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D(2) dopamine receptor D(1A) dopamine receptor Voltage- dependent P/Q-type calcium channel subunit alpha-1A Voltage- dependent L-type calcium channel subunit beta-1 Voltage- dependent calcium channel subunit alpha-2/delta-2 Sodium- dependent dopamine transporter Synaptic vesicular amine transporter Aromatic-L- amino-acid decarboxylase Tyrosine 3-monooxygenase Dopamine Ca+ Perphenazine Perphenazine Ca+ Dopamine Dopamine Perphenazine Perphenazine Perphenazine L-Dopa CO2 L-Tyrosine Tetrahydrobiopterin O2 Dihydrobiopterin H2O Na+ Na+ Pyridoxal 5'-phosphate Gi signaling cascade Fe2+ Cytosol Postsynaptic Neuron Presynaptic Neuron Cytosol Synaptic Vesicle Synapse Perphenazine is a D1 and D2 receptor antagonist. D2 receptors in the mesolimbic pathway are responsible for producing the positive symptoms in schizophrenia ↓ Positive, negative and cognitive symptoms of schizophrenia and psychosis Excess dopamine in the brain triggers positive symptoms of schizophrenia Brain Mesolimbic pathway Blood vessel - blood brain barrier Passive Diffusion Passive Diffusion Perphenazine is taken orally
DRD2 DRD1 CACNA1A CACNB1 CACNA2D2 SLC6A3 SLC18A2 DDC TH Dopamine Calcium Perphenazine Perphenazine Calcium Dopamine Dopamine Perphenazine Perphenazine Perphenazine L-Dopa Carbon dioxide L-Tyrosine Tetrahydrobiopterin Oxygen Dihydrobiopterin Water Sodium Sodium Gi signaling cascade
DRD2 DRD1 CACNA1A CACNB1 CACNA2D2 SLC6A3 SLC18A2 DDC TH LDP Ca+ Pzc Pzc Ca+ LDP LDP Pzc Pzc Pzc L-Dopa CO2 Tyr BH4 O2 BH3 H2O Na+ Na+ Pyr-5'P Gi si c Fe2+ Cytosol Postsynaptic Neuron Presynaptic Neuron Cytosol Synaptic Vesicle Synapse Perphenazine is a D1 and D2 receptor antagonist. D2 receptors in the mesolimbic pathway are responsible for producing the positive symptoms in schizophrenia ↓ Positive, negative and cognitive symptoms of schizophrenia and psychosis Excess dopamine in the brain triggers positive symptoms of schizophrenia Brain Mesolimbic pathway Blood vessel - blood brain barrier Passive Diffusion Passive Diffusion Perphenazine is taken orally
DRD2 DRD1 CACNA1A CACNB1 CACNA2D2 SLC6A3 SLC18A2 DDC TH LDP Ca2+ Pzc Pzc Ca2+ LDP LDP Pzc Pzc Pzc L-Dopa CO2 Tyr BH4 O2 BH3 H2O Na+ Na+ Gi si c