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D(2) dopamine receptor Voltage- dependent P/Q-type calcium channel subunit alpha-1A Voltage- dependent L-type calcium channel subunit beta-1 Voltage- dependent calcium channel subunit alpha-2/delta-2 Sodium- dependent dopamine transporter Synaptic vesicular amine transporter Aromatic-L- amino-acid decarboxylase Tyrosine 3-monooxygenase Dopamine Ca+ Fluspirilene Ca+ Dopamine Dopamine Fluspirilene Fluspirilene Fluspirilene L-Dopa CO2 L-Tyrosine Tetrahydrobiopterin O2 Dihydrobiopterin H2O Na+ Na+ Pyridoxal 5'-phosphate Gi signaling cascade Fe2+ Cytosol Postsynaptic Neuron Presynaptic Neuron Cytosol Synaptic Vesicle Synapse Fluspirilene is a D2 receptor antagonist. D2 receptors in the mesolimbic pathway are responsible for producing symptoms in psychosis antipsychotic effect Brain Mesolimbic pathway Blood vessel - blood brain barrier Passive Diffusion Fluspirilene is a relatively long-acting injectable depot Large deltoid or gluteal muscle of upper arm or butt cheek
DRD2 CACNA1A CACNB1 CACNA2D2 SLC6A3 SLC18A2 DDC TH Dopamine Calcium Fluspirilene Calcium Dopamine Dopamine Fluspirilene Fluspirilene Fluspirilene L-Dopa Carbon dioxide L-Tyrosine Tetrahydrobiopterin Oxygen Dihydrobiopterin Water Sodium Sodium Gi signaling cascade
DRD2 CACNA1A CACNB1 CACNA2D2 SLC6A3 SLC18A2 DDC TH LDP Ca+ Imap Ca+ LDP LDP Imap Imap Imap L-Dopa CO2 Tyr BH4 O2 BH3 H2O Na+ Na+ Pyr-5'P Gi si c Fe2+ Cytosol Postsynaptic Neuron Presynaptic Neuron Cytosol Synaptic Vesicle Synapse Fluspirilene is a D2 receptor antagonist. D2 receptors in the mesolimbic pathway are responsible for producing symptoms in psychosis antipsychotic effect Brain Mesolimbic pathway Blood vessel - blood brain barrier Passive Diffusion Fluspirilene is a relatively long-acting injectable depot Large deltoid or gluteal muscle of upper arm or butt cheek
DRD2 CACNA1A CACNB1 CACNA2D2 SLC6A3 SLC18A2 DDC TH LDP Ca2+ Imap Ca2+ LDP LDP Imap Imap Imap L-Dopa CO2 Tyr BH4 O2 BH3 H2O Na+ Na+ Gi si c