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5- hydroxytryptamine receptor 2A 5- hydroxytryptamine receptor 2C Alpha-1A adrenergic receptor Beta-1 adrenergic receptor Beta-2 adrenergic receptor Sodium- dependent noradrenaline transporter Sodium- dependent serotonin transporter Voltage- dependent P/Q-type calcium channel subunit alpha-1A Voltage- dependent L-type calcium channel subunit beta-1 Voltage- dependent calcium channel subunit alpha-2/delta-2 Synaptic vesicular amine transporter Voltage- dependent P/Q-type calcium channel subunit alpha-1A Voltage- dependent L-type calcium channel subunit beta-1 Voltage- dependent calcium channel subunit alpha-2/delta-2 Synaptic vesicular amine transporter Aromatic-L- amino-acid decarboxylase Dopamine beta- hydroxylase Tyrosine 3-monooxygenase Tryptophan 5-hydroxylase 1 Aromatic-L- amino-acid decarboxylase Ca+ Norepinephrine Ca+ Serotonin Serotonin Norepinephrine Trimipramine Trimipramine Ca+ Norepinephrine Ca+ Serotonin Trimipramine Trimipramine Trimipramine Trimipramine L-Dopa Dopamine CO2 Ascorbic acid O2 Dehydroascorbic acid H2O L-Tyrosine Tetrahydrobiopterin O2 Dihydrobiopterin H2O L-Tryptophan Tetrahydrobiopterin O2 5-Hydroxy-L-tryptophan 4a-Hydroxytetrahydrobiopterin CO2 Pyridoxal 5'-phosphate Pyrroloquinoline quinone Copper Fe2+ Fe2+ Pyridoxal 5'-phosphate Gq signaling cascade Gq signaling cascade Gs signaling cascade Cytosol Postsynaptic Neuron Presynaptic Neuron Cytosol Synaptic Vesicle Synaptic Vesicle Cytosol Cytosol Presynaptic Neuron Postsynaptic Neuron Synapse Synapse Mood Improvement Serotonin is synthesized and stored in synaptic vesicles at the nerve terminal Trimipramine inhibits the serotonin reuptake transporter, thereby increasing synaptic serotonin Serotonin activates 5HT2A and 5HT2C receptors, which are responsible for mood improvements Norepinephrine is synthesized and stored in synaptic vesicles at the nerve terminal Trimipramine inhibits the norepinephrine reuptake transporter, thereby increasing synaptic norepinephrine levels Mood Improvement Norepinephrine activates post synaptic adrenergic receptors which are responsible for mood improvements Blood-Brain Barrier Diffusion Blood-Brain Barrier Diffusion
HTR2A HTR2C ADRA1A ADRB1 ADRB2 SLC6A2 SLC6A4 CACNA1A CACNB1 CACNA2D2 SLC18A2 CACNA1A CACNB1 CACNA2D2 SLC18A2 DDC DBH TH TPH1 DDC Calcium Norepinephrine Calcium Serotonin Serotonin Norepinephrine Trimipramine Trimipramine Calcium Norepinephrine Calcium Serotonin Trimipramine Trimipramine Trimipramine Trimipramine L-Dopa Dopamine Carbon dioxide Ascorbic acid Oxygen Dehydroascorbic acid Water L-Tyrosine Tetrahydrobiopterin Oxygen Dihydrobiopterin Water L-Tryptophan Tetrahydrobiopterin Oxygen 5-Hydroxy-L- tryptophan 4a- Hydroxytetrahydrobiopterin Carbon dioxide Gq signaling cascade Gq signaling cascade Gs signaling cascade
HTR2A HTR2C ADRA1A ADRB1 ADRB2 SLC6A2 SLC6A4 CACNA1A CACNB1 CACNA2D2 SLC18A2 CACNA1A CACNB1 CACNA2D2 SLC18A2 DDC DBH TH TPH1 DDC Ca+ Norpp Ca+ 5-HT 5-HT Norpp RP-7162 RP-7162 Ca+ Norpp Ca+ 5-HT RP-7162 RP-7162 RP-7162 RP-7162 L-Dopa LDP CO2 VitC O2 DHAA H2O Tyr BH4 O2 BH3 H2O Trp BH4 O2 5-HTP 4aHtHbp CO2 Pyr-5'P Pqq Cu Fe2+ Fe2+ Pyr-5'P Gq si c Gq si c G s c Cytosol Postsynaptic Neuron Presynaptic Neuron Cytosol Synaptic Vesicle Synaptic Vesicle Cytosol Cytosol Presynaptic Neuron Postsynaptic Neuron Synapse Synapse Mood Improvement Serotonin is synthesized and stored in synaptic vesicles at the nerve terminal Trimipramine inhibits the serotonin reuptake transporter, thereby increasing synaptic serotonin Serotonin activates 5HT2A and 5HT2C receptors, which are responsible for mood improvements Norepinephrine is synthesized and stored in synaptic vesicles at the nerve terminal Trimipramine inhibits the norepinephrine reuptake transporter, thereby increasing synaptic norepinephrine levels Mood Improvement Norepinephrine activates post synaptic adrenergic receptors which are responsible for mood improvements Blood-Brain Barrier Diffusion Blood-Brain Barrier Diffusion
HTR2A HTR2C ADRA1A ADRB1 ADRB2 SLC6A2 SLC6A4 CACNA1A CACNB1 CACNA2D2 SLC18A2 CACNA1A CACNB1 CACNA2D2 SLC18A2 DDC DBH TH TPH1 DDC Ca2+ Norpp Ca2+ 5-HT 5-HT Norpp RP-7162 RP-7162 Ca2+ Norpp Ca2+ 5-HT RP-7162 RP-7162 RP-7162 RP-7162 L-Dopa LDP CO2 VitC O2 DHAA H2O Tyr BH4 O2 BH3 H2O Trp BH4 O2 5-HTP 4aHtHbp CO2 Gq si c Gq si c G s c