Sulodexide mixture of glycosaminoglycans (GAGs), dermatan sulfate (DS) and fast-moving heparin. Its mechanism of action inhibits coagulation by inhibiting antithrombin III thus stopping the conversion of prothrombin and thrombin. Doing that also inhibits the conversion of fibrinogen to fibrin halting the clotting factor. Sulodexide is administered via oral, intravenous or intramuscular, it is mainly metabolized by the liver. It is eliminated through renal, fecal and bile routes, and sometimes adverse effects occur that relate to the gastrointestinal system. Some other adverse reaction to sulodexide despite being fairly well tolerated includes diarrhea, epigastralgia, dyspepsia, heartburn and dizziness. Some allergic reactions can cause skin rash but these occurrences are rare.

Sulodexide Pathway References