Reference/CAS 51-41-2
type: UnificationXref
id: 51-41-2
db: CAS

Reference/CAS 7722-84-1
type: UnificationXref
id: 7722-84-1
db: CAS

Dihydrobiopterin
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 64277
xref: Reference/ChemSpider 247
xref: Reference/HMDB HMDB0000038
xref: Reference/KEGG Compound C02953
xref: Reference/BioCyc BIOPTERIN
xref: Reference/CAS 6779-87-9
xref: Reference/PubChem-compound 252
chemical formula: C9H13N5O3
molecular weight: 239.10184
structure: ChemicalStructure/PW C000027

1.14.17.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000977 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000052 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000031 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000142 Cytosol/Stoichiometry/1.0
right: Norepinephrine
right: Dehydroascorbic acid
right: Water
spontaneous: false
EC number: 1.14.17.1
left: Ascorbic acid
left: Oxygen
left: Dopamine
name: Ascorbic acid + Dopamine + Oxygen → Dehydroascorbic acid + Norepinephrine + Water
conversion direction: LEFT_TO_RIGHT

Synaptic vesicular amine transporter
type: Protein
cellular location: Exocytic Vesicle
entity reference: Synaptic vesicular amine transporter

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Sodium-dependent noradrenaline transporter
type: Protein
cellular location: Presynaptic membrane
entity reference: Sodium-dependent noradrenaline transporter

BiologicalState789
type: BioSource
cell type: Neuron
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Brain, Neuron
tissue: Brain

Reference/ChEBI CHEBI 16134
type: UnificationXref
id: CHEBI:16134
db: ChEBI

direct_interaction
type: InteractionVocabulary

Reference/HMDB HMDB0003125
type: UnificationXref
id: HMDB0003125
db: HMDB

Tyrosine 3-monooxygenase
type: ProteinReference
xref: Reference/UniProt P07101
organism: BiologicalState789

Compound/PW C000103 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Tyrosine
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

ChemicalStructure/PW C001783
type: ChemicalStructure
structure format: SMILES
structure data: OO

Reference/GENE ONTOLOGY GO 0070382
type: UnificationXref
id: GO:0070382
db: GENE ONTOLOGY

Compound/PW C000052 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dopamine
stoichiometric coefficient: 1.0

Ammonia
type: SmallMoleculeReference
xref: Reference/BioCyc AMMONIA
xref: Reference/CAS 7664-41-7
xref: Reference/HMDB HMDB0000051
xref: Reference/PubChem-compound 222
xref: Reference/KEGG Compound C00014
xref: Reference/ChEBI CHEBI 16134
xref: Reference/ChemSpider 217
chemical formula: H3N
molecular weight: 17.026548
structure: ChemicalStructure/PW C000035

L-Tyrosine
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Tyrosine

Ascorbic acid
type: SmallMoleculeReference
xref: Reference/BioCyc ASCORBATE
xref: Reference/ChemSpider 10189562
xref: Reference/KEGG Compound C00072
xref: Reference/ChEBI CHEBI 29073
xref: Reference/CAS 50-81-7
xref: Reference/PubChem-compound 54670067
xref: Reference/HMDB HMDB0000044
chemical formula: C6H8O6
molecular weight: 176.03209
structure: ChemicalStructure/PW C000031

Sodium-dependent noradrenaline transporter
type: Protein
entity reference: Sodium-dependent noradrenaline transporter

Reference/SMPDB SMP0124452
type: UnificationXref
id: SMP0124452
db: SMPDB

Alpha-1A adrenergic receptor
type: ProteinReference
xref: Reference/UniProt P35348
organism: BiologicalState789

Brain
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000142

Reference/ChemSpider 5833
type: UnificationXref
id: 5833
db: ChemSpider

Compound/PW C001065 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 1.0

Interaction4028
type: MolecularInteraction
interaction type: direct_interaction
name: Trace amine-associated receptor 1 inhibits Sodium-dependent noradrenaline transporter
participant: Trace amine-associated receptor 1
participant: Sodium-dependent noradrenaline transporter

Reference/UniProt P09172
type: UnificationXref
id: P09172
db: UniProt

Reference/KEGG Compound C05577
type: UnificationXref
id: C05577
db: KEGG Compound

Reference/ChemSpider 247
type: UnificationXref
id: 247
db: ChemSpider

ChemicalStructure/PW C000103
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CC1=CC=C(O)C=C1)C(O)=O

Reference/HMDB HMDB0000787
type: UnificationXref
id: HMDB0000787
db: HMDB

Aromatic-L-amino-acid decarboxylase
type: ProteinReference
xref: Reference/UniProt P20711
organism: BiologicalState789

Reference/BioCyc L-DOPA
type: UnificationXref
id: L-DOPA
db: BioCyc

Compound/PW C002683 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3,4-Dihydroxymandelaldehyde
stoichiometric coefficient: 1.0

Reference/PathWhiz PW128220
type: UnificationXref
id: PW128220
db: PathWhiz

Reference/PubChem-compound 6047
type: UnificationXref
id: 6047
db: PubChem-compound

Reference/ChemSpider 952
type: UnificationXref
id: 952
db: ChemSpider

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Reference/ChemSpider 10189562
type: UnificationXref
id: 10189562
db: ChemSpider

Reference/ChemSpider 274
type: UnificationXref
id: 274
db: ChemSpider

Amine oxidase [flavin-containing] A
type: ProteinReference
xref: Reference/UniProt P21397
organism: BiologicalState789

Reference/ChemSpider 7991951
type: UnificationXref
id: 7991951
db: ChemSpider

ReactionCatalysis847
type: Catalysis
controller: Amine oxidase [flavin-containing] A
controlled: 1.4.3.4
control type: ACTIVATION

Reference/BioCyc TYR
type: UnificationXref
id: TYR
db: BioCyc

Norepinephrine
type: SmallMolecule
cellular location: Exocytic Vesicle
entity reference: Norepinephrine

Synaptic vesicular amine transporter
type: Protein
entity reference: Synaptic vesicular amine transporter

Presynaptic membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0042734

SubPathwayInteraction121182
type: Interaction
name: SubPathway121182Reaction
name: SubPathwayReaction
participant: Beta-1 adrenergic receptor

SubPathwayInteraction121181
type: Interaction
name: SubPathwayReaction
name: SubPathway121181Reaction
participant: Norepinephrine

SubPathwayInteraction121184
type: Interaction
name: SubPathway121184Reaction
name: SubPathwayReaction
participant: Alpha-2A adrenergic receptor

Compound/PW C000027 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dihydrobiopterin
stoichiometric coefficient: 1.0

Ammonia
type: SmallMolecule
cellular location: Cytosol
entity reference: Ammonia

SubPathwayInteraction121183
type: Interaction
name: SubPathway121183Reaction
name: SubPathwayReaction
participant: Alpha-1A adrenergic receptor

Reference/UniProt P35348
type: UnificationXref
id: P35348
db: UniProt

SubPathwayInteraction121180
type: Interaction
name: SubPathwayReaction
name: SubPathway121180Reaction
participant: Norepinephrine

Norepinephrine Alpha 1A Adrenergic Blood Vessel Relaxation Pathway
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway121180
pathway component: SubPathwayInteraction121180
xref: Reference/SMPDB SMP0125166
xref: Reference/PathWhiz PW126707
name: SubPathway

Reference/ChEBI CHEBI 16240
type: UnificationXref
id: CHEBI:16240
db: ChEBI

Compound/PW C000142 Synapse/Stoichiometry/1.0
type: Stoichiometry
physical entity: Norepinephrine
stoichiometric coefficient: 1.0

Methamphetamine
type: SmallMolecule
cellular location: Presynaptic membrane
entity reference: Methamphetamine

Reference/PubChem-compound 252
type: UnificationXref
id: 252
db: PubChem-compound

Sodium-dependent noradrenaline transporter
type: Protein
cellular location: Extracellular Space
entity reference: Sodium-dependent noradrenaline transporter

Sapropterin
type: SmallMolecule
cellular location: Cytosol
entity reference: Sapropterin

Norepinephrine
type: SmallMolecule
cellular location: post-synaptic membrane
entity reference: Norepinephrine

Dehydroascorbic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Dehydroascorbic acid

3,4-Dihydroxymandelaldehyde
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 27852
xref: Reference/PubChem-compound 151725
xref: Reference/ChemSpider 133725
xref: Reference/CAS 13023-73-9
xref: Reference/HMDB HMDB0006242
xref: Reference/KEGG Compound C05577
chemical formula: C8H8O4
molecular weight: 168.04225
structure: ChemicalStructure/PW C002683

Reference/SMPDB SMP0126618
type: UnificationXref
id: SMP0126618
db: SMPDB

Dopamine
type: SmallMolecule
cellular location: Cytosol
entity reference: Dopamine

Norepinephrine
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00547
xref: Reference/ChEBI CHEBI 18357
xref: Reference/CAS 51-41-2
xref: Reference/HMDB HMDB0000216
xref: Reference/PubChem-compound 439260
xref: Reference/ChemSpider 388394
xref: Reference/BioCyc NOREPINEPHRINE
chemical formula: C8H11NO3
molecular weight: 169.0739
structure: ChemicalStructure/PW C000142

Sapropterin
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000787
xref: Reference/KEGG Compound C00272
xref: Reference/ChEBI CHEBI 64491
xref: Reference/PubChem-compound 9816201
xref: Reference/ChemSpider 7991951
xref: Reference/CAS 62989-33-7
chemical formula: C9H15N5O3
molecular weight: 241.1175
structure: ChemicalStructure/PW C000627

Interaction4074
type: MolecularInteraction
interaction type: direct_interaction
name: Methamphetamine activates Alpha-2A adrenergic receptor
participant: Methamphetamine
participant: Alpha-2A adrenergic receptor

Interaction4073
type: MolecularInteraction
interaction type: direct_interaction
name: Methamphetamine inhibits Amine oxidase [flavin-containing] A
participant: Amine oxidase [flavin-containing] A
participant: Methamphetamine

Reference/ChEBI CHEBI 18357
type: UnificationXref
id: CHEBI:18357
db: ChEBI

Interaction4070
type: MolecularInteraction
interaction type: direct_interaction
name: Methamphetamine inhibits Sodium-dependent noradrenaline transporter
participant: Methamphetamine
participant: Sodium-dependent noradrenaline transporter

Reference/ChEBI CHEBI 15765
type: UnificationXref
id: CHEBI:15765
db: ChEBI

Interaction4072
type: MolecularInteraction
interaction type: direct_interaction
name: Methamphetamine activates Trace amine-associated receptor 1
participant: Trace amine-associated receptor 1
participant: Methamphetamine

Interaction4071
type: MolecularInteraction
interaction type: direct_interaction
name: Methamphetamine inhibits vesicular monoamine transporter 2
participant: Synaptic vesicular amine transporter
participant: Methamphetamine

Carbon dioxide
type: SmallMolecule
cellular location: Cytosol
entity reference: Carbon dioxide

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Reference/BioCyc CPD-6641
type: UnificationXref
id: CPD-6641
db: BioCyc

Reference/KEGG Compound C00355
type: UnificationXref
id: C00355
db: KEGG Compound

Reference/PubChem-compound 681
type: UnificationXref
id: 681
db: PubChem-compound

Reference/ChemSpider 217
type: UnificationXref
id: 217
db: ChemSpider

Transport14168
type: Transport
participant stoichiometry: Protein/1814 Presynaptic membrane/Stoichiometry/1.0
participant stoichiometry: Protein/1814 Cytosol/Stoichiometry/1.0
right: Sodium-dependent noradrenaline transporter
spontaneous: true
left: Sodium-dependent noradrenaline transporter
name: Sodium-dependent noradrenaline transporter (→) Transport: Homo sapiens, Brain, Neuron, Presynaptic membrane to Homo sapiens, Brain, Neuron, Cytosol
conversion direction: REVERSIBLE

Transport14167
type: Transport
participant stoichiometry: Compound/PW C009782 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C009782 Cytosol/Stoichiometry/1.0
right: Methamphetamine
spontaneous: false
left: Methamphetamine
name: Methamphetamine (→) Transport: Homo sapiens, Brain, Neuron, Extracellular Space to Homo sapiens, Brain, Neuron, Cytosol
conversion direction: LEFT_TO_RIGHT

Transport14164
type: Transport
participant stoichiometry: Compound/PW C009782 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C009782 Cytosol/Stoichiometry/1.0
right: Methamphetamine
spontaneous: true
left: Methamphetamine
name: Methamphetamine (→) Transport: Homo sapiens, Brain, Neuron, Extracellular Space to Homo sapiens, Brain, Neuron, Cytosol
conversion direction: REVERSIBLE

Transport14163
type: Transport
participant stoichiometry: Compound/PW C009782 Exocytic Vesicle/Stoichiometry/1.0
participant stoichiometry: Compound/PW C009782 Cytosol/Stoichiometry/1.0
right: Methamphetamine
spontaneous: false
left: Methamphetamine
name: Methamphetamine (→) Transport: Homo sapiens, Brain, Neuron, Cytosol to Homo sapiens, Brain, Neuron, Exocytic Vesicle
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0000216
type: UnificationXref
id: HMDB0000216
db: HMDB

Transport14165
type: Transport
participant stoichiometry: Compound/PW C000142 Exocytic Vesicle/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000142 Cytosol/Stoichiometry/1.0
right: Norepinephrine
spontaneous: true
left: Norepinephrine
name: Norepinephrine (→) Transport: Homo sapiens, Brain, Neuron, Exocytic Vesicle to Homo sapiens, Brain, Neuron, Cytosol
conversion direction: REVERSIBLE

Reference/CAS 124-38-9
type: UnificationXref
id: 124-38-9
db: CAS

1.4.3.4
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000035 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001783 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000142 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002683 Cytosol/Stoichiometry/1.0
right: Ammonia
right: Hydrogen peroxide
right: 3,4-Dihydroxymandelaldehyde
spontaneous: false
EC number: 1.4.3.4
left: Norepinephrine
left: Oxygen
left: Water
name: Norepinephrine + Oxygen + Water → 3,4-Dihydroxymandelaldehyde + Ammonia + Hydrogen peroxide
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C00007
type: UnificationXref
id: C00007
db: KEGG Compound

Norepinephrine
type: SmallMolecule
cellular location: Synapse
entity reference: Norepinephrine
name: SubPathwayInput

Reference/KEGG Compound C03758
type: UnificationXref
id: C03758
db: KEGG Compound

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/CAS 50-81-7
type: UnificationXref
id: 50-81-7
db: CAS

Trace amine-associated receptor 1
type: Protein
cellular location: Presynaptic membrane
entity reference: Trace amine-associated receptor 1

Alpha-2A adrenergic receptor
type: ProteinReference
xref: Reference/UniProt P08913
organism: BiologicalState789

Trace amine-associated receptor 1
type: ProteinReference
xref: Reference/UniProt Q96RJ0
organism: BiologicalState789

Reference/ChEBI CHEBI 18243
type: UnificationXref
id: CHEBI:18243
db: ChEBI

Epinephrine B2-Adrenergic Bronchodilation Pathway
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway121181
pathway component: SubPathwayInteraction121181
xref: Reference/SMPDB SMP0124452
xref: Reference/PathWhiz PW125908
name: SubPathway

ChemicalStructure/PW C000142
type: ChemicalStructure
structure format: SMILES
structure data: NC[C@H](O)C1=CC(O)=C(O)C=C1

Reference/UniProt P20711
type: UnificationXref
id: P20711
db: UniProt

ChemicalStructure/PW C002683
type: ChemicalStructure
structure format: SMILES
structure data: OC(C=O)C1=CC(O)=C(O)C=C1

Reference/ChemSpider 182283
type: UnificationXref
id: 182283
db: ChemSpider

Reference/PubChem-compound 10836
type: UnificationXref
id: 10836
db: PubChem-compound

Reference/PubChem-compound 9816201
type: UnificationXref
id: 9816201
db: PubChem-compound

Reference/CAS 7664-41-7
type: UnificationXref
id: 7664-41-7
db: CAS

Compound/PW C009782 Exocytic Vesicle/Stoichiometry/1.0
type: Stoichiometry
physical entity: Methamphetamine
stoichiometric coefficient: 1.0

Sodium-dependent noradrenaline transporter
type: ProteinReference
xref: Reference/UniProt P23975

Reference/CELL TYPE ONTOLOGY CL 0000540
type: UnificationXref
id: CL:0000540
db: CELL TYPE ONTOLOGY

Sodium-dependent noradrenaline transporter
type: Protein
cellular location: Cytosol
entity reference: Sodium-dependent noradrenaline transporter

Neuron
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000540

Reference/KEGG Compound C00011
type: UnificationXref
id: C00011
db: KEGG Compound

ChemicalStructure/PW C001316
type: ChemicalStructure
structure format: SMILES
structure data: O=C=O

Compound/PW C009782 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Methamphetamine
stoichiometric coefficient: 1.0

Methamphetamine
type: SmallMolecule
cellular location: Cytosol
entity reference: Methamphetamine

Dopamine beta-hydroxylase
type: ProteinReference
xref: Reference/UniProt P09172
organism: BiologicalState789

Reference/PubChem-compound 222
type: UnificationXref
id: 222
db: PubChem-compound

Reference/ChEBI CHEBI 17242
type: UnificationXref
id: CHEBI:17242
db: ChEBI

Reference/KEGG Compound C00014
type: UnificationXref
id: C00014
db: KEGG Compound

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Reference/ChEBI CHEBI 27852
type: UnificationXref
id: CHEBI:27852
db: ChEBI

Reference/UniProt P21397
type: UnificationXref
id: P21397
db: UniProt

Alpha-1A adrenergic receptor
type: Protein
cellular location: post-synaptic membrane
entity reference: Alpha-1A adrenergic receptor
name: SubPathwayInput

Methamphetamine
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 6809
xref: Reference/KEGG Compound C07164
xref: Reference/HMDB HMDB0015517
xref: Reference/CAS 537-46-2
xref: Reference/PubChem-compound 10836
xref: Reference/ChemSpider 10379
chemical formula: C10H15N
molecular weight: 149.12045
structure: ChemicalStructure/PW C009782

Protein/1814 Presynaptic membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sodium-dependent noradrenaline transporter
stoichiometric coefficient: 1.0

Dopamine
type: SmallMoleculeReference
xref: Reference/CAS 51-61-6
xref: Reference/KEGG Compound C03758
xref: Reference/ChemSpider 661
xref: Reference/BioCyc DOPAMINE
xref: Reference/HMDB HMDB0000073
xref: Reference/PubChem-compound 681
xref: Reference/ChEBI CHEBI 18243
chemical formula: C8H11NO2
molecular weight: 153.07898
structure: ChemicalStructure/PW C000052

Dehydroascorbic acid
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00425
xref: Reference/BioCyc L-DEHYDRO-ASCORBATE
xref: Reference/CAS 490-83-5
xref: Reference/ChemSpider 182283
xref: Reference/PubChem-compound 210328
xref: Reference/ChEBI CHEBI 17242
xref: Reference/HMDB HMDB0001264
chemical formula: C6H6O6
molecular weight: 174.01643
structure: ChemicalStructure/PW C000977

Gi Signalling Cascade
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway121184
pathway component: SubPathwayInteraction121184
name: SubPathway

Gq Signalling Cascade
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway121183
pathway component: SubPathwayInteraction121183
name: SubPathway

Gs Signalling cascade
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway121182
pathway component: SubPathwayInteraction121182
name: SubPathway

Methamphetamine Norepinephrine Reuptake Inhibitor Action Pathway
type: Pathway
pathway order: PathwayEnzymeReaction/2534483
pathway order: PathwayEnzymeReaction/2534488
pathway order: PathwayEnzymeReaction/2534486
pathway order: PathwayEnzymeReaction/2534487
pathway order: PathwayTransport/2534498
pathway order: PathwayTransport/2534499
pathway order: PathwayInteraction/3581
pathway order: PathwayInteraction/3141
pathway order: PathwayInteraction/3140
pathway order: PathwayInteraction/4074
pathway order: PathwayInteraction/4073
pathway order: PathwayInteraction/4072
pathway order: PathwayInteraction/4071
pathway order: PathwayInteraction/4070
pathway order: PathwayTransport/2534505
pathway order: PathwaySubPathway/121183
pathway order: PathwaySubPathway/121182
pathway order: PathwaySubPathway/121184
pathway order: PathwayInteraction/4028
pathway order: PathwaySubPathway/121181
pathway order: PathwayTransport/2534500
pathway order: PathwaySubPathway/121180
pathway order: PathwayTransport/2534501
pathway order: PathwayTransport/2534502
pathway order: PathwayTransport/2534503
pathway order: PathwayTransport/2534504
pathway component: Interaction4074
pathway component: ReactionCatalysis213
pathway component: Interaction4073
pathway component: Interaction3140
pathway component: Interaction3581
pathway component: Interaction3141
pathway component: Interaction4070
pathway component: 1.14.17.1
pathway component: Interaction4072
pathway component: Interaction4071
pathway component: Transport14168
pathway component: Transport14167
pathway component: Transport14164
pathway component: Transport14163
pathway component: Transport14165
pathway component: ReactionCatalysis847
pathway component: TransportCatalysis5069
pathway component: 1.4.3.4
pathway component: 1.14.16.2
pathway component: Gi Signalling Cascade
pathway component: Gq Signalling Cascade
pathway component: Gs Signalling cascade
pathway component: Norepinephrine Alpha 1A Adrenergic Blood Vessel Relaxation Pathway
pathway component: Interaction4028
pathway component: Epinephrine B2-Adrenergic Bronchodilation Pathway
pathway component: TransportCatalysis5071
pathway component: Transport14112
pathway component: Transport14115
pathway component: Transport14114
pathway component: TransportCatalysis5070
pathway component: 4.1.1.28
pathway component: TransportCatalysis5097
pathway component: ReactionCatalysis118
pathway component: ReactionCatalysis214
pathway component: TransportCatalysis5095
xref: Reference/PathWhiz PW128220
xref: Reference/SMPDB SMP0126618
organism: Homo sapiens

Alpha-2A adrenergic receptor
type: Protein
cellular location: post-synaptic membrane
entity reference: Alpha-2A adrenergic receptor
name: SubPathwayInput

Tyrosine 3-monooxygenase
type: Protein
cellular location: Cytosol
entity reference: Tyrosine 3-monooxygenase

ChemicalStructure/PW C000117
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CC1=CC=C(O)C(O)=C1)C(O)=O

Reference/KEGG Compound C00027
type: UnificationXref
id: C00027
db: KEGG Compound

Alpha-2A adrenergic receptor
type: Protein
cellular location: Synapse
entity reference: Alpha-2A adrenergic receptor

post-synaptic membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0045211

Reference/KEGG Compound C00272
type: UnificationXref
id: C00272
db: KEGG Compound

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Reference/PubChem-compound 54670067
type: UnificationXref
id: 54670067
db: PubChem-compound

3,4-Dihydroxymandelaldehyde
type: SmallMolecule
cellular location: Cytosol
entity reference: 3,4-Dihydroxymandelaldehyde

Methamphetamine
type: SmallMolecule
cellular location: Exocytic Vesicle
entity reference: Methamphetamine

Reference/ChEBI CHEBI 6809
type: UnificationXref
id: CHEBI:6809
db: ChEBI

Synaptic vesicular amine transporter
type: ProteinReference
xref: Reference/UniProt Q05940

Interaction3581
type: MolecularInteraction
interaction type: direct_interaction
name: Norepinephrine activates Alpha-2A adrenergic receptor
participant: Norepinephrine
participant: Alpha-2A adrenergic receptor

Beta-1 adrenergic receptor
type: Protein
cellular location: post-synaptic membrane
entity reference: Beta-1 adrenergic receptor
name: SubPathwayInput

Reference/BRENDA TISSUE ONTOLOGY BTO 0000142
type: UnificationXref
id: BTO:0000142
db: BRENDA TISSUE ONTOLOGY

ChemicalStructure/PW C000052
type: ChemicalStructure
structure format: SMILES
structure data: NCCC1=CC(O)=C(O)C=C1

Reference/BioCyc HYDROGEN-PEROXIDE
type: UnificationXref
id: HYDROGEN-PEROXIDE
db: BioCyc

Reference/PubChem-compound 210328
type: UnificationXref
id: 210328
db: PubChem-compound

Compound/PW C000142 Exocytic Vesicle/Stoichiometry/1.0
type: Stoichiometry
physical entity: Norepinephrine
stoichiometric coefficient: 1.0

Reference/BioCyc BIOPTERIN
type: UnificationXref
id: BIOPTERIN
db: BioCyc

ChemicalStructure/PW C009782
type: ChemicalStructure
structure format: SMILES
structure data: CN[C@@H](C)CC1=CC=CC=C1

Reference/UniProt P08913
type: UnificationXref
id: P08913
db: UniProt

Compound/PW C000977 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dehydroascorbic acid
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0015517
type: UnificationXref
id: HMDB0015517
db: HMDB

Reference/UniProt Q05940
type: UnificationXref
id: Q05940
db: UniProt

Protein/1814 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sodium-dependent noradrenaline transporter
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000977
type: ChemicalStructure
structure format: SMILES
structure data: [H][C@@]1(OC(=O)C(=O)C1=O)[C@H](O)CO

Reference/GENE ONTOLOGY GO 0045211
type: UnificationXref
id: GO:0045211
db: GENE ONTOLOGY

Transport14112
type: Transport
participant stoichiometry: Compound/PW C000142 Exocytic Vesicle/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000142 Cytosol/Stoichiometry/1.0
right: Norepinephrine
spontaneous: false
left: Norepinephrine
name: Norepinephrine (→) Transport: Homo sapiens, Brain, Neuron, Cytosol to Homo sapiens, Brain, Neuron, Exocytic Vesicle
conversion direction: LEFT_TO_RIGHT

Reference/ChemSpider 763
type: UnificationXref
id: 763
db: ChemSpider

Transport14115
type: Transport
participant stoichiometry: Compound/PW C000142 Synapse/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000142 Cytosol/Stoichiometry/1.0
right: Norepinephrine
spontaneous: false
left: Norepinephrine
name: Norepinephrine (→) Transport: Homo sapiens, Brain, Neuron, Synapse to Homo sapiens, Brain, Neuron, Cytosol
conversion direction: LEFT_TO_RIGHT

Transport14114
type: Transport
participant stoichiometry: Compound/PW C000142 Synapse/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000142 Cytosol/Stoichiometry/1.0
right: Norepinephrine
spontaneous: false
left: Norepinephrine
name: Norepinephrine (→) Transport: Homo sapiens, Brain, Neuron, Cytosol to Homo sapiens, Brain, Neuron, Synapse
conversion direction: LEFT_TO_RIGHT

Reference/CAS 59-92-7
type: UnificationXref
id: 59-92-7
db: CAS

TransportCatalysis5097
type: Catalysis
controller: Sodium-dependent noradrenaline transporter
controlled: Transport14167
control type: ACTIVATION

Reference/HMDB HMDB0006242
type: UnificationXref
id: HMDB0006242
db: HMDB

TransportCatalysis5095
type: Catalysis
controller: Synaptic vesicular amine transporter
controlled: Transport14163
control type: ACTIVATION

ReactionCatalysis213
type: Catalysis
controller: Tyrosine 3-monooxygenase
controlled: 1.14.16.2
control type: ACTIVATION

Reference/PubChem-compound 784
type: UnificationXref
id: 784
db: PubChem-compound

Reference/CAS 51-61-6
type: UnificationXref
id: 51-61-6
db: CAS

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

Reference/PathWhiz PW125908
type: UnificationXref
id: PW125908
db: PathWhiz

ChemicalStructure/PW C000027
type: ChemicalStructure
structure format: SMILES

Reference/CAS 62989-33-7
type: UnificationXref
id: 62989-33-7
db: CAS

Compound/PW C000627 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sapropterin
stoichiometric coefficient: 1.0

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Ascorbic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Ascorbic acid

Reference/HMDB HMDB0000158
type: UnificationXref
id: HMDB0000158
db: HMDB

Oxygen
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001377
xref: Reference/ChemSpider 952
xref: Reference/KEGG Compound C00007
xref: Reference/ChEBI CHEBI 15379
xref: Reference/PubChem-compound 977
xref: Reference/BioCyc CPD-6641
xref: Reference/CAS 7782-44-7
chemical formula: O2
molecular weight: 31.98983
structure: ChemicalStructure/PW C001065

ChemicalStructure/PW C000031
type: ChemicalStructure
structure format: SMILES
structure data: [H][C@@]1(OC(=O)C(O)=C1O)[C@@H](O)CO

Reference/HMDB HMDB0000038
type: UnificationXref
id: HMDB0000038
db: HMDB

Exocytic Vesicle
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0070382

Reference/BioCyc AMMONIA
type: UnificationXref
id: AMMONIA
db: BioCyc

ChemicalStructure/PW C000035
type: ChemicalStructure
structure format: SMILES
structure data: N

Reference/PubChem-compound 151725
type: UnificationXref
id: 151725
db: PubChem-compound

Dihydrobiopterin
type: SmallMolecule
cellular location: Cytosol
entity reference: Dihydrobiopterin

Reference/CAS 13023-73-9
type: UnificationXref
id: 13023-73-9
db: CAS

Water
type: SmallMolecule
cellular location: Cytosol
entity reference: Water

Reference/BioCyc NOREPINEPHRINE
type: UnificationXref
id: NOREPINEPHRINE
db: BioCyc

1.14.16.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000103 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000117 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000027 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000627 Cytosol/Stoichiometry/1.0
right: L-Dopa
right: Dihydrobiopterin
right: Water
spontaneous: false
EC number: 1.14.16.2
left: Sapropterin
left: Oxygen
left: L-Tyrosine
name: L-Tyrosine + Oxygen + Sapropterin → Dihydrobiopterin + L-Dopa + Water
conversion direction: LEFT_TO_RIGHT

Reference/CAS 60-18-4
type: UnificationXref
id: 60-18-4
db: CAS

Reference/BioCyc DOPAMINE
type: UnificationXref
id: DOPAMINE
db: BioCyc

Reference/ChEBI CHEBI 16526
type: UnificationXref
id: CHEBI:16526
db: ChEBI

Reference/UniProt Q96RJ0
type: UnificationXref
id: Q96RJ0
db: UniProt

Compound/PW C009782 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Methamphetamine
stoichiometric coefficient: 1.0

Reference/CAS 7782-44-7
type: UnificationXref
id: 7782-44-7
db: CAS

Reference/HMDB HMDB0001377
type: UnificationXref
id: HMDB0001377
db: HMDB

Compound/PW C000035 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ammonia
stoichiometric coefficient: 1.0

Reference/ChemSpider 661
type: UnificationXref
id: 661
db: ChemSpider

Reference/KEGG Compound C00072
type: UnificationXref
id: C00072
db: KEGG Compound

Amine oxidase [flavin-containing] A
type: Protein
cellular location: Cytosol
entity reference: Amine oxidase [flavin-containing] A

Compound/PW C001420 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000044
type: UnificationXref
id: HMDB0000044
db: HMDB

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Interaction3140
type: MolecularInteraction
interaction type: direct_interaction
name: Norepinephrine activates Alpha-1A adrenergic receptor
participant: Norepinephrine
participant: Alpha-1A adrenergic receptor

Interaction3141
type: MolecularInteraction
interaction type: direct_interaction
name: Norepinephrine activates Beta-1 adrenergic receptor
participant: Norepinephrine
participant: Beta-1 adrenergic receptor

Compound/PW C001783 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen peroxide
stoichiometric coefficient: 1.0

Reference/UniProt P07101
type: UnificationXref
id: P07101
db: UniProt

L-Tyrosine
type: SmallMoleculeReference
xref: Reference/CAS 60-18-4
xref: Reference/PubChem-compound 6057
xref: Reference/HMDB HMDB0000158
xref: Reference/ChEBI CHEBI 17895
xref: Reference/KEGG Compound C00082
xref: Reference/ChemSpider 5833
xref: Reference/BioCyc TYR
chemical formula: C9H11NO3
molecular weight: 181.0739
structure: ChemicalStructure/PW C000103

Reference/ChEBI CHEBI 64491
type: UnificationXref
id: CHEBI:64491
db: ChEBI

Reference/CAS 537-46-2
type: UnificationXref
id: 537-46-2
db: CAS

Beta-1 adrenergic receptor
type: ProteinReference
xref: Reference/UniProt P08588
organism: BiologicalState789

Reference/ChemSpider 388394
type: UnificationXref
id: 388394
db: ChemSpider

Carbon dioxide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 280
xref: Reference/ChEBI CHEBI 16526
xref: Reference/ChemSpider 274
xref: Reference/HMDB HMDB0001967
xref: Reference/CAS 124-38-9
xref: Reference/KEGG Compound C00011
chemical formula: CO2
molecular weight: 43.98983
structure: ChemicalStructure/PW C001316

Hydrogen peroxide
type: SmallMolecule
cellular location: Cytosol
entity reference: Hydrogen peroxide

Compound/PW C000031 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ascorbic acid
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001065
type: ChemicalStructure
structure format: SMILES
structure data: O=O

Reference/KEGG Compound C00082
type: UnificationXref
id: C00082
db: KEGG Compound

Reference/HMDB HMDB0000051
type: UnificationXref
id: HMDB0000051
db: HMDB

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Reference/HMDB HMDB0001264
type: UnificationXref
id: HMDB0001264
db: HMDB

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/PubChem-compound 6057
type: UnificationXref
id: 6057
db: PubChem-compound

Norepinephrine
type: SmallMolecule
cellular location: Cytosol
entity reference: Norepinephrine

Reference/ChEBI CHEBI 15379
type: UnificationXref
id: CHEBI:15379
db: ChEBI

L-Dopa
type: SmallMoleculeReference
xref: Reference/ChemSpider 5824
xref: Reference/CAS 59-92-7
xref: Reference/ChEBI CHEBI 15765
xref: Reference/HMDB HMDB0000181
xref: Reference/BioCyc L-DOPA
xref: Reference/KEGG Compound C00355
xref: Reference/PubChem-compound 6047
chemical formula: C9H11NO4
molecular weight: 197.0688
structure: ChemicalStructure/PW C000117

Reference/PathWhiz PW126707
type: UnificationXref
id: PW126707
db: PathWhiz

Oxygen
type: SmallMolecule
cellular location: Cytosol
entity reference: Oxygen

Reference/BioCyc L-DEHYDRO-ASCORBATE
type: UnificationXref
id: L-DEHYDRO-ASCORBATE
db: BioCyc

Reference/KEGG Compound C07164
type: UnificationXref
id: C07164
db: KEGG Compound

Reference/PubChem-compound 280
type: UnificationXref
id: 280
db: PubChem-compound

Reference/CAS 490-83-5
type: UnificationXref
id: 490-83-5
db: CAS

Reference/HMDB HMDB0000181
type: UnificationXref
id: HMDB0000181
db: HMDB

Compound/PW C000142 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Norepinephrine
stoichiometric coefficient: 1.0

Reference/ChemSpider 10379
type: UnificationXref
id: 10379
db: ChemSpider

ReactionCatalysis214
type: Catalysis
controller: Aromatic-L-amino-acid decarboxylase
controlled: 4.1.1.28
control type: ACTIVATION

Reference/ChemSpider 5824
type: UnificationXref
id: 5824
db: ChemSpider

Reference/ChEBI CHEBI 64277
type: UnificationXref
id: CHEBI:64277
db: ChEBI

Compound/PW C000117 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Dopa
stoichiometric coefficient: 1.0

Methamphetamine
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Methamphetamine

Reference/ChEBI CHEBI 29073
type: UnificationXref
id: CHEBI:29073
db: ChEBI

Reference/PubChem-compound 439260
type: UnificationXref
id: 439260
db: PubChem-compound

Reference/ChemSpider 133725
type: UnificationXref
id: 133725
db: ChemSpider

Reference/KEGG Compound C02953
type: UnificationXref
id: C02953
db: KEGG Compound

ChemicalStructure/PW C000627
type: ChemicalStructure
structure format: SMILES

Reference/CAS 6779-87-9
type: UnificationXref
id: 6779-87-9
db: CAS

Reference/UniProt P23975
type: UnificationXref
id: P23975
db: UniProt

L-Dopa
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Dopa

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Hydrogen peroxide
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0003125
xref: Reference/PubChem-compound 784
xref: Reference/ChemSpider 763
xref: Reference/CAS 7722-84-1
xref: Reference/BioCyc HYDROGEN-PEROXIDE
xref: Reference/ChEBI CHEBI 16240
xref: Reference/KEGG Compound C00027
chemical formula: H2O2
molecular weight: 34.005478
structure: ChemicalStructure/PW C001783

TransportCatalysis5069
type: Catalysis
controller: Synaptic vesicular amine transporter
controlled: Transport14112
control type: ACTIVATION

Methamphetamine
type: SmallMolecule
cellular location: Synapse
entity reference: Methamphetamine

Reference/HMDB HMDB0000073
type: UnificationXref
id: HMDB0000073
db: HMDB

Reference/GENE ONTOLOGY GO 0042734
type: UnificationXref
id: GO:0042734
db: GENE ONTOLOGY

Dopamine beta-hydroxylase
type: Protein
cellular location: Cytosol
entity reference: Dopamine beta-hydroxylase

Reference/GENE ONTOLOGY GO 0045202
type: UnificationXref
id: GO:0045202
db: GENE ONTOLOGY

Reference/KEGG Compound C00547
type: UnificationXref
id: C00547
db: KEGG Compound

Reference/SMPDB SMP0125166
type: UnificationXref
id: SMP0125166
db: SMPDB

Reference/ChEBI CHEBI 17895
type: UnificationXref
id: CHEBI:17895
db: ChEBI

Reference/KEGG Compound C00425
type: UnificationXref
id: C00425
db: KEGG Compound

Reference/PubChem-compound 977
type: UnificationXref
id: 977
db: PubChem-compound

Compound/PW C001316 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

Reference/UniProt P08588
type: UnificationXref
id: P08588
db: UniProt

Reference/HMDB HMDB0001967
type: UnificationXref
id: HMDB0001967
db: HMDB

Reference/BioCyc ASCORBATE
type: UnificationXref
id: ASCORBATE
db: BioCyc

TransportCatalysis5071
type: Catalysis
controller: Sodium-dependent noradrenaline transporter
controlled: Transport14115
control type: ACTIVATION

TransportCatalysis5070
type: Catalysis
controller: Sodium-dependent noradrenaline transporter
controlled: Transport14114
control type: ACTIVATION

4.1.1.28
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000117 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000052 Cytosol/Stoichiometry/1.0
right: Carbon dioxide
right: Dopamine
spontaneous: false
EC number: 4.1.1.28
left: L-Dopa
name: L-Dopa → Carbon dioxide + Dopamine
conversion direction: LEFT_TO_RIGHT

ReactionCatalysis118
type: Catalysis
controller: Dopamine beta-hydroxylase
controlled: 1.14.17.1
control type: ACTIVATION

Aromatic-L-amino-acid decarboxylase
type: Protein
cellular location: Cytosol
entity reference: Aromatic-L-amino-acid decarboxylase

Synapse
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0045202