Myosin light chain kinase, smooth muscle
type: ProteinReference
xref: Reference/UniProt Q15746
organism: Homo sapiens

Actin, cytoplasmic 1
type: Protein
cellular location: Cytosol
entity reference: Actin, cytoplasmic 1

Actin (Homo sapiens)_Myosin LC-P (Homo sapiens)
type: Complex
component stoichiometry: Protein/8281 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/3041 Cytosol/Stoichiometry/1.0
cellular location: Cytosol
component: Actin, cytoplasmic 1
component: Myosin light chain 3
name: SubPathwayInput

Interaction5001
type: MolecularInteraction
interaction type: direct_interaction
name: D(1A) dopamine receptor activates Gq protein signaling cascade
participant: D(1A) dopamine receptor
participant: Guanine nucleotide-binding protein G(q) subunit alpha

Reference/UniProt P28482
type: UnificationXref
id: P28482
db: UniProt

Reference/HMDB HMDB0014497
type: UnificationXref
id: HMDB0014497
db: HMDB

Interaction3748
type: MolecularInteraction
interaction type: direct_interaction
name: Inositol 1,4,5-trisphosphate activates inositol 1,4,5-trisphosphate receptor type 3
participant: Inositol 1,4,5-trisphosphate
participant: Inositol 1,4,5-trisphosphate receptor type 3

direct_interaction
type: InteractionVocabulary

Inositol 1,4,5-trisphosphate receptor type 3
type: Protein
cellular location: Sarcoplasmic Reticulum
entity reference: Inositol 1,4,5-trisphosphate receptor type 3

Cytosolic phospholipase A2
type: Protein
cellular location: Cytosol
entity reference: Cytosolic phospholipase A2
name: SubPathwayInput

Serine/threonine-protein phosphatase PP1-beta catalytic subunit
type: Protein
cellular location: Cytosol
entity reference: Serine/threonine-protein phosphatase PP1-beta catalytic subunit

Reaction179577
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
participant stoichiometry: BoundComplex/506 Cytosol/Stoichiometry/1.0
right: Calcium_Calmodulin (Homo sapiens)
spontaneous: false
left: Calcium
name: Calcium → Calcium + Calmodulin (Homo sapiens)
conversion direction: LEFT_TO_RIGHT

Reference/SMPDB SMP0126513
type: UnificationXref
id: SMP0126513
db: SMPDB

Calcium
type: SmallMolecule
cellular location: Cytosol
entity reference: Calcium

ChemicalStructure/PW C097005
type: ChemicalStructure
structure format: SMILES

Voltage-dependent calcium channel subunit alpha-2/delta-2
type: Protein
cellular location: Cell Membrane
entity reference: Voltage-dependent calcium channel subunit alpha-2/delta-2

D(1A) dopamine receptor
type: Protein
entity reference: D(1A) dopamine receptor

Reference/UniProt P21728
type: UnificationXref
id: P21728
db: UniProt

Reference/GENE ONTOLOGY GO 0016529
type: UnificationXref
id: GO:0016529
db: GENE ONTOLOGY

TransportCatalysis4854
type: Catalysis
controller: Inositol 1,4,5-trisphosphate receptor type 3
controlled: Transport13821
control type: ACTIVATION

Reaction217849
type: BiochemicalReaction
participant stoichiometry: Protein/23905 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/23906 Cytosol/Stoichiometry/1.0
right: Protein phosphatase 1 regulatory subunit 14A
spontaneous: false
left: Protein phosphatase 1 regulatory subunit 14A
name: CPI-17 → CPI-17-P
conversion direction: LEFT_TO_RIGHT

L type Calcium channel
type: Complex
component stoichiometry: Protein/2720/Stoichiometry/1.0
component stoichiometry: Protein/2706/Stoichiometry/2.0
component stoichiometry: Protein/2712/Stoichiometry/1.0
component: Voltage-dependent calcium channel subunit alpha-2/delta-2
component: Voltage-dependent L-type calcium channel subunit beta-1
component: Voltage-dependent P/Q-type calcium channel subunit alpha-1A

Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Reference/CELL TYPE ONTOLOGY CL 0002366
type: UnificationXref
id: CL:0002366
db: CELL TYPE ONTOLOGY

Reference/PubChem-compound 8226
type: UnificationXref
id: 8226
db: PubChem-compound

Reference/ChEBI CHEBI 16595
type: UnificationXref
id: CHEBI:16595
db: ChEBI

Interaction3528
type: MolecularInteraction
interaction type: direct_interaction
name: Gq protein signaling cascade activates Phospholipase C
participant: Guanine nucleotide-binding protein G(q) subunit alpha
participant: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Sarcoplasmic Reticulum
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0016529

Reference/UniProt Q9NQ66
type: UnificationXref
id: Q9NQ66
db: UniProt

Protein/2720 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Voltage-dependent L-type calcium channel subunit beta-1
stoichiometric coefficient: 1.0

Reference/CAS 85166-31-0
type: UnificationXref
id: 85166-31-0
db: CAS

Compound/Generic369 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Diacylglycerol
stoichiometric coefficient: 1.0

Reference/UniProt Q96A00
type: UnificationXref
id: Q96A00
db: UniProt

Protein kinase C alpha type
type: ProteinReference
xref: Reference/UniProt P17252
organism: Homo sapiens

Reference/PathWhiz PW128112
type: UnificationXref
id: PW128112
db: PathWhiz

Reaction217850
type: BiochemicalReaction
participant stoichiometry: Protein/23907 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/23734 Cytosol/Stoichiometry/1.0
right: Serine/threonine-protein phosphatase PP1-beta catalytic subunit
spontaneous: false
left: Serine/threonine-protein phosphatase PP1-beta catalytic subunit
name: Myosin light chain phosphatase → Myosin light chain phosphatase-P
conversion direction: LEFT_TO_RIGHT

Reaction217851
type: BiochemicalReaction
participant stoichiometry: BoundComplex/566 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/8281 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/3041 Cytosol/Stoichiometry/1.0
right: Actin (Homo sapiens)_Myosin LC-P (Homo sapiens)
spontaneous: false
left: Actin, cytoplasmic 1
left: Myosin light chain 3
name: Actin + Myosin LC-P → Actin (Homo sapiens) + Myosin LC-P (Homo sapiens)
conversion direction: LEFT_TO_RIGHT

Interaction3752
type: MolecularInteraction
interaction type: direct_interaction
name: Mitogen-activated protein kinase activates Cytosolic phospholipase A2
participant: Cytosolic phospholipase A2
participant: Mitogen-activated protein kinase

Interaction3754
type: MolecularInteraction
interaction type: direct_interaction
name: Gq protein signaling cascade activates Transforming protein RhoA
participant: Guanine nucleotide-binding protein G(q) subunit alpha
participant: Transforming protein RhoA

Uterus
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0001424

Compound/PW C097005 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphatidylinositol 4,5-bisphosphate
stoichiometric coefficient: 1.0

Protein/1597 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calmodulin-1
stoichiometric coefficient: 1.0

Reaction217852
type: BiochemicalReaction
participant stoichiometry: Protein/23906 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/23907 Cytosol/Stoichiometry/1.0
right: Serine/threonine-protein phosphatase PP1-beta catalytic subunit
spontaneous: false
left: Protein phosphatase 1 regulatory subunit 14A
name: CPI-17-P → Myosin light chain phosphatase-P
conversion direction: LEFT_TO_RIGHT

Protein/2712/Stoichiometry/1.0
type: Stoichiometry
physical entity: Voltage-dependent P/Q-type calcium channel subunit alpha-1A
stoichiometric coefficient: 1.0

Reaction217853
type: BiochemicalReaction
participant stoichiometry: Protein/23907 Cytosol/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/7533 Cytosol/Stoichiometry/1.0
right: Serine/threonine-protein phosphatase PP1-beta catalytic subunit
spontaneous: false
left: Rho-associated protein kinase 1
name: Rho-associated protein kinase 1 → Myosin light chain phosphatase-P
conversion direction: LEFT_TO_RIGHT

Interaction3750
type: MolecularInteraction
interaction type: direct_interaction
name: Protein kinase C activates Mitogen-activated protein kinase
participant: Mitogen-activated protein kinase
participant: Protein kinase C alpha type

Reference/UniProt P62140
type: UnificationXref
id: P62140
db: UniProt

Protein/8281 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Actin, cytoplasmic 1
stoichiometric coefficient: 1.0

Reference/ChemSpider 266
type: UnificationXref
id: 266
db: ChemSpider

Interaction3755
type: MolecularInteraction
interaction type: direct_interaction
name: Transforming protein RhoA activates Rho-associated protein kinase 1
participant: Transforming protein RhoA
participant: Rho-associated protein kinase 1

Protein phosphatase 1 regulatory subunit 14A
type: Protein
cellular location: Cytosol
entity reference: Protein phosphatase 1 regulatory subunit 14A

Interaction3756
type: MolecularInteraction
interaction type: direct_interaction
name: Gq protein signaling cascade activates L type Calcium channel
participant: L type Calcium channel
participant: Guanine nucleotide-binding protein G(q) subunit alpha

Protein/23907 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Serine/threonine-protein phosphatase PP1-beta catalytic subunit
stoichiometric coefficient: 1.0

ReactionCatalysis207193
type: Catalysis
controller: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
controlled: 3.1.4.11
control type: ACTIVATION

Reference/UniProt P17252
type: UnificationXref
id: P17252
db: UniProt

Voltage-dependent L-type calcium channel subunit beta-1
type: Protein
cellular location: Cell Membrane
entity reference: Voltage-dependent L-type calcium channel subunit beta-1

Protein/2706 Cell Membrane/Stoichiometry/2.0
type: Stoichiometry
physical entity: Voltage-dependent calcium channel subunit alpha-2/delta-2
stoichiometric coefficient: 2.0

Mitogen-activated protein kinase 1
type: ProteinReference
xref: Reference/UniProt P28482
organism: Homo sapiens

Voltage-dependent P/Q-type calcium channel subunit alpha-1A
type: Protein
cellular location: Cell Membrane
entity reference: Voltage-dependent P/Q-type calcium channel subunit alpha-1A

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Compound/PW C001155 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Inositol 1,4,5-trisphosphate
stoichiometric coefficient: 1.0

Calmodulin-1
type: ProteinReference
xref: Reference/UniProt P0DP23
organism: Homo sapiens

Rho-associated protein kinase 1
type: ProteinReference
xref: Reference/UniProt Q13464
organism: Homo sapiens

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
type: Protein
cellular location: Cytosol
entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1

Serine/threonine-protein phosphatase PP1-beta catalytic subunit
type: Protein
cellular location: Cytosol
entity reference: Serine/threonine-protein phosphatase PP1-beta catalytic subunit

Compound/PW C000353 Sarcoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Reference/GENE ONTOLOGY GO 0005886
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

Reference/BioCyc inositol 1,4,5-trisphosphate
type: UnificationXref
id: inositol_1,4,5-trisphosphate
db: BioCyc

BiologicalState1479
type: BioSource
cell type: Myometrium
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Uterus, Myometrium
tissue: Uterus

Interaction5031
type: MolecularInteraction
interaction type: direct_interaction
name: Methylergonovine activates D(1A) dopamine receptor
participant: Methylergonovine
participant: D(1A) dopamine receptor

Voltage-dependent calcium channel subunit alpha-2/delta-2
type: Protein
entity reference: Voltage-dependent calcium channel subunit alpha-2/delta-2

Methylergometrine Mechanism of Action Action Pathway
type: Pathway
pathway order: PathwayInteraction/5031
pathway order: PathwayInteraction/509
pathway order: PathwaySubPathway/121323
pathway order: PathwaySubPathway/121322
pathway order: PathwayTransport/2535727
pathway order: PathwayInteraction/3528
pathway order: PathwayInteraction/3748
pathway order: PathwayInteraction/5001
pathway order: PathwayInteraction/2849
pathway order: PathwaySubPathway/121321
pathway order: PathwayEnzymeReaction/2535703
pathway order: PathwayEnzymeReaction/2535702
pathway order: PathwayInteraction/3756
pathway order: PathwayEnzymeReaction/2535701
pathway order: PathwayInteraction/3755
pathway order: PathwayEnzymeReaction/2535700
pathway order: PathwayInteraction/3754
pathway order: PathwayEnzymeReaction/2535707
pathway order: PathwayEnzymeReaction/2535706
pathway order: PathwayInteraction/3752
pathway order: PathwayEnzymeReaction/2535705
pathway order: PathwayTransport/2535710
pathway order: PathwayEnzymeReaction/2535704
pathway order: PathwayInteraction/3750
pathway order: PathwayTransport/2535711
pathway order: PathwayEnzymeReaction/2535709
pathway order: PathwayEnzymeReaction/2535708
pathway component: TransportCatalysis4854
pathway component: Reaction217849
pathway component: TransportCatalysis2234
pathway component: 3.1.4.11
pathway component: Interaction5001
pathway component: ReactionCatalysis203360
pathway component: Interaction3528
pathway component: Interaction3748
pathway component: Transport11095
pathway component: Reaction213775
pathway component: Interaction5031
pathway component: 3.1.3.16
pathway component: Reaction179577
pathway component: Reaction217850
pathway component: Reaction217851
pathway component: Interaction3752
pathway component: ReactionCatalysis203359
pathway component: Interaction3754
pathway component: Muscle Contraction
pathway component: Prostaglandin Synthesis
pathway component: Muscle Relaxation
pathway component: Reaction217852
pathway component: Reaction213774
pathway component: Reaction217853
pathway component: Transport13821
pathway component: Interaction3750
pathway component: ReactionCatalysis207375
pathway component: Transport15883
pathway component: Interaction2849
pathway component: Interaction509
pathway component: Interaction3755
pathway component: Interaction3756
pathway component: ReactionCatalysis207193
xref: Reference/PathWhiz PW128112
xref: Reference/SMPDB SMP0126513
organism: Homo sapiens

Reference/ChemSpider 7933
type: UnificationXref
id: 7933
db: ChemSpider

Protein/1350 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Rho-associated protein kinase 1
stoichiometric coefficient: 2.0

Reference/UniProt Q9NY47
type: UnificationXref
id: Q9NY47
db: UniProt

Reference/ChemSpider 388562
type: UnificationXref
id: 388562
db: ChemSpider

Reference/HMDB HMDB0000464
type: UnificationXref
id: HMDB0000464
db: HMDB

Reference/UniProt P50148
type: UnificationXref
id: P50148
db: UniProt

Reference/PubChem-compound 24742074
type: UnificationXref
id: 24742074
db: PubChem-compound

Mitogen-activated protein kinase 3
type: Protein
cellular location: Cytosol
entity reference: Mitogen-activated protein kinase 3

D(1A) dopamine receptor
type: ProteinReference
xref: Reference/UniProt P21728
organism: BiologicalState1479

Guanine nucleotide-binding protein G(q) subunit alpha
type: Protein
entity reference: Guanine nucleotide-binding protein G(q) subunit alpha

Voltage-dependent P/Q-type calcium channel subunit alpha-1A
type: Protein
entity reference: Voltage-dependent P/Q-type calcium channel subunit alpha-1A

Serine/threonine-protein phosphatase PP1-beta catalytic subunit
type: ProteinReference
xref: Reference/UniProt P62140
organism: Homo sapiens

Protein/23734 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Serine/threonine-protein phosphatase PP1-beta catalytic subunit
stoichiometric coefficient: 1.0

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Phosphatidylinositol 4,5-bisphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Phosphatidylinositol 4,5-bisphosphate

ChemicalStructure/PW C008877
type: ChemicalStructure
structure format: SMILES

Reference/CAS 14127-61-8
type: UnificationXref
id: 14127-61-8
db: CAS

ChemicalStructure/PW C000353
type: ChemicalStructure
structure format: SMILES
structure data: [Ca++]

Reference/UniProt P60709
type: UnificationXref
id: P60709
db: UniProt

Transforming protein RhoA
type: ProteinReference
xref: Reference/UniProt P61586
organism: Homo sapiens

Calcium
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Calcium

Reference/UniProt P0DP23
type: UnificationXref
id: P0DP23
db: UniProt

Voltage-dependent L-type calcium channel subunit beta-1
type: Protein
entity reference: Voltage-dependent L-type calcium channel subunit beta-1

Phosphatidylinositol 4,5-bisphosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 24742074
chemical formula: C47H80O19P3
molecular weight: 1041.4507
structure: ChemicalStructure/PW C097005

Calmodulin-1
type: Protein
cellular location: Cytosol
entity reference: Calmodulin-1

Protein kinase C alpha type
type: Protein
cellular location: Cytosol
entity reference: Protein kinase C alpha type

Inositol 1,4,5-trisphosphate receptor type 3
type: Protein
entity reference: Inositol 1,4,5-trisphosphate receptor type 3

Reference/UniProt P27361
type: UnificationXref
id: P27361
db: UniProt

Inositol 1,4,5-trisphosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001498
xref: Reference/PubChem-compound 439456
xref: Reference/CAS 85166-31-0
xref: Reference/BioCyc inositol 1,4,5-trisphosphate
xref: Reference/KEGG Compound C01245
xref: Reference/ChEBI CHEBI 16595
xref: Reference/ChemSpider 388562
chemical formula: C6H15O15P3
molecular weight: 419.96237
structure: ChemicalStructure/PW C001155

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Reference/ChEBI CHEBI 29108
type: UnificationXref
id: CHEBI:29108
db: ChEBI

Myometrium
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0002366

Mitogen-activated protein kinase 1
type: Protein
cellular location: Cytosol
entity reference: Mitogen-activated protein kinase 1

Rho-associated protein kinase 1
type: Complex
component stoichiometry: Protein/1350 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Rho-associated protein kinase 1

Reference/UniProt P61586
type: UnificationXref
id: P61586
db: UniProt

Reference/UniProt P08590
type: UnificationXref
id: P08590
db: UniProt

Reference/KEGG Compound C01245
type: UnificationXref
id: C01245
db: KEGG Compound

Transport11095
type: Transport
participant stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
right: Calcium
spontaneous: false
left: Calcium
name: Calcium (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

SubPathwayInteraction121322
type: Interaction
name: SubPathwayReaction
name: SubPathway121322Reaction
participant: Cytosolic phospholipase A2

SubPathwayInteraction121321
type: Interaction
name: SubPathway121321Reaction
name: SubPathwayReaction
participant: Myosin light chain 3

Transforming protein RhoA
type: Protein
cellular location: Cytosol
entity reference: Transforming protein RhoA

SubPathwayInteraction121323
type: Interaction
name: SubPathway121323Reaction
name: SubPathwayReaction
participant: Actin (Homo sapiens)_Myosin LC-P (Homo sapiens)

Diacylglycerol
type: SmallMolecule
cellular location: Cytosol
entity reference: Diacylglycerol

Compound/PW C000353 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Diacylglycerol
type: SmallMoleculeReference

Rho-associated protein kinase 1
type: Protein
cellular location: Cytosol
entity reference: Rho-associated protein kinase 1

Protein/2712 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Voltage-dependent P/Q-type calcium channel subunit alpha-1A
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein G(q) subunit alpha
type: Protein
cellular location: Cell Membrane
entity reference: Guanine nucleotide-binding protein G(q) subunit alpha

Protein phosphatase 1 regulatory subunit 14A
type: Protein
cellular location: Cytosol
entity reference: Protein phosphatase 1 regulatory subunit 14A

Transport13821
type: Transport
participant stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353 Sarcoplasmic Reticulum/Stoichiometry/1.0
right: Calcium
spontaneous: false
left: Calcium
name: Calcium (→) Transport: Homo sapiens, Cell, Sarcoplasmic Reticulum to Homo sapiens, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

ChemicalStructure/PW C001155
type: ChemicalStructure
structure format: SMILES

Reference/UniProt Q02641
type: UnificationXref
id: Q02641
db: UniProt

ReactionCatalysis207375
type: Catalysis
controller: Protein kinase C alpha type
controlled: Reaction217849
control type: ACTIVATION

Interaction509
type: MolecularInteraction
interaction type: direct_interaction
name: Diacylglycerol activates Protein kinase C
participant: Diacylglycerol
participant: Protein kinase C alpha type

L type Calcium channel
type: Complex
component stoichiometry: Protein/2706 Cell Membrane/Stoichiometry/2.0
component stoichiometry: Protein/2720 Cell Membrane/Stoichiometry/1.0
component stoichiometry: Protein/2712 Cell Membrane/Stoichiometry/1.0
cellular location: Cell Membrane
component: Voltage-dependent calcium channel subunit alpha-2/delta-2
component: Voltage-dependent P/Q-type calcium channel subunit alpha-1A
component: Voltage-dependent L-type calcium channel subunit beta-1

Reference/UniProt Q15746
type: UnificationXref
id: Q15746
db: UniProt

BoundComplex/506 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium_Calmodulin (Homo sapiens)
stoichiometric coefficient: 1.0

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

Reference/PubChem-compound 439456
type: UnificationXref
id: 439456
db: PubChem-compound

Voltage-dependent calcium channel subunit alpha-2/delta-2
type: ProteinReference
xref: Reference/UniProt Q9NY47

Reaction213775
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
participant stoichiometry: BoundComplex/506 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/1597 Cytosol/Stoichiometry/1.0
right: Calcium_Calmodulin (Homo sapiens)
spontaneous: false
left: Calcium
left: Calmodulin-1
name: Calcium + Calmodulin → Calcium + Calmodulin (Homo sapiens)
conversion direction: LEFT_TO_RIGHT

3.1.3.16
type: BiochemicalReaction
participant stoichiometry: Protein/3041 Cytosol/Stoichiometry/1.0
right: Myosin light chain 3
spontaneous: false
EC number: 3.1.3.16
left: Myosin light chain 3
name: Myosin LC-P → Myosin light chain 3
conversion direction: LEFT_TO_RIGHT

Protein/3041 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Myosin light chain 3
stoichiometric coefficient: 1.0

Protein/23906 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Protein phosphatase 1 regulatory subunit 14A
stoichiometric coefficient: 1.0

Voltage-dependent P/Q-type calcium channel subunit alpha-1A
type: ProteinReference
xref: Reference/UniProt O00555

Guanine nucleotide-binding protein G(q) subunit alpha
type: ProteinReference
xref: Reference/UniProt P50148
organism: Homo sapiens

Mitogen-activated protein kinase 3
type: ProteinReference
xref: Reference/UniProt P27361
organism: Homo sapiens

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
type: ProteinReference
xref: Reference/UniProt Q9NQ66
organism: Homo sapiens

Reaction213774
type: BiochemicalReaction
participant stoichiometry: Protein/3041 Cytosol/Stoichiometry/1.0
right: Myosin light chain 3
spontaneous: false
left: Myosin light chain 3
name: Myosin light chain 3 → Myosin LC-P
conversion direction: LEFT_TO_RIGHT

Cytosolic phospholipase A2
type: ProteinReference
xref: Reference/UniProt P47712
organism: Homo sapiens

Compound/PW C008877/Stoichiometry/1.0
type: Stoichiometry
physical entity: Methylergonovine
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001498
type: UnificationXref
id: HMDB0001498
db: HMDB

Myosin light chain kinase, smooth muscle
type: Protein
cellular location: Cytosol
entity reference: Myosin light chain kinase, smooth muscle

BoundComplex/566 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Actin (Homo sapiens)_Myosin LC-P (Homo sapiens)
stoichiometric coefficient: 1.0

Reference/UniProt P47712
type: UnificationXref
id: P47712
db: UniProt

Reference/CAS 113-42-8
type: UnificationXref
id: 113-42-8
db: CAS

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Inositol 1,4,5-trisphosphate receptor type 3
type: ProteinReference
xref: Reference/UniProt Q14573

Voltage-dependent L-type calcium channel subunit beta-1
type: ProteinReference
xref: Reference/UniProt Q02641

Guanine nucleotide-binding protein G(q) subunit alpha
type: Protein
cellular location: Cytosol
entity reference: Guanine nucleotide-binding protein G(q) subunit alpha

Reference/KEGG Compound C00076
type: UnificationXref
id: C00076
db: KEGG Compound

3.1.4.11
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001155 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C097005 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/Generic369 Cytosol/Stoichiometry/1.0
right: Diacylglycerol
right: Inositol 1,4,5-trisphosphate
spontaneous: false
EC number: 3.1.4.11
left: Phosphatidylinositol 4,5-bisphosphate
name: Phosphatidylinositol 4,5-bisphosphate → Diacylglycerol + Inositol 1,4,5-trisphosphate
conversion direction: LEFT_TO_RIGHT

ReactionCatalysis203360
type: Catalysis
controller: Serine/threonine-protein phosphatase PP1-beta catalytic subunit
controlled: 3.1.3.16
control type: ACTIVATION

Reference/BioCyc CA+2
type: UnificationXref
id: CA%2b2
db: BioCyc

Protein/23905 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Protein phosphatase 1 regulatory subunit 14A
stoichiometric coefficient: 1.0

Inositol 1,4,5-trisphosphate
type: SmallMolecule
cellular location: Sarcoplasmic Reticulum
entity reference: Inositol 1,4,5-trisphosphate

Protein/2720/Stoichiometry/1.0
type: Stoichiometry
physical entity: Voltage-dependent L-type calcium channel subunit beta-1
stoichiometric coefficient: 1.0

Methylergonovine
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 775307
xref: Reference/ChemSpider 7933
xref: Reference/CAS 113-42-8
xref: Reference/PubChem-compound 8226
xref: Reference/HMDB HMDB0014497
chemical formula: C20H25N3O2
molecular weight: 339.19467
structure: ChemicalStructure/PW C008877

Calcium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000464
xref: Reference/BioCyc CA+2
xref: Reference/ChemSpider 266
xref: Reference/ChEBI CHEBI 29108
xref: Reference/CAS 14127-61-8
xref: Reference/KEGG Compound C00076
xref: Reference/PubChem-compound 271
chemical formula: Ca
molecular weight: 39.96259
structure: ChemicalStructure/PW C000353

Mitogen-activated protein kinase
type: Complex
cellular location: Cytosol
component: Mitogen-activated protein kinase 3
component: Mitogen-activated protein kinase 1

Reference/UniProt O00555
type: UnificationXref
id: O00555
db: UniProt

Cell Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005886

Reference/UniProt Q14573
type: UnificationXref
id: Q14573
db: UniProt

Actin, cytoplasmic 1
type: ProteinReference
xref: Reference/UniProt P60709
organism: Homo sapiens

Reference/PubChem-compound 271
type: UnificationXref
id: 271
db: PubChem-compound

Muscle Contraction
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway121323
pathway component: SubPathwayInteraction121323
name: SubPathway

Prostaglandin Synthesis
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway121322
pathway component: SubPathwayInteraction121322
name: SubPathway

Muscle Relaxation
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway121321
pathway component: SubPathwayInteraction121321
name: SubPathway

Transport15883
type: Transport
participant stoichiometry: Compound/PW C008877/Stoichiometry/1.0
right: Methylergonovine
spontaneous: false
left: Methylergonovine
name: Methylergonovine (→) Transport: Homo sapiens, Blood Vessel to Homo sapiens, Uterus, Myometrium
conversion direction: LEFT_TO_RIGHT

Interaction2849
type: MolecularInteraction
interaction type: direct_interaction
name: Calcium + Calmodulin (Homo sapiens) activates Myosin light chain kinase, smooth muscle
participant: Myosin light chain kinase, smooth muscle
participant: Calcium_Calmodulin (Homo sapiens)

Myosin light chain 3
type: Protein
cellular location: Cytosol
entity reference: Myosin light chain 3
name: SubPathwayInput

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
type: Protein
cellular location: Cell Membrane
entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1

Reference/BRENDA TISSUE ONTOLOGY BTO 0001424
type: UnificationXref
id: BTO:0001424
db: BRENDA TISSUE ONTOLOGY

TransportCatalysis2234
type: Catalysis
controller: L type Calcium channel
controlled: Transport11095
control type: ACTIVATION

Myosin light chain 3
type: ProteinReference
xref: Reference/UniProt P08590
organism: Homo sapiens

Methylergonovine
type: SmallMolecule
entity reference: Methylergonovine

Reference/ChEBI CHEBI 775307
type: UnificationXref
id: CHEBI:775307
db: ChEBI

ProteinComplex/7533 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Rho-associated protein kinase 1
stoichiometric coefficient: 1.0

Protein/2706/Stoichiometry/2.0
type: Stoichiometry
physical entity: Voltage-dependent calcium channel subunit alpha-2/delta-2
stoichiometric coefficient: 2.0

Reference/UniProt Q13464
type: UnificationXref
id: Q13464
db: UniProt

Protein phosphatase 1 regulatory subunit 14A
type: ProteinReference
xref: Reference/UniProt Q96A00
organism: Homo sapiens

Protein phosphatase 1 regulatory subunit 14A
type: ProteinReference
xref: Reference/UniProt Q96A00
organism: Homo sapiens

Serine/threonine-protein phosphatase PP1-beta catalytic subunit
type: ProteinReference
xref: Reference/UniProt P62140
organism: Homo sapiens

ReactionCatalysis203359
type: Catalysis
controller: Myosin light chain kinase, smooth muscle
controlled: Reaction213774
control type: ACTIVATION

Calcium
type: SmallMolecule
cellular location: Sarcoplasmic Reticulum
entity reference: Calcium

Inositol 1,4,5-trisphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Inositol 1,4,5-trisphosphate

Calcium_Calmodulin (Homo sapiens)
type: Complex
component stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/1597 Cytosol/Stoichiometry/1.0
cellular location: Cytosol
component: Calcium
component: Calmodulin-1