Loader
Loading Pathway...
Glutamate receptor 1 Glutamate receptor 2 Glutamate [NMDA] receptor subunit epsilon-1 Glutamate [NMDA] receptor subunit zeta-1 Glutamate [NMDA] receptor subunit epsilon-3 Glutamate [NMDA] receptor subunit epsilon-2 Glutamate [NMDA] receptor subunit epsilon-4 Glutamate [NMDA] receptor subunit 3A Glutamate [NMDA] receptor subunit 3B Sodium channel protein type 5 subunit alpha Voltage- dependent T-type calcium channel subunit alpha-1H Voltage- dependent T-type calcium channel subunit alpha-1G Potassium voltage-gated channel subfamily D member 2 Kv channel- interacting protein 2 Voltage- dependent T-type calcium channel subunit alpha-1H Voltage- dependent T-type calcium channel subunit alpha-1G Glutamate Zonisamide K+ K+ Glutamate Na+ Na+ Ca+ Ca+ Ca+ Ca+ Na+ Na+ Ca+ Ca+ Zonisamide Zonisamide Depolarization axon width = 9 Presynaptic Neuron Post-synaptic Neuron Since no action potential arrives to the nerve terminal, calcium entry does not occur and neurotransmitters like glutamate are not released from synaptic vesicles into the synapse. Zonisamide blocks both sodium and calcium channels, preventing the entry of sodium and calcium into the neuron. Membrane Potential (mV) 0 40 -70 Hyperpolarization Repolarization Peak action potential Resting potential The depolarization phase of the action potential is inhibited, therefore, the action potential cannot be generated. ACTION POTENTIAL Time (ms) Synaptic Vesicle The post synaptic neuron is unable to depolarize due to the inhibition of neurotransmitter release Zonisamide is administered as an oral capsule
Mitochondria GRIA1 GRIA2 GRIN2A GRIN1 GRIN2C GRIN2B GRIN2D GRIN3A GRIN3B SCN5A CACNA1H CACNA1G KCND2 KCNIP2 CACNA1H CACNA1G Glutamate Zonisamide Potassium Potassium Glutamate Sodium Sodium Calcium Calcium Calcium Calcium Sodium Sodium Calcium Calcium Zonisamide Zonisamide
GRIA1 GRIA2 GRIN2A GRIN1 GRIN2C GRIN2B GRIN2D GRIN3A GRIN3B SCN5A CACNA1H CACNA1G KCND2 KCNIP2 CACNA1H CACNA1G Gluta Zonisam K+ K+ Gluta Na+ Na+ Ca+ Ca+ Ca+ Ca+ Na+ Na+ Ca+ Ca+ Zonisam Zonisam Depolarization axon width = 9 Presynaptic Neuron Post-synaptic Neuron Since no action potential arrives to the nerve terminal, calcium entry does not occur and neurotransmitters like glutamate are not released from synaptic vesicles into the synapse. Zonisamide blocks both sodium and calcium channels, preventing the entry of sodium and calcium into the neuron. Membrane Potential (mV) 0 40 -70 Hyperpolarization Repolarization Peak action potential Resting potential The depolarization phase of the action potential is inhibited, therefore, the action potential cannot be generated. ACTION POTENTIAL Time (ms) Synaptic Vesicle The post synaptic neuron is unable to depolarize due to the inhibition of neurotransmitter release Zonisamide is administered as an oral capsule
Mitochondria GRIA1 GRIA2 GRIN2A GRIN1 GRIN2C GRIN2B GRIN2D GRIN3A GRIN3B SCN5A CACNA1H CACNA1G KCND2 KCNIP2 CACNA1H CACNA1G Gluta Zonisam K+ K+ Gluta Na+ Na+ Ca2+ Ca2+ Ca2+ Ca2+ Na+ Na+ Ca2+ Ca2+ Zonisam Zonisam