Reference/CAS 57576-52-0
type: UnificationXref
id: 57576-52-0
db: CAS

Sulfasalazine
type: SmallMolecule
cellular location: Microvillus
entity reference: Sulfasalazine

Reference/BioCyc PROSTAGLANDIN-H2
type: UnificationXref
id: PROSTAGLANDIN-H2
db: BioCyc

Arachidonic acid
type: SmallMoleculeReference
xref: Reference/CAS 506-32-1
xref: Reference/BioCyc ARACHIDONIC ACID
xref: Reference/ChEBI CHEBI 15843
xref: Reference/KEGG Compound C00219
xref: Reference/HMDB HMDB0001043
xref: Reference/ChemSpider 392692
xref: Reference/PubChem-compound 444899
chemical formula: C20H32O2
molecular weight: 304.24023
structure: ChemicalStructure/PW C000821

Reference/ChEBI CHEBI 15843
type: UnificationXref
id: CHEBI:15843
db: ChEBI

Reference/HMDB HMDB0014933
type: UnificationXref
id: HMDB0014933
db: HMDB

Thromboxane A2
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Thromboxane A2

Reference/PubChem-compound 445049
type: UnificationXref
id: 445049
db: PubChem-compound

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Reference/PubChem-compound 5280360
type: UnificationXref
id: 5280360
db: PubChem-compound

Protein/910 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Arachidonate 5-lipoxygenase
stoichiometric coefficient: 1.0

Prostaglandin E2
type: SmallMoleculeReference
xref: Reference/CAS 363-24-6
xref: Reference/ChemSpider 4444059
xref: Reference/KEGG Compound C00584
xref: Reference/BioCyc 5Z13E-15S-1115-DIHYDROXY-9-OXOPROS
xref: Reference/PubChem-compound 5280360
xref: Reference/ChEBI CHEBI 15551
xref: Reference/HMDB HMDB0001220
chemical formula: C20H32O5
molecular weight: 352.22498
structure: ChemicalStructure/PW C000949

Reference/ChemSpider 10605946
type: UnificationXref
id: 10605946
db: ChemSpider

direct_interaction
type: InteractionVocabulary

Thromboxane A2
type: SmallMoleculeReference
xref: Reference/CAS 57576-52-0
xref: Reference/PubChem-compound 5280497
xref: Reference/ChemSpider 4444137
xref: Reference/BioCyc ALPHA11-ALPHA-EPOXY-15-HYDROXYTHROMBA
xref: Reference/ChEBI CHEBI 15627
xref: Reference/KEGG Compound C02198
xref: Reference/HMDB HMDB0001452
chemical formula: C20H32O5
molecular weight: 352.22498
structure: ChemicalStructure/PW C001121

Reference/ChEBI CHEBI 6775
type: UnificationXref
id: CHEBI:6775
db: ChEBI

Cytosolic phospholipase A2
type: Protein
cellular location: Cytosol
entity reference: Cytosolic phospholipase A2

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Reference/CAS 72059-45-1
type: UnificationXref
id: 72059-45-1
db: CAS

Prostaglandin G/H synthase 1
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: Prostaglandin G/H synthase 1

Prostaglandin G/H synthase 1
type: Protein
cellular location: Cytosol
entity reference: Prostaglandin G/H synthase 1

Reference/PubChem-compound 4075
type: UnificationXref
id: 4075
db: PubChem-compound

Reference/HMDB HMDB0014389
type: UnificationXref
id: HMDB0014389
db: HMDB

Reaction212945
type: BiochemicalReaction
participant stoichiometry: Compound/Generic41 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001814 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001068 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/Generic40 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Prostaglandin G2
right: Reduced acceptor
spontaneous: false
left: Water
left: Acceptor
left: Prostaglandin H2
name: Acceptor + Prostaglandin H2 + Water ← Prostaglandin G2 + Reduced acceptor
conversion direction: RIGHT_TO_LEFT

Reference/UniProt O94956
type: UnificationXref
id: O94956
db: UniProt

Leukotriene A4
type: SmallMolecule
cellular location: Cytosol
entity reference: Leukotriene A4

Reference/PubChem-compound 5282411
type: UnificationXref
id: 5282411
db: PubChem-compound

Reference/UniProt P24557
type: UnificationXref
id: P24557
db: UniProt

Reaction219341
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001030 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/910 Cytosol/Stoichiometry/1.0
right: Leukotriene A4
spontaneous: true
left: Arachidonate 5-lipoxygenase
name: Arachidonate 5-lipoxygenase → Leukotriene A4
conversion direction: LEFT_TO_RIGHT

Compound/Generic617 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phospholipids
stoichiometric coefficient: 1.0

Arachidonate 5-lipoxygenase
type: Protein
entity reference: Arachidonate 5-lipoxygenase

Reference/UniProt Q9NPD5
type: UnificationXref
id: Q9NPD5
db: UniProt

Reference/ChemSpider 4444137
type: UnificationXref
id: 4444137
db: ChemSpider

Reference/KEGG Compound C00219
type: UnificationXref
id: C00219
db: KEGG Compound

Compound/PW C001068 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Prostaglandin H2
stoichiometric coefficient: 1.0

Reference/PubChem-compound 5280383
type: UnificationXref
id: 5280383
db: PubChem-compound

Reference/CELL TYPE ONTOLOGY CL 0000066
type: UnificationXref
id: CL:0000066
db: CELL TYPE ONTOLOGY

Reaction213363
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000821 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/Generic617 Cytosol/Stoichiometry/1.0
right: Arachidonic acid
spontaneous: false
left: Phospholipids
name: Phospholipids → Arachidonic acid
conversion direction: LEFT_TO_RIGHT

Reaction219344
type: BiochemicalReaction
participant stoichiometry: Compound/PW C008786 Microvillus/Stoichiometry/1.0
participant stoichiometry: Compound/PW C009343 Microvillus/Stoichiometry/1.0
participant stoichiometry: Compound/PW C009259 Microvillus/Stoichiometry/1.0
right: Sulfapyridine
right: Mesalazine
spontaneous: false
left: Sulfasalazine
name: Sulfasalazine → Mesalazine + Sulfapyridine
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C02198
type: UnificationXref
id: C02198
db: KEGG Compound

Reference/ChEBI CHEBI 15022
type: UnificationXref
id: CHEBI:15022
db: ChEBI

Reference/ChemSpider 952
type: UnificationXref
id: 952
db: ChemSpider

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

5.3.99.5
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001068 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001121 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Thromboxane A2
spontaneous: false
EC number: 5.3.99.5
left: Prostaglandin H2
name: Prostaglandin H2 → Thromboxane A2
conversion direction: LEFT_TO_RIGHT

Reference/BRENDA TISSUE ONTOLOGY BTO 0000648
type: UnificationXref
id: BTO:0000648
db: BRENDA TISSUE ONTOLOGY

Reference/UniProt P35354
type: UnificationXref
id: P35354
db: UniProt

Reference/UniProt Q16647
type: UnificationXref
id: Q16647
db: UniProt

Microvillus
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005902

Reference/KEGG Compound C00584
type: UnificationXref
id: C00584
db: KEGG Compound

Compound/PW C008786 Microvillus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Mesalazine
stoichiometric coefficient: 1.0

Compound/PW C001121 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Thromboxane A2
stoichiometric coefficient: 1.0

Reference/UniProt O14684
type: UnificationXref
id: O14684
db: UniProt

Reference/KEGG Compound C01312
type: UnificationXref
id: C01312
db: KEGG Compound

Reference/BioCyc CPD-8892
type: UnificationXref
id: CPD-8892
db: BioCyc

Reference/CAS 363-24-6
type: UnificationXref
id: 363-24-6
db: CAS

Mesalazine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 4075
xref: Reference/HMDB HMDB0014389
xref: Reference/ChemSpider 3933
xref: Reference/ChEBI CHEBI 6775
xref: Reference/CAS 89-57-6
chemical formula: C7H7NO3
molecular weight: 153.04259
structure: ChemicalStructure/PW C008786

Reference/PubChem-compound 5280497
type: UnificationXref
id: 5280497
db: PubChem-compound

Mesalazine
type: SmallMolecule
entity reference: Mesalazine

ChemicalStructure/PW C009259
type: ChemicalStructure
structure format: SMILES

Epithelial Cell
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000066

Protein/76 Cytosol/Stoichiometry/3.0
type: Stoichiometry
physical entity: Prostaglandin E synthase
stoichiometric coefficient: 3.0

Reference/CAS 144-83-2
type: UnificationXref
id: 144-83-2
db: CAS

Reference/KEGG Compound C00909
type: UnificationXref
id: C00909
db: KEGG Compound

Reference/HMDB HMDB0015028
type: UnificationXref
id: HMDB0015028
db: HMDB

Mesalazine
type: SmallMolecule
cellular location: Cytosol
entity reference: Mesalazine

Acceptor
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Acceptor

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Reference/BioCyc CPD-6641
type: UnificationXref
id: CPD-6641
db: BioCyc

Phospholipids
type: SmallMoleculeReference

Compound/PW C001065 Endoplasmic Reticulum Membrane/Stoichiometry/2.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 2.0

Reference/ChemSpider 4444074
type: UnificationXref
id: 4444074
db: ChemSpider

Thromboxane-A synthase
type: ProteinReference
xref: Reference/UniProt P24557
organism: BiologicalState76

Reference/CAS 42935-17-1
type: UnificationXref
id: 42935-17-1
db: CAS

NADPH azoreductase
type: ProteinReference
xref: Reference/UniProt Q9FAW5
organism: BiologicalState62

Reference/ChEBI CHEBI 15651
type: UnificationXref
id: CHEBI:15651
db: ChEBI

ReactionCatalysis188
type: Catalysis
controller: Prostaglandin E synthase
controlled: 5.3.99.3
control type: ACTIVATION

Reference/KEGG Compound C00007
type: UnificationXref
id: C00007
db: KEGG Compound

Oxygen
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Oxygen

Solute carrier organic anion transporter family member 2B1
type: Protein
entity reference: Solute carrier organic anion transporter family member 2B1

Compound/Generic41 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acceptor
stoichiometric coefficient: 1.0

ReactionCatalysis187
type: Catalysis
controller: Prostacyclin synthase
controlled: 5.3.99.4
control type: ACTIVATION

BiologicalState76
type: BioSource
cell type: Epithelial Cell
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Intestine, Epithelial Cell
tissue: Intestine

Prostaglandin G/H synthase 2
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: Prostaglandin G/H synthase 2

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Prostaglandin G/H synthase 1
type: ProteinReference
xref: Reference/UniProt P23219
organism: BiologicalState76

Prostaglandin G/H synthase 2
type: ProteinReference
xref: Reference/UniProt P35354
organism: BiologicalState76

Reference/KEGG Compound C07316
type: UnificationXref
id: C07316
db: KEGG Compound

Arachidonate 5-lipoxygenase
type: ProteinReference
xref: Reference/UniProt P09917
organism: BiologicalState76

ReactionCatalysis208785
type: Catalysis
controller: NADPH azoreductase
controlled: Reaction219344
control type: ACTIVATION

Solute carrier organic anion transporter family member 1B3
type: Protein
entity reference: Solute carrier organic anion transporter family member 1B3

Protein/914 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Prostaglandin G/H synthase 1
stoichiometric coefficient: 2.0

Reference/ChEBI CHEBI 9334
type: UnificationXref
id: CHEBI:9334
db: ChEBI

Intestine
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000648

ChemicalStructure/PW C008786
type: ChemicalStructure
structure format: SMILES
structure data: NC1=CC(C(O)=O)=C(O)C=C1

Compound/PW C000949 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Prostaglandin E2
stoichiometric coefficient: 1.0

ReactionCatalysis738
type: Catalysis
controller: Prostaglandin G/H synthase 2
controlled: 1.14.99.1
control type: ACTIVATION

Arachidonic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Arachidonic acid

Protein/914 Endoplasmic Reticulum Membrane/Stoichiometry/2.0
type: Stoichiometry
physical entity: Prostaglandin G/H synthase 1
stoichiometric coefficient: 2.0

Reference/ChemSpider 4444059
type: UnificationXref
id: 4444059
db: ChemSpider

ReactionCatalysis73
type: Catalysis
controller: Prostaglandin G/H synthase 1
controlled: 1.14.99.1
control type: ACTIVATION

Transport14946
type: Transport
participant stoichiometry: Compound/PW C008786 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C008786 Extracellular Space/Stoichiometry/1.0
right: Mesalazine
spontaneous: false
left: Mesalazine
name: Mesalazine (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 444899
type: UnificationXref
id: 444899
db: PubChem-compound

Prostaglandin G2
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0003235
xref: Reference/PubChem-compound 5280883
xref: Reference/ChEBI CHEBI 27647
xref: Reference/CAS 51982-36-6
xref: Reference/KEGG Compound C05956
xref: Reference/ChemSpider 4444406
chemical formula: C20H32O6
molecular weight: 368.21988
structure: ChemicalStructure/PW C001814

ReactionCatalysis77
type: Catalysis
controller: Thromboxane-A synthase
controlled: 5.3.99.5
control type: ACTIVATION

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Reference/UniProt P23219
type: UnificationXref
id: P23219
db: UniProt

Solute carrier organic anion transporter family member 1B1
type: Protein
entity reference: Solute carrier organic anion transporter family member 1B1

Compound/PW C009259 Microvillus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sulfasalazine
stoichiometric coefficient: 1.0

Reference/ChemSpider 392800
type: UnificationXref
id: 392800
db: ChemSpider

Compound/PW C001068 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Prostaglandin H2
stoichiometric coefficient: 1.0

Prostaglandin I2
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15552
xref: Reference/ChemSpider 4445566
xref: Reference/HMDB HMDB0001335
xref: Reference/BioCyc 5Z13E-15S-69-ALPHA-EPOXY-11-ALPHA
xref: Reference/PubChem-compound 5282411
xref: Reference/CAS 35121-78-9
xref: Reference/KEGG Compound C01312
chemical formula: C20H32O5
molecular weight: 352.22498
structure: ChemicalStructure/PW C001028

Reference/KEGG Compound C05956
type: UnificationXref
id: C05956
db: KEGG Compound

Leukotriene A4
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15651
xref: Reference/HMDB HMDB0001337
xref: Reference/CAS 72059-45-1
xref: Reference/PubChem-compound 5280383
xref: Reference/ChemSpider 4444074
xref: Reference/BioCyc CPD-8892
xref: Reference/KEGG Compound C00909
chemical formula: C20H30O3
molecular weight: 318.21948
structure: ChemicalStructure/PW C001030

Phospholipids
type: SmallMolecule
cellular location: Cytosol
entity reference: Phospholipids

Reference/HMDB HMDB0001335
type: UnificationXref
id: HMDB0001335
db: HMDB

Transport15103
type: Transport
participant stoichiometry: Compound/PW C009259/Stoichiometry/1.0
participant stoichiometry: Compound/PW C009259 Microvillus/Stoichiometry/1.0
right: Sulfasalazine
spontaneous: false
left: Sulfasalazine
name: Sulfasalazine (→) Transport: Homo sapiens to Homo sapiens, Intestine, Microvillus
conversion direction: LEFT_TO_RIGHT

Arachidonic acid
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Arachidonic acid

Reference/HMDB HMDB0001337
type: UnificationXref
id: HMDB0001337
db: HMDB

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Compound/PW C001814 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Prostaglandin G2
stoichiometric coefficient: 1.0

Reference/BioCyc ALPHA11-ALPHA-EPOXY-15-HYDROXYTHROMBA
type: UnificationXref
id: ALPHA11-ALPHA-EPOXY-15-HYDROXYTHROMBA
db: BioCyc

Reference/ChEBI CHEBI 15627
type: UnificationXref
id: CHEBI:15627
db: ChEBI

BiologicalState62
type: BioSource
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Intestine
tissue: Intestine

Reference/HMDB HMDB0001452
type: UnificationXref
id: HMDB0001452
db: HMDB

Compound/PW C000821 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Arachidonic acid
stoichiometric coefficient: 1.0

Endoplasmic Reticulum Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005789

Mesalazine
type: SmallMolecule
cellular location: Microvillus
entity reference: Mesalazine

Reference/PubChem-compound 5336
type: UnificationXref
id: 5336
db: PubChem-compound

ChemicalStructure/PW C001814
type: ChemicalStructure
structure format: SMILES

Compound/PW C008786 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Mesalazine
stoichiometric coefficient: 1.0

Reference/PubChem-compound 5280883
type: UnificationXref
id: 5280883
db: PubChem-compound

Compound/PW C001030 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Leukotriene A4
stoichiometric coefficient: 1.0

TransportCatalysis5640
type: Catalysis
controller: Solute carrier organic anion transporter family member 2B1
controlled: Transport14946
control type: ACTIVATION

Compound/Generic40 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Reduced acceptor
stoichiometric coefficient: 1.0

Reference/ChemSpider 392692
type: UnificationXref
id: 392692
db: ChemSpider

Reference/HMDB HMDB0001220
type: UnificationXref
id: HMDB0001220
db: HMDB

Reference/SMPDB SMP0126115
type: UnificationXref
id: SMP0126115
db: SMPDB

Reference/ChemSpider 3933
type: UnificationXref
id: 3933
db: ChemSpider

Prostaglandin E synthase
type: ProteinReference
xref: Reference/UniProt O14684
organism: BiologicalState76

Reference/ChEBI CHEBI 15339
type: UnificationXref
id: CHEBI:15339
db: ChEBI

Reduced acceptor
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Reduced acceptor

ChemicalStructure/PW C001028
type: ChemicalStructure
structure format: SMILES

Prostaglandin E synthase
type: Complex
component stoichiometry: Protein/76 Cytosol/Stoichiometry/3.0
cellular location: Cytosol
component: Prostaglandin E synthase

Compound/PW C009343 Microvillus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sulfapyridine
stoichiometric coefficient: 1.0

Reference/UniProt Q9Y6L6
type: UnificationXref
id: Q9Y6L6
db: UniProt

Solute carrier organic anion transporter family member 1B3
type: ProteinReference
xref: Reference/UniProt Q9NPD5

Sulfasalazine
type: SmallMoleculeReference
xref: Reference/CAS 599-79-1
xref: Reference/HMDB HMDB0014933
xref: Reference/ChEBI CHEBI 9334
xref: Reference/KEGG Compound C07316
xref: Reference/ChemSpider 10605946
chemical formula: C18H14N4O5S
molecular weight: 398.06848
structure: ChemicalStructure/PW C009259

Sulfasalazine
type: SmallMolecule
entity reference: Sulfasalazine

ChemicalStructure/PW C001030
type: ChemicalStructure
structure format: SMILES
structure data: CCCCC\C=C/C\C=C/C=C/C=C/[C@@H]1O[C@H]1CCCC(O)=O

Prostaglandin G/H synthase 2
type: Protein
cellular location: Cytosol
entity reference: Prostaglandin G/H synthase 2

ChemicalStructure/PW C000949
type: ChemicalStructure
structure format: SMILES

Thromboxane-A synthase
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: Thromboxane-A synthase

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

ChemicalStructure/PW C000821
type: ChemicalStructure
structure format: SMILES
structure data: CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O

Reference/UniProt Q9FAW5
type: UnificationXref
id: Q9FAW5
db: UniProt

ReactionCatalysis202577
type: Catalysis
controller: Prostaglandin G/H synthase 1
controlled: Reaction212945
control type: ACTIVATION

ReactionCatalysis202578
type: Catalysis
controller: Prostaglandin G/H synthase 2
controlled: Reaction212945
control type: ACTIVATION

Acceptor
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15339

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reduced acceptor
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15022

Compound/PW C001420 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Water
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Water

ChemicalStructure/PW C001121
type: ChemicalStructure
structure format: SMILES

Oxygen
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001377
xref: Reference/ChemSpider 952
xref: Reference/KEGG Compound C00007
xref: Reference/ChEBI CHEBI 15379
xref: Reference/PubChem-compound 977
xref: Reference/BioCyc CPD-6641
xref: Reference/CAS 7782-44-7
chemical formula: O2
molecular weight: 31.98983
structure: ChemicalStructure/PW C001065

Prostaglandin H2
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00427
xref: Reference/ChEBI CHEBI 15554
xref: Reference/CAS 42935-17-1
xref: Reference/BioCyc PROSTAGLANDIN-H2
xref: Reference/ChemSpider 392800
xref: Reference/PubChem-compound 445049
xref: Reference/HMDB HMDB0001381
chemical formula: C20H32O5
molecular weight: 352.22498
structure: ChemicalStructure/PW C001068

Prostacyclin synthase
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: Prostacyclin synthase

Reference/GENE ONTOLOGY GO 0005789
type: UnificationXref
id: GO:0005789
db: GENE ONTOLOGY

Solute carrier organic anion transporter family member 1B1
type: ProteinReference
xref: Reference/UniProt Q9Y6L6

Solute carrier organic anion transporter family member 2B1
type: ProteinReference
xref: Reference/UniProt O94956

Sulfapyridine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0015028
xref: Reference/ChemSpider 5145
xref: Reference/PubChem-compound 5336
xref: Reference/ChEBI CHEBI 132842
xref: Reference/CAS 144-83-2
chemical formula: C11H11N3O2S
molecular weight: 249.05719
structure: ChemicalStructure/PW C009343

Reference/ChEBI CHEBI 15552
type: UnificationXref
id: CHEBI:15552
db: ChEBI

Reference/ChEBI CHEBI 15554
type: UnificationXref
id: CHEBI:15554
db: ChEBI

Prostacyclin synthase
type: ProteinReference
xref: Reference/UniProt Q16647
organism: BiologicalState76

Compound/PW C008786 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Mesalazine
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15551
type: UnificationXref
id: CHEBI:15551
db: ChEBI

Cytosolic phospholipase A2
type: ProteinReference
xref: Reference/UniProt P47712
organism: BiologicalState76

Reference/CAS 7782-44-7
type: UnificationXref
id: 7782-44-7
db: CAS

Reference/HMDB HMDB0001377
type: UnificationXref
id: HMDB0001377
db: HMDB

Sulfapyridine
type: SmallMolecule
cellular location: Microvillus
entity reference: Sulfapyridine

Reference/BioCyc 5Z13E-15S-69-ALPHA-EPOXY-11-ALPHA
type: UnificationXref
id: 5Z13E-15S-69-ALPHA-EPOXY-11-ALPHA
db: BioCyc

Arachidonate 5-lipoxygenase
type: Protein
cellular location: Cytosol
entity reference: Arachidonate 5-lipoxygenase

Reference/ChEBI CHEBI 27647
type: UnificationXref
id: CHEBI:27647
db: ChEBI

Prostaglandin H2
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Prostaglandin H2

Reference/UniProt P47712
type: UnificationXref
id: P47712
db: UniProt

Compound/PW C000821 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Arachidonic acid
stoichiometric coefficient: 1.0

Reference/UniProt P09917
type: UnificationXref
id: P09917
db: UniProt

Reference/CAS 89-57-6
type: UnificationXref
id: 89-57-6
db: CAS

Reference/ChemSpider 4444406
type: UnificationXref
id: 4444406
db: ChemSpider

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/ChemSpider 4445566
type: UnificationXref
id: 4445566
db: ChemSpider

Prostaglandin G/H synthase 1
type: Complex
component stoichiometry: Protein/914 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Prostaglandin G/H synthase 1

ReactionCatalysis202959
type: Catalysis
controller: Cytosolic phospholipase A2
controlled: Reaction213363
control type: ACTIVATION

Mesalazine
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Mesalazine

Prostaglandin H2
type: SmallMolecule
cellular location: Cytosol
entity reference: Prostaglandin H2

Interaction4477
type: MolecularInteraction
interaction type: direct_interaction
name: Mesalazine inhibits Prostaglandin G/H synthase 1
participant: Prostaglandin G/H synthase 1
participant: Mesalazine

Interaction4479
type: MolecularInteraction
interaction type: direct_interaction
name: Mesalazine inhibits Prostaglandin G/H synthase 2
participant: Prostaglandin G/H synthase 2
participant: Mesalazine

ChemicalStructure/PW C001065
type: ChemicalStructure
structure format: SMILES
structure data: O=O

ChemicalStructure/PW C001068
type: ChemicalStructure
structure format: SMILES

Reference/CAS 51982-36-6
type: UnificationXref
id: 51982-36-6
db: CAS

Reference/BioCyc 5Z13E-15S-1115-DIHYDROXY-9-OXOPROS
type: UnificationXref
id: 5Z13E-15S-1115-DIHYDROXY-9-OXOPROS
db: BioCyc

Reference/HMDB HMDB0001381
type: UnificationXref
id: HMDB0001381
db: HMDB

ChemicalStructure/PW C009343
type: ChemicalStructure
structure format: SMILES
structure data: NC1=CC=C(C=C1)S(=O)(=O)NC1=CC=CC=N1

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/ChEBI CHEBI 15379
type: UnificationXref
id: CHEBI:15379
db: ChEBI

Prostaglandin E2
type: SmallMolecule
cellular location: Cytosol
entity reference: Prostaglandin E2

Sulfasalazine Action Pathway
type: Pathway
pathway order: PathwayEnzymeReaction/2524388
pathway order: PathwayTransport/2527305
pathway order: PathwayTransport/2524391
pathway order: PathwayTransport/2524392
pathway order: PathwayEnzymeReaction/2524384
pathway order: PathwayInteraction/4479
pathway order: PathwayEnzymeReaction/2524385
pathway order: PathwayEnzymeReaction/2524386
pathway order: PathwayInteraction/4477
pathway order: PathwayInteraction/4488
pathway order: PathwayEnzymeReaction/2524387
pathway order: PathwayEnzymeReaction/2524398
pathway order: PathwayEnzymeReaction/2524380
pathway order: PathwayEnzymeReaction/2524381
pathway order: PathwayTransport/2524390
pathway order: PathwayEnzymeReaction/2524382
pathway order: PathwayEnzymeReaction/2524383
pathway component: ReactionCatalysis202959
pathway component: Interaction4477
pathway component: ReactionCatalysis202577
pathway component: Reaction213363
pathway component: ReactionCatalysis73
pathway component: ReactionCatalysis202578
pathway component: Transport14946
pathway component: Interaction4479
pathway component: Reaction219344
pathway component: ReactionCatalysis77
pathway component: 5.3.99.4
pathway component: 5.3.99.3
pathway component: 5.3.99.5
pathway component: TransportCatalysis5640
pathway component: 1.14.99.1
pathway component: TransportCatalysis5638
pathway component: ReactionCatalysis188
pathway component: ReactionCatalysis187
pathway component: Reaction212945
pathway component: Interaction4488
pathway component: TransportCatalysis5639
pathway component: ReactionCatalysis208785
pathway component: Transport15103
pathway component: Reaction219341
pathway component: ReactionCatalysis738
xref: Reference/SMPDB SMP0126115
xref: Reference/PathWhiz PW127695
organism: Homo sapiens

Compound/PW C001028 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Prostaglandin I2
stoichiometric coefficient: 1.0

Mesalazine
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Mesalazine

Reference/ChemSpider 5145
type: UnificationXref
id: 5145
db: ChemSpider

Prostaglandin I2
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Prostaglandin I2

Compound/PW C009259/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sulfasalazine
stoichiometric coefficient: 1.0

5.3.99.4
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001028 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001068 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Prostaglandin I2
spontaneous: false
EC number: 5.3.99.4
left: Prostaglandin H2
name: Prostaglandin H2 → Prostaglandin I2
conversion direction: LEFT_TO_RIGHT

5.3.99.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000949 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001068 Cytosol/Stoichiometry/1.0
right: Prostaglandin E2
spontaneous: false
EC number: 5.3.99.3
left: Prostaglandin H2
name: Prostaglandin H2 → Prostaglandin E2
conversion direction: LEFT_TO_RIGHT

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Reference/GENE ONTOLOGY GO 0005902
type: UnificationXref
id: GO:0005902
db: GENE ONTOLOGY

Reference/PathWhiz PW127695
type: UnificationXref
id: PW127695
db: PathWhiz

1.14.99.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000821 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001814 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Endoplasmic Reticulum Membrane/Stoichiometry/2.0
right: Prostaglandin G2
spontaneous: false
EC number: 1.14.99.1
left: Oxygen
left: Arachidonic acid
name: Arachidonic acid + 2 Oxygen → Prostaglandin G2
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0001043
type: UnificationXref
id: HMDB0001043
db: HMDB

Prostaglandin E synthase
type: Protein
cellular location: Cytosol
entity reference: Prostaglandin E synthase

Reference/CAS 35121-78-9
type: UnificationXref
id: 35121-78-9
db: CAS

Reference/KEGG Compound C00427
type: UnificationXref
id: C00427
db: KEGG Compound

TransportCatalysis5638
type: Catalysis
controller: Solute carrier organic anion transporter family member 1B1
controlled: Transport14946
control type: ACTIVATION

Reference/CAS 506-32-1
type: UnificationXref
id: 506-32-1
db: CAS

Prostaglandin G2
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Prostaglandin G2

Reference/PubChem-compound 977
type: UnificationXref
id: 977
db: PubChem-compound

Interaction4488
type: MolecularInteraction
interaction type: direct_interaction
name: Mesalazine inhibits Arachidonate 5-lipoxygenase
participant: Mesalazine
participant: Arachidonate 5-lipoxygenase

Reference/ChEBI CHEBI 132842
type: UnificationXref
id: CHEBI:132842
db: ChEBI

TransportCatalysis5639
type: Catalysis
controller: Solute carrier organic anion transporter family member 1B3
controlled: Transport14946
control type: ACTIVATION

Reference/HMDB HMDB0003235
type: UnificationXref
id: HMDB0003235
db: HMDB

Reference/BioCyc ARACHIDONIC ACID
type: UnificationXref
id: ARACHIDONIC_ACID
db: BioCyc

Reference/CAS 599-79-1
type: UnificationXref
id: 599-79-1
db: CAS

Prostaglandin G/H synthase 1
type: Complex
component stoichiometry: Protein/914 Endoplasmic Reticulum Membrane/Stoichiometry/2.0
cellular location: Endoplasmic Reticulum Membrane
component: Prostaglandin G/H synthase 1

NADPH azoreductase
type: Protein
cellular location: Microvillus
entity reference: NADPH azoreductase