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D(2) dopamine receptor Voltage- dependent P/Q-type calcium channel subunit alpha-1A Voltage- dependent L-type calcium channel subunit beta-1 Voltage- dependent calcium channel subunit alpha-2/delta-2 Sodium- dependent dopamine transporter Synaptic vesicular amine transporter Aromatic-L- amino-acid decarboxylase Tyrosine 3-monooxygenase Dopamine Ca+ Promazine Ca+ Dopamine Dopamine Promazine L-Dopa CO2 L-Tyrosine Tetrahydrobiopterin O2 Dihydrobiopterin H2O Na+ Na+ Pyridoxal 5'-phosphate Gi signaling cascade Fe2+ Cytosol Postsynaptic Neuron Presynaptic Neuron Cytosol Synaptic Vesicle Synapse Promazine is a D2 receptor antagonist. Promazine acts as an antagonist to other receptors such as 5HT2A, 5HT2C, M1, HI and Alpha 1A receptors ↓ Positive, negative and cognitive symptoms of schizophrenia Excess dopamine in the brain triggers positive symptoms of schizophrenia Brain Mesolimbic pathway Blood Brain Barrier Promazine is injected intravenously and intramuscularly. It readily diffuses into the brain via lipid mediated diffusion. passive diffusion
DRD2 CACNA1A CACNB1 CACNA2D2 SLC6A3 SLC18A2 DDC TH Dopamine Calcium Promazine Calcium Dopamine Dopamine Promazine L-Dopa Carbon dioxide L-Tyrosine Tetrahydrobiopterin Oxygen Dihydrobiopterin Water Sodium Sodium Gi signaling cascade
DRD2 CACNA1A CACNB1 CACNA2D2 SLC6A3 SLC18A2 DDC TH LDP Ca+ Promazi Ca+ LDP LDP Promazi L-Dopa CO2 Tyr BH4 O2 BH3 H2O Na+ Na+ Pyr-5'P Gi si c Fe2+ Cytosol Postsynaptic Neuron Presynaptic Neuron Cytosol Synaptic Vesicle Synapse Promazine is a D2 receptor antagonist. Promazine acts as an antagonist to other receptors such as 5HT2A, 5HT2C, M1, HI and Alpha 1A receptors ↓ Positive, negative and cognitive symptoms of schizophrenia Excess dopamine in the brain triggers positive symptoms of schizophrenia Brain Mesolimbic pathway Blood Brain Barrier Promazine is injected intravenously and intramuscularly. It readily diffuses into the brain via lipid mediated diffusion. passive diffusion
DRD2 CACNA1A CACNB1 CACNA2D2 SLC6A3 SLC18A2 DDC TH LDP Ca2+ Promazi Ca2+ LDP LDP Promazi L-Dopa CO2 Tyr BH4 O2 BH3 H2O Na+ Na+ Gi si c