Reference/ChEBI CHEBI 16015
type: UnificationXref
id: CHEBI:16015
db: ChEBI

Purine nucleoside phosphorylase
type: Protein
cellular location: Cytosol
entity reference: Purine nucleoside phosphorylase

Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

Reaction213228
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040526 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C109120 Cytosol/Stoichiometry/1.0
right: Thiodeoxyguanosine-5'-triphosphate
spontaneous: false
left: Thiodeoxyguanosine 5'-diphosphate
name: Thiodeoxyguanosine 5'-diphosphate → Thiodeoxyguanosine-5'-triphosphate
conversion direction: LEFT_TO_RIGHT

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Ribose-phosphate pyrophosphokinase 3
type: Complex
component stoichiometry: Protein/537 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Ribose-phosphate pyrophosphokinase 3

Reference/UniProt P63000
type: UnificationXref
id: P63000
db: UniProt

direct_interaction
type: InteractionVocabulary

Reference/PubChem-compound 439153
type: UnificationXref
id: 439153
db: PubChem-compound

Reference/BioCyc 10-FORMYL-THF
type: UnificationXref
id: 10-FORMYL-THF
db: BioCyc

Reference/HMDB HMDB0001185
type: UnificationXref
id: HMDB0001185
db: HMDB

Reference/KEGG Compound C03838
type: UnificationXref
id: C03838
db: KEGG Compound

Reference/ChEBI CHEBI 20506
type: UnificationXref
id: CHEBI:20506
db: ChEBI

Reference/ChEBI CHEBI 16027
type: UnificationXref
id: CHEBI:16027
db: ChEBI

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Reference/ChEBI CHEBI 17111
type: UnificationXref
id: CHEBI:17111
db: ChEBI

Reference/BioCyc 5-P-RIBOSYL-N-FORMYLGLYCINEAMIDE
type: UnificationXref
id: 5-P-RIBOSYL-N-FORMYLGLYCINEAMIDE
db: BioCyc

Reference/ChemSpider 18714427
type: UnificationXref
id: 18714427
db: ChemSpider

Reference/ChemSpider 559142
type: UnificationXref
id: 559142
db: ChemSpider

Reference/ChEBI CHEBI 16235
type: UnificationXref
id: CHEBI:16235
db: ChEBI

Tetrahydrofolic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Tetrahydrofolic acid

ReactionCatalysis730
type: Catalysis
controller: Phosphoribosylformylglycinamidine synthase
controlled: 6.3.5.3
control type: ACTIVATION

Reference/ChEBI CHEBI 18413
type: UnificationXref
id: CHEBI:18413
db: ChEBI

S-Adenosylmethionine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 24762165
xref: Reference/KEGG Compound C00019
xref: Reference/ChemSpider 31983
xref: Reference/ChEBI CHEBI 15414
xref: Reference/CAS 485-80-3
xref: Reference/BioCyc S-ADENOSYLMETHIONINE
xref: Reference/HMDB HMDB0001185
chemical formula: C15H23N6O5S
molecular weight: 399.14505
structure: ChemicalStructure/PW C000921

Reference/ChemSpider 5746
type: UnificationXref
id: 5746
db: ChemSpider

Compound/PW C000921 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: S-Adenosylmethionine
stoichiometric coefficient: 1.0

NADH
type: SmallMolecule
cellular location: Cytosol
entity reference: NADH

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

D-Ribose 5-phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: D-Ribose 5-phosphate

Reference/KEGG Compound C00212
type: UnificationXref
id: C00212
db: KEGG Compound

Reference/CAS 7540-64-9
type: UnificationXref
id: 7540-64-9
db: CAS

ReactionCatalysis728
type: Catalysis
controller: Trifunctional purine biosynthetic protein adenosine-3
controlled: Reaction483
control type: ACTIVATION

ReactionCatalysis729
type: Catalysis
controller: Trifunctional purine biosynthetic protein adenosine-3
controlled: Reaction1065
control type: ACTIVATION

Reference/HMDB HMDB0061339
type: UnificationXref
id: HMDB0061339
db: HMDB

10-Formyltetrahydrofolate
type: SmallMolecule
cellular location: Cytosol
entity reference: 10-Formyltetrahydrofolate

ReactionCatalysis721
type: Catalysis
controller: Purine nucleoside phosphorylase
controlled: 2.4.2.1
control type: ACTIVATION

Reference/ChemSpider 5858
type: UnificationXref
id: 5858
db: ChemSpider

Equilibrative nucleoside transporter 1
type: ProteinReference
xref: Reference/UniProt Q99808

Compound/PW C000034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine
stoichiometric coefficient: 1.0

Reference/PubChem-compound 3034391
type: UnificationXref
id: 3034391
db: PubChem-compound

Sodium/nucleoside cotransporter 2
type: Protein
entity reference: Sodium/nucleoside cotransporter 2

Amidophosphoribosyltransferase
type: Protein
cellular location: Cytosol
entity reference: Amidophosphoribosyltransferase

Thiodeoxyguanosine-5'-triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Thiodeoxyguanosine-5'-triphosphate
name: SubPathwayInput

Compound/PW C000078 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glycine
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00101
type: UnificationXref
id: C00101
db: KEGG Compound

Reference/CAS 10074-18-7
type: UnificationXref
id: 10074-18-7
db: CAS

Reference/PubChem-compound 439167
type: UnificationXref
id: 439167
db: PubChem-compound

Reference/BioCyc PPI
type: UnificationXref
id: PPI
db: BioCyc

Reference/KEGG Compound C00119
type: UnificationXref
id: C00119
db: KEGG Compound

Reference/UniProt P51580
type: UnificationXref
id: P51580
db: UniProt

Compound/PW C000086 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanine
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00117
type: UnificationXref
id: C00117
db: KEGG Compound

Reference/ChemSpider 388313
type: UnificationXref
id: 388313
db: ChemSpider

Compound/PW C000414 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

ChemicalStructure/PW C040547
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C040546
type: ChemicalStructure
structure format: SMILES

L-Glutamine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000641
xref: Reference/ChEBI CHEBI 18050
xref: Reference/ChemSpider 5746
xref: Reference/BioCyc GLN
xref: Reference/KEGG Compound C00064
xref: Reference/PubChem-compound 5961
xref: Reference/CAS 56-85-9
chemical formula: C5H10N2O3
molecular weight: 146.06914
structure: ChemicalStructure/PW C000500

Reference/ChemSpider 8319071
type: UnificationXref
id: 8319071
db: ChemSpider

ChemicalStructure/PW C000921
type: ChemicalStructure
structure format: SMILES

Reference/CAS 979-92-0
type: UnificationXref
id: 979-92-0
db: CAS

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Compound/PW C001144 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

Compound/PW C000170 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00234
type: UnificationXref
id: C00234
db: KEGG Compound

S-Adenosylhomocysteine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 25246222
xref: Reference/ChemSpider 388301
xref: Reference/BioCyc ADENOSYL-HOMO-CYS
xref: Reference/CAS 979-92-0
xref: Reference/KEGG Compound C00021
xref: Reference/ChEBI CHEBI 16680
xref: Reference/HMDB HMDB0000939
chemical formula: C14H20N6O5S
molecular weight: 384.12158
structure: ChemicalStructure/PW C000749

SubPathwayInteraction120834
type: Interaction
name: SubPathwayReaction
name: SubPathway120834Reaction
participant: Adenine
participant: Phosphoribosylformylglycineamidine
participant: Guanosine

Hypoxanthine-guanine phosphoribosyltransferase
type: Complex
component stoichiometry: Protein/458 Cytosol/Stoichiometry/4.0
cellular location: Cytosol
component: Hypoxanthine-guanine phosphoribosyltransferase

Compound/PW C001146 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ribose 1-phosphate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 122347
type: UnificationXref
id: 122347
db: PubChem-compound

Reference/CAS 7664-38-2
type: UnificationXref
id: 7664-38-2
db: CAS

Mercaptopurine
type: SmallMolecule
entity reference: Mercaptopurine

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

Reference/BioCyc ADENINE
type: UnificationXref
id: ADENINE
db: BioCyc

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Adenosine
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine

Reference/KEGG Compound C00242
type: UnificationXref
id: C00242
db: KEGG Compound

Reference/ChEBI CHEBI 18361
type: UnificationXref
id: CHEBI:18361
db: ChEBI

Reference/KEGG Compound C00004
type: UnificationXref
id: C00004
db: KEGG Compound

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

Reference/KEGG Compound C00003
type: UnificationXref
id: C00003
db: KEGG Compound

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

Reference/CAS 135-16-0
type: UnificationXref
id: 135-16-0
db: CAS

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

2.7.6.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000190 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001191 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000032 Cytosol/Stoichiometry/1.0
right: Adenosine monophosphate
right: Phosphoribosyl pyrophosphate
spontaneous: false
EC number: 2.7.6.1
left: Adenosine triphosphate
left: D-Ribose 5-phosphate
name: Adenosine triphosphate + D-Ribose 5-phosphate ↔ Adenosine monophosphate + Phosphoribosyl pyrophosphate
conversion direction: REVERSIBLE

ChemicalStructure/PW C109120
type: ChemicalStructure
structure format: SMILES

SubPathwayInteraction120820
type: Interaction
name: SubPathway120820Reaction
name: SubPathwayReaction
participant: Adenine

5-Phosphoribosylamine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001128
xref: Reference/ChEBI CHEBI 37737
xref: Reference/BioCyc 5-P-BETA-D-RIBOSYL-AMINE
xref: Reference/ChemSpider 388939
xref: Reference/KEGG Compound C03090
xref: Reference/PubChem-compound 439905
chemical formula: C5H12NO7P
molecular weight: 229.03514
structure: ChemicalStructure/PW C000882

Reference/CAS 37721-04-3
type: UnificationXref
id: 37721-04-3
db: CAS

Reference/UniProt P20839
type: UnificationXref
id: P20839
db: UniProt

Reference/HMDB HMDB0061266
type: UnificationXref
id: HMDB0061266
db: HMDB

Reference/KEGG Compound C00019
type: UnificationXref
id: C00019
db: KEGG Compound

NAD
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15846
xref: Reference/HMDB HMDB0000902
xref: Reference/CAS 53-84-9
xref: Reference/KEGG Compound C00003
xref: Reference/PubChem-compound 5893
xref: Reference/BioCyc NAD
xref: Reference/ChemSpider 5682
chemical formula: C21H27N7O14P2
molecular weight: 663.10913
structure: ChemicalStructure/PW C000721

Reference/CAS 118-00-3
type: UnificationXref
id: 118-00-3
db: CAS

Reference/PubChem-compound 7339
type: UnificationXref
id: 7339
db: PubChem-compound

Reference/HMDB HMDB0000902
type: UnificationXref
id: HMDB0000902
db: HMDB

Reference/HMDB HMDB0015167
type: UnificationXref
id: HMDB0015167
db: HMDB

Reference/KEGG Compound C00013
type: UnificationXref
id: C00013
db: KEGG Compound

SubPathwayInteraction120856
type: Interaction
name: SubPathway120856Reaction
name: SubPathwayReaction

Compound/PW C000190 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphoribosyl pyrophosphate
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 18349
type: UnificationXref
id: CHEBI:18349
db: ChEBI

ReactionCatalysis763
type: Catalysis
controller: Purine nucleoside phosphorylase
controlled: 2.4.2.1
control type: ACTIVATION

Reference/ChemSpider 388301
type: UnificationXref
id: 388301
db: ChemSpider

6-Methylthiopurine 5'-monophosphate ribonucleotide
type: SmallMolecule
cellular location: Cytosol
entity reference: 6-Methylthiopurine 5'-monophosphate ribonucleotide

Compound/PW C009464/Stoichiometry/1.0
type: Stoichiometry
physical entity: Mercaptopurine
stoichiometric coefficient: 1.0

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Reference/KEGG Compound C00021
type: UnificationXref
id: C00021
db: KEGG Compound

Reference/CAS 53-84-9
type: UnificationXref
id: 53-84-9
db: CAS

Reference/KEGG Compound C00020
type: UnificationXref
id: C00020
db: KEGG Compound

Reference/PubChem-compound 10143562
type: UnificationXref
id: 10143562
db: PubChem-compound

L-Glutamic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Glutamic acid

Reference/KEGG Compound C00147
type: UnificationXref
id: C00147
db: KEGG Compound

Reference/KEGG Compound C00025
type: UnificationXref
id: C00025
db: KEGG Compound

Reference/KEGG Compound C00387
type: UnificationXref
id: C00387
db: KEGG Compound

Reference/ChEBI CHEBI 26078
type: UnificationXref
id: CHEBI:26078
db: ChEBI

Reaction1065
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001221 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001007 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001355 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000774 Cytosol/Stoichiometry/1.0
right: Tetrahydrofolic acid
right: 5'-Phosphoribosyl-N-formylglycinamide
spontaneous: false
left: Glycineamideribotide
left: 10-Formyltetrahydrofolate
name: 10-Formyltetrahydrofolate + Glycineamideribotide → 5'-Phosphoribosyl-N-formylglycinamide + Tetrahydrofolic acid
conversion direction: LEFT_TO_RIGHT

Reference/UniProt O43868
type: UnificationXref
id: O43868
db: UniProt

Reference/CAS 73-24-5
type: UnificationXref
id: 73-24-5
db: CAS

Reference/PubChem-compound 764
type: UnificationXref
id: 764
db: PubChem-compound

Compound/PW C001191 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Ribose 5-phosphate
stoichiometric coefficient: 1.0

Thioguanosine 5'-diphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Thioguanosine 5'-diphosphate

ChemicalStructure/PW C040506
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C040505
type: ChemicalStructure
structure format: SMILES
structure data: OC1=NC2=C(N=CN2OP(O)(O)=O)C(S)=N1

ChemicalStructure/PW C040504
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C00037
type: UnificationXref
id: C00037
db: KEGG Compound

ChemicalStructure/PW C001144
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000133
type: UnificationXref
id: HMDB0000133
db: HMDB

Reference/BioCyc AMP
type: UnificationXref
id: AMP
db: BioCyc

Amidophosphoribosyltransferase
type: Complex
component stoichiometry: Protein/325 Cytosol/Stoichiometry/4.0
cellular location: Cytosol
component: Amidophosphoribosyltransferase

ChemicalStructure/PW C001146
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 667490
type: UnificationXref
id: 667490
db: PubChem-compound

Reference/KEGG Compound C16619
type: UnificationXref
id: C16619
db: KEGG Compound

Reference/KEGG Compound C16615
type: UnificationXref
id: C16615
db: KEGG Compound

Phosphoribosylformylglycineamidine
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 18413
xref: Reference/BioCyc 5-PHOSPHORIBOSYL-N-FORMYLGLYCINEAMIDINE
xref: Reference/HMDB HMDB0000999
xref: Reference/CAS 37721-04-3
xref: Reference/PubChem-compound 440417
xref: Reference/KEGG Compound C04640
xref: Reference/ChemSpider 7830994
chemical formula: C8H16N3O8P
molecular weight: 313.0675
structure: ChemicalStructure/PW C000791

Reference/HMDB HMDB0000250
type: UnificationXref
id: HMDB0000250
db: HMDB

ChemicalStructure/PW C000170
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(=O)OP(O)(O)=O

Reference/HMDB HMDB0000132
type: UnificationXref
id: HMDB0000132
db: HMDB

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

Compound/PW C040520 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 6-Methylthiopurine 5'-monophosphate ribonucleotide
stoichiometric coefficient: 1.0

Interaction3213
type: MolecularInteraction
interaction type: direct_interaction
name: 6-Methylthiopurine 5'-monophosphate ribonucleotide inhibits Amidophosphoribosyltransferase
participant: 6-Methylthiopurine 5'-monophosphate ribonucleotide
participant: Amidophosphoribosyltransferase

Reference/KEGG Compound C04646
type: UnificationXref
id: C04646
db: KEGG Compound

2.4.2.14
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000190 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000882 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000500 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170 Cytosol/Stoichiometry/1.0
right: L-Glutamine
right: Phosphoribosyl pyrophosphate
right: Water
spontaneous: false
EC number: 2.4.2.14
left: Pyrophosphate
left: 5-Phosphoribosylamine
left: L-Glutamic acid
name: 5-Phosphoribosylamine + L-Glutamic acid + Pyrophosphate ↔ L-Glutamine + Phosphoribosyl pyrophosphate + Water
conversion direction: REVERSIBLE

Phosphoribosylformylglycinamidine synthase
type: ProteinReference
xref: Reference/UniProt O15067
organism: Homo sapiens

Reference/KEGG Compound C04640
type: UnificationXref
id: C04640
db: KEGG Compound

Reference/CAS 56-85-9
type: UnificationXref
id: 56-85-9
db: CAS

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

Glycineamideribotide
type: SmallMolecule
cellular location: Cytosol
entity reference: Glycineamideribotide

Reference/ChemSpider 7062
type: UnificationXref
id: 7062
db: ChemSpider

Reference/CAS 73-40-5
type: UnificationXref
id: 73-40-5
db: CAS

ReactionCatalysis1614
type: Catalysis
controller: Inosine-5'-monophosphate dehydrogenase 1
controlled: 1.1.1.205
control type: ACTIVATION

Reference/HMDB HMDB0000148
type: UnificationXref
id: HMDB0000148
db: HMDB

ReactionCatalysis1613
type: Catalysis
controller: Thiopurine S-methyltransferase
controlled: 2.1.1.67
control type: ACTIVATION

Reference/CAS 15867-02-4
type: UnificationXref
id: 15867-02-4
db: CAS

ChemicalStructure/PW C040520
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C040526
type: ChemicalStructure
structure format: SMILES

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Amidophosphoribosyltransferase
type: ProteinReference
xref: Reference/UniProt Q06203
organism: Homo sapiens

Reference/UniProt Q06203
type: UnificationXref
id: Q06203
db: UniProt

Trifunctional purine biosynthetic protein adenosine-3
type: ProteinReference
xref: Reference/UniProt P22102
organism: Homo sapiens

Reference/HMDB HMDB0001487
type: UnificationXref
id: HMDB0001487
db: HMDB

ReactionCatalysis1621
type: Catalysis
controller: GMP synthase [glutamine-hydrolyzing]
controlled: 6.3.5.2
control type: ACTIVATION

Reference/CAS 61-19-8
type: UnificationXref
id: 61-19-8
db: CAS

Thiodeoxyguanosine 5'-diphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Thiodeoxyguanosine 5'-diphosphate

ChemicalStructure/PW C000032
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000034
type: UnificationXref
id: HMDB0000034
db: HMDB

Reference/HMDB HMDB0001489
type: UnificationXref
id: HMDB0001489
db: HMDB

Reference/HMDB HMDB0001128
type: UnificationXref
id: HMDB0001128
db: HMDB

GMP synthase [glutamine-hydrolyzing]
type: ProteinReference
xref: Reference/UniProt P49915
organism: Homo sapiens

Reference/CAS 56-86-0
type: UnificationXref
id: 56-86-0
db: CAS

ChemicalStructure/PW C000034
type: ChemicalStructure
structure format: SMILES

Mercaptopurine
type: SmallMoleculeReference
xref: Reference/KEGG Compound C01756
xref: Reference/ChemSpider 580869
xref: Reference/PubChem-compound 667490
xref: Reference/HMDB HMDB0015167
xref: Reference/CAS 50-44-2
xref: Reference/ChEBI CHEBI 2208
chemical formula: C5H4N4S
molecular weight: 152.01567
structure: ChemicalStructure/PW C009464

Compound/PW C040546 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Thioguanosine 5'-diphosphate
stoichiometric coefficient: 1.0

NAD
type: SmallMolecule
cellular location: Cytosol
entity reference: NAD

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Phosphoric acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Phosphoric acid

10-Formyltetrahydrofolate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000972
xref: Reference/PubChem-compound 122347
xref: Reference/ChemSpider 109092
xref: Reference/ChEBI CHEBI 15637
xref: Reference/CAS 2800-34-2
xref: Reference/BioCyc 10-FORMYL-THF
xref: Reference/KEGG Compound C00234
chemical formula: C20H23N7O7
molecular weight: 473.1659
structure: ChemicalStructure/PW C000774

Reference/CAS 56-40-6
type: UnificationXref
id: 56-40-6
db: CAS

ChemicalStructure/PW C001007
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C00064
type: UnificationXref
id: C00064
db: KEGG Compound

Reference/BioCyc 5-PHOSPHO-RIBOSYL-GLYCINEAMIDE
type: UnificationXref
id: 5-PHOSPHO-RIBOSYL-GLYCINEAMIDE
db: BioCyc

Reference/CAS 2800-34-2
type: UnificationXref
id: 2800-34-2
db: CAS

Reference/CAS 58-61-7
type: UnificationXref
id: 58-61-7
db: CAS

Hypoxanthine-guanine phosphoribosyltransferase
type: ProteinReference
xref: Reference/UniProt P00492
organism: Homo sapiens

GMP synthase [glutamine-hydrolyzing]
type: Complex
component stoichiometry: Protein/560 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: GMP synthase [glutamine-hydrolyzing]

Reference/HMDB HMDB0000045
type: UnificationXref
id: HMDB0000045
db: HMDB

S-Adenosylhomocysteine
type: SmallMolecule
cellular location: Cytosol
entity reference: S-Adenosylhomocysteine

Reference/ChemSpider 2298861
type: UnificationXref
id: 2298861
db: ChemSpider

Reference/HMDB HMDB0000280
type: UnificationXref
id: HMDB0000280
db: HMDB

Reference/HMDB HMDB0060415
type: UnificationXref
id: HMDB0060415
db: HMDB

Reference/HMDB HMDB0060416
type: UnificationXref
id: HMDB0060416
db: HMDB

Reference/PathWhiz PW128074
type: UnificationXref
id: PW128074
db: PathWhiz

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/ChemSpider 31983
type: UnificationXref
id: 31983
db: ChemSpider

Compound/PW C040526 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Thiodeoxyguanosine 5'-diphosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

Compound/PW C040504 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 6-Thioinosine-5'-monophosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 979
type: UnificationXref
id: 979
db: ChemSpider

Reference/ChemSpider 730
type: UnificationXref
id: 730
db: ChemSpider

Compound/PW C001007 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 5'-Phosphoribosyl-N-formylglycinamide
stoichiometric coefficient: 1.0

Phosphoric acid
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/ChEBI CHEBI 26078
xref: Reference/CAS 7664-38-2
xref: Reference/PubChem-compound 1004
xref: Reference/ChemSpider 979
xref: Reference/HMDB HMDB0002142
chemical formula: H3O4P
molecular weight: 97.9769
structure: ChemicalStructure/PW C001441

Ribose-phosphate pyrophosphokinase 3
type: Protein
cellular location: Cytosol
entity reference: Ribose-phosphate pyrophosphokinase 3

Compound/PW C000774 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 10-Formyltetrahydrofolate
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000050
type: UnificationXref
id: HMDB0000050
db: HMDB

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

ChemicalStructure/PW C000095
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCC(O)=O)C(O)=O

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

Compound/PW C040506 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 6-Thioguanosine monophosphate
stoichiometric coefficient: 1.0

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

Reference/ChEBI CHEBI 80609
type: UnificationXref
id: CHEBI:80609
db: ChEBI

Protein/2369 Cytosol/Stoichiometry/3.0
type: Stoichiometry
physical entity: Purine nucleoside phosphorylase
stoichiometric coefficient: 3.0

Adenine
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenine
name: SubPathwayOutput
name: SubPathwayInput

Phosphoribosyl pyrophosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Phosphoribosyl pyrophosphate

Reference/BioCyc RIBOSE-5P
type: UnificationXref
id: RIBOSE-5P
db: BioCyc

ChemicalStructure/PW C001191
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 439905
type: UnificationXref
id: 439905
db: PubChem-compound

Thiopurine S-methyltransferase
type: Protein
cellular location: Cytosol
entity reference: Thiopurine S-methyltransferase

Equilibrative nucleoside transporter 1
type: Protein
entity reference: Equilibrative nucleoside transporter 1

Reference/PubChem-compound 644102
type: UnificationXref
id: 644102
db: PubChem-compound

Reference/PubChem-compound 6083
type: UnificationXref
id: 6083
db: PubChem-compound

Reference/PubChem-compound 160913
type: UnificationXref
id: 160913
db: PubChem-compound

Glycine
type: SmallMolecule
cellular location: Cytosol
entity reference: Glycine

Compound/PW C001441 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphoric acid
stoichiometric coefficient: 1.0

Reference/PubChem-compound 25246222
type: UnificationXref
id: 25246222
db: PubChem-compound

Compound/PW C001221 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Tetrahydrofolic acid
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 1267082
type: UnificationXref
id: CHEBI:1267082
db: ChEBI

Reference/ChEBI CHEBI 18050
type: UnificationXref
id: CHEBI:18050
db: ChEBI

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

ChemicalStructure/PW C000078
type: ChemicalStructure
structure format: SMILES
structure data: NCC(O)=O

ChemicalStructure/PW C000190
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 54923
type: UnificationXref
id: 54923
db: ChemSpider

Reference/ChemSpider 388939
type: UnificationXref
id: 388939
db: ChemSpider

5'-Phosphoribosyl-N-formylglycinamide
type: SmallMolecule
cellular location: Cytosol
entity reference: 5'-Phosphoribosyl-N-formylglycinamide

Reference/BioCyc NADH
type: UnificationXref
id: NADH
db: BioCyc

Reference/BioCyc NAD
type: UnificationXref
id: NAD
db: BioCyc

Ribose-phosphate pyrophosphokinase 3
type: ProteinReference
xref: Reference/UniProt P21108
organism: Homo sapiens

Thiopurine S-methyltransferase
type: ProteinReference
xref: Reference/UniProt P51580
organism: Homo sapiens

Compound/PW C001104 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 744
type: UnificationXref
id: 744
db: ChemSpider

ChemicalStructure/PW C000087
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C000086
type: ChemicalStructure
structure format: SMILES
structure data: NC1=NC(=O)C2=C(N1)N=CN2

Reference/BioCyc 5-P-BETA-D-RIBOSYL-AMINE
type: UnificationXref
id: 5-P-BETA-D-RIBOSYL-AMINE
db: BioCyc

Reference/HMDB HMDB0002142
type: UnificationXref
id: HMDB0002142
db: HMDB

Reference/HMDB HMDB0002022
type: UnificationXref
id: HMDB0002022
db: HMDB

Reference/ChemSpider 141370
type: UnificationXref
id: 141370
db: ChemSpider

TransportCatalysis5803
type: Catalysis
controller: Equilibrative nucleoside transporter 1
controlled: Transport15500
control type: ACTIVATION

Reference/ChemSpider 30572
type: UnificationXref
id: 30572
db: ChemSpider

Inosine-5'-monophosphate dehydrogenase 1
type: ProteinReference
xref: Reference/UniProt P20839
organism: Homo sapiens

Reference/BioCyc RIBOSE-1P
type: UnificationXref
id: RIBOSE-1P
db: BioCyc

TransportCatalysis5804
type: Catalysis
controller: Sodium/nucleoside cotransporter 2
controlled: Transport15500
control type: ACTIVATION

Compound/PW C000749 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: S-Adenosylhomocysteine
stoichiometric coefficient: 1.0

Adenosine monophosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine monophosphate

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Adenosine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 60961
xref: Reference/ChEBI CHEBI 16335
xref: Reference/ChemSpider 54923
xref: Reference/HMDB HMDB0000050
xref: Reference/CAS 58-61-7
xref: Reference/KEGG Compound C00212
xref: Reference/BioCyc ADENOSINE
chemical formula: C10H13N5O4
molecular weight: 267.09674
structure: ChemicalStructure/PW C000034

Adenosine monophosphate
type: SmallMoleculeReference
xref: Reference/CAS 61-19-8
xref: Reference/ChemSpider 5858
xref: Reference/HMDB HMDB0000045
xref: Reference/BioCyc AMP
xref: Reference/ChEBI CHEBI 16027
xref: Reference/PubChem-compound 6083
xref: Reference/KEGG Compound C00020
chemical formula: C10H14N5O7P
molecular weight: 347.06308
structure: ChemicalStructure/PW C000032

Inosine-5'-monophosphate dehydrogenase 1
type: Complex
component stoichiometry: Protein/826 Cytosol/Stoichiometry/4.0
cellular location: Cytosol
component: Inosine-5'-monophosphate dehydrogenase 1

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

5'-Phosphoribosyl-N-formylglycinamide
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001308
xref: Reference/CAS 349-34-8
xref: Reference/PubChem-compound 130805
xref: Reference/ChemSpider 115687
xref: Reference/KEGG Compound C04376
xref: Reference/BioCyc 5-P-RIBOSYL-N-FORMYLGLYCINEAMIDE
chemical formula: C8H15N2O9P
molecular weight: 314.0515
structure: ChemicalStructure/PW C001007

Reference/PubChem-compound 1004
type: UnificationXref
id: 1004
db: PubChem-compound

Reference/PubChem-compound 5961
type: UnificationXref
id: 5961
db: PubChem-compound

Phosphoribosylformylglycinamidine synthase
type: Protein
cellular location: Cytosol
entity reference: Phosphoribosylformylglycinamidine synthase

6-Thioinosine-5'-monophosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: 6-Thioinosine-5'-monophosphate

Reference/ChEBI CHEBI 37737
type: UnificationXref
id: CHEBI:37737
db: ChEBI

Reference/ChEBI CHEBI 15846
type: UnificationXref
id: CHEBI:15846
db: ChEBI

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

Reference/UniProt P00491
type: UnificationXref
id: P00491
db: UniProt

Reference/UniProt P00492
type: UnificationXref
id: P00492
db: UniProt

6.3.5.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040505 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000500 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040506 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000032 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170 Cytosol/Stoichiometry/1.0
right: Adenosine monophosphate
right: 6-Thioguanosine monophosphate
right: Pyrophosphate
spontaneous: false
EC number: 6.3.5.2
left: L-Glutamine
left: Adenosine triphosphate
left: Thioxanthine monophosphate
left: Water
name: Adenosine triphosphate + L-Glutamine + Thioxanthine monophosphate + Water → 6-Thioguanosine monophosphate + Adenosine monophosphate + Pyrophosphate
conversion direction: LEFT_TO_RIGHT

6-Thioinosine-5'-monophosphate
type: SmallMoleculeReference
xref: Reference/ChemSpider 2298861
xref: Reference/CAS 53-83-8
xref: Reference/PubChem-compound 3034391
xref: Reference/HMDB HMDB0060416
xref: Reference/KEGG Compound C04646
chemical formula: C10H13N4O7PS
molecular weight: 364.02426
structure: ChemicalStructure/PW C040504

Thioxanthine monophosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0060876
chemical formula: C5H5N4O5PS
molecular weight: 263.97183
structure: ChemicalStructure/PW C040505

6-Thioguanosine monophosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 3034646
xref: Reference/ChEBI CHEBI 1267082
xref: Reference/KEGG Compound C16619
xref: Reference/HMDB HMDB0060415
xref: Reference/CAS 15867-02-4
xref: Reference/ChemSpider 2299082
chemical formula: C10H14N5O7PS
molecular weight: 379.03516
structure: ChemicalStructure/PW C040506

Reference/KEGG Compound C04376
type: UnificationXref
id: C04376
db: KEGG Compound

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

ChemicalStructure/PW C000791
type: ChemicalStructure
structure format: SMILES

Protein/560 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: GMP synthase [glutamine-hydrolyzing]
stoichiometric coefficient: 2.0

Tetrahydrofolic acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 20506
xref: Reference/ChemSpider 18714427
xref: Reference/HMDB HMDB0001846
xref: Reference/PubChem-compound 13781857
xref: Reference/BioCyc THF
xref: Reference/CAS 135-16-0
xref: Reference/KEGG Compound C00101
chemical formula: C19H23N7O6
molecular weight: 445.171
structure: ChemicalStructure/PW C001221

1.1.1.205
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040504 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040505 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Cytosol/Stoichiometry/1.0
right: Thioxanthine monophosphate
right: NADH
spontaneous: false
EC number: 1.1.1.205
left: NAD
left: 6-Thioinosine-5'-monophosphate
left: Water
name: 6-Thioinosine-5'-monophosphate + NAD + Water → NADH + Thioxanthine monophosphate
conversion direction: LEFT_TO_RIGHT

2.1.1.67
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000749 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040520 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040504 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000921 Cytosol/Stoichiometry/1.0
right: S-Adenosylhomocysteine
right: 6-Methylthiopurine 5'-monophosphate ribonucleotide
spontaneous: false
EC number: 2.1.1.67
left: 6-Thioinosine-5'-monophosphate
left: S-Adenosylmethionine
name: 6-Thioinosine-5'-monophosphate + S-Adenosylmethionine → 6-Methylthiopurine 5'-monophosphate ribonucleotide + S-Adenosylhomocysteine
conversion direction: LEFT_TO_RIGHT

Reference/ChEBI CHEBI 16908
type: UnificationXref
id: CHEBI:16908
db: ChEBI

Reference/BioCyc ADENOSYL-HOMO-CYS
type: UnificationXref
id: ADENOSYL-HOMO-CYS
db: BioCyc

Pyrophosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Pyrophosphate

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: H3O4P
molecular weight: 97.9769
structure: ChemicalStructure/PW C001104

Reference/CAS 485-80-3
type: UnificationXref
id: 485-80-3
db: CAS

Reference/CAS 50-44-2
type: UnificationXref
id: 50-44-2
db: CAS

ReactionCatalysis44
type: Catalysis
controller: Amidophosphoribosyltransferase
controlled: 2.4.2.14
control type: ACTIVATION

Compound/PW C040547 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Thioguanosine 5'-triphosphate
stoichiometric coefficient: 1.0

Protein/537 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Ribose-phosphate pyrophosphokinase 3
stoichiometric coefficient: 2.0

Glycineamideribotide
type: SmallMoleculeReference
xref: Reference/KEGG Compound C03838
xref: Reference/ChemSpider 141370
xref: Reference/ChEBI CHEBI 18349
xref: Reference/CAS 10074-18-7
xref: Reference/PubChem-compound 160913
xref: Reference/BioCyc 5-PHOSPHO-RIBOSYL-GLYCINEAMIDE
xref: Reference/HMDB HMDB0002022
chemical formula: C7H15N2O8P
molecular weight: 286.0566
structure: ChemicalStructure/PW C001355

Adenine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000034
xref: Reference/BioCyc ADENINE
xref: Reference/PubChem-compound 190
xref: Reference/ChemSpider 185
xref: Reference/KEGG Compound C00147
xref: Reference/ChEBI CHEBI 16708
xref: Reference/CAS 73-24-5
chemical formula: C5H5N5
molecular weight: 135.05449
structure: ChemicalStructure/PW C000024

Reference/BioCyc THF
type: UnificationXref
id: THF
db: BioCyc

Reference/BioCyc GLY
type: UnificationXref
id: GLY
db: BioCyc

Ras-related C3 botulinum toxin substrate 1
type: ProteinReference
xref: Reference/UniProt P63000
organism: Homo sapiens

Reference/CAS 7021-52-5
type: UnificationXref
id: 7021-52-5
db: CAS

Reference/CAS 58-68-4
type: UnificationXref
id: 58-68-4
db: CAS

ChemicalStructure/PW C001221
type: ChemicalStructure
structure format: SMILES

Phosphoribosyl pyrophosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00119
xref: Reference/ChemSpider 7062
xref: Reference/CAS 7540-64-9
xref: Reference/HMDB HMDB0000280
xref: Reference/PubChem-compound 7339
xref: Reference/BioCyc PRPP
xref: Reference/ChEBI CHEBI 17111
chemical formula: C5H13O14P3
molecular weight: 389.9518
structure: ChemicalStructure/PW C000190

Transport15499
type: Transport
participant stoichiometry: Compound/PW C009464/Stoichiometry/1.0
right: Mercaptopurine
spontaneous: true
left: Mercaptopurine
name: Mercaptopurine (→) Transport: Homo sapiens, Intestine to Homo sapiens, Blood Vessel
conversion direction: REVERSIBLE

Reference/UniProt P22102
type: UnificationXref
id: P22102
db: UniProt

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=O

Reference/BioCyc GUANOSINE
type: UnificationXref
id: GUANOSINE
db: BioCyc

Reference/HMDB HMDB0001548
type: UnificationXref
id: HMDB0001548
db: HMDB

Compound/PW C000500 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamine
stoichiometric coefficient: 1.0

Reference/GENE ONTOLOGY GO 0005886
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

Reference/ChEBI CHEBI 15637
type: UnificationXref
id: CHEBI:15637
db: ChEBI

Glycine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000123
xref: Reference/BioCyc GLY
xref: Reference/ChemSpider 730
xref: Reference/PubChem-compound 5257127
xref: Reference/CAS 56-40-6
xref: Reference/ChEBI CHEBI 15428
xref: Reference/KEGG Compound C00037
chemical formula: C2H5NO2
molecular weight: 75.03203
structure: ChemicalStructure/PW C000078

Reference/ChEBI CHEBI 15414
type: UnificationXref
id: CHEBI:15414
db: ChEBI

Reaction1846
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040546 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040526 Cytosol/Stoichiometry/1.0
right: Thiodeoxyguanosine 5'-diphosphate
spontaneous: false
left: Thioguanosine 5'-diphosphate
name: Thioguanosine 5'-diphosphate → Thiodeoxyguanosine 5'-diphosphate
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

Reference/HMDB HMDB0001308
type: UnificationXref
id: HMDB0001308
db: HMDB

Compound/PW C000721 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

ReactionCatalysis1532
type: Catalysis
controller: Hypoxanthine-guanine phosphoribosyltransferase
controlled: 2.4.2.8
control type: ACTIVATION

Reference/PubChem-compound 5257127
type: UnificationXref
id: 5257127
db: PubChem-compound

Reference/BioCyc 5-PHOSPHORIBOSYL-N-FORMYLGLYCINEAMIDINE
type: UnificationXref
id: 5-PHOSPHORIBOSYL-N-FORMYLGLYCINEAMIDINE
db: BioCyc

ChemicalStructure/PW C001355
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C000024
type: ChemicalStructure
structure format: SMILES
structure data: NC1=C2NC=NC2=NC=N1

Reference/BioCyc GLN
type: UnificationXref
id: GLN
db: BioCyc

Reaction1844
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040546 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040506 Cytosol/Stoichiometry/1.0
right: Thioguanosine 5'-diphosphate
spontaneous: false
left: 6-Thioguanosine monophosphate
name: 6-Thioguanosine monophosphate → Thioguanosine 5'-diphosphate
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0060876
type: UnificationXref
id: HMDB0060876
db: HMDB

Reference/BioCyc GLT
type: UnificationXref
id: GLT
db: BioCyc

Protein/826 Cytosol/Stoichiometry/4.0
type: Stoichiometry
physical entity: Inosine-5'-monophosphate dehydrogenase 1
stoichiometric coefficient: 4.0

Thioguanosine 5'-triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Thioguanosine 5'-triphosphate

Guanosine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000133
xref: Reference/BioCyc GUANOSINE
xref: Reference/CAS 118-00-3
xref: Reference/ChemSpider 6544
xref: Reference/PubChem-compound 6802
xref: Reference/ChEBI CHEBI 16750
xref: Reference/KEGG Compound C00387
chemical formula: C10H13N5O5
molecular weight: 283.09167
structure: ChemicalStructure/PW C000087

Guanine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 764
xref: Reference/ChEBI CHEBI 16235
xref: Reference/CAS 73-40-5
xref: Reference/BioCyc GUANINE
xref: Reference/KEGG Compound C00242
xref: Reference/HMDB HMDB0000132
xref: Reference/ChemSpider 744
chemical formula: C5H5N5O
molecular weight: 151.04941
structure: ChemicalStructure/PW C000086

Reference/HMDB HMDB0060875
type: UnificationXref
id: HMDB0060875
db: HMDB

Reference/HMDB HMDB0060874
type: UnificationXref
id: HMDB0060874
db: HMDB

Reference/PubChem-compound 60961
type: UnificationXref
id: 60961
db: PubChem-compound

Reference/PubChem-compound 3034646
type: UnificationXref
id: 3034646
db: PubChem-compound

Reference/BioCyc GUANINE
type: UnificationXref
id: GUANINE
db: BioCyc

Reference/UniProt O15067
type: UnificationXref
id: O15067
db: UniProt

Reference/PubChem-compound 6802
type: UnificationXref
id: 6802
db: PubChem-compound

Reference/BioCyc S-ADENOSYLMETHIONINE
type: UnificationXref
id: S-ADENOSYLMETHIONINE
db: BioCyc

ChemicalStructure/PW C001441
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=O

Interaction3209
type: MolecularInteraction
interaction type: direct_interaction
name: Thioguanosine 5'-triphosphate inhibits Ras-related C3 botulinum toxin substrate 1
participant: Ras-related C3 botulinum toxin substrate 1
participant: Thioguanosine 5'-triphosphate

Compound/PW C009464 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Mercaptopurine
stoichiometric coefficient: 1.0

Pyrophosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 644102
xref: Reference/BioCyc PPI
xref: Reference/ChemSpider 559142
xref: Reference/ChEBI CHEBI 18361
xref: Reference/HMDB HMDB0000250
xref: Reference/CAS 14000-31-8
xref: Reference/KEGG Compound C00013
chemical formula: H4O7P2
molecular weight: 177.94322
structure: ChemicalStructure/PW C000170

NADH
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001487
xref: Reference/CAS 58-68-4
xref: Reference/PubChem-compound 439153
xref: Reference/BioCyc NADH
xref: Reference/ChemSpider 388299
xref: Reference/KEGG Compound C00004
xref: Reference/ChEBI CHEBI 16908
chemical formula: C21H29N7O14P2
molecular weight: 665.12476
structure: ChemicalStructure/PW C001144

Ribose 1-phosphate
type: SmallMoleculeReference
xref: Reference/CAS 14075-00-4
xref: Reference/ChEBI CHEBI 16300
xref: Reference/HMDB HMDB0001489
xref: Reference/PubChem-compound 439236
xref: Reference/ChemSpider 388373
xref: Reference/BioCyc RIBOSE-1P
xref: Reference/KEGG Compound C00620
chemical formula: C5H11O8P
molecular weight: 230.01915
structure: ChemicalStructure/PW C001146

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Trifunctional purine biosynthetic protein adenosine-3
type: Protein
cellular location: Cytosol
entity reference: Trifunctional purine biosynthetic protein adenosine-3

Reference/KEGG Compound C03090
type: UnificationXref
id: C03090
db: KEGG Compound

Reference/ChEBI CHEBI 16708
type: UnificationXref
id: CHEBI:16708
db: ChEBI

Reference/HMDB HMDB0000123
type: UnificationXref
id: HMDB0000123
db: HMDB

Adenosine triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine triphosphate

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

GMP synthase [glutamine-hydrolyzing]
type: Protein
cellular location: Cytosol
entity reference: GMP synthase [glutamine-hydrolyzing]

Reference/UniProt Q99808
type: UnificationXref
id: Q99808
db: UniProt

Purine nucleoside phosphorylase
type: ProteinReference
xref: Reference/UniProt P00491
organism: Homo sapiens

Sodium/nucleoside cotransporter 2
type: ProteinReference
xref: Reference/UniProt O43868

ChemicalStructure/PW C000721
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

Guanine
type: SmallMolecule
cellular location: Cytosol
entity reference: Guanine
name: SubPathwayInput

Reference/ChemSpider 5682
type: UnificationXref
id: 5682
db: ChemSpider

Protein/458 Cytosol/Stoichiometry/4.0
type: Stoichiometry
physical entity: Hypoxanthine-guanine phosphoribosyltransferase
stoichiometric coefficient: 4.0

Reference/ChEBI CHEBI 52742
type: UnificationXref
id: CHEBI:52742
db: ChEBI

Compound/PW C001355 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glycineamideribotide
stoichiometric coefficient: 1.0

Hypoxanthine-guanine phosphoribosyltransferase
type: Protein
cellular location: Cytosol
entity reference: Hypoxanthine-guanine phosphoribosyltransferase

Compound/PW C040505 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Thioxanthine monophosphate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 53936469
type: UnificationXref
id: 53936469
db: PubChem-compound

5-Phosphoribosylamine
type: SmallMolecule
cellular location: Cytosol
entity reference: 5-Phosphoribosylamine

Reaction1893
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040546 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040547 Cytosol/Stoichiometry/1.0
right: Thioguanosine 5'-triphosphate
spontaneous: false
left: Thioguanosine 5'-diphosphate
name: Thioguanosine 5'-diphosphate → Thioguanosine 5'-triphosphate
conversion direction: LEFT_TO_RIGHT

Reference/CAS 14000-31-8
type: UnificationXref
id: 14000-31-8
db: CAS

Reference/ChEBI CHEBI 16300
type: UnificationXref
id: CHEBI:16300
db: ChEBI

Reference/SMPDB SMP0126475
type: UnificationXref
id: SMP0126475
db: SMPDB

Reference/CAS 53-83-8
type: UnificationXref
id: 53-83-8
db: CAS

Reference/PubChem-compound 440417
type: UnificationXref
id: 440417
db: PubChem-compound

S-Adenosylmethionine
type: SmallMolecule
cellular location: Cytosol
entity reference: S-Adenosylmethionine

Reference/HMDB HMDB0000939
type: UnificationXref
id: HMDB0000939
db: HMDB

Reference/UniProt P49915
type: UnificationXref
id: P49915
db: UniProt

Adenosine diphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine diphosphate

Purines De novo biosynthesis
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway120834
pathway component: SubPathwayInteraction120834
name: SubPathway

Compound/PW C000032 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine monophosphate
stoichiometric coefficient: 1.0

6.3.5.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001441 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001007 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000500 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000791 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
right: Adenosine diphosphate
right: Phosphoric acid
right: Phosphoribosylformylglycineamidine
right: L-Glutamic acid
spontaneous: false
EC number: 6.3.5.3
left: Adenosine triphosphate
left: L-Glutamine
left: 5'-Phosphoribosyl-N-formylglycinamide
left: Water
name: 5'-Phosphoribosyl-N-formylglycinamide + Adenosine triphosphate + L-Glutamine + Water → Adenosine diphosphate + L-Glutamic acid + Phosphoribosylformylglycineamidine + Phosphoric acid
conversion direction: LEFT_TO_RIGHT

Reaction483
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001355 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000882 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000078 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
right: Phosphate
right: Glycineamideribotide
right: Adenosine diphosphate
spontaneous: false
left: Glycine
left: Adenosine triphosphate
left: 5-Phosphoribosylamine
name: 5-Phosphoribosylamine + Adenosine triphosphate + Glycine → Adenosine diphosphate + Glycineamideribotide + Phosphate
conversion direction: LEFT_TO_RIGHT

Reference/CAS 14075-00-4
type: UnificationXref
id: 14075-00-4
db: CAS

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

Reference/ChemSpider 388299
type: UnificationXref
id: 388299
db: ChemSpider

SubPathwayInteraction120817
type: Interaction
name: SubPathwayReaction
name: SubPathway120817Reaction
participant: Guanosine

SubPathwayInteraction120816
type: Interaction
name: SubPathway120816Reaction
name: SubPathwayReaction
participant: Ras-related C3 botulinum toxin substrate 1

Compound/PW C001034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16750
type: UnificationXref
id: CHEBI:16750
db: ChEBI

SubPathwayInteraction120818
type: Interaction
name: SubPathway120818Reaction
name: SubPathwayReaction
participant: Guanine

SubPathwayInteraction120815
type: Interaction
name: SubPathway120815Reaction
name: SubPathwayReaction
participant: Thiodeoxyguanosine-5'-triphosphate

Phosphoribosylformylglycineamidine
type: SmallMolecule
cellular location: Cytosol
entity reference: Phosphoribosylformylglycineamidine
name: SubPathwayInput

Purine nucleoside phosphorylase
type: Complex
component stoichiometry: Protein/2369 Cytosol/Stoichiometry/3.0
cellular location: Cytosol
component: Purine nucleoside phosphorylase

2.4.2.8
type: BiochemicalReaction
participant stoichiometry: Compound/PW C009464 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000190 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040504 Cytosol/Stoichiometry/1.0
right: 6-Thioinosine-5'-monophosphate
spontaneous: false
EC number: 2.4.2.8
left: Mercaptopurine
left: Phosphoribosyl pyrophosphate
name: Mercaptopurine + Phosphoribosyl pyrophosphate → 6-Thioinosine-5'-monophosphate
conversion direction: LEFT_TO_RIGHT

Water
type: SmallMolecule
cellular location: Cytosol
entity reference: Water

L-Glutamic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 33032
xref: Reference/ChEBI CHEBI 16015
xref: Reference/ChemSpider 30572
xref: Reference/HMDB HMDB0000148
xref: Reference/CAS 56-86-0
xref: Reference/BioCyc GLT
xref: Reference/KEGG Compound C00025
chemical formula: C5H9NO4
molecular weight: 147.05316
structure: ChemicalStructure/PW C000095

Reference/PubChem-compound 33032
type: UnificationXref
id: 33032
db: PubChem-compound

Reference/PubChem-compound 10091038
type: UnificationXref
id: 10091038
db: PubChem-compound

Compound/PW C000095 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamic acid
stoichiometric coefficient: 1.0

Thioxanthine monophosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Thioxanthine monophosphate

Reference/CAS 349-34-8
type: UnificationXref
id: 349-34-8
db: CAS

Reference/ChemSpider 6544
type: UnificationXref
id: 6544
db: ChemSpider

Reference/KEGG Compound C00620
type: UnificationXref
id: C00620
db: KEGG Compound

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

Ras-related C3 botulinum toxin substrate 1
type: Protein
cellular location: Cell Membrane
entity reference: Ras-related C3 botulinum toxin substrate 1
name: SubPathwayInput

Compound/PW C000087 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanosine
stoichiometric coefficient: 1.0

Antibodies Production
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway120856
pathway component: SubPathwayInteraction120856
name: SubPathway

Compound/PW C109120 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Thiodeoxyguanosine-5'-triphosphate
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15428
type: UnificationXref
id: CHEBI:15428
db: ChEBI

Reference/ChemSpider 115687
type: UnificationXref
id: 115687
db: ChemSpider

Compound/PW C001420 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

D-Ribose 5-phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00117
xref: Reference/ChEBI CHEBI 52742
xref: Reference/ChemSpider 388313
xref: Reference/HMDB HMDB0001548
xref: Reference/BioCyc RIBOSE-5P
xref: Reference/PubChem-compound 439167
xref: Reference/CAS 4300-28-1
chemical formula: C5H11O8P
molecular weight: 230.01915
structure: ChemicalStructure/PW C001191

Reference/UniProt P21108
type: UnificationXref
id: P21108
db: UniProt

Reference/ChEBI CHEBI 2208
type: UnificationXref
id: CHEBI:2208
db: ChEBI

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Reference/ChEBI CHEBI 16335
type: UnificationXref
id: CHEBI:16335
db: ChEBI

6-Methylthiopurine 5'-monophosphate ribonucleotide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 10091038
xref: Reference/ChEBI CHEBI 80609
xref: Reference/CAS 7021-52-5
xref: Reference/ChemSpider 8266575
xref: Reference/HMDB HMDB0061339
xref: Reference/KEGG Compound C16615
chemical formula: C11H15N4O7PS
molecular weight: 378.03992
structure: ChemicalStructure/PW C040520

Thiodeoxyguanosine 5'-diphosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0061266
chemical formula: C10H15N5O10P2S
molecular weight: 459.0015
structure: ChemicalStructure/PW C040526

Reference/PubChem-compound 130805
type: UnificationXref
id: 130805
db: PubChem-compound

Reference/ChemSpider 8266575
type: UnificationXref
id: 8266575
db: ChemSpider

Reference/PubChem-compound 5893
type: UnificationXref
id: 5893
db: PubChem-compound

Inosine-5'-monophosphate dehydrogenase 1
type: Protein
cellular location: Cytosol
entity reference: Inosine-5'-monophosphate dehydrogenase 1

Reference/HMDB HMDB0000972
type: UnificationXref
id: HMDB0000972
db: HMDB

Mercaptopurine
type: SmallMolecule
cellular location: Cytosol
entity reference: Mercaptopurine

Reference/PubChem-compound 439236
type: UnificationXref
id: 439236
db: PubChem-compound

ChemicalStructure/PW C000774
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C009464
type: ChemicalStructure
structure format: SMILES
structure data: S=C1N=CNC2=C1NC=N2

Reference/BioCyc ADENOSINE
type: UnificationXref
id: ADENOSINE
db: BioCyc

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Cell Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005886

6-Thioguanosine monophosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: 6-Thioguanosine monophosphate

Mercaptopurine Action Pathway (New)
type: Pathway
pathway order: PathwaySubPathway/120818
pathway order: PathwaySubPathway/120817
pathway order: PathwaySubPathway/120816
pathway order: PathwaySubPathway/120815
pathway order: PathwaySubPathway/120834
pathway order: PathwaySubPathway/120856
pathway order: PathwayEnzymeReaction/2531110
pathway order: PathwayTransport/2531203
pathway order: PathwayInteraction/3209
pathway order: PathwayTransport/2531202
pathway order: PathwayEnzymeReaction/2531111
pathway order: PathwayTransport/2531201
pathway order: PathwayEnzymeReaction/2531257
pathway order: PathwayEnzymeReaction/2531113
pathway order: PathwayEnzymeReaction/2531137
pathway order: PathwayEnzymeReaction/2531118
pathway order: PathwayEnzymeReaction/2531119
pathway order: PathwaySubPathway/120820
pathway order: PathwayEnzymeReaction/2531141
pathway order: PathwayEnzymeReaction/2531121
pathway order: PathwayEnzymeReaction/2531142
pathway order: PathwayEnzymeReaction/2531123
pathway order: PathwayEnzymeReaction/2531122
pathway order: PathwayEnzymeReaction/2531125
pathway order: PathwayEnzymeReaction/2531124
pathway order: PathwayInteraction/3213
pathway order: PathwayEnzymeReaction/2531109
pathway component: TransportCatalysis5803
pathway component: ReactionCatalysis730
pathway component: Reaction213228
pathway component: 6.3.5.2
pathway component: DNA and RNA Synthesis
pathway component: TransportCatalysis5804
pathway component: ReactionCatalysis1621
pathway component: Interaction3209
pathway component: Transport15499
pathway component: ReactionCatalysis728
pathway component: ReactionCatalysis729
pathway component: 1.1.1.205
pathway component: 2.4.2.8
pathway component: 2.1.1.67
pathway component: Reaction1893
pathway component: ReactionCatalysis721
pathway component: ReactionCatalysis763
pathway component: Reaction1846
pathway component: 2.4.2.1
pathway component: Interaction3213
pathway component: 2.4.2.14
pathway component: ReactionCatalysis44
pathway component: Transport15500
pathway component: Regulation of Apoptosis of Activated T Cells
pathway component: ReactionCatalysis1532
pathway component: 2.7.6.1
pathway component: Reaction1065
pathway component: DNA Synthesis
pathway component: ReactionCatalysis1614
pathway component: Purines De novo biosynthesis
pathway component: Antibodies Production
pathway component: ReactionCatalysis1613
pathway component: Reaction1844
pathway component: 6.3.5.3
pathway component: ReactionCatalysis698
pathway component: Reaction483
xref: Reference/SMPDB SMP0126475
xref: Reference/PathWhiz PW128074
organism: Homo sapiens

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Phosphate

Compound/PW C000024 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenine
stoichiometric coefficient: 1.0

Compound/PW C000882 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 5-Phosphoribosylamine
stoichiometric coefficient: 1.0

ReactionCatalysis698
type: Catalysis
controller: Ribose-phosphate pyrophosphokinase 3
controlled: 2.7.6.1
control type: ACTIVATION

L-Glutamine
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Glutamine

Reference/ChemSpider 580869
type: UnificationXref
id: 580869
db: ChemSpider

Thioguanosine 5'-diphosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 53936469
xref: Reference/HMDB HMDB0060874
chemical formula: C10H15N5O10P2S
molecular weight: 459.0015
structure: ChemicalStructure/PW C040546

Thioguanosine 5'-triphosphate
type: SmallMoleculeReference
xref: Reference/ChemSpider 8319071
xref: Reference/PubChem-compound 10143562
xref: Reference/HMDB HMDB0060875
chemical formula: C10H16N5O13P3S
molecular weight: 538.96783
structure: ChemicalStructure/PW C040547

Guanosine
type: SmallMolecule
cellular location: Cytosol
entity reference: Guanosine
name: SubPathwayOutput
name: SubPathwayInput

Reference/ChemSpider 388373
type: UnificationXref
id: 388373
db: ChemSpider

DNA and RNA Synthesis
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway120820
pathway component: SubPathwayInteraction120820
name: SubPathway

ChemicalStructure/PW C000500
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCC(N)=O)C(O)=O

ChemicalStructure/PW C000749
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 7830994
type: UnificationXref
id: 7830994
db: ChemSpider

Reference/BioCyc PRPP
type: UnificationXref
id: PRPP
db: BioCyc

Thioguanosine 5'-triphosphate
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Thioguanosine 5'-triphosphate

Reference/PubChem-compound 190
type: UnificationXref
id: 190
db: PubChem-compound

Reference/ChemSpider 2299082
type: UnificationXref
id: 2299082
db: ChemSpider

Ribose 1-phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Ribose 1-phosphate

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

Reference/KEGG Compound C01756
type: UnificationXref
id: C01756
db: KEGG Compound

Reference/ChemSpider 109092
type: UnificationXref
id: 109092
db: ChemSpider

2.4.2.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000086 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000087 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001146 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytosol/Stoichiometry/1.0
right: Guanine
right: Ribose 1-phosphate
spontaneous: false
EC number: 2.4.2.1
left: Phosphate
left: Guanosine
name: Guanosine + Phosphate ↔ Guanine + Ribose 1-phosphate
conversion direction: REVERSIBLE

Reference/HMDB HMDB0001846
type: UnificationXref
id: HMDB0001846
db: HMDB

Reference/HMDB HMDB0000999
type: UnificationXref
id: HMDB0000999
db: HMDB

Protein/325 Cytosol/Stoichiometry/4.0
type: Stoichiometry
physical entity: Amidophosphoribosyltransferase
stoichiometric coefficient: 4.0

Reference/ChEBI CHEBI 16680
type: UnificationXref
id: CHEBI:16680
db: ChEBI

Transport15500
type: Transport
participant stoichiometry: Compound/PW C009464 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C009464/Stoichiometry/1.0
right: Mercaptopurine
spontaneous: false
left: Mercaptopurine
name: Mercaptopurine (→) Transport: Homo sapiens, Blood Vessel to Homo sapiens, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 24762165
type: UnificationXref
id: 24762165
db: PubChem-compound

Regulation of Apoptosis of Activated T Cells
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway120816
pathway component: SubPathwayInteraction120816
name: SubPathway

Thiodeoxyguanosine-5'-triphosphate
type: SmallMoleculeReference
chemical formula: C10H16N5O12P3S
molecular weight: 522.9729
structure: ChemicalStructure/PW C109120

DNA and RNA Synthesis
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway120817
pathway component: SubPathwayInteraction120817
name: SubPathway

Reference/HMDB HMDB0000641
type: UnificationXref
id: HMDB0000641
db: HMDB

DNA Synthesis
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway120815
pathway component: SubPathwayInteraction120815
name: SubPathway

ChemicalStructure/PW C000882
type: ChemicalStructure
structure format: SMILES

2.4.2.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000024 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001146 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytosol/Stoichiometry/1.0
right: Adenine
right: Ribose 1-phosphate
spontaneous: false
EC number: 2.4.2.1
left: Phosphate
left: Adenosine
name: Adenosine + Phosphate ↔ Adenine + Ribose 1-phosphate
conversion direction: REVERSIBLE

Reference/ChemSpider 185
type: UnificationXref
id: 185
db: ChemSpider

Reference/PubChem-compound 13781857
type: UnificationXref
id: 13781857
db: PubChem-compound

Compound/PW C000791 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphoribosylformylglycineamidine
stoichiometric coefficient: 1.0

Reference/CAS 4300-28-1
type: UnificationXref
id: 4300-28-1
db: CAS

DNA and RNA Synthesis
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway120818
pathway component: SubPathwayInteraction120818
name: SubPathway