Interaction4032
type: MolecularInteraction
interaction type: direct_interaction
name: Norepinephrine activates Beta-2 adrenergic receptor
participant: Norepinephrine
participant: Beta-2 adrenergic receptor

Reference/CAS 51-41-2
type: UnificationXref
id: 51-41-2
db: CAS

1.14.17.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000977 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000052 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000031 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000142 Cytosol/Stoichiometry/1.0
right: Norepinephrine
right: Dehydroascorbic acid
right: Water
spontaneous: false
EC number: 1.14.17.1
left: Ascorbic acid
left: Oxygen
left: Dopamine
name: Ascorbic acid + Dopamine + Oxygen → Dehydroascorbic acid + Norepinephrine + Water
conversion direction: LEFT_TO_RIGHT

Dihydrobiopterin
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 64277
xref: Reference/ChemSpider 247
xref: Reference/HMDB HMDB0000038
xref: Reference/KEGG Compound C02953
xref: Reference/BioCyc BIOPTERIN
xref: Reference/CAS 6779-87-9
xref: Reference/PubChem-compound 252
chemical formula: C9H13N5O3
molecular weight: 239.10184
structure: ChemicalStructure/PW C000027

Transport10963
type: Transport
participant stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
right: Calcium
spontaneous: false
left: Calcium
name: Calcium (→) Transport: Homo sapiens, Brain, Neuron, Extracellular Space to Homo sapiens, Brain, Neuron, Cytosol
conversion direction: LEFT_TO_RIGHT

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Gs signaling cascade
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway120564
pathway component: SubPathwayInteraction120564
name: SubPathway

Gq signaling cascade
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway120563
pathway component: SubPathwayInteraction120563
name: SubPathway

BiologicalState789
type: BioSource
cell type: Neuron
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Brain, Neuron
tissue: Brain

Reference/ChemSpider 49516
type: UnificationXref
id: 49516
db: ChemSpider

Reference/PathWhiz PW127948
type: UnificationXref
id: PW127948
db: PathWhiz

direct_interaction
type: InteractionVocabulary

Tyrosine 3-monooxygenase
type: ProteinReference
xref: Reference/UniProt P07101
organism: BiologicalState789

Compound/PW C000103 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Tyrosine
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Reference/GENE ONTOLOGY GO 0070382
type: UnificationXref
id: GO:0070382
db: GENE ONTOLOGY

Compound/PW C000052 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dopamine
stoichiometric coefficient: 1.0

L-Tyrosine
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Tyrosine

Ascorbic acid
type: SmallMoleculeReference
xref: Reference/BioCyc ASCORBATE
xref: Reference/ChemSpider 10189562
xref: Reference/KEGG Compound C00072
xref: Reference/ChEBI CHEBI 29073
xref: Reference/CAS 50-81-7
xref: Reference/PubChem-compound 54670067
xref: Reference/HMDB HMDB0000044
chemical formula: C6H8O6
molecular weight: 176.03209
structure: ChemicalStructure/PW C000031

Compound/PW C000019 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Tetrahydrobiopterin
stoichiometric coefficient: 1.0

Sodium-dependent noradrenaline transporter
type: Protein
entity reference: Sodium-dependent noradrenaline transporter

Alpha-1A adrenergic receptor
type: ProteinReference
xref: Reference/UniProt P35348
organism: BiologicalState789

Brain
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000142

Reference/ChemSpider 5833
type: UnificationXref
id: 5833
db: ChemSpider

Compound/PW C001065 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 1.0

Reference/PubChem-compound 1125
type: UnificationXref
id: 1125
db: PubChem-compound

Calcium
type: SmallMolecule
cellular location: Cytosol
entity reference: Calcium

Compound/PW C008823 Synapse/Stoichiometry/1.0
type: Stoichiometry
physical entity: Atomoxetine
stoichiometric coefficient: 1.0

Reference/UniProt P09172
type: UnificationXref
id: P09172
db: UniProt

Reference/ChemSpider 247
type: UnificationXref
id: 247
db: ChemSpider

ChemicalStructure/PW C000103
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CC1=CC=C(O)C=C1)C(O)=O

Aromatic-L-amino-acid decarboxylase
type: ProteinReference
xref: Reference/UniProt P20711
organism: BiologicalState789

Reference/BioCyc L-DOPA
type: UnificationXref
id: L-DOPA
db: BioCyc

ReactionCatalysis207629
type: Catalysis
controller: Tyrosine 3-monooxygenase
controlled: Reaction218277
control type: ACTIVATION

L type Calcium channel
type: Complex
component stoichiometry: Protein/2720/Stoichiometry/1.0
component stoichiometry: Protein/2706/Stoichiometry/2.0
component stoichiometry: Protein/2712/Stoichiometry/1.0
component: Voltage-dependent calcium channel subunit alpha-2/delta-2
component: Voltage-dependent L-type calcium channel subunit beta-1
component: Voltage-dependent P/Q-type calcium channel subunit alpha-1A

Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Reference/PubChem-compound 6047
type: UnificationXref
id: 6047
db: PubChem-compound

Reference/ChemSpider 952
type: UnificationXref
id: 952
db: ChemSpider

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Reference/ChemSpider 10189562
type: UnificationXref
id: 10189562
db: ChemSpider

Reference/ChemSpider 274
type: UnificationXref
id: 274
db: ChemSpider

Reference/ChEBI CHEBI 127342
type: UnificationXref
id: CHEBI:127342
db: ChEBI

Reference/BioCyc TYR
type: UnificationXref
id: TYR
db: BioCyc

Norepinephrine
type: SmallMolecule
cellular location: Exocytic Vesicle
entity reference: Norepinephrine

Synaptic vesicular amine transporter
type: Protein
entity reference: Synaptic vesicular amine transporter

Tetrahydrobiopterin
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00272
xref: Reference/HMDB HMDB0000027
xref: Reference/CAS 17528-72-2
xref: Reference/BioCyc TETRA-H-BIOPTERIN
xref: Reference/PubChem-compound 1125
xref: Reference/ChemSpider 1093
xref: Reference/ChEBI CHEBI 15372
chemical formula: C9H15N5O3
molecular weight: 241.1175
structure: ChemicalStructure/PW C000019

Compound/PW C000027 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dihydrobiopterin
stoichiometric coefficient: 1.0

Reference/UniProt P35348
type: UnificationXref
id: P35348
db: UniProt

Compound/PW C000142 Synapse/Stoichiometry/1.0
type: Stoichiometry
physical entity: Norepinephrine
stoichiometric coefficient: 1.0

Reference/PubChem-compound 252
type: UnificationXref
id: 252
db: PubChem-compound

Protein/2712/Stoichiometry/1.0
type: Stoichiometry
physical entity: Voltage-dependent P/Q-type calcium channel subunit alpha-1A
stoichiometric coefficient: 1.0

Norepinephrine
type: SmallMolecule
cellular location: post-synaptic membrane
entity reference: Norepinephrine

Dehydroascorbic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Dehydroascorbic acid

Reference/ChemSpider 266
type: UnificationXref
id: 266
db: ChemSpider

Dopamine
type: SmallMolecule
cellular location: Cytosol
entity reference: Dopamine

Norepinephrine
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00547
xref: Reference/ChEBI CHEBI 18357
xref: Reference/CAS 51-41-2
xref: Reference/HMDB HMDB0000216
xref: Reference/PubChem-compound 439260
xref: Reference/ChemSpider 388394
xref: Reference/BioCyc NOREPINEPHRINE
chemical formula: C8H11NO3
molecular weight: 169.0739
structure: ChemicalStructure/PW C000142

Reference/ChEBI CHEBI 18357
type: UnificationXref
id: CHEBI:18357
db: ChEBI

Reference/ChEBI CHEBI 15765
type: UnificationXref
id: CHEBI:15765
db: ChEBI

Carbon dioxide
type: SmallMolecule
cellular location: Cytosol
entity reference: Carbon dioxide

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Reference/BioCyc CPD-6641
type: UnificationXref
id: CPD-6641
db: BioCyc

Reference/KEGG Compound C00355
type: UnificationXref
id: C00355
db: KEGG Compound

Reference/PubChem-compound 681
type: UnificationXref
id: 681
db: PubChem-compound

Reference/HMDB HMDB0000216
type: UnificationXref
id: HMDB0000216
db: HMDB

Reference/CAS 124-38-9
type: UnificationXref
id: 124-38-9
db: CAS

Reference/CAS 83015-26-3
type: UnificationXref
id: 83015-26-3
db: CAS

Voltage-dependent calcium channel subunit alpha-2/delta-2
type: Protein
entity reference: Voltage-dependent calcium channel subunit alpha-2/delta-2

Reference/KEGG Compound C00007
type: UnificationXref
id: C00007
db: KEGG Compound

Norepinephrine
type: SmallMolecule
cellular location: Synapse
entity reference: Norepinephrine

Reference/KEGG Compound C03758
type: UnificationXref
id: C03758
db: KEGG Compound

Reference/CAS 50-81-7
type: UnificationXref
id: 50-81-7
db: CAS

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

ChemicalStructure/PW C000019
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 18243
type: UnificationXref
id: CHEBI:18243
db: ChEBI

Reference/UniProt Q9NY47
type: UnificationXref
id: Q9NY47
db: UniProt

Reference/HMDB HMDB0000464
type: UnificationXref
id: HMDB0000464
db: HMDB

ChemicalStructure/PW C000142
type: ChemicalStructure
structure format: SMILES
structure data: NC[C@H](O)C1=CC(O)=C(O)C=C1

Reference/UniProt P20711
type: UnificationXref
id: P20711
db: UniProt

Reference/ChemSpider 182283
type: UnificationXref
id: 182283
db: ChemSpider

Tetrahydrobiopterin
type: SmallMolecule
cellular location: Cytosol
entity reference: Tetrahydrobiopterin

Sodium-dependent noradrenaline transporter
type: ProteinReference
xref: Reference/UniProt P23975

Reference/CELL TYPE ONTOLOGY CL 0000540
type: UnificationXref
id: CL:0000540
db: CELL TYPE ONTOLOGY

Neuron
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000540

Reference/KEGG Compound C00011
type: UnificationXref
id: C00011
db: KEGG Compound

ChemicalStructure/PW C001316
type: ChemicalStructure
structure format: SMILES
structure data: O=C=O

Reference/PubChem-compound 54841
type: UnificationXref
id: 54841
db: PubChem-compound

Voltage-dependent P/Q-type calcium channel subunit alpha-1A
type: Protein
entity reference: Voltage-dependent P/Q-type calcium channel subunit alpha-1A

Dopamine beta-hydroxylase
type: ProteinReference
xref: Reference/UniProt P09172
organism: BiologicalState789

Reference/ChEBI CHEBI 17242
type: UnificationXref
id: CHEBI:17242
db: ChEBI

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Alpha-1A adrenergic receptor
type: Protein
cellular location: post-synaptic membrane
entity reference: Alpha-1A adrenergic receptor
name: SubPathwayInput

Reference/CAS 14127-61-8
type: UnificationXref
id: 14127-61-8
db: CAS

ChemicalStructure/PW C000353
type: ChemicalStructure
structure format: SMILES
structure data: [Ca++]

Dopamine
type: SmallMoleculeReference
xref: Reference/CAS 51-61-6
xref: Reference/KEGG Compound C03758
xref: Reference/ChemSpider 661
xref: Reference/BioCyc DOPAMINE
xref: Reference/HMDB HMDB0000073
xref: Reference/PubChem-compound 681
xref: Reference/ChEBI CHEBI 18243
chemical formula: C8H11NO2
molecular weight: 153.07898
structure: ChemicalStructure/PW C000052

Dehydroascorbic acid
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00425
xref: Reference/BioCyc L-DEHYDRO-ASCORBATE
xref: Reference/CAS 490-83-5
xref: Reference/ChemSpider 182283
xref: Reference/PubChem-compound 210328
xref: Reference/ChEBI CHEBI 17242
xref: Reference/HMDB HMDB0001264
chemical formula: C6H6O6
molecular weight: 174.01643
structure: ChemicalStructure/PW C000977

Calcium
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Calcium

Tyrosine 3-monooxygenase
type: Protein
cellular location: Cytosol
entity reference: Tyrosine 3-monooxygenase

ChemicalStructure/PW C000117
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CC1=CC=C(O)C(O)=C1)C(O)=O

Voltage-dependent L-type calcium channel subunit beta-1
type: Protein
entity reference: Voltage-dependent L-type calcium channel subunit beta-1

post-synaptic membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0045211

Reference/KEGG Compound C00272
type: UnificationXref
id: C00272
db: KEGG Compound

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Reference/ChEBI CHEBI 29108
type: UnificationXref
id: CHEBI:29108
db: ChEBI

Reference/PubChem-compound 54670067
type: UnificationXref
id: 54670067
db: PubChem-compound

Transport15581
type: Transport
participant stoichiometry: Compound/PW C008823 Synapse/Stoichiometry/1.0
participant stoichiometry: Compound/PW C008823/Stoichiometry/1.0
right: Atomoxetine
spontaneous: true
left: Atomoxetine
name: Atomoxetine (→) Transport: Homo sapiens, Blood Vessel to Homo sapiens, Brain, Neuron, Synapse
conversion direction: REVERSIBLE

Synaptic vesicular amine transporter
type: ProteinReference
xref: Reference/UniProt Q05940

Beta-1 adrenergic receptor
type: Protein
cellular location: post-synaptic membrane
entity reference: Beta-1 adrenergic receptor
name: SubPathwayInput

Reference/BRENDA TISSUE ONTOLOGY BTO 0000142
type: UnificationXref
id: BTO:0000142
db: BRENDA TISSUE ONTOLOGY

ChemicalStructure/PW C000052
type: ChemicalStructure
structure format: SMILES
structure data: NCCC1=CC(O)=C(O)C=C1

Reference/BioCyc TETRA-H-BIOPTERIN
type: UnificationXref
id: TETRA-H-BIOPTERIN
db: BioCyc

Reference/PubChem-compound 210328
type: UnificationXref
id: 210328
db: PubChem-compound

Compound/PW C000142 Exocytic Vesicle/Stoichiometry/1.0
type: Stoichiometry
physical entity: Norepinephrine
stoichiometric coefficient: 1.0

Reference/BioCyc BIOPTERIN
type: UnificationXref
id: BIOPTERIN
db: BioCyc

Compound/PW C008823/Stoichiometry/1.0
type: Stoichiometry
physical entity: Atomoxetine
stoichiometric coefficient: 1.0

Compound/PW C000977 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dehydroascorbic acid
stoichiometric coefficient: 1.0

Compound/PW C000353 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Reference/SMPDB SMP0126353
type: UnificationXref
id: SMP0126353
db: SMPDB

Reference/UniProt Q05940
type: UnificationXref
id: Q05940
db: UniProt

Transport14116
type: Transport
participant stoichiometry: Compound/PW C000142 Exocytic Vesicle/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000142 Synapse/Stoichiometry/1.0
right: Norepinephrine
spontaneous: false
left: Norepinephrine
name: Norepinephrine (→) Transport: Homo sapiens, Brain, Neuron, Exocytic Vesicle to Homo sapiens, Brain, Neuron, Synapse
conversion direction: LEFT_TO_RIGHT

Atomoxetine
type: SmallMolecule
cellular location: Synapse
entity reference: Atomoxetine

ChemicalStructure/PW C000977
type: ChemicalStructure
structure format: SMILES
structure data: [H][C@@]1(OC(=O)C(=O)C1=O)[C@H](O)CO

Reference/UniProt Q02641
type: UnificationXref
id: Q02641
db: UniProt

Reference/GENE ONTOLOGY GO 0045211
type: UnificationXref
id: GO:0045211
db: GENE ONTOLOGY

Transport14112
type: Transport
participant stoichiometry: Compound/PW C000142 Exocytic Vesicle/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000142 Cytosol/Stoichiometry/1.0
right: Norepinephrine
spontaneous: false
left: Norepinephrine
name: Norepinephrine (→) Transport: Homo sapiens, Brain, Neuron, Cytosol to Homo sapiens, Brain, Neuron, Exocytic Vesicle
conversion direction: LEFT_TO_RIGHT

Transport14115
type: Transport
participant stoichiometry: Compound/PW C000142 Synapse/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000142 Cytosol/Stoichiometry/1.0
right: Norepinephrine
spontaneous: false
left: Norepinephrine
name: Norepinephrine (→) Transport: Homo sapiens, Brain, Neuron, Synapse to Homo sapiens, Brain, Neuron, Cytosol
conversion direction: LEFT_TO_RIGHT

Reference/CAS 59-92-7
type: UnificationXref
id: 59-92-7
db: CAS

Reference/HMDB HMDB0000027
type: UnificationXref
id: HMDB0000027
db: HMDB

Reference/HMDB HMDB0014434
type: UnificationXref
id: HMDB0014434
db: HMDB

Reference/CAS 51-61-6
type: UnificationXref
id: 51-61-6
db: CAS

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

ChemicalStructure/PW C000027
type: ChemicalStructure
structure format: SMILES

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Ascorbic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Ascorbic acid

ChemicalStructure/PW C000031
type: ChemicalStructure
structure format: SMILES
structure data: [H][C@@]1(OC(=O)C(O)=C1O)[C@@H](O)CO

Oxygen
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001377
xref: Reference/ChemSpider 952
xref: Reference/KEGG Compound C00007
xref: Reference/ChEBI CHEBI 15379
xref: Reference/PubChem-compound 977
xref: Reference/BioCyc CPD-6641
xref: Reference/CAS 7782-44-7
chemical formula: O2
molecular weight: 31.98983
structure: ChemicalStructure/PW C001065

Reference/HMDB HMDB0000158
type: UnificationXref
id: HMDB0000158
db: HMDB

Reference/HMDB HMDB0000038
type: UnificationXref
id: HMDB0000038
db: HMDB

Exocytic Vesicle
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0070382

Dihydrobiopterin
type: SmallMolecule
cellular location: Cytosol
entity reference: Dihydrobiopterin

Voltage-dependent calcium channel subunit alpha-2/delta-2
type: ProteinReference
xref: Reference/UniProt Q9NY47

Reference/BioCyc NOREPINEPHRINE
type: UnificationXref
id: NOREPINEPHRINE
db: BioCyc

Water
type: SmallMolecule
cellular location: Cytosol
entity reference: Water

Reference/CAS 60-18-4
type: UnificationXref
id: 60-18-4
db: CAS

Reference/BioCyc DOPAMINE
type: UnificationXref
id: DOPAMINE
db: BioCyc

Voltage-dependent P/Q-type calcium channel subunit alpha-1A
type: ProteinReference
xref: Reference/UniProt O00555

Reference/ChEBI CHEBI 16526
type: UnificationXref
id: CHEBI:16526
db: ChEBI

Reference/ChemSpider 1093
type: UnificationXref
id: 1093
db: ChemSpider

Reference/CAS 7782-44-7
type: UnificationXref
id: 7782-44-7
db: CAS

Reference/HMDB HMDB0001377
type: UnificationXref
id: HMDB0001377
db: HMDB

Atomoxetine
type: SmallMolecule
entity reference: Atomoxetine

Reference/ChemSpider 661
type: UnificationXref
id: 661
db: ChemSpider

Reference/KEGG Compound C00072
type: UnificationXref
id: C00072
db: KEGG Compound

Atomoxetine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0014434
xref: Reference/ChEBI CHEBI 127342
xref: Reference/PubChem-compound 54841
xref: Reference/CAS 83015-26-3
xref: Reference/ChemSpider 49516
chemical formula: C17H21NO
molecular weight: 255.16231
structure: ChemicalStructure/PW C008823

Compound/PW C001420 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000044
type: UnificationXref
id: HMDB0000044
db: HMDB

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Interaction3140
type: MolecularInteraction
interaction type: direct_interaction
name: Norepinephrine activates Alpha-1A adrenergic receptor
participant: Norepinephrine
participant: Alpha-1A adrenergic receptor

Interaction3141
type: MolecularInteraction
interaction type: direct_interaction
name: Norepinephrine activates Beta-1 adrenergic receptor
participant: Norepinephrine
participant: Beta-1 adrenergic receptor

Reference/UniProt P07101
type: UnificationXref
id: P07101
db: UniProt

Voltage-dependent L-type calcium channel subunit beta-1
type: ProteinReference
xref: Reference/UniProt Q02641

Reference/CAS 17528-72-2
type: UnificationXref
id: 17528-72-2
db: CAS

L-Tyrosine
type: SmallMoleculeReference
xref: Reference/CAS 60-18-4
xref: Reference/PubChem-compound 6057
xref: Reference/HMDB HMDB0000158
xref: Reference/ChEBI CHEBI 17895
xref: Reference/KEGG Compound C00082
xref: Reference/ChemSpider 5833
xref: Reference/BioCyc TYR
chemical formula: C9H11NO3
molecular weight: 181.0739
structure: ChemicalStructure/PW C000103

Beta-1 adrenergic receptor
type: ProteinReference
xref: Reference/UniProt P08588
organism: BiologicalState789

Reference/ChemSpider 388394
type: UnificationXref
id: 388394
db: ChemSpider

Reference/KEGG Compound C00076
type: UnificationXref
id: C00076
db: KEGG Compound

Carbon dioxide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 280
xref: Reference/ChEBI CHEBI 16526
xref: Reference/ChemSpider 274
xref: Reference/HMDB HMDB0001967
xref: Reference/CAS 124-38-9
xref: Reference/KEGG Compound C00011
chemical formula: CO2
molecular weight: 43.98983
structure: ChemicalStructure/PW C001316

Reaction218277
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000103 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000117 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000027 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000019 Cytosol/Stoichiometry/1.0
right: L-Dopa
right: Dihydrobiopterin
right: Water
spontaneous: false
left: Oxygen
left: L-Tyrosine
left: Tetrahydrobiopterin
name: L-Tyrosine + Oxygen + Tetrahydrobiopterin ↔ Dihydrobiopterin + L-Dopa + Water
conversion direction: REVERSIBLE

Compound/PW C000031 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ascorbic acid
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001065
type: ChemicalStructure
structure format: SMILES
structure data: O=O

Reference/BioCyc CA+2
type: UnificationXref
id: CA%2b2
db: BioCyc

Protein/2720/Stoichiometry/1.0
type: Stoichiometry
physical entity: Voltage-dependent L-type calcium channel subunit beta-1
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00082
type: UnificationXref
id: C00082
db: KEGG Compound

Calcium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000464
xref: Reference/BioCyc CA+2
xref: Reference/ChemSpider 266
xref: Reference/ChEBI CHEBI 29108
xref: Reference/CAS 14127-61-8
xref: Reference/KEGG Compound C00076
xref: Reference/PubChem-compound 271
chemical formula: Ca
molecular weight: 39.96259
structure: ChemicalStructure/PW C000353

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Reference/HMDB HMDB0001264
type: UnificationXref
id: HMDB0001264
db: HMDB

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/UniProt O00555
type: UnificationXref
id: O00555
db: UniProt

Norepinephrine
type: SmallMolecule
cellular location: Cytosol
entity reference: Norepinephrine

Reference/PubChem-compound 6057
type: UnificationXref
id: 6057
db: PubChem-compound

Reference/ChEBI CHEBI 15379
type: UnificationXref
id: CHEBI:15379
db: ChEBI

Beta-2 adrenergic receptor
type: Complex
cellular location: post-synaptic membrane
name: SubPathwayInput

L-Dopa
type: SmallMoleculeReference
xref: Reference/ChemSpider 5824
xref: Reference/CAS 59-92-7
xref: Reference/ChEBI CHEBI 15765
xref: Reference/HMDB HMDB0000181
xref: Reference/BioCyc L-DOPA
xref: Reference/KEGG Compound C00355
xref: Reference/PubChem-compound 6047
chemical formula: C9H11NO4
molecular weight: 197.0688
structure: ChemicalStructure/PW C000117

Atomoxetine Action Pathway (New)
type: Pathway
pathway order: PathwayInteraction/3140
pathway order: PathwaySubPathway/120564
pathway order: PathwaySubPathway/120563
pathway order: PathwayTransport/2528498
pathway order: PathwayTransport/2528499
pathway order: PathwayTransport/2528500
pathway order: PathwayTransport/2528501
pathway order: PathwayInteraction/3933
pathway order: PathwayInteraction/4229
pathway order: PathwayTransport/2532033
pathway order: PathwayEnzymeReaction/2528496
pathway order: PathwayEnzymeReaction/2528497
pathway order: PathwayEnzymeReaction/2528495
pathway order: PathwayInteraction/3141
pathway order: PathwayInteraction/4032
pathway component: Interaction3140
pathway component: Interaction4032
pathway component: Interaction3141
pathway component: TransportCatalysis2122
pathway component: 1.14.17.1
pathway component: ReactionCatalysis207629
pathway component: Transport10963
pathway component: Gs signaling cascade
pathway component: Reaction218277
pathway component: Transport14116
pathway component: Gq signaling cascade
pathway component: TransportCatalysis5071
pathway component: Transport14112
pathway component: Transport14115
pathway component: Interaction4229
pathway component: Interaction3933
pathway component: TransportCatalysis5069
pathway component: Transport15581
pathway component: 4.1.1.28
pathway component: ReactionCatalysis118
pathway component: ReactionCatalysis214
xref: Reference/PathWhiz PW127948
xref: Reference/SMPDB SMP0126353
organism: Homo sapiens

Reference/PubChem-compound 271
type: UnificationXref
id: 271
db: PubChem-compound

Reference/ChEBI CHEBI 15372
type: UnificationXref
id: CHEBI:15372
db: ChEBI

Oxygen
type: SmallMolecule
cellular location: Cytosol
entity reference: Oxygen

ChemicalStructure/PW C008823
type: ChemicalStructure
structure format: SMILES
structure data: CNCC[C@@H](OC1=CC=CC=C1C)C1=CC=CC=C1

Reference/BioCyc L-DEHYDRO-ASCORBATE
type: UnificationXref
id: L-DEHYDRO-ASCORBATE
db: BioCyc

Interaction4229
type: MolecularInteraction
interaction type: direct_interaction
name: Atomoxetine inhibits Sodium-dependent noradrenaline transporter
participant: Sodium-dependent noradrenaline transporter
participant: Atomoxetine

Reference/PubChem-compound 280
type: UnificationXref
id: 280
db: PubChem-compound

Reference/CAS 490-83-5
type: UnificationXref
id: 490-83-5
db: CAS

Interaction3933
type: MolecularInteraction
interaction type: direct_interaction
name: Calcium activates Norepinephrine
participant: Norepinephrine
participant: Calcium

Reference/HMDB HMDB0000181
type: UnificationXref
id: HMDB0000181
db: HMDB

Compound/PW C000142 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Norepinephrine
stoichiometric coefficient: 1.0

ReactionCatalysis214
type: Catalysis
controller: Aromatic-L-amino-acid decarboxylase
controlled: 4.1.1.28
control type: ACTIVATION

Reference/ChemSpider 5824
type: UnificationXref
id: 5824
db: ChemSpider

Reference/ChEBI CHEBI 64277
type: UnificationXref
id: CHEBI:64277
db: ChEBI

Compound/PW C000117 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Dopa
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 29073
type: UnificationXref
id: CHEBI:29073
db: ChEBI

Reference/PubChem-compound 439260
type: UnificationXref
id: 439260
db: PubChem-compound

Reference/KEGG Compound C02953
type: UnificationXref
id: C02953
db: KEGG Compound

Reference/CAS 6779-87-9
type: UnificationXref
id: 6779-87-9
db: CAS

Reference/UniProt P23975
type: UnificationXref
id: P23975
db: UniProt

L-Dopa
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Dopa

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

TransportCatalysis5069
type: Catalysis
controller: Synaptic vesicular amine transporter
controlled: Transport14112
control type: ACTIVATION

Reference/HMDB HMDB0000073
type: UnificationXref
id: HMDB0000073
db: HMDB

Protein/2706/Stoichiometry/2.0
type: Stoichiometry
physical entity: Voltage-dependent calcium channel subunit alpha-2/delta-2
stoichiometric coefficient: 2.0

Dopamine beta-hydroxylase
type: Protein
cellular location: Cytosol
entity reference: Dopamine beta-hydroxylase

Reference/GENE ONTOLOGY GO 0045202
type: UnificationXref
id: GO:0045202
db: GENE ONTOLOGY

Reference/KEGG Compound C00547
type: UnificationXref
id: C00547
db: KEGG Compound

Reference/KEGG Compound C00425
type: UnificationXref
id: C00425
db: KEGG Compound

Reference/ChEBI CHEBI 17895
type: UnificationXref
id: CHEBI:17895
db: ChEBI

Reference/PubChem-compound 977
type: UnificationXref
id: 977
db: PubChem-compound

TransportCatalysis2122
type: Catalysis
controller: L type Calcium channel
controlled: Transport10963
control type: ACTIVATION

Compound/PW C001316 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

Reference/UniProt P08588
type: UnificationXref
id: P08588
db: UniProt

Reference/HMDB HMDB0001967
type: UnificationXref
id: HMDB0001967
db: HMDB

Reference/BioCyc ASCORBATE
type: UnificationXref
id: ASCORBATE
db: BioCyc

TransportCatalysis5071
type: Catalysis
controller: Sodium-dependent noradrenaline transporter
controlled: Transport14115
control type: ACTIVATION

SubPathwayInteraction120563
type: Interaction
name: SubPathwayReaction
name: SubPathway120563Reaction
participant: Alpha-1A adrenergic receptor

4.1.1.28
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000117 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000052 Cytosol/Stoichiometry/1.0
right: Carbon dioxide
right: Dopamine
spontaneous: false
EC number: 4.1.1.28
left: L-Dopa
name: L-Dopa → Carbon dioxide + Dopamine
conversion direction: LEFT_TO_RIGHT

Sodium-dependent noradrenaline transporter
type: Protein
cellular location: Synapse
entity reference: Sodium-dependent noradrenaline transporter

SubPathwayInteraction120564
type: Interaction
name: SubPathway120564Reaction
name: SubPathwayReaction
participant: Beta-2 adrenergic receptor
participant: Beta-1 adrenergic receptor

ReactionCatalysis118
type: Catalysis
controller: Dopamine beta-hydroxylase
controlled: 1.14.17.1
control type: ACTIVATION

Aromatic-L-amino-acid decarboxylase
type: Protein
cellular location: Cytosol
entity reference: Aromatic-L-amino-acid decarboxylase

Synapse
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0045202