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Pathway Description
Escitalopram Mechanism of Action Action Pathway New
Homo sapiens
Drug Action Pathway
Escitalopram is the therapeutic active S- enantiomer of citalopram. It is classified as a selective serotonin reuptake inhibitor used to treat depression and anxiety. It's mechanism of action it to bind selectively bind to the sodium dependent serotonin transporter and blocking the recycling of serotonin from the synapse. As serotonin accumulates it restores the serotonergic function of the 5-hydroxytryptamine 1A receptor leading to decreased anxiety and depressive moods. Escitalopram is one of the safest SSRI treatments as it has the highest degree of selectivity for the serotonin transporter (SERT) and therefore doesn't bind to other off-target functions. Following administration, it has a high bio-availability also making it an ideal drug to treat anxiety and depression. It is mainly administered through an oral route in the form of a tablet.
References
Escitalopram Mechanism of Action Pathway New References
Yohn C. N, Gergues M. M, Samuels B. A. The role of 5-HT receptors in depression. Mol Brain 10: 28, 2017.
Pastoor D, Gobburu J: Clinical pharmacology review of escitalopram for the treatment of depression. Expert Opin Drug Metab Toxicol. 2014 Jan;10(1):121-8. doi: 10.1517/17425255.2014.863873. Epub 2013 Nov 30.
Pubmed: 24289655
Rao N: The clinical pharmacokinetics of escitalopram. Clin Pharmacokinet. 2007;46(4):281-90. doi: 10.2165/00003088-200746040-00002.
Pubmed: 17375980
Florio V, Porcelli S, Saria A, Serretti A, Conca A: Escitalopram plasma levels and antidepressant response. Eur Neuropsychopharmacol. 2017 Sep;27(9):940-944. doi: 10.1016/j.euroneuro.2017.06.009. Epub 2017 Jun 23.
Pubmed: 28648553
Bakshi A, Tadi P: Biochemistry, Serotonin.
Pubmed: 32809691
Azorin JM, Llorca PM, Despiegel N, Verpillat P: [Escitalopram is more effective than citalopram for the treatment of severe major depressive disorder]. Encephale. 2004 Mar-Apr;30(2):158-66. doi: 10.1016/s0013-7006(04)95427-9.
Pubmed: 15107719
Wishart, D., Knox, C., Guo, A., Shrivastava, S., Hassanali, M., Stothard, P., . . . Woolsey, J. (2005, June). Citalopram. Retrieved June 21, 2023, from https://go.drugbank.com/drugs/DB00215
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