Zoledronate (→) Transport: Homo sapiens, Cell, Extracellular Space to Homo sapiens, Cell, Endocytic Vesicle
Hydroxymethylglutaryl-CoA synthase, cytoplasmic
Zoledronate (→) Transport: Homo sapiens, Cell, Endocytic Vesicle to Homo sapiens, Bone, Cytosol
3-hydroxymethyl-3-methylglutaryl-CoA lyase, cytoplasmic
Acetyl-CoA acetyltransferase, mitochondrial
Zoledronate inhibits Farnesyl pyrophosphate synthase
Geranyl-PP + Isopentenyl pyrophosphate → Farnesyl pyrophosphate + Pyrophosphate
Zoledronate inhibits Geranylgeranyl pyrophosphate synthase
2 Farnesyl pyrophosphate + Hydrogen Ion + NADPH → NADP + 2 Pyrophosphate + Squalene
Acetoacetyl-CoA + Acetyl-CoA + Water → 3-Hydroxy-3-methylglutaryl-CoA + Coenzyme A
Adenosine triphosphate + Mevalonate → Adenosine diphosphate + Mevalonate-5P
Adenosine triphosphate + Mevalonate-5P → Adenosine diphosphate + Mevalonate-5PP
Adenosine triphosphate + Mevalonate-5PP → Adenosine diphosphate + Carbon dioxide + Isopentenyl-PP + Phosphate
Dimethylallylpyrophosphate + Isopentenyl-PP → Geranyl-PP + Pyrophosphate
Farnesyl pyrophosphate + Isopentenyl pyrophosphate → Geranylgeranyl-PP + Pyrophosphate
Zoledronate (→) Transport: Homo sapiens, Blood Vessel to Homo sapiens, Bone, Cytosol
2 Acetyl-CoA ↔ Acetoacetyl-CoA + Coenzyme A
3-Hydroxy-3-methylglutaryl-CoA + Hydrogen Ion + NADPH → Coenzyme A + Mevalonate + NADP