Reference/CAS 57576-52-0
type: UnificationXref
id: 57576-52-0
db: CAS

Reference/UniProt O95477
type: UnificationXref
id: O95477
db: UniProt

Reference/ChemSpider 17215925
type: UnificationXref
id: 17215925
db: ChemSpider

Annexin A1
type: Protein
cellular location: Cytosol
entity reference: Annexin A1

Arachidonic acid
type: SmallMoleculeReference
xref: Reference/CAS 506-32-1
xref: Reference/BioCyc ARACHIDONIC ACID
xref: Reference/ChEBI CHEBI 15843
xref: Reference/KEGG Compound C00219
xref: Reference/HMDB HMDB0001043
xref: Reference/ChemSpider 392692
xref: Reference/PubChem-compound 444899
chemical formula: C20H32O2
molecular weight: 304.24023
structure: ChemicalStructure/PW C000821

Reference/ChEBI CHEBI 15843
type: UnificationXref
id: CHEBI:15843
db: ChEBI

Reference/BioCyc PROSTAGLANDIN-H2
type: UnificationXref
id: PROSTAGLANDIN-H2
db: BioCyc

Thromboxane A2
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Thromboxane A2

Reference/PubChem-compound 5283078
type: UnificationXref
id: 5283078
db: PubChem-compound

Reference/PubChem-compound 445049
type: UnificationXref
id: 445049
db: PubChem-compound

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Reference/PubChem-compound 5280360
type: UnificationXref
id: 5280360
db: PubChem-compound

Reference/CAS 5655-17-4
type: UnificationXref
id: 5655-17-4
db: CAS

Reference/UniProt P04150
type: UnificationXref
id: P04150
db: UniProt

Prostaglandin E2
type: SmallMoleculeReference
xref: Reference/CAS 363-24-6
xref: Reference/ChemSpider 4444059
xref: Reference/KEGG Compound C00584
xref: Reference/BioCyc 5Z13E-15S-1115-DIHYDROXY-9-OXOPROS
xref: Reference/PubChem-compound 5280360
xref: Reference/ChEBI CHEBI 15551
xref: Reference/HMDB HMDB0001220
chemical formula: C20H32O5
molecular weight: 352.22498
structure: ChemicalStructure/PW C000949

direct_interaction
type: InteractionVocabulary

Reference/UniProt P41222
type: UnificationXref
id: P41222
db: UniProt

Thromboxane A2
type: SmallMoleculeReference
xref: Reference/CAS 57576-52-0
xref: Reference/PubChem-compound 5280497
xref: Reference/ChemSpider 4444137
xref: Reference/BioCyc ALPHA11-ALPHA-EPOXY-15-HYDROXYTHROMBA
xref: Reference/ChEBI CHEBI 15627
xref: Reference/KEGG Compound C02198
xref: Reference/HMDB HMDB0001452
chemical formula: C20H32O5
molecular weight: 352.22498
structure: ChemicalStructure/PW C001121

Reference/PathWhiz PW127830
type: UnificationXref
id: PW127830
db: PathWhiz

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Cytosolic phospholipase A2
type: Protein
cellular location: Cytosol
entity reference: Cytosolic phospholipase A2

Fluticasone_Glucocorticoid receptor (Homo sapiens)
type: Complex
component stoichiometry: Compound/PW C113517 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/5763 Cytosol/Stoichiometry/1.0
cellular location: Cytosol
component: Glucocorticoid receptor
component: Fluticasone

Transport15052
type: Transport
participant stoichiometry: Compound/PW C113517 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C113517 Extracellular Space/Stoichiometry/1.0
right: Fluticasone
spontaneous: true
left: Fluticasone
name: Fluticasone (→) Transport: Homo sapiens, Cell, Extracellular Space to Homo sapiens, Cell, Cytosol
conversion direction: REVERSIBLE

Transport15053
type: Transport
participant stoichiometry: BoundComplex/619 Nucleus/Stoichiometry/1.0
participant stoichiometry: BoundComplex/619 Cytosol/Stoichiometry/1.0
right: Fluticasone_Glucocorticoid receptor (Homo sapiens)
spontaneous: false
left: Fluticasone_Glucocorticoid receptor (Homo sapiens)
name: Fluticasone + Glucocorticoid receptor (Homo sapiens) (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Cell, Nucleus
conversion direction: LEFT_TO_RIGHT

Fluticasone
type: SmallMolecule
cellular location: Cytosol
entity reference: Fluticasone

Prostaglandin G/H synthase 1
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: Prostaglandin G/H synthase 1

Reference/ChemSpider 4446204
type: UnificationXref
id: 4446204
db: ChemSpider

Reference/PubChem-compound 497299
type: UnificationXref
id: 497299
db: PubChem-compound

Prostaglandin F2a
type: SmallMolecule
cellular location: Cytosol
entity reference: Prostaglandin F2a

Reaction212945
type: BiochemicalReaction
participant stoichiometry: Compound/Generic41 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001814 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001068 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/Generic40 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Prostaglandin G2
right: Reduced acceptor
spontaneous: false
left: Water
left: Acceptor
left: Prostaglandin H2
name: Acceptor + Prostaglandin H2 + Water ← Prostaglandin G2 + Reduced acceptor
conversion direction: RIGHT_TO_LEFT

Fluticasone
type: SmallMoleculeReference
xref: Reference/ChemSpider 4470631
xref: Reference/ChEBI CHEBI 5134
xref: Reference/CAS 90566-53-3
xref: Reference/PubChem-compound 96024676
xref: Reference/KEGG Compound D07981
chemical formula: C22H27F3O4S
molecular weight: 444.1582

Compound/PW C000143 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

Glucocorticoid receptor (Homo sapiens)_Heat shock protein HSP 90-alpha (Homo sapiens)_Heat shock protein 70 (Homo sapiens)_Peptidyl-prolyl cis-trans isomerase FKBP4 (Homo sapiens)
type: Complex
component stoichiometry: Protein/4773 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/5763 Cytosol/Stoichiometry/1.0
component stoichiometry: ProteinComplex/1067 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/1934 Cytosol/Stoichiometry/1.0
cellular location: Cytosol
component: Glucocorticoid receptor
component: Heat shock protein HSP 90-alpha
component: Peptidyl-prolyl cis-trans isomerase FKBP4
component: Heat shock 70 kDa protein 1A/1B

BoundComplex/519 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glucocorticoid receptor (Homo sapiens)_Heat shock protein HSP 90-alpha (Homo sapiens)_Heat shock protein 70 (Homo sapiens)_Peptidyl-prolyl cis-trans isomerase FKBP4 (Homo sapiens)
stoichiometric coefficient: 1.0

Glucocorticoid receptor
type: Protein
cellular location: Cytosol
entity reference: Glucocorticoid receptor

Reference/UniProt P24557
type: UnificationXref
id: P24557
db: UniProt

Reference/PubChem-compound 5282411
type: UnificationXref
id: 5282411
db: PubChem-compound

Reaction885
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000146 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000889 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000949 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Cytosol/Stoichiometry/1.0
right: Prostaglandin F2a
right: NADP
spontaneous: false
left: Prostaglandin E2
left: NADPH
name: NADPH + Prostaglandin E2 → NADP + Prostaglandin F2a
conversion direction: LEFT_TO_RIGHT

Reaction884
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000146 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C006776 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001084 Cytosol/Stoichiometry/1.0
right: 11-Epi-PGF2a
right: NADP
spontaneous: false
left: Prostaglandin D2
left: NADPH
name: NADPH + Prostaglandin D2 → 11-Epi-PGF2a + NADP
conversion direction: LEFT_TO_RIGHT

Reference/CAS 53-59-8
type: UnificationXref
id: 53-59-8
db: CAS

Reference/ChemSpider 4444137
type: UnificationXref
id: 4444137
db: ChemSpider

Reference/KEGG Compound C00219
type: UnificationXref
id: C00219
db: KEGG Compound

Fluticasone Action Pathway
type: Pathway
pathway order: PathwayEnzymeReaction/2526417
pathway order: PathwayEnzymeReaction/2526416
pathway order: PathwayEnzymeReaction/2526419
pathway order: PathwayEnzymeReaction/2526418
pathway order: PathwayEnzymeReaction/2526413
pathway order: PathwayEnzymeReaction/2526423
pathway order: PathwayEnzymeReaction/2526415
pathway order: PathwayEnzymeReaction/2526414
pathway order: PathwayEnzymeReaction/2526425
pathway order: PathwayTransport/2526428
pathway order: PathwaySubPathway/120302
pathway order: PathwaySubPathway/120301
pathway order: PathwayTransport/2526471
pathway order: PathwayTransport/2526493
pathway order: PathwayEnzymeReaction/2526420
pathway order: PathwayInteraction/3137
pathway order: PathwayEnzymeReaction/2526422
pathway order: PathwayEnzymeReaction/2526421
pathway order: PathwayEnzymeReaction/2526472
pathway component: Reaction179744
pathway component: ReactionCatalysis169627
pathway component: Eicosanoids
pathway component: ReactionCatalysis202577
pathway component: ReactionCatalysis191
pathway component: ReactionCatalysis73
pathway component: ReactionCatalysis202578
pathway component: Linoleic Acid Metabolism
pathway component: ReactionCatalysis77
pathway component: 5.3.99.4
pathway component: 5.3.99.3
pathway component: 5.3.99.5
pathway component: Transport15052
pathway component: Transport15053
pathway component: 1.14.99.1
pathway component: 5.3.99.2
pathway component: ReactionCatalysis467
pathway component: ReactionCatalysis466
pathway component: ReactionCatalysis188
pathway component: Reaction219418
pathway component: ReactionCatalysis187
pathway component: Reaction212945
pathway component: TransportCatalysis2026
pathway component: Interaction3137
pathway component: Transport10856
pathway component: Reaction213034
pathway component: ReactionCatalysis202660
pathway component: Reaction885
pathway component: ReactionCatalysis738
pathway component: Reaction884
xref: Reference/SMPDB SMP0126244
xref: Reference/PathWhiz PW127830
organism: Homo sapiens

Compound/PW C001068 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Prostaglandin H2
stoichiometric coefficient: 1.0

Reference/KEGG Compound C02198
type: UnificationXref
id: C02198
db: KEGG Compound

Reference/KEGG Compound C00696
type: UnificationXref
id: C00696
db: KEGG Compound

Reference/ChEBI CHEBI 15022
type: UnificationXref
id: CHEBI:15022
db: ChEBI

Reference/ChEBI CHEBI 16474
type: UnificationXref
id: CHEBI:16474
db: ChEBI

Reference/ChemSpider 952
type: UnificationXref
id: 952
db: ChemSpider

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Reference/HMDB HMDB0001403
type: UnificationXref
id: HMDB0001403
db: HMDB

ChemicalStructure/PW C006776
type: ChemicalStructure
structure format: SMILES

5.3.99.5
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001068 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001121 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Thromboxane A2
spontaneous: false
EC number: 5.3.99.5
left: Prostaglandin H2
name: Prostaglandin H2 → Thromboxane A2
conversion direction: LEFT_TO_RIGHT

BoundComplex/520 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Peptidyl-prolyl cis-trans isomerase FKBP4 (Homo sapiens)_Heat shock protein HSP 90-alpha (Homo sapiens)_Heat shock protein 70 (Homo sapiens)
stoichiometric coefficient: 1.0

Reference/UniProt P35354
type: UnificationXref
id: P35354
db: UniProt

ChemicalStructure/PW C001084
type: ChemicalStructure
structure format: SMILES

Reference/UniProt P16152
type: UnificationXref
id: P16152
db: UniProt

Reference/UniProt Q16647
type: UnificationXref
id: Q16647
db: UniProt

Reference/BioCyc 5Z13E-15S-9-ALPHA11-ALPHA15-TRIHY
type: UnificationXref
id: 5Z13E-15S-9-ALPHA11-ALPHA15-TRIHY
db: BioCyc

Fluticasone
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Fluticasone

Reference/ChEBI CHEBI 73858
type: UnificationXref
id: CHEBI:73858
db: ChEBI

Reference/KEGG Compound C00584
type: UnificationXref
id: C00584
db: KEGG Compound

Annexin A1
type: ProteinReference
xref: Reference/UniProt P04083
organism: Homo sapiens

Reference/PubChem-compound 16219824
type: UnificationXref
id: 16219824
db: PubChem-compound

Prostaglandin-H2 D-isomerase
type: ProteinReference
xref: Reference/UniProt P41222
organism: Homo sapiens

Reference/CAS 551-11-1
type: UnificationXref
id: 551-11-1
db: CAS

Compound/PW C001121 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Thromboxane A2
stoichiometric coefficient: 1.0

Reference/UniProt O14684
type: UnificationXref
id: O14684
db: UniProt

Reference/KEGG Compound C01312
type: UnificationXref
id: C01312
db: KEGG Compound

Reference/CAS 363-24-6
type: UnificationXref
id: 363-24-6
db: CAS

Compound/PW C113517 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Fluticasone
stoichiometric coefficient: 1.0

Reference/PubChem-compound 5280497
type: UnificationXref
id: 5280497
db: PubChem-compound

NADPH
type: SmallMoleculeReference
xref: Reference/CAS 53-57-6
xref: Reference/HMDB HMDB0000221
xref: Reference/PubChem-compound 22833512
xref: Reference/BioCyc NADPH
xref: Reference/ChemSpider 17215925
xref: Reference/KEGG Compound C00005
xref: Reference/ChEBI CHEBI 16474
chemical formula: C21H30N7O17P3
molecular weight: 745.0911
structure: ChemicalStructure/PW C000146

NADP
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00006
xref: Reference/CAS 53-59-8
xref: Reference/BioCyc NAD(P)
xref: Reference/HMDB HMDB0000217
xref: Reference/ChEBI CHEBI 18009
xref: Reference/PubChem-compound 5886
xref: Reference/ChemSpider 5675
chemical formula: C21H28N7O17P3
molecular weight: 743.07544
structure: ChemicalStructure/PW C000143

Protein/76 Cytosol/Stoichiometry/3.0
type: Stoichiometry
physical entity: Prostaglandin E synthase
stoichiometric coefficient: 3.0

Compound/PW C113517 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Fluticasone
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0008048
type: UnificationXref
id: HMDB0008048
db: HMDB

Prostaglandin-H2 D-isomerase
type: Protein
cellular location: Cytosol
entity reference: Prostaglandin-H2 D-isomerase

Reference/BioCyc NADPH
type: UnificationXref
id: NADPH
db: BioCyc

Acceptor
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Acceptor

Compound/PW C000146 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

ReactionCatalysis191
type: Catalysis
controller: Prostaglandin-H2 D-isomerase
controlled: 5.3.99.2
control type: ACTIVATION

Reference/BioCyc CPD-6641
type: UnificationXref
id: CPD-6641
db: BioCyc

Compound/PW C001065 Endoplasmic Reticulum Membrane/Stoichiometry/2.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 2.0

Thromboxane-A synthase
type: ProteinReference
xref: Reference/UniProt P24557
organism: Homo sapiens

Reference/BioCyc PHOSPHATIDYLCHOLINE
type: UnificationXref
id: PHOSPHATIDYLCHOLINE
db: BioCyc

Reference/CAS 42935-17-1
type: UnificationXref
id: 42935-17-1
db: CAS

Reference/HMDB HMDB0000217
type: UnificationXref
id: HMDB0000217
db: HMDB

Reference/HMDB HMDB0010384
type: UnificationXref
id: HMDB0010384
db: HMDB

Reference/KEGG Compound C00007
type: UnificationXref
id: C00007
db: KEGG Compound

Oxygen
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Oxygen

ReactionCatalysis188
type: Catalysis
controller: Prostaglandin E synthase
controlled: 5.3.99.3
control type: ACTIVATION

Compound/Generic41 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acceptor
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00006
type: UnificationXref
id: C00006
db: KEGG Compound

Reaction219418
type: BiochemicalReaction
participant stoichiometry: Compound/PW C113517 Cytosol/Stoichiometry/1.0
participant stoichiometry: BoundComplex/520 Cytosol/Stoichiometry/1.0
participant stoichiometry: BoundComplex/619 Cytosol/Stoichiometry/1.0
participant stoichiometry: BoundComplex/519 Cytosol/Stoichiometry/1.0
right: Fluticasone_Glucocorticoid receptor (Homo sapiens)
right: Peptidyl-prolyl cis-trans isomerase FKBP4 (Homo sapiens)_Heat shock protein HSP 90-alpha (Homo sapiens)_Heat shock protein 70 (Homo sapiens)
spontaneous: false
left: Fluticasone
left: Glucocorticoid receptor (Homo sapiens)_Heat shock protein HSP 90-alpha (Homo sapiens)_Heat shock protein 70 (Homo sapiens)_Peptidyl-prolyl cis-trans isomerase FKBP4 (Homo sapiens)
name: Fluticasone + Glucocorticoid receptor (Homo sapiens) + Heat shock protein HSP 90-alpha (Homo sapiens) + Heat shock protein 70 (Homo sapiens) + Peptidyl-prolyl cis-trans isomerase FKBP4 (Homo sapiens) → Fluticasone + Glucocorticoid receptor (Homo sapiens) + Peptidyl-prolyl cis-trans isomerase FKBP4 (Homo sapiens) + Heat shock protein HSP 90-alpha (Homo sapiens) + Heat shock protein 70 (Homo sapiens)
conversion direction: LEFT_TO_RIGHT

ReactionCatalysis187
type: Catalysis
controller: Prostacyclin synthase
controlled: 5.3.99.4
control type: ACTIVATION

Reference/ChEBI CHEBI 18009
type: UnificationXref
id: CHEBI:18009
db: ChEBI

Prostaglandin G/H synthase 2
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: Prostaglandin G/H synthase 2

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Prostaglandin G/H synthase 1
type: ProteinReference
xref: Reference/UniProt P23219
organism: Homo sapiens

Prostaglandin G/H synthase 2
type: ProteinReference
xref: Reference/UniProt P35354
organism: Homo sapiens

Reference/KEGG Compound C00005
type: UnificationXref
id: C00005
db: KEGG Compound

NADPH
type: SmallMolecule
cellular location: Cytosol
entity reference: NADPH

ChemicalStructure/PW C000143
type: ChemicalStructure
structure format: SMILES

Aldo-keto reductase family 1 member C3
type: ProteinReference
xref: Reference/UniProt P42330
organism: Homo sapiens

Reference/HMDB HMDB0000221
type: UnificationXref
id: HMDB0000221
db: HMDB

ChemicalStructure/PW C000146
type: ChemicalStructure
structure format: SMILES

Compound/PW C000949 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Prostaglandin E2
stoichiometric coefficient: 1.0

ReactionCatalysis738
type: Catalysis
controller: Prostaglandin G/H synthase 2
controlled: 1.14.99.1
control type: ACTIVATION

Reference/GENE ONTOLOGY GO 0005634
type: UnificationXref
id: GO:0005634
db: GENE ONTOLOGY

Protein/2103 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Heat shock protein HSP 90-alpha
stoichiometric coefficient: 2.0

Reference/CAS 53-57-6
type: UnificationXref
id: 53-57-6
db: CAS

Arachidonic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Arachidonic acid
name: SubPathwayOutput
name: SubPathwayInput

Heat shock 70 kDa protein 1A/1B
type: ProteinReference
xref: Reference/UniProt P08107
organism: Homo sapiens

Protein/914 Endoplasmic Reticulum Membrane/Stoichiometry/2.0
type: Stoichiometry
physical entity: Prostaglandin G/H synthase 1
stoichiometric coefficient: 2.0

Reference/ChemSpider 4444059
type: UnificationXref
id: 4444059
db: ChemSpider

Fluticasone
type: SmallMolecule
cellular location: Nucleus
entity reference: Fluticasone

Eicosanoids
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway120302
pathway component: SubPathwayInteraction120302
name: SubPathway

Compound/PW C004097 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: PC(18:0/20:4(5Z,8Z,11Z,14Z))
stoichiometric coefficient: 1.0

Peptidyl-prolyl cis-trans isomerase FKBP4 (Homo sapiens)_Heat shock protein HSP 90-alpha (Homo sapiens)_Heat shock protein 70 (Homo sapiens)
type: Complex
component stoichiometry: Protein/4773 Cytosol/Stoichiometry/1.0
component stoichiometry: ProteinComplex/1067 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/1934 Cytosol/Stoichiometry/1.0
cellular location: Cytosol
component: Heat shock protein HSP 90-alpha
component: Peptidyl-prolyl cis-trans isomerase FKBP4
component: Heat shock 70 kDa protein 1A/1B

Reference/PubChem-compound 448457
type: UnificationXref
id: 448457
db: PubChem-compound

ATP-binding cassette sub-family A member 1
type: Protein
entity reference: ATP-binding cassette sub-family A member 1

Heat shock protein HSP 90-alpha
type: ProteinReference
xref: Reference/UniProt P07900
organism: Homo sapiens

ReactionCatalysis73
type: Catalysis
controller: Prostaglandin G/H synthase 1
controlled: 1.14.99.1
control type: ACTIVATION

Linoleic Acid Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway120301
pathway component: SubPathwayInteraction120301
name: SubPathway

Reference/PubChem-compound 444899
type: UnificationXref
id: 444899
db: PubChem-compound

Prostaglandin G2
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0003235
xref: Reference/PubChem-compound 5280883
xref: Reference/ChEBI CHEBI 27647
xref: Reference/CAS 51982-36-6
xref: Reference/KEGG Compound C05956
xref: Reference/ChemSpider 4444406
chemical formula: C20H32O6
molecular weight: 368.21988
structure: ChemicalStructure/PW C001814

ReactionCatalysis77
type: Catalysis
controller: Thromboxane-A synthase
controlled: 5.3.99.5
control type: ACTIVATION

Annexin A1
type: Protein
cellular location: Nucleus
entity reference: Annexin A1

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Reference/UniProt P23219
type: UnificationXref
id: P23219
db: UniProt

Reference/BioCyc NAD(P)
type: UnificationXref
id: NAD(P)
db: BioCyc

LysoPC(18:0/0:0)
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0010384
xref: Reference/KEGG Compound C04230
xref: Reference/PubChem-compound 497299
xref: Reference/ChemSpider 435389
xref: Reference/ChEBI CHEBI 73858
xref: Reference/CAS 5655-17-4
xref: Reference/BioCyc PHOSPHATIDYLCHOLINE
chemical formula: C26H54NO7P
molecular weight: 523.3638
structure: ChemicalStructure/PW C006393

PC(18:0/20:4(5Z,8Z,11Z,14Z))
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 74965
xref: Reference/PubChem-compound 16219824
xref: Reference/KEGG Compound C00157
xref: Reference/BioCyc PHOSPHATIDYLCHOLINE
xref: Reference/ChemSpider 17347139
xref: Reference/HMDB HMDB0008048
chemical formula: C46H84NO8P
molecular weight: 809.59344
structure: ChemicalStructure/PW C004097

Reference/ChemSpider 392800
type: UnificationXref
id: 392800
db: ChemSpider

Compound/PW C001068 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Prostaglandin H2
stoichiometric coefficient: 1.0

Reference/KEGG Compound C05959
type: UnificationXref
id: C05959
db: KEGG Compound

Prostaglandin I2
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15552
xref: Reference/ChemSpider 4445566
xref: Reference/HMDB HMDB0001335
xref: Reference/BioCyc 5Z13E-15S-69-ALPHA-EPOXY-11-ALPHA
xref: Reference/PubChem-compound 5282411
xref: Reference/CAS 35121-78-9
xref: Reference/KEGG Compound C01312
chemical formula: C20H32O5
molecular weight: 352.22498
structure: ChemicalStructure/PW C001028

Reference/KEGG Compound C05956
type: UnificationXref
id: C05956
db: KEGG Compound

Peptidyl-prolyl cis-trans isomerase FKBP4
type: ProteinReference
xref: Reference/UniProt Q02790
organism: Homo sapiens

Reference/HMDB HMDB0011137
type: UnificationXref
id: HMDB0011137
db: HMDB

ReactionCatalysis202660
type: Catalysis
controller: Cytosolic phospholipase A2
controlled: Reaction213034
control type: ACTIVATION

Reference/HMDB HMDB0001335
type: UnificationXref
id: HMDB0001335
db: HMDB

Arachidonic acid
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Arachidonic acid

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Compound/PW C001814 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Prostaglandin G2
stoichiometric coefficient: 1.0

Reference/BioCyc ALPHA11-ALPHA-EPOXY-15-HYDROXYTHROMBA
type: UnificationXref
id: ALPHA11-ALPHA-EPOXY-15-HYDROXYTHROMBA
db: BioCyc

Carbonyl reductase [NADPH] 1
type: Protein
cellular location: Cytosol
entity reference: Carbonyl reductase [NADPH] 1

Reference/ChEBI CHEBI 15627
type: UnificationXref
id: CHEBI:15627
db: ChEBI

NADP
type: SmallMolecule
cellular location: Cytosol
entity reference: NADP

Reference/HMDB HMDB0001452
type: UnificationXref
id: HMDB0001452
db: HMDB

Reference/ChemSpider 17347139
type: UnificationXref
id: 17347139
db: ChemSpider

Reaction179744
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000889 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001068 Cytosol/Stoichiometry/1.0
right: Prostaglandin F2a
spontaneous: false
left: Prostaglandin H2
name: Prostaglandin H2 → Prostaglandin F2a
conversion direction: LEFT_TO_RIGHT

Reference/SMPDB SMP0126244
type: UnificationXref
id: SMP0126244
db: SMPDB

Compound/PW C000821 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Arachidonic acid
stoichiometric coefficient: 1.0

Compound/PW C006393 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: LysoPC(18:0/0:0)
stoichiometric coefficient: 1.0

Endoplasmic Reticulum Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005789

ChemicalStructure/PW C001814
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C00157
type: UnificationXref
id: C00157
db: KEGG Compound

Reference/ChemSpider 435389
type: UnificationXref
id: 435389
db: ChemSpider

Protein/5763 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glucocorticoid receptor
stoichiometric coefficient: 1.0

Reference/PubChem-compound 5280883
type: UnificationXref
id: 5280883
db: PubChem-compound

Reference/BioCyc 5Z13E-15S-9-ALPHA15-DIHYDROXY-11-O
type: UnificationXref
id: 5Z13E-15S-9-ALPHA15-DIHYDROXY-11-O
db: BioCyc

11-Epi-PGF2a
type: SmallMoleculeReference
xref: Reference/PubChem-compound 53480669
xref: Reference/KEGG Compound C05959
xref: Reference/HMDB HMDB0011137
xref: Reference/ChEBI CHEBI 27595
chemical formula: C20H34O5
molecular weight: 354.24063
structure: ChemicalStructure/PW C006776

ChemicalStructure/PW C004097
type: ChemicalStructure
structure format: SMILES

Compound/Generic40 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Reduced acceptor
stoichiometric coefficient: 1.0

Reference/ChemSpider 392692
type: UnificationXref
id: 392692
db: ChemSpider

Reference/HMDB HMDB0001220
type: UnificationXref
id: HMDB0001220
db: HMDB

Prostaglandin D2
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15555
xref: Reference/ChemSpider 395250
xref: Reference/HMDB HMDB0001403
xref: Reference/BioCyc 5Z13E-15S-9-ALPHA15-DIHYDROXY-11-O
xref: Reference/PubChem-compound 448457
xref: Reference/KEGG Compound C00696
xref: Reference/CAS 41598-07-6
chemical formula: C20H32O5
molecular weight: 352.22498
structure: ChemicalStructure/PW C001084

ChemicalStructure/PW C006393
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 53480669
type: UnificationXref
id: 53480669
db: PubChem-compound

Prostaglandin E synthase
type: ProteinReference
xref: Reference/UniProt O14684
organism: Homo sapiens

Heat shock protein HSP 90-alpha
type: Protein
cellular location: Cytosol
entity reference: Heat shock protein HSP 90-alpha

Reference/ChEBI CHEBI 15339
type: UnificationXref
id: CHEBI:15339
db: ChEBI

TransportCatalysis2026
type: Catalysis
controller: ATP-binding cassette sub-family A member 1
controlled: Transport10856
control type: ACTIVATION

Carbonyl reductase [NADPH] 1
type: ProteinReference
xref: Reference/UniProt P16152
organism: Homo sapiens

Reduced acceptor
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Reduced acceptor

Glucocorticoid receptor
type: ProteinReference
xref: Reference/UniProt P04150
organism: Homo sapiens

ChemicalStructure/PW C001028
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 5675
type: UnificationXref
id: 5675
db: ChemSpider

Prostaglandin E synthase
type: Complex
component stoichiometry: Protein/76 Cytosol/Stoichiometry/3.0
cellular location: Cytosol
component: Prostaglandin E synthase

Reference/PubChem-compound 96024676
type: UnificationXref
id: 96024676
db: PubChem-compound

Compound/PW C006776 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 11-Epi-PGF2a
stoichiometric coefficient: 1.0

BoundComplex/619 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Fluticasone_Glucocorticoid receptor (Homo sapiens)
stoichiometric coefficient: 1.0

Glucocorticoid receptor
type: Protein
cellular location: Nucleus
entity reference: Glucocorticoid receptor

Prostaglandin D2
type: SmallMolecule
cellular location: Cytosol
entity reference: Prostaglandin D2

Thromboxane-A synthase
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: Thromboxane-A synthase

ChemicalStructure/PW C000949
type: ChemicalStructure
structure format: SMILES

Prostaglandin F2a
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15553
xref: Reference/ChemSpider 4446204
xref: Reference/BioCyc 5Z13E-15S-9-ALPHA11-ALPHA15-TRIHY
xref: Reference/HMDB HMDB0001139
xref: Reference/KEGG Compound C00639
xref: Reference/PubChem-compound 5283078
xref: Reference/CAS 551-11-1
chemical formula: C20H34O5
molecular weight: 354.24063
structure: ChemicalStructure/PW C000889

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

ChemicalStructure/PW C000821
type: ChemicalStructure
structure format: SMILES
structure data: CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O

ReactionCatalysis202577
type: Catalysis
controller: Prostaglandin G/H synthase 1
controlled: Reaction212945
control type: ACTIVATION

ReactionCatalysis202578
type: Catalysis
controller: Prostaglandin G/H synthase 2
controlled: Reaction212945
control type: ACTIVATION

Acceptor
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15339

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

11-Epi-PGF2a
type: SmallMolecule
cellular location: Cytosol
entity reference: 11-Epi-PGF2a

Reduced acceptor
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15022

Compound/PW C001420 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Water
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Water

ChemicalStructure/PW C001121
type: ChemicalStructure
structure format: SMILES

Oxygen
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001377
xref: Reference/ChemSpider 952
xref: Reference/KEGG Compound C00007
xref: Reference/ChEBI CHEBI 15379
xref: Reference/PubChem-compound 977
xref: Reference/BioCyc CPD-6641
xref: Reference/CAS 7782-44-7
chemical formula: O2
molecular weight: 31.98983
structure: ChemicalStructure/PW C001065

Prostaglandin H2
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00427
xref: Reference/ChEBI CHEBI 15554
xref: Reference/CAS 42935-17-1
xref: Reference/BioCyc PROSTAGLANDIN-H2
xref: Reference/ChemSpider 392800
xref: Reference/PubChem-compound 445049
xref: Reference/HMDB HMDB0001381
chemical formula: C20H32O5
molecular weight: 352.22498
structure: ChemicalStructure/PW C001068

Prostacyclin synthase
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: Prostacyclin synthase

Reference/GENE ONTOLOGY GO 0005789
type: UnificationXref
id: GO:0005789
db: GENE ONTOLOGY

Reference/UniProt Q02790
type: UnificationXref
id: Q02790
db: UniProt

Peptidyl-prolyl cis-trans isomerase FKBP4
type: Protein
cellular location: Cytosol
entity reference: Peptidyl-prolyl cis-trans isomerase FKBP4

BoundComplex/619 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Fluticasone_Glucocorticoid receptor (Homo sapiens)
stoichiometric coefficient: 1.0

Water
type: SmallMolecule
cellular location: Cytosol
entity reference: Water

Reference/KEGG Compound D07981
type: UnificationXref
id: D07981
db: KEGG Compound

Heat shock 70 kDa protein 1A/1B
type: Protein
cellular location: Cytosol
entity reference: Heat shock 70 kDa protein 1A/1B

Reference/ChEBI CHEBI 15553
type: UnificationXref
id: CHEBI:15553
db: ChEBI

Reference/ChemSpider 4470631
type: UnificationXref
id: 4470631
db: ChemSpider

Reference/ChEBI CHEBI 15552
type: UnificationXref
id: CHEBI:15552
db: ChEBI

Reference/ChEBI CHEBI 15555
type: UnificationXref
id: CHEBI:15555
db: ChEBI

Protein/5763 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glucocorticoid receptor
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15554
type: UnificationXref
id: CHEBI:15554
db: ChEBI

Compound/PW C113517 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Fluticasone
stoichiometric coefficient: 1.0

ATP-binding cassette sub-family A member 1
type: ProteinReference
xref: Reference/UniProt O95477

Prostacyclin synthase
type: ProteinReference
xref: Reference/UniProt Q16647
organism: Homo sapiens

Reference/ChEBI CHEBI 15551
type: UnificationXref
id: CHEBI:15551
db: ChEBI

Reference/CAS 7782-44-7
type: UnificationXref
id: 7782-44-7
db: CAS

Cytosolic phospholipase A2
type: ProteinReference
xref: Reference/UniProt P47712
organism: Homo sapiens

Reference/HMDB HMDB0001377
type: UnificationXref
id: HMDB0001377
db: HMDB

Reference/BioCyc 5Z13E-15S-69-ALPHA-EPOXY-11-ALPHA
type: UnificationXref
id: 5Z13E-15S-69-ALPHA-EPOXY-11-ALPHA
db: BioCyc

Reference/HMDB HMDB0001139
type: UnificationXref
id: HMDB0001139
db: HMDB

Reference/ChEBI CHEBI 27647
type: UnificationXref
id: CHEBI:27647
db: ChEBI

Prostaglandin H2
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Prostaglandin H2

Reference/UniProt P47712
type: UnificationXref
id: P47712
db: UniProt

Compound/PW C000821 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Arachidonic acid
stoichiometric coefficient: 1.0

Compound/PW C001420 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/ChemSpider 4444406
type: UnificationXref
id: 4444406
db: ChemSpider

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/ChemSpider 4445566
type: UnificationXref
id: 4445566
db: ChemSpider

Reference/KEGG Compound C00639
type: UnificationXref
id: C00639
db: KEGG Compound

Prostaglandin H2
type: SmallMolecule
cellular location: Cytosol
entity reference: Prostaglandin H2

ChemicalStructure/PW C000889
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C001065
type: ChemicalStructure
structure format: SMILES
structure data: O=O

Aldo-keto reductase family 1 member C3
type: Protein
cellular location: Cytosol
entity reference: Aldo-keto reductase family 1 member C3

Reference/CAS 51982-36-6
type: UnificationXref
id: 51982-36-6
db: CAS

ChemicalStructure/PW C001068
type: ChemicalStructure
structure format: SMILES

ProteinComplex/1067 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Heat shock protein HSP 90-alpha
stoichiometric coefficient: 1.0

Reference/BioCyc 5Z13E-15S-1115-DIHYDROXY-9-OXOPROS
type: UnificationXref
id: 5Z13E-15S-1115-DIHYDROXY-9-OXOPROS
db: BioCyc

Reference/HMDB HMDB0001381
type: UnificationXref
id: HMDB0001381
db: HMDB

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Compound/PW C001084 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Prostaglandin D2
stoichiometric coefficient: 1.0

Reference/UniProt P07900
type: UnificationXref
id: P07900
db: UniProt

Reference/ChEBI CHEBI 27595
type: UnificationXref
id: CHEBI:27595
db: ChEBI

ReactionCatalysis467
type: Catalysis
controller: Carbonyl reductase [NADPH] 1
controlled: Reaction885
control type: ACTIVATION

Protein/1934 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Heat shock 70 kDa protein 1A/1B
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

ReactionCatalysis466
type: Catalysis
controller: Aldo-keto reductase family 1 member C3
controlled: Reaction884
control type: ACTIVATION

Reference/ChEBI CHEBI 15379
type: UnificationXref
id: CHEBI:15379
db: ChEBI

Fluticasone_Glucocorticoid receptor (Homo sapiens)
type: Complex
component stoichiometry: Compound/PW C113517 Nucleus/Stoichiometry/1.0
component stoichiometry: Protein/5763 Nucleus/Stoichiometry/1.0
cellular location: Nucleus
component: Fluticasone
component: Glucocorticoid receptor

Compound/PW C000889 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Prostaglandin F2a
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 74965
type: UnificationXref
id: CHEBI:74965
db: ChEBI

Prostaglandin E2
type: SmallMolecule
cellular location: Cytosol
entity reference: Prostaglandin E2

Reference/PubChem-compound 5886
type: UnificationXref
id: 5886
db: PubChem-compound

Interaction3137
type: MolecularInteraction
interaction type: direct_interaction
name: Annexin A1 inhibits Cytosolic phospholipase A2
participant: Annexin A1
participant: Cytosolic phospholipase A2

Reference/CAS 90566-53-3
type: UnificationXref
id: 90566-53-3
db: CAS

Reaction213034
type: BiochemicalReaction
participant stoichiometry: Compound/PW C006393 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C004097 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000821 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
right: LysoPC(18:0/0:0)
right: Arachidonic acid
spontaneous: false
left: PC(18:0/20:4(5Z,8Z,11Z,14Z))
left: Water
name: PC(18:0/20:4(5Z,8Z,11Z,14Z)) + Water → Arachidonic acid + LysoPC(18:0/0:0)
conversion direction: LEFT_TO_RIGHT

Reference/UniProt P04083
type: UnificationXref
id: P04083
db: UniProt

LysoPC(18:0/0:0)
type: SmallMolecule
cellular location: Cytosol
entity reference: LysoPC(18:0/0:0)

Protein/4773 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Peptidyl-prolyl cis-trans isomerase FKBP4
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 5134
type: UnificationXref
id: CHEBI:5134
db: ChEBI

Reference/ChemSpider 395250
type: UnificationXref
id: 395250
db: ChemSpider

PC(18:0/20:4(5Z,8Z,11Z,14Z))
type: SmallMolecule
cellular location: Cytosol
entity reference: PC(18:0/20:4(5Z,8Z,11Z,14Z))

Compound/PW C001028 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Prostaglandin I2
stoichiometric coefficient: 1.0

SubPathwayInteraction120302
type: Interaction
name: SubPathwayReaction
name: SubPathway120302Reaction
participant: Arachidonic acid

SubPathwayInteraction120301
type: Interaction
name: SubPathwayReaction
name: SubPathway120301Reaction
participant: Arachidonic acid

ReactionCatalysis169627
type: Catalysis
controller: Aldo-keto reductase family 1 member C3
controlled: Reaction179744
control type: ACTIVATION

Prostaglandin I2
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Prostaglandin I2

Reference/CAS 41598-07-6
type: UnificationXref
id: 41598-07-6
db: CAS

5.3.99.4
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001028 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001068 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Prostaglandin I2
spontaneous: false
EC number: 5.3.99.4
left: Prostaglandin H2
name: Prostaglandin H2 → Prostaglandin I2
conversion direction: LEFT_TO_RIGHT

5.3.99.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000949 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001068 Cytosol/Stoichiometry/1.0
right: Prostaglandin E2
spontaneous: false
EC number: 5.3.99.3
left: Prostaglandin H2
name: Prostaglandin H2 → Prostaglandin E2
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 22833512
type: UnificationXref
id: 22833512
db: PubChem-compound

Reference/UniProt P42330
type: UnificationXref
id: P42330
db: UniProt

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

1.14.99.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000821 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001814 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Endoplasmic Reticulum Membrane/Stoichiometry/2.0
right: Prostaglandin G2
spontaneous: false
EC number: 1.14.99.1
left: Oxygen
left: Arachidonic acid
name: Arachidonic acid + 2 Oxygen → Prostaglandin G2
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0001043
type: UnificationXref
id: HMDB0001043
db: HMDB

5.3.99.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001068 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001084 Cytosol/Stoichiometry/1.0
right: Prostaglandin D2
spontaneous: false
EC number: 5.3.99.2
left: Prostaglandin H2
name: Prostaglandin H2 → Prostaglandin D2
conversion direction: LEFT_TO_RIGHT

Prostaglandin E synthase
type: Protein
cellular location: Cytosol
entity reference: Prostaglandin E synthase

Reference/CAS 35121-78-9
type: UnificationXref
id: 35121-78-9
db: CAS

Nucleus
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005634

Reference/KEGG Compound C00427
type: UnificationXref
id: C00427
db: KEGG Compound

Reference/CAS 506-32-1
type: UnificationXref
id: 506-32-1
db: CAS

Prostaglandin G2
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Prostaglandin G2

Heat shock protein HSP 90-alpha
type: Complex
component stoichiometry: Protein/2103 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Heat shock protein HSP 90-alpha

Reference/UniProt P08107
type: UnificationXref
id: P08107
db: UniProt

Reference/PubChem-compound 977
type: UnificationXref
id: 977
db: PubChem-compound

Protein/2673 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Annexin A1
stoichiometric coefficient: 1.0

Transport10856
type: Transport
participant stoichiometry: Protein/2673 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/2673 Nucleus/Stoichiometry/1.0
right: Annexin A1
spontaneous: false
left: Annexin A1
name: Annexin A1 (→) Transport: Homo sapiens, Cell, Nucleus to Homo sapiens, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C04230
type: UnificationXref
id: C04230
db: KEGG Compound

Reference/HMDB HMDB0003235
type: UnificationXref
id: HMDB0003235
db: HMDB

Reference/BioCyc ARACHIDONIC ACID
type: UnificationXref
id: ARACHIDONIC_ACID
db: BioCyc

Protein/2673 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Annexin A1
stoichiometric coefficient: 1.0

Prostaglandin G/H synthase 1
type: Complex
component stoichiometry: Protein/914 Endoplasmic Reticulum Membrane/Stoichiometry/2.0
cellular location: Endoplasmic Reticulum Membrane
component: Prostaglandin G/H synthase 1