Solifenacin is a muscarinic antagonist with antispasmodic properties used to treat urge urinary incontinence, urgency, and urinary frequency associated with an overactive bladder. It can be found under the brand name Vesicare. It has a long duration of action as it is usually taken once daily. Solifenacin is a competitive muscarinic receptor antagonist. Solifenacin's antagonism of the M3 receptor prevents contraction of the detrusor muscle, while antagonism of the M2 receptor may prevent contraction of smooth muscle in the bladder. Solifenacin works to decrease bladder activity by inhibiting contraction of the smooth muscle wall surrounding the bladder. As a potent and selective muscarinic receptor antagonist, solifenacin acts specifically at the M3 receptor site. Possible side effects of using solifenacin may include dry mouth, headache, dizziness, and vertigo. Solifenacine is administered as an oral tablet.

Solifenacin M3 Bladder Muscle Relaxation Pathway References