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DNA topoisomerase 2-alpha Mitoxantrone nuclear transporter Canalicular multispecific organic anion transporter 2 Mitoxantrone Mitoxantrone Mitoxantrone Magnesium DNA and RNA synthesis DNA repair DNA strand break Mitoxantrone inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex. This prevents the religation portion of the ligation-religation reacction topoisomerase II catalyzes, leading to DNA damage. Repair of DNA strand breaks cannot occur since DNA toposiomerase II is non-functional. This leads to errors in DNA synthesis. Cancer cell Nucleus Apoptosis Mitoxantrone enters the cell via the canalicular multispecific organic anion transporter 2 and is transported into the nucleus. DNA damage promotes apoptosis of the cancer cell. Cytosol Mitoxantrone forms a complex with DNA by intercalation between base pairs. This results in DNA strand breaks, partial unwinding of DNA at the site of intercalation and inhibition of DNA and RNA synthesis. Blood vessel
Nucleus TOP2A Unknown ABCC3 Mitoxantrone Mitoxantrone Mitoxantrone DNA and RNA synthesis
TOP2A ABCC3 Mitoxan Mitoxan Mitoxan Mg2+ D a R s DNA repair DNA strand break Mitoxantrone inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex. This prevents the religation portion of the ligation-religation reacction topoisomerase II catalyzes, leading to DNA damage. Repair of DNA strand breaks cannot occur since DNA toposiomerase II is non-functional. This leads to errors in DNA synthesis. Cancer cell Nucleus Apoptosis Mitoxantrone enters the cell via the canalicular multispecific organic anion transporter 2 and is transported into the nucleus. DNA damage promotes apoptosis of the cancer cell. Cytosol Mitoxantrone forms a complex with DNA by intercalation between base pairs. This results in DNA strand breaks, partial unwinding of DNA at the site of intercalation and inhibition of DNA and RNA synthesis. Blood vessel
Nucleus TOP2A ABCC3 Mitoxan Mitoxan Mitoxan D a R s