ALPHA-EPOXY-15-HYDROXYTHROMBA
type: UnificationXref
id: ALPHA11-ALPHA-EPOXY-15-HYDROXYTHROMBA
db: BioCyc

Reference/ChEBI CHEBI 15627
type: UnificationXref
id: CHEBI:15627
db: ChEBI

Reference/HMDB HMDB0001452
type: UnificationXref
id: HMDB0001452
db: HMDB

Compound/PW C000821 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Arachidonic acid
stoichiometric coefficient: 1.0

Endoplasmic Reticulum Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005789

ChemicalStructure/PW C001814
type: ChemicalStructure
structure format: SMILES

Loxoprofen trans-OH metabolite
type: SmallMoleculeReference
xref: Reference/ChemSpider 8213221
xref: Reference/ChEBI CHEBI 76204
chemical formula: C15H20O3
molecular weight: 248.14125

Reference/PathWhiz PW127678
type: UnificationXref
id: PW127678
db: PathWhiz

Reference/PubChem-compound 5280883
type: UnificationXref
id: 5280883
db: PubChem-compound

Compound/Generic40 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Reduced acceptor
stoichiometric coefficient: 1.0

Reference/ChemSpider 392692
type: UnificationXref
id: 392692
db: ChemSpider

Reference/ChemSpider 3828
type: UnificationXref
id: 3828
db: ChemSpider

Reference/HMDB HMDB0001220
type: UnificationXref
id: HMDB0001220
db: HMDB

Prostaglandin E synthase
type: ProteinReference
xref: Reference/UniProt O14684
organism: Homo sapiens

Reference/HMDB HMDB0041920
type: UnificationXref
id: HMDB0041920
db: HMDB

Reference/ChEBI CHEBI 15339
type: UnificationXref
id: CHEBI:15339
db: ChEBI

Carbonyl reductase [NADPH] 1
type: ProteinReference
xref: Reference/UniProt P16152
organism: BiologicalState973

Reduced acceptor
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Reduced acceptor

ChemicalStructure/PW C001028
type: ChemicalStructure
structure format: SMILES

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

Compound/PW C113477 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Loxoprofen trans-OH metabolite
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000949
type: ChemicalStructure
structure format: SMILES

Thromboxane-A synthase
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: Thromboxane-A synthase

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

ChemicalStructure/PW C000821
type: ChemicalStructure
structure format: SMILES
structure data: CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O

ReactionCatalysis202577
type: Catalysis
controller: Prostaglandin G/H synthase 1
controlled: Reaction212945
control type: ACTIVATION

ReactionCatalysis202578
type: Catalysis
controller: Prostaglandin G/H synthase 2
controlled: Reaction212945
control type: ACTIVATION

Acceptor
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15339

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reduced acceptor
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15022

Compound/PW C001420 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Water
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Water

ChemicalStructure/PW C001121
type: ChemicalStructure
structure format: SMILES

Oxygen
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001377
xref: Reference/ChemSpider 952
xref: Reference/KEGG Compound C00007
xref: Reference/ChEBI CHEBI 15379
xref: Reference/PubChem-compound 977
xref: Reference/BioCyc CPD-6641
xref: Reference/CAS 7782-44-7
chemical formula: O2
molecular weight: 31.98983
structure: ChemicalStructure/PW C001065

Prostaglandin H2
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00427
xref: Reference/ChEBI CHEBI 15554
xref: Reference/CAS 42935-17-1
xref: Reference/BioCyc PROSTAGLANDIN-H2
xref: Reference/ChemSpider 392800
xref: Reference/PubChem-compound 445049
xref: Reference/HMDB HMDB0001381
chemical formula: C20H32O5
molecular weight: 352.22498
structure: ChemicalStructure/PW C001068

Prostacyclin synthase
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: Prostacyclin synthase

Reference/GENE ONTOLOGY GO 0005789
type: UnificationXref
id: GO:0005789
db: GENE ONTOLOGY

Reference/ChEBI CHEBI 15552
type: UnificationXref
id: CHEBI:15552
db: ChEBI

Reference/ChEBI CHEBI 15554
type: UnificationXref
id: CHEBI:15554
db: ChEBI

Loxoprofen Action Pathway
type: Pathway
pathway order: PathwayEnzymeReaction/2523886
pathway order: PathwayInteraction/4482
pathway order: PathwayEnzymeReaction/2523887
pathway order: PathwayEnzymeReaction/2523882
pathway order: PathwayEnzymeReaction/2523883
pathway order: PathwayEnzymeReaction/2523884
pathway order: PathwayEnzymeReaction/2523885
pathway order: PathwayTransport/2529943
pathway order: PathwayTransport/2529945
pathway order: PathwayTransport/2529942
pathway order: PathwayEnzymeReaction/2523880
pathway order: PathwayEnzymeReaction/2527288
pathway order: PathwayEnzymeReaction/2523881
pathway order: PathwayInteraction/4483
pathway component: ReactionCatalysis188
pathway component: Interaction4483
pathway component: ReactionCatalysis202959
pathway component: Interaction4482
pathway component: TransportCatalysis5756
pathway component: ReactionCatalysis187
pathway component: Reaction212945
pathway component: ReactionCatalysis202577
pathway component: Reaction213363
pathway component: ReactionCatalysis73
pathway component: ReactionCatalysis202578
pathway component: Reaction219339
pathway component: ReactionCatalysis77
pathway component: 5.3.99.4
pathway component: Transport15247
pathway component: 5.3.99.3
pathway component: Transport15246
pathway component: ReactionCatalysis208781
pathway component: Transport15098
pathway component: 5.3.99.5
pathway component: ReactionCatalysis738
pathway component: 1.14.99.1
xref: Reference/PathWhiz PW127678
xref: Reference/SMPDB SMP0126099
organism: Homo sapiens

Prostacyclin synthase
type: ProteinReference
xref: Reference/UniProt Q16647
organism: Homo sapiens

BiologicalState973
type: BioSource
cell type: Hepatocyte
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Liver, Hepatocyte
tissue: Liver

Reference/ChEBI CHEBI 15551
type: UnificationXref
id: CHEBI:15551
db: ChEBI

Cytosolic phospholipase A2
type: ProteinReference
xref: Reference/UniProt P47712
organism: Homo sapiens

Reference/CAS 7782-44-7
type: UnificationXref
id: 7782-44-7
db: CAS

Reference/HMDB HMDB0001377
type: UnificationXref
id: HMDB0001377
db: HMDB

Reference/BioCyc 5Z13E-15S-69-ALPHA-EPOXY-11-ALPHA
type: UnificationXref
id: 5Z13E-15S-69-ALPHA-EPOXY-11-ALPHA
db: BioCyc

Reference/PubChem-compound 3965
type: UnificationXref
id: 3965
db: PubChem-compound

Reference/ChEBI CHEBI 27647
type: UnificationXref
id: CHEBI:27647
db: ChEBI

Prostaglandin H2
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Prostaglandin H2

Reference/UniProt P47712
type: UnificationXref
id: P47712
db: UniProt

Compound/PW C000821 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Arachidonic acid
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 76172
type: UnificationXref
id: CHEBI:76172
db: ChEBI

Loxoprofen
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0041920
xref: Reference/CAS 68767-14-6
xref: Reference/PubChem-compound 3965
xref: Reference/ChEBI CHEBI 76172
xref: Reference/ChemSpider 3828
chemical formula: C15H18O3
molecular weight: 246.1256
structure: ChemicalStructure/PW C022674

Reference/ChemSpider 4444406
type: UnificationXref
id: 4444406
db: ChemSpider

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/ChemSpider 4445566
type: UnificationXref
id: 4445566
db: ChemSpider

ReactionCatalysis202959
type: Catalysis
controller: Cytosolic phospholipase A2
controlled: Reaction213363
control type: ACTIVATION

ChemicalStructure/PW C001065
type: ChemicalStructure
structure format: SMILES
structure data: O=O

Transport15098
type: Transport
participant stoichiometry: Compound/PW C022674/Stoichiometry/1.0
participant stoichiometry: Compound/PW C022674 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Loxoprofen
spontaneous: false
left: Loxoprofen
name: Loxoprofen (→) Transport: Homo sapiens to Homo sapiens, Liver, Hepatocyte, Endoplasmic Reticulum Membrane
conversion direction: LEFT_TO_RIGHT

ChemicalStructure/PW C001068
type: ChemicalStructure
structure format: SMILES

Reference/CAS 51982-36-6
type: UnificationXref
id: 51982-36-6
db: CAS

Reference/BioCyc 5Z13E-15S-1115-DIHYDROXY-9-OXOPROS
type: UnificationXref
id: 5Z13E-15S-1115-DIHYDROXY-9-OXOPROS
db: BioCyc

Reference/HMDB HMDB0001381
type: UnificationXref
id: HMDB0001381
db: HMDB

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Compound/PW C022674/Stoichiometry/1.0
type: Stoichiometry
physical entity: Loxoprofen
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/ChEBI CHEBI 15379
type: UnificationXref
id: CHEBI:15379
db: ChEBI

Compound/PW C001028 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Prostaglandin I2
stoichiometric coefficient: 1.0

ChemicalStructure/PW C022674
type: ChemicalStructure
structure format: SMILES
structure data: CC(C(O)=O)C1=CC=C(CC2CCCC2=O)C=C1

Prostaglandin I2
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Prostaglandin I2

5.3.99.4
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001028 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001068 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Prostaglandin I2
spontaneous: false
EC number: 5.3.99.4
left: Prostaglandin H2
name: Prostaglandin H2 → Prostaglandin I2
conversion direction: LEFT_TO_RIGHT

5.3.99.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000949 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001068 Cytoplasm/Stoichiometry/1.0
right: Prostaglandin E2
spontaneous: false
EC number: 5.3.99.3
left: Prostaglandin H2
name: Prostaglandin H2 → Prostaglandin E2
conversion direction: LEFT_TO_RIGHT

Prostaglandin H2
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Prostaglandin H2

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

1.14.99.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000821 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001814 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Endoplasmic Reticulum Membrane/Stoichiometry/2.0
right: Prostaglandin G2
spontaneous: false
EC number: 1.14.99.1
left: Oxygen
left: Arachidonic acid
name: Arachidonic acid + 2 Oxygen → Prostaglandin G2
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0001043
type: UnificationXref
id: HMDB0001043
db: HMDB

Reference/CAS 35121-78-9
type: UnificationXref
id: 35121-78-9
db: CAS

Reference/KEGG Compound C00427
type: UnificationXref
id: C00427
db: KEGG Compound

Reference/CAS 506-32-1
type: UnificationXref
id: 506-32-1
db: CAS

Prostaglandin G2
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Prostaglandin G2

Interaction4483
type: MolecularInteraction
interaction type: direct_interaction
name: Loxoprofen trans-OH metabolite inhibits Prostaglandin G/H synthase 2
participant: Loxoprofen trans-OH metabolite
participant: Prostaglandin G/H synthase 2

Interaction4482
type: MolecularInteraction
interaction type: direct_interaction
name: Loxoprofen trans-OH metabolite inhibits Prostaglandin G/H synthase 1
participant: Loxoprofen trans-OH metabolite
participant: Prostaglandin G/H synthase 1

TransportCatalysis5756
type: Catalysis
controller: Solute carrier family 22 member 6
controlled: Transport15247
control type: ACTIVATION

Reference/PubChem-compound 977
type: UnificationXref
id: 977
db: PubChem-compound

Compound/PW C001068 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Prostaglandin H2
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0003235
type: UnificationXref
id: HMDB0003235
db: HMDB

Reference/BioCyc ARACHIDONIC ACID
type: UnificationXref
id: ARACHIDONIC_ACID
db: BioCyc

Prostaglandin G/H synthase 1
type: Complex
component stoichiometry: Protein/914 Endoplasmic Reticulum Membrane/Stoichiometry/2.0
cellular location: Endoplasmic Reticulum Membrane
component: Prostaglandin G/H synthase 1