Fondaparinux is an anticoagulant mainly used to treat venous thromboembolism, this is accomplished by inhibiting Factor X, stopping the formation of the prothrombinase complex which halts thrombus formation. By inhibiting Factor X the conversion of prothrombin to thrombin cannot occur which subsequently stops the conversion of fibrinogen to fibrin. Without fibrin, the meshwork to form a thrombus or blood clot is inhibited. It is further potentiated as fondaparinux activates antithrombin III that also inhibits coagulation factor X. It is administered via subcutaneous injection, it is not metabolized but rather excreted via the kidney function unchanged or altered. Caution should be taken as with any anticoagulant as there is a higher risk of bleeding and or hemorrhage. Avoiding herbs and supplements with anticoagulant and antiplatelet activity such as garlic, ginger, ginseng and ginkgo.

Fondaparinux Pathway References