Compound/PW C000714 Synapse/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetylcholine
stoichiometric coefficient: 1.0

Acetic acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15366
xref: Reference/BioCyc ACET
xref: Reference/CAS 64-19-7
xref: Reference/KEGG Compound C00033
xref: Reference/ChemSpider 171
xref: Reference/HMDB HMDB0000042
xref: Reference/PubChem-compound 176
chemical formula: C2H4O2
molecular weight: 60.02113
structure: ChemicalStructure/PW C000029

Reference/PubChem-compound 923
type: UnificationXref
id: 923
db: PubChem-compound

Acetyl-CoA
type: SmallMoleculeReference
xref: Reference/BioCyc ACETYL-COA
xref: Reference/PubChem-compound 444493
xref: Reference/HMDB HMDB0001206
xref: Reference/ChemSpider 392413
xref: Reference/CAS 72-89-9
xref: Reference/ChEBI CHEBI 15351
xref: Reference/KEGG Compound C00024
chemical formula: C23H38N7O17P3S
molecular weight: 809.1258
structure: ChemicalStructure/PW C000940

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

ReactionCatalysis207644
type: Catalysis
controller: Acetylcholinesterase
controlled: Reaction218289
control type: ACTIVATION

BiologicalState789
type: BioSource
cell type: Neuron
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Brain, Neuron
tissue: Brain

ReactionCatalysis207643
type: Catalysis
controller: Choline O-acetyltransferase
controlled: Reaction218288
control type: ACTIVATION

direct_interaction
type: InteractionVocabulary

Reference/HMDB HMDB0000895
type: UnificationXref
id: HMDB0000895
db: HMDB

Reference/CAS 64-19-7
type: UnificationXref
id: 64-19-7
db: CAS

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Reference/GENE ONTOLOGY GO 0070382
type: UnificationXref
id: GO:0070382
db: GENE ONTOLOGY

Acetyl-CoA
type: SmallMolecule
cellular location: Cytosol
entity reference: Acetyl-CoA

Reference/HMDB HMDB0000097
type: UnificationXref
id: HMDB0000097
db: HMDB

Serine/threonine-protein phosphatase PP1-beta catalytic subunit
type: Protein
cellular location: Cytosol
entity reference: Serine/threonine-protein phosphatase PP1-beta catalytic subunit

Acetylcholine
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15355
xref: Reference/CAS 51-84-3
xref: Reference/HMDB HMDB0000895
xref: Reference/ChemSpider 182
xref: Reference/KEGG Compound C01996
xref: Reference/BioCyc ACETYLCHOLINE
xref: Reference/PubChem-compound 187
chemical formula: C7H16NO2
molecular weight: 146.1181
structure: ChemicalStructure/PW C000714

Reference/PathWhiz PW128013
type: UnificationXref
id: PW128013
db: PathWhiz

Brain
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000142

ChemicalStructure/PW C000458
type: ChemicalStructure
structure format: SMILES
structure data: [Na+]

Calcium
type: SmallMolecule
cellular location: Cytosol
entity reference: Calcium

Neuronal acetylcholine receptor subunit beta-2
type: Protein
entity reference: Neuronal acetylcholine receptor subunit beta-2

Neuronal acetylcholine receptor subunit alpha-4
type: Protein
entity reference: Neuronal acetylcholine receptor subunit alpha-4

ReactionCatalysis207656
type: Catalysis
controller: Myosin light chain kinase 2, skeletal/cardiac muscle
controlled: 2.7.11.18
control type: ACTIVATION

Compound/PW C000065 Synapse/Stoichiometry/1.0
type: Stoichiometry
physical entity: Choline
stoichiometric coefficient: 1.0

Reference/PubChem-compound 6816
type: UnificationXref
id: 6816
db: PubChem-compound

Protein/5733 Synapse/Stoichiometry/2.0
type: Stoichiometry
physical entity: Neuronal acetylcholine receptor subunit beta-2
stoichiometric coefficient: 2.0

Compound/PW C000065/Stoichiometry/1.0
type: Stoichiometry
physical entity: Choline
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 2627
type: UnificationXref
id: CHEBI:2627
db: ChEBI

Reference/GENE ONTOLOGY GO 0016529
type: UnificationXref
id: GO:0016529
db: GENE ONTOLOGY

TransportCatalysis4975
type: Catalysis
controller: High affinity choline transporter 1
controlled: Transport13993
control type: ACTIVATION

TransportCatalysis4974
type: Catalysis
controller: Vesicular acetylcholine transporter
controlled: Transport13991
control type: ACTIVATION

Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Nicotinic Acetylcholine Receptor
type: Complex
component stoichiometry: Protein/5733/Stoichiometry/2.0
component stoichiometry: Protein/5734/Stoichiometry/2.0
component: Neuronal acetylcholine receptor subunit beta-2
component: Neuronal acetylcholine receptor subunit alpha-4

Acetylcholine
type: SmallMolecule
entity reference: Acetylcholine

Reference/KEGG Compound C07773
type: UnificationXref
id: C07773
db: KEGG Compound

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Sarcoplasmic Reticulum
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0016529

Voltage-dependent L-type calcium channel subunit alpha-1F
type: Protein
cellular location: Cytosol
entity reference: Voltage-dependent L-type calcium channel subunit alpha-1F

Reference/UniProt Q13936
type: UnificationXref
id: Q13936
db: UniProt

Reference/BioCyc ACETYLCHOLINE
type: UnificationXref
id: ACETYLCHOLINE
db: BioCyc

Voltage-dependent L-type calcium channel subunit alpha-1D
type: Protein
entity reference: Voltage-dependent L-type calcium channel subunit alpha-1D

TransportCatalysis4982
type: Catalysis
controller: Nicotinic Acetylcholine Receptor
controlled: Transport14000
control type: ACTIVATION

TransportCatalysis4983
type: Catalysis
controller: Voltage-dependent L-type calcium channel
controlled: Transport14001
control type: ACTIVATION

Protein/1597 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calmodulin-1
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0015254
type: UnificationXref
id: HMDB0015254
db: HMDB

Acetic acid
type: SmallMolecule
entity reference: Acetic acid

Acetylcholinesterase
type: Protein
entity reference: Acetylcholinesterase

ChemicalStructure/PW C001099
type: ChemicalStructure
structure format: SMILES

Reference/UniProt P62140
type: UnificationXref
id: P62140
db: UniProt

Reference/ChemSpider 266
type: UnificationXref
id: 266
db: ChemSpider

Vesicular acetylcholine transporter
type: Protein
entity reference: Vesicular acetylcholine transporter

Compound/PW C000714 Exocytic Vesicle/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetylcholine
stoichiometric coefficient: 1.0

High affinity choline transporter 1
type: Protein
entity reference: High affinity choline transporter 1

Protein/5734/Stoichiometry/2.0
type: Stoichiometry
physical entity: Neuronal acetylcholine receptor subunit alpha-4
stoichiometric coefficient: 2.0

Compound/PW C000458 Synapse/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 1.0

Protein/5733/Stoichiometry/2.0
type: Stoichiometry
physical entity: Neuronal acetylcholine receptor subunit beta-2
stoichiometric coefficient: 2.0

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Calmodulin-1
type: ProteinReference
xref: Reference/UniProt P0DP23
organism: Homo sapiens

Reference/KEGG Compound C00114
type: UnificationXref
id: C00114
db: KEGG Compound

Voltage-dependent L-type calcium channel subunit alpha-1C
type: Protein
entity reference: Voltage-dependent L-type calcium channel subunit alpha-1C

Choline O-acetyltransferase
type: ProteinReference
xref: Reference/UniProt P28329
organism: BiologicalState789

Transport13992
type: Transport
participant stoichiometry: Compound/PW C000714 Synapse/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000714 Exocytic Vesicle/Stoichiometry/1.0
right: Acetylcholine
spontaneous: false
left: Acetylcholine
name: Acetylcholine (→) Transport: Homo sapiens, Brain, Neuron, Exocytic Vesicle to Homo sapiens, Brain, Neuron, Synapse
conversion direction: LEFT_TO_RIGHT

Transport13991
type: Transport
participant stoichiometry: Compound/PW C000714 Exocytic Vesicle/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000714 Cytosol/Stoichiometry/1.0
right: Acetylcholine
spontaneous: false
left: Acetylcholine
name: Acetylcholine (→) Transport: Homo sapiens, Brain, Neuron, Cytosol to Homo sapiens, Brain, Neuron, Exocytic Vesicle
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0001423
type: UnificationXref
id: HMDB0001423
db: HMDB

Transport13993
type: Transport
participant stoichiometry: Compound/PW C000065 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000065 Synapse/Stoichiometry/1.0
right: Choline
spontaneous: false
left: Choline
name: Choline (→) Transport: Homo sapiens, Brain, Neuron, Synapse to Homo sapiens, Brain, Neuron, Cytosol
conversion direction: LEFT_TO_RIGHT

Reference/UniProt P17787
type: UnificationXref
id: P17787
db: UniProt

Compound/PW C000353 Sarcoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Reference/UniProt P28329
type: UnificationXref
id: P28329
db: UniProt

Voltage-dependent calcium channel subunit alpha-2/delta-2
type: Protein
entity reference: Voltage-dependent calcium channel subunit alpha-2/delta-2

Compound/PW C000940 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetyl-CoA
stoichiometric coefficient: 1.0

Choline
type: SmallMolecule
cellular location: Cytosol
entity reference: Choline

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/KEGG Compound C01330
type: UnificationXref
id: C01330
db: KEGG Compound

Reference/UniProt Q9NY47
type: UnificationXref
id: Q9NY47
db: UniProt

Reference/HMDB HMDB0000464
type: UnificationXref
id: HMDB0000464
db: HMDB

Acetylcholinesterase
type: Protein
cellular location: Synapse
entity reference: Acetylcholinesterase

Reference/UniProt O60840
type: UnificationXref
id: O60840
db: UniProt

Myosin light chain kinase 2, skeletal/cardiac muscle
type: ProteinReference
xref: Reference/UniProt Q9H1R3
organism: Homo sapiens

Reference/HMDB HMDB0000588
type: UnificationXref
id: HMDB0000588
db: HMDB

Sodium
type: SmallMolecule
cellular location: Synapse
entity reference: Sodium

SubPathwayControl120700
type: Interaction
name: SubPathway120700Control
name: ActivatingSubPathwayControl
participant: Myosin light chain 3
participant: Muscle Contraction

SubPathwayControl120701
type: Interaction
name: SubPathway120701Control
name: ActivatingSubPathwayControl
participant: Myosin light chain 3
participant: Muscle Relaxation

Voltage-dependent L-type calcium channel subunit alpha-1S
type: Protein
entity reference: Voltage-dependent L-type calcium channel subunit alpha-1S

Coenzyme A
type: SmallMolecule
cellular location: Cytosol
entity reference: Coenzyme A

Neuronal acetylcholine receptor subunit alpha-4
type: ProteinReference
xref: Reference/UniProt P43681

Reference/CELL TYPE ONTOLOGY CL 0000540
type: UnificationXref
id: CL:0000540
db: CELL TYPE ONTOLOGY

Neuron
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000540

Neuronal acetylcholine receptor subunit beta-2
type: ProteinReference
xref: Reference/UniProt P17787

Reference/KEGG Compound C00010
type: UnificationXref
id: C00010
db: KEGG Compound

Reference/UniProt Q01668
type: UnificationXref
id: Q01668
db: UniProt

Voltage-dependent N-type calcium channel subunit alpha-1B
type: Protein
entity reference: Voltage-dependent N-type calcium channel subunit alpha-1B

Serine/threonine-protein phosphatase PP1-beta catalytic subunit
type: ProteinReference
xref: Reference/UniProt P62140
organism: Homo sapiens

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Voltage-dependent L-type calcium channel subunit alpha-1F
type: Protein
entity reference: Voltage-dependent L-type calcium channel subunit alpha-1F

Reference/HMDB HMDB0001206
type: UnificationXref
id: HMDB0001206
db: HMDB

Reference/CAS 14127-61-8
type: UnificationXref
id: 14127-61-8
db: CAS

ChemicalStructure/PW C000353
type: ChemicalStructure
structure format: SMILES
structure data: [Ca++]

Ambenonium
type: SmallMoleculeReference
xref: Reference/KEGG Compound C07773
xref: Reference/CAS 7648-98-8
xref: Reference/ChemSpider 2046
xref: Reference/PubChem-compound 2131
xref: Reference/HMDB HMDB0015254
xref: Reference/ChEBI CHEBI 2627
chemical formula: C28H42Cl2N4O2
molecular weight: 536.2685
structure: ChemicalStructure/PW C009541

Reference/SMPDB SMP0126415
type: UnificationXref
id: SMP0126415
db: SMPDB

Calcium
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Calcium

Reference/BioCyc CPD-563
type: UnificationXref
id: CPD-563
db: BioCyc

Reference/UniProt Q16572
type: UnificationXref
id: Q16572
db: UniProt

Voltage-dependent L-type calcium channel
type: Complex
cellular location: Cytosol
component: Voltage-dependent L-type calcium channel subunit alpha-1F
component: Voltage-dependent L-type calcium channel subunit alpha-1C
component: Voltage-dependent L-type calcium channel subunit alpha-1D
component: Voltage-dependent L-type calcium channel subunit alpha-1S

Reference/UniProt P0DP23
type: UnificationXref
id: P0DP23
db: UniProt

Voltage-dependent L-type calcium channel subunit beta-1
type: Protein
entity reference: Voltage-dependent L-type calcium channel subunit beta-1

Calmodulin-1
type: Protein
cellular location: Cytosol
entity reference: Calmodulin-1

Voltage-dependent L-type calcium channel subunit beta-4
type: Protein
entity reference: Voltage-dependent L-type calcium channel subunit beta-4

Reference/KEGG Compound C00024
type: UnificationXref
id: C00024
db: KEGG Compound

Reference/BRENDA TISSUE ONTOLOGY BTO 0001484
type: UnificationXref
id: BTO:0001484
db: BRENDA TISSUE ONTOLOGY

Acetylcholinesterase
type: ProteinReference
xref: Reference/UniProt P22303

Reference/BioCyc ACET
type: UnificationXref
id: ACET
db: BioCyc

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Reference/ChEBI CHEBI 29108
type: UnificationXref
id: CHEBI:29108
db: ChEBI

Compound/PW C000714/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetylcholine
stoichiometric coefficient: 1.0

Compound/PW C000065 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Choline
stoichiometric coefficient: 1.0

Choline
type: SmallMolecule
entity reference: Choline

Choline
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15354
xref: Reference/ChemSpider 299
xref: Reference/BioCyc CPD-563
xref: Reference/PubChem-compound 305
xref: Reference/CAS 62-49-7
xref: Reference/HMDB HMDB0000097
xref: Reference/KEGG Compound C00114
chemical formula: C5H14NO
molecular weight: 104.10754
structure: ChemicalStructure/PW C000065

Reference/ChEBI CHEBI 29101
type: UnificationXref
id: CHEBI:29101
db: ChEBI

Acetylcholine
type: SmallMolecule
cellular location: Synapse
entity reference: Acetylcholine

Voltage-dependent L-type calcium channel subunit alpha-1C
type: Protein
cellular location: Cytosol
entity reference: Voltage-dependent L-type calcium channel subunit alpha-1C

Reference/KEGG Compound C00033
type: UnificationXref
id: C00033
db: KEGG Compound

Reference/UniProt P08590
type: UnificationXref
id: P08590
db: UniProt

Reference/ChemSpider 899
type: UnificationXref
id: 899
db: ChemSpider

Reference/BRENDA TISSUE ONTOLOGY BTO 0000142
type: UnificationXref
id: BTO:0000142
db: BRENDA TISSUE ONTOLOGY

Reference/ChEBI CHEBI 1146900
type: UnificationXref
id: CHEBI:1146900
db: ChEBI

Reference/UniProt P22303
type: UnificationXref
id: P22303
db: UniProt

Water
type: SmallMolecule
entity reference: Water

Transport14001
type: Transport
participant stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353 Sarcoplasmic Reticulum/Stoichiometry/1.0
right: Calcium
spontaneous: false
left: Calcium
name: Calcium (→) Transport: Homo sapiens, Cell, Sarcoplasmic Reticulum to Homo sapiens, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Transport14000
type: Transport
participant stoichiometry: Compound/PW C000458 Synapse/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Cytosol/Stoichiometry/1.0
right: Sodium
spontaneous: false
left: Sodium
name: Sodium (→) Transport: Homo sapiens, Nervous System, Neuron, Synapse to Homo sapiens, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

N-type calcium channel
type: Complex
component: Voltage-dependent calcium channel subunit alpha-2/delta-2
component: Voltage-dependent L-type calcium channel subunit beta-1
component: Voltage-dependent L-type calcium channel subunit beta-4
component: Voltage-dependent N-type calcium channel subunit alpha-1B

ChemicalStructure/PW C009541
type: ChemicalStructure
structure format: SMILES
structure data: CC[N+](CC)(CCNC(=O)C(=O)NCC[N+](CC)(CC)CC1=CC=CC=C1Cl)CC1=CC=CC=C1Cl

Voltage-dependent L-type calcium channel subunit alpha-1D
type: ProteinReference
xref: Reference/UniProt Q01668

Myosin light chain kinase 2, skeletal/cardiac muscle
type: Protein
cellular location: Cytosol
entity reference: Myosin light chain kinase 2, skeletal/cardiac muscle

Voltage-dependent L-type calcium channel subunit alpha-1C
type: ProteinReference
xref: Reference/UniProt Q13936

BiologicalState37
type: BioSource
cell type: Neuron
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Nervous System, Neuron
tissue: Nervous System

Compound/PW C000353 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Reference/BioCyc CO-A
type: UnificationXref
id: CO-A
db: BioCyc

Interaction4785
type: MolecularInteraction
interaction type: direct_interaction
name: Ambenonium inhibits Acetylcholinesterase
participant: Acetylcholinesterase
participant: Ambenonium

Reference/ChemSpider 2046
type: UnificationXref
id: 2046
db: ChemSpider

Reference/CAS 72-89-9
type: UnificationXref
id: 72-89-9
db: CAS

Reference/UniProt Q02641
type: UnificationXref
id: Q02641
db: UniProt

ChemicalStructure/PW C000065
type: ChemicalStructure
structure format: SMILES
structure data: C[N+](C)(C)CCO

Coenzyme A
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 1146900
xref: Reference/HMDB HMDB0001423
xref: Reference/PubChem-compound 6816
xref: Reference/BioCyc CO-A
xref: Reference/ChemSpider 6557
xref: Reference/CAS 85-61-0
xref: Reference/KEGG Compound C00010
chemical formula: C21H36N7O16P3S
molecular weight: 767.11523
structure: ChemicalStructure/PW C001099

Transport11084
type: Transport
participant stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
right: Calcium
spontaneous: false
left: Calcium
name: Calcium (→) Transport: Homo sapiens, Brain, Neuron, Extracellular Space to Homo sapiens, Brain, Neuron, Cytosol
conversion direction: LEFT_TO_RIGHT

Compound/PW C000714 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetylcholine
stoichiometric coefficient: 1.0

Reference/CAS 17341-25-2
type: UnificationXref
id: 17341-25-2
db: CAS

Reference/CAS 51-84-3
type: UnificationXref
id: 51-84-3
db: CAS

Vesicular acetylcholine transporter
type: ProteinReference
xref: Reference/UniProt Q16572

BoundComplex/506 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium_Calmodulin (Homo sapiens)
stoichiometric coefficient: 1.0

Reference/ChemSpider 6557
type: UnificationXref
id: 6557
db: ChemSpider

Reference/PubChem-compound 305
type: UnificationXref
id: 305
db: PubChem-compound

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

ChemicalStructure/PW C000029
type: ChemicalStructure
structure format: SMILES
structure data: CC(O)=O

ChemicalStructure/PW C000940
type: ChemicalStructure
structure format: SMILES

High affinity choline transporter 1
type: ProteinReference
xref: Reference/UniProt Q9GZV3

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Voltage-dependent L-type calcium channel subunit alpha-1S
type: Protein
cellular location: Cytosol
entity reference: Voltage-dependent L-type calcium channel subunit alpha-1S

Exocytic Vesicle
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0070382

Neuronal acetylcholine receptor subunit alpha-4
type: Protein
cellular location: Synapse
entity reference: Neuronal acetylcholine receptor subunit alpha-4

Interaction3928
type: MolecularInteraction
interaction type: direct_interaction
name: Acetylcholine activates Nicotinic Acetylcholine Receptor
participant: Nicotinic Acetylcholine Receptor
participant: Acetylcholine

Voltage-dependent calcium channel subunit alpha-2/delta-2
type: ProteinReference
xref: Reference/UniProt Q9NY47

Interaction3929
type: MolecularInteraction
interaction type: direct_interaction
name: Sodium activates Voltage-dependent L-type calcium channel
participant: Voltage-dependent L-type calcium channel
participant: Sodium

Compound/PW C000029/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetic acid
stoichiometric coefficient: 1.0

Reaction213775
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
participant stoichiometry: BoundComplex/506 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/1597 Cytosol/Stoichiometry/1.0
right: Calcium_Calmodulin (Homo sapiens)
spontaneous: false
left: Calcium
left: Calmodulin-1
name: Calcium + Calmodulin → Calcium + Calmodulin (Homo sapiens)
conversion direction: LEFT_TO_RIGHT

3.1.3.16
type: BiochemicalReaction
participant stoichiometry: Protein/3041 Cytosol/Stoichiometry/1.0
right: Myosin light chain 3
spontaneous: false
EC number: 3.1.3.16
left: Myosin light chain 3
name: Myosin LC-P → Myosin light chain 3
conversion direction: LEFT_TO_RIGHT

Voltage-dependent N-type calcium channel subunit alpha-1B
type: ProteinReference
xref: Reference/UniProt Q00975

Reference/UniProt Q9GZV3
type: UnificationXref
id: Q9GZV3
db: UniProt

Ambenonium Action Pathway
type: Pathway
pathway order: PathwayEnzymeReaction/2529745
pathway order: PathwayTransport/2529749
pathway order: PathwaySubPathway/120700
pathway order: PathwaySubPathway/120701
pathway order: PathwayTransport/2529746
pathway order: PathwayInteraction/3918
pathway order: PathwayInteraction/3929
pathway order: PathwayTransport/2529747
pathway order: PathwayInteraction/3928
pathway order: PathwayTransport/2529748
pathway order: PathwayTransport/2529750
pathway order: PathwayTransport/2529751
pathway order: PathwayInteraction/3930
pathway order: PathwayEnzymeReaction/2529744
pathway order: PathwayEnzymeReaction/2529743
pathway order: PathwayEnzymeReaction/2529742
pathway order: PathwayInteraction/4785
pathway order: PathwayEnzymeReaction/2529741
pathway component: TransportCatalysis4975
pathway component: TransportCatalysis4974
pathway component: ReactionCatalysis207644
pathway component: ReactionCatalysis207643
pathway component: ReactionCatalysis203360
pathway component: Transport13992
pathway component: Transport13991
pathway component: Transport13993
pathway component: Transport14001
pathway component: Transport14000
pathway component: Interaction3928
pathway component: Interaction3929
pathway component: Reaction213775
pathway component: TransportCatalysis2226
pathway component: 3.1.3.16
pathway component: TransportCatalysis4982
pathway component: TransportCatalysis4983
pathway component: Interaction4785
pathway component: Reaction218289
pathway component: Reaction218288
pathway component: Interaction3930
pathway component: ReactionCatalysis207656
pathway component: Transport11084
pathway component: 2.7.11.18
pathway component: SubPathwayControl120700
pathway component: SubPathwayControl120701
pathway component: Interaction3918
xref: Reference/SMPDB SMP0126415
xref: Reference/PathWhiz PW128013
organism: Homo sapiens

Voltage-dependent L-type calcium channel subunit alpha-1F
type: ProteinReference
xref: Reference/UniProt O60840

Protein/3041 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Myosin light chain 3
stoichiometric coefficient: 1.0

Reference/UniProt Q9H1R3
type: UnificationXref
id: Q9H1R3
db: UniProt

ChemicalStructure/PW C000714
type: ChemicalStructure
structure format: SMILES
structure data: CC(=O)OCC[N+](C)(C)C

Acetylcholine
type: SmallMolecule
cellular location: Exocytic Vesicle
entity reference: Acetylcholine

Reference/HMDB HMDB0000042
type: UnificationXref
id: HMDB0000042
db: HMDB

Interaction3918
type: MolecularInteraction
interaction type: direct_interaction
name: Calcium activates Acetylcholine
participant: Acetylcholine
participant: Calcium

Voltage-dependent L-type calcium channel subunit alpha-1S
type: ProteinReference
xref: Reference/UniProt Q13698

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/ChEBI CHEBI 15366
type: UnificationXref
id: CHEBI:15366
db: ChEBI

Reference/UniProt O00305
type: UnificationXref
id: O00305
db: UniProt

Voltage-dependent L-type calcium channel subunit beta-1
type: ProteinReference
xref: Reference/UniProt Q02641

Voltage-dependent L-type calcium channel subunit beta-4
type: ProteinReference
xref: Reference/UniProt O00305

Reference/ChemSpider 392413
type: UnificationXref
id: 392413
db: ChemSpider

Protein/5734 Synapse/Stoichiometry/2.0
type: Stoichiometry
physical entity: Neuronal acetylcholine receptor subunit alpha-4
stoichiometric coefficient: 2.0

Reference/KEGG Compound C00076
type: UnificationXref
id: C00076
db: KEGG Compound

Sodium
type: SmallMolecule
cellular location: Cytosol
entity reference: Sodium

Reference/UniProt P43681
type: UnificationXref
id: P43681
db: UniProt

Compound/PW C000458 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 1.0

ReactionCatalysis203360
type: Catalysis
controller: Serine/threonine-protein phosphatase PP1-beta catalytic subunit
controlled: 3.1.3.16
control type: ACTIVATION

Neuronal acetylcholine receptor subunit beta-2
type: Protein
cellular location: Synapse
entity reference: Neuronal acetylcholine receptor subunit beta-2

Reference/BioCyc CA+2
type: UnificationXref
id: CA%2b2
db: BioCyc

Reference/ChemSpider 299
type: UnificationXref
id: 299
db: ChemSpider

Calcium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000464
xref: Reference/BioCyc CA+2
xref: Reference/ChemSpider 266
xref: Reference/ChEBI CHEBI 29108
xref: Reference/CAS 14127-61-8
xref: Reference/KEGG Compound C00076
xref: Reference/PubChem-compound 271
chemical formula: Ca
molecular weight: 39.96259
structure: ChemicalStructure/PW C000353

Reference/ChemSpider 171
type: UnificationXref
id: 171
db: ChemSpider

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Voltage-dependent L-type calcium channel subunit alpha-1D
type: Protein
cellular location: Cytosol
entity reference: Voltage-dependent L-type calcium channel subunit alpha-1D

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

TransportCatalysis2226
type: Catalysis
controller: N-type calcium channel
controlled: Transport11084
control type: ACTIVATION

Choline
type: SmallMolecule
cellular location: Synapse
entity reference: Choline

Reaction218289
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000029/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000714/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000065/Stoichiometry/1.0
right: Choline
right: Acetic acid
spontaneous: false
left: Water
left: Acetylcholine
name: Acetylcholine + Water ↔ Acetic acid + Choline
conversion direction: REVERSIBLE

Reaction218288
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001099 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000940 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000065 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000714 Cytosol/Stoichiometry/1.0
right: Acetylcholine
right: Coenzyme A
spontaneous: false
left: Choline
left: Acetyl-CoA
name: Acetyl-CoA + Choline ↔ Acetylcholine + Coenzyme A
conversion direction: REVERSIBLE

Reference/PubChem-compound 271
type: UnificationXref
id: 271
db: PubChem-compound

Interaction3930
type: MolecularInteraction
interaction type: direct_interaction
name: Calcium + Calmodulin (Homo sapiens) activates Myosin light chain kinase
participant: Myosin light chain kinase 2, skeletal/cardiac muscle
participant: Calcium_Calmodulin (Homo sapiens)

Reference/PubChem-compound 2131
type: UnificationXref
id: 2131
db: PubChem-compound

Choline O-acetyltransferase
type: Protein
cellular location: Cytosol
entity reference: Choline O-acetyltransferase

Compound/PW C001420/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Ambenonium
type: SmallMolecule
cellular location: Synapse
entity reference: Ambenonium

Myosin light chain 3
type: Protein
cellular location: Cytosol
entity reference: Myosin light chain 3
name: SubPathwayActivator

2.7.11.18
type: BiochemicalReaction
participant stoichiometry: Protein/3041 Cytosol/Stoichiometry/1.0
right: Myosin light chain 3
spontaneous: false
EC number: 2.7.11.18
left: Myosin light chain 3
name: Myosin light chain 3 → Myosin LC-P
conversion direction: LEFT_TO_RIGHT

Nicotinic Acetylcholine Receptor
type: Complex
component stoichiometry: Protein/5734 Synapse/Stoichiometry/2.0
component stoichiometry: Protein/5733 Synapse/Stoichiometry/2.0
cellular location: Synapse
component: Neuronal acetylcholine receptor subunit beta-2
component: Neuronal acetylcholine receptor subunit alpha-4

Acetylcholine
type: SmallMolecule
cellular location: Cytosol
entity reference: Acetylcholine

Reference/PubChem-compound 444493
type: UnificationXref
id: 444493
db: PubChem-compound

Reference/UniProt Q00975
type: UnificationXref
id: Q00975
db: UniProt

Reference/PubChem-compound 187
type: UnificationXref
id: 187
db: PubChem-compound

Myosin light chain 3
type: ProteinReference
xref: Reference/UniProt P08590
organism: Homo sapiens

Reference/BioCyc ACETYL-COA
type: UnificationXref
id: ACETYL-COA
db: BioCyc

Compound/PW C001099 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coenzyme A
stoichiometric coefficient: 1.0

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Muscle Contraction
type: Pathway
name: ActivatingSubPathway

Muscle Relaxation
type: Pathway
name: ActivatingSubPathway

Reference/UniProt Q13698
type: UnificationXref
id: Q13698
db: UniProt

Reference/GENE ONTOLOGY GO 0045202
type: UnificationXref
id: GO:0045202
db: GENE ONTOLOGY

Reference/ChEBI CHEBI 15355
type: UnificationXref
id: CHEBI:15355
db: ChEBI

Reference/ChEBI CHEBI 15354
type: UnificationXref
id: CHEBI:15354
db: ChEBI

Reference/CAS 7648-98-8
type: UnificationXref
id: 7648-98-8
db: CAS

Sodium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000588
xref: Reference/PubChem-compound 923
xref: Reference/KEGG Compound C01330
xref: Reference/ChEBI CHEBI 29101
xref: Reference/ChemSpider 899
xref: Reference/CAS 17341-25-2
chemical formula: Na
molecular weight: 22.989769
structure: ChemicalStructure/PW C000458

Reference/CAS 62-49-7
type: UnificationXref
id: 62-49-7
db: CAS

Reference/ChEBI CHEBI 15351
type: UnificationXref
id: CHEBI:15351
db: ChEBI

Reference/KEGG Compound C01996
type: UnificationXref
id: C01996
db: KEGG Compound

Reference/PubChem-compound 176
type: UnificationXref
id: 176
db: PubChem-compound

Calcium
type: SmallMolecule
cellular location: Sarcoplasmic Reticulum
entity reference: Calcium

Reference/CAS 85-61-0
type: UnificationXref
id: 85-61-0
db: CAS

Calcium_Calmodulin (Homo sapiens)
type: Complex
component stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/1597 Cytosol/Stoichiometry/1.0
cellular location: Cytosol
component: Calcium
component: Calmodulin-1

Nervous System
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0001484

Reference/ChemSpider 182
type: UnificationXref
id: 182
db: ChemSpider

Voltage-dependent L-type calcium channel
type: Complex
component: Voltage-dependent L-type calcium channel subunit alpha-1S
component: Voltage-dependent L-type calcium channel subunit alpha-1D
component: Voltage-dependent L-type calcium channel subunit alpha-1C
component: Voltage-dependent L-type calcium channel subunit alpha-1F

Synapse
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0045202