Reference/ChemSpider 388357
type: UnificationXref
id: 388357
db: ChemSpider

Reference/ChemSpider 17215925
type: UnificationXref
id: 17215925
db: ChemSpider

Compound/PW C040034 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Acetyl-CoA
type: SmallMoleculeReference
xref: Reference/BioCyc ACETYL-COA
xref: Reference/PubChem-compound 444493
xref: Reference/HMDB HMDB0001206
xref: Reference/ChemSpider 392413
xref: Reference/CAS 72-89-9
xref: Reference/ChEBI CHEBI 15351
xref: Reference/KEGG Compound C00024
chemical formula: C23H38N7O17P3S
molecular weight: 809.1258
structure: ChemicalStructure/PW C000940

Reaction212814
type: BiochemicalReaction
participant stoichiometry: Protein/23389/Stoichiometry/1.0
participant stoichiometry: DNA/47/Stoichiometry/1.0
participant stoichiometry: BoundComplex/517/Stoichiometry/1.0
right: Sterol regulatory element-binding protein 1 (Homo sapiens)_Promoter
spontaneous: false
left: Promoter
left: Sterol regulatory element-binding protein 1
name: Promoter + Sterol regulatory element-binding protein 1 → Sterol regulatory element-binding protein 1 (Homo sapiens) + Promoter
conversion direction: LEFT_TO_RIGHT

Sterol regulatory element-binding protein cleavage-activating protein
type: Protein
cellular location: Golgi Apparatus
entity reference: Sterol regulatory element-binding protein cleavage-activating protein

Protein/23389 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sterol regulatory element-binding protein 1
stoichiometric coefficient: 1.0

Reference/ChemSpider 388353
type: UnificationXref
id: 388353
db: ChemSpider

SCAP/SREBF
type: Complex
cellular location: Endoplasmic Reticulum Membrane
component: Sterol regulatory element-binding protein cleavage-activating protein
component: Sterol regulatory element-binding protein 1

direct_interaction
type: InteractionVocabulary

Reference/BioCyc CHOLESTEROL
type: UnificationXref
id: CHOLESTEROL
db: BioCyc

SCAP/SREBF
type: Complex
cellular location: Golgi Apparatus
component: Sterol regulatory element-binding protein 1
component: Sterol regulatory element-binding protein cleavage-activating protein

Acetoacetyl-CoA
type: SmallMolecule
entity reference: Acetoacetyl-CoA

Reaction212815
type: BiochemicalReaction
participant stoichiometry: Protein/1764/Stoichiometry/1.0
participant stoichiometry: DNA/343/Stoichiometry/1.0
right: Low-density lipoprotein receptor
spontaneous: false
left: Low-density lipoprotein receptor
name: Low-density lipoprotein receptor → Low-density lipoprotein receptor
conversion direction: LEFT_TO_RIGHT

Unknown
type: ProteinReference

Acetyl-CoA
type: SmallMolecule
cellular location: Cytosol
entity reference: Acetyl-CoA

Pitavastatin
type: SmallMoleculeReference
xref: Reference/PubChem-compound 5282452
xref: Reference/HMDB HMDB0041991
xref: Reference/ChEBI CHEBI 32020
xref: Reference/KEGG Compound C13334
xref: Reference/ChemSpider 4445604
xref: Reference/CAS 147511-69-1
chemical formula: C25H24FNO4
molecular weight: 421.16895
structure: ChemicalStructure/PW C022726

Pitavastatin
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: Pitavastatin

Cholesterol
type: SmallMolecule
entity reference: Cholesterol
name: SubPathwayOutput

Membrane-bound transcription factor site-1 protease
type: ProteinReference
xref: Reference/UniProt Q14703
organism: Homo sapiens

Sterol regulatory element-binding protein cleavage-activating protein
type: Protein
entity reference: Sterol regulatory element-binding protein cleavage-activating protein

Reference/PubChem-compound 6816
type: UnificationXref
id: 6816
db: PubChem-compound

Glycolysis
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway121324
pathway component: SubPathwayInteraction121324
xref: Reference/SMPDB SMP0000040
xref: Reference/PathWhiz PW000146
name: SubPathway

Sterol regulatory element-binding protein 1
type: Protein
cellular location: Golgi Apparatus
entity reference: Sterol regulatory element-binding protein 1

Cholesterol
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000067
xref: Reference/ChEBI CHEBI 16113
xref: Reference/BioCyc CHOLESTEROL
xref: Reference/KEGG Compound C00187
xref: Reference/ChemSpider 5775
xref: Reference/PubChem-compound 5997
xref: Reference/CAS 57-88-5
chemical formula: C27H46O
molecular weight: 386.35486
structure: ChemicalStructure/PW C000047

Insulin-induced gene 1 protein
type: Protein
entity reference: Insulin-induced gene 1 protein

Reference/ChEBI CHEBI 16113
type: UnificationXref
id: CHEBI:16113
db: ChEBI

Reference/CAS 1553-55-5
type: UnificationXref
id: 1553-55-5
db: CAS

Reference/CAS 53-59-8
type: UnificationXref
id: 53-59-8
db: CAS

DNA/343/Stoichiometry/1.0
type: Stoichiometry
physical entity: Low-density lipoprotein receptor
stoichiometric coefficient: 1.0

Sterol regulatory element-binding protein 1 (Homo sapiens)_Promoter
type: Complex
component stoichiometry: Protein/23389/Stoichiometry/1.0
component stoichiometry: DNA/47/Stoichiometry/1.0
component: Promoter
component: Sterol regulatory element-binding protein 1

Compound/PW C000940/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetyl-CoA
stoichiometric coefficient: 1.0

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

Reference/PubChem-compound 5997
type: UnificationXref
id: 5997
db: PubChem-compound

Promoter
type: DnaReference

Reference/KEGG Compound C00332
type: UnificationXref
id: C00332
db: KEGG Compound

Reference/ChEBI CHEBI 16474
type: UnificationXref
id: CHEBI:16474
db: ChEBI

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Importin subunit beta-1
type: Protein
entity reference: Importin subunit beta-1

Reference/GENE ONTOLOGY GO 0000139
type: UnificationXref
id: GO:0000139
db: GENE ONTOLOGY

Sterol regulatory element-binding protein 1
type: Protein
entity reference: Sterol regulatory element-binding protein 1

3-hydroxymethyl-3-methylglutaryl-CoA lyase, cytoplasmic
type: ProteinReference
xref: Reference/UniProt Q8TB92
organism: Homo sapiens

Acetyl-CoA
type: SmallMolecule
entity reference: Acetyl-CoA
name: SubPathwayOutput

Compound/PW C001142 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetoacetyl-CoA
stoichiometric coefficient: 1.0

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

ChemicalStructure/PW C001099
type: ChemicalStructure
structure format: SMILES

Low-density lipoprotein receptor
type: Dna
entity reference: Low-density lipoprotein receptor

Hydroxymethylglutaryl-CoA synthase, cytoplasmic
type: Protein
entity reference: Hydroxymethylglutaryl-CoA synthase, cytoplasmic

NADPH
type: SmallMoleculeReference
xref: Reference/CAS 53-57-6
xref: Reference/HMDB HMDB0000221
xref: Reference/PubChem-compound 22833512
xref: Reference/BioCyc NADPH
xref: Reference/ChemSpider 17215925
xref: Reference/KEGG Compound C00005
xref: Reference/ChEBI CHEBI 16474
chemical formula: C21H30N7O17P3
molecular weight: 745.0911
structure: ChemicalStructure/PW C000146

Hydrogen Ion
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: Hydrogen Ion

Reference/HMDB HMDB0041991
type: UnificationXref
id: HMDB0041991
db: HMDB

NADP
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00006
xref: Reference/CAS 53-59-8
xref: Reference/BioCyc NAD(P)
xref: Reference/HMDB HMDB0000217
xref: Reference/ChEBI CHEBI 18009
xref: Reference/PubChem-compound 5886
xref: Reference/ChemSpider 5675
chemical formula: C21H28N7O17P3
molecular weight: 743.07544
structure: ChemicalStructure/PW C000143

Low-density lipoprotein receptor
type: Protein
cellular location: Nucleoplasm
entity reference: Low-density lipoprotein receptor

Protein/36 Cytosol/Stoichiometry/4.0
type: Stoichiometry
physical entity: Acetyl-CoA acetyltransferase, mitochondrial
stoichiometric coefficient: 4.0

Pitavastatin
type: SmallMolecule
entity reference: Pitavastatin

Reference/BioCyc NADPH
type: UnificationXref
id: NADPH
db: BioCyc

ReactionCatalysis202795
type: Catalysis
controller: 3-hydroxymethyl-3-methylglutaryl-CoA lyase, cytoplasmic
controlled: 4.1.3.4
control type: ACTIVATION

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

DNA/47/Stoichiometry/1.0
type: Stoichiometry
physical entity: Promoter
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00356
type: UnificationXref
id: C00356
db: KEGG Compound

3-hydroxymethyl-3-methylglutaryl-CoA lyase, cytoplasmic
type: Protein
cellular location: Endoplasmic Reticulum
entity reference: 3-hydroxymethyl-3-methylglutaryl-CoA lyase, cytoplasmic

Hydroxymethylglutaryl-CoA synthase, cytoplasmic
type: Complex
component stoichiometry: Protein/51/Stoichiometry/2.0
component: Hydroxymethylglutaryl-CoA synthase, cytoplasmic

ChemicalStructure/PW C109113
type: ChemicalStructure
structure format: SMILES
structure data: C[C@@](O)(CCO)CC(O)=O

Reference/SMPDB SMP0000040
type: UnificationXref
id: SMP0000040
db: SMPDB

Reference/HMDB HMDB0001423
type: UnificationXref
id: HMDB0001423
db: HMDB

3-Hydroxy-3-methylglutaryl-CoA
type: SmallMolecule
entity reference: 3-Hydroxy-3-methylglutaryl-CoA

Reference/HMDB HMDB0000217
type: UnificationXref
id: HMDB0000217
db: HMDB

Insulin-induced gene 1 protein
type: ProteinReference
xref: Reference/UniProt O15503

Reference/GENE ONTOLOGY GO 0005886
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

Membrane-bound transcription factor site-2 protease
type: ProteinReference
xref: Reference/UniProt O43462
organism: Homo sapiens

Reference/ChemSpider 4445604
type: UnificationXref
id: 4445604
db: ChemSpider

Reference/KEGG Compound C00006
type: UnificationXref
id: C00006
db: KEGG Compound

Interaction5032
type: MolecularInteraction
interaction type: direct_interaction
name: Pitavastatin inhibits HMG-CoA reductase
participant: Pitavastatin
participant: 3-hydroxymethyl-3-methylglutaryl-CoA lyase, cytoplasmic

Compound/PW C000940 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetyl-CoA
stoichiometric coefficient: 1.0

ProteinComplex/14191/Stoichiometry/1.0
type: Stoichiometry
physical entity: INSIG/SCAP/SREBF
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 18009
type: UnificationXref
id: CHEBI:18009
db: ChEBI

ReactionCatalysis202444
type: Catalysis
controller: Membrane-bound transcription factor site-1 protease
controlled: 3.4.21.112
control type: ACTIVATION

NADP
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: NADP

ReactionCatalysis202445
type: Catalysis
controller: Membrane-bound transcription factor site-2 protease
controlled: 3.4.21.112
control type: ACTIVATION

Reference/KEGG Compound C00005
type: UnificationXref
id: C00005
db: KEGG Compound

NADPH
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: NADPH

Acetyl-CoA acetyltransferase, mitochondrial
type: ProteinReference
xref: Reference/UniProt P24752
organism: Homo sapiens

ChemicalStructure/PW C000143
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000221
type: UnificationXref
id: HMDB0000221
db: HMDB

Sterol regulatory element-binding protein cleavage-activating protein
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: Sterol regulatory element-binding protein cleavage-activating protein

Acetoacetyl-CoA
type: SmallMolecule
cellular location: Cytosol
entity reference: Acetoacetyl-CoA

ChemicalStructure/PW C000146
type: ChemicalStructure
structure format: SMILES

ProteinComplex/14189 Golgi Apparatus Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: SCAP/SREBF
stoichiometric coefficient: 1.0

Reference/UniProt P24752
type: UnificationXref
id: P24752
db: UniProt

Reference/GENE ONTOLOGY GO 0005634
type: UnificationXref
id: GO:0005634
db: GENE ONTOLOGY

Reference/CAS 57-88-5
type: UnificationXref
id: 57-88-5
db: CAS

Reference/UniProt Q14974
type: UnificationXref
id: Q14974
db: UniProt

Reference/CAS 53-57-6
type: UnificationXref
id: 53-57-6
db: CAS

Reference/SMPDB SMP0126665
type: UnificationXref
id: SMP0126665
db: SMPDB

Compound/PW C001063 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-Hydroxy-3-methylglutaryl-CoA
stoichiometric coefficient: 1.0

Reference/PathWhiz PW128268
type: UnificationXref
id: PW128268
db: PathWhiz

Sterol regulatory element-binding protein cleavage-activating protein
type: ProteinReference
xref: Reference/UniProt Q12770

Reference/KEGG Compound C00010
type: UnificationXref
id: C00010
db: KEGG Compound

TransportCatalysis5905
type: Catalysis
controller: Solute carrier organic anion transporter family member 1B1
controlled: Transport15885
control type: ACTIVATION

Compound/PW C022726/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pitavastatin
stoichiometric coefficient: 1.0

Acetoacetyl-CoA
type: SmallMoleculeReference
xref: Reference/BioCyc ACETOACETYL-COA
xref: Reference/PubChem-compound 439214
xref: Reference/ChEBI CHEBI 15345
xref: Reference/CAS 1420-36-6
xref: Reference/HMDB HMDB0001484
xref: Reference/KEGG Compound C00332
xref: Reference/ChemSpider 388353
chemical formula: C25H40N7O18P3S
molecular weight: 851.13635
structure: ChemicalStructure/PW C001142

Reference/BioCyc NAD(P)
type: UnificationXref
id: NAD(P)
db: BioCyc

Acetyl-CoA acetyltransferase, mitochondrial
type: Complex
component stoichiometry: Protein/36 Cytosol/Stoichiometry/4.0
cellular location: Cytosol
component: Acetyl-CoA acetyltransferase, mitochondrial

Reference/BioCyc 3-HYDROXY-3-METHYL-GLUTARYL-COA
type: UnificationXref
id: 3-HYDROXY-3-METHYL-GLUTARYL-COA
db: BioCyc

Reference/HMDB HMDB0001206
type: UnificationXref
id: HMDB0001206
db: HMDB

Reference/UniProt O15503
type: UnificationXref
id: O15503
db: UniProt

Solute carrier organic anion transporter family member 1B1
type: Protein
entity reference: Solute carrier organic anion transporter family member 1B1

Protein/23389 Golgi Apparatus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sterol regulatory element-binding protein 1
stoichiometric coefficient: 1.0

2.3.3.10
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001142/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000940/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001063/Stoichiometry/1.0
right: 3-Hydroxy-3-methylglutaryl-CoA
spontaneous: false
EC number: 2.3.3.10
left: Acetoacetyl-CoA
left: Acetyl-CoA
name: Acetoacetyl-CoA + Acetyl-CoA → 3-Hydroxy-3-methylglutaryl-CoA
conversion direction: LEFT_TO_RIGHT

Reference/UniProt Q14703
type: UnificationXref
id: Q14703
db: UniProt

Mevalonate
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: Mevalonate

Reference/UniProt Q12770
type: UnificationXref
id: Q12770
db: UniProt

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Reaction212802
type: BiochemicalReaction
participant stoichiometry: ProteinComplex/14191/Stoichiometry/1.0
participant stoichiometry: Protein/23390/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/14189/Stoichiometry/1.0
right: Insulin-induced gene 1 protein
right: SCAP/SREBF
spontaneous: false
left: INSIG/SCAP/SREBF
name: INSIG/SCAP/SREBF → Insulin-induced gene 1 protein + SCAP/SREBF
conversion direction: LEFT_TO_RIGHT

ProteinComplex/14189 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: SCAP/SREBF
stoichiometric coefficient: 1.0

Reference/ChemSpider 5775
type: UnificationXref
id: 5775
db: ChemSpider

Importin subunit beta-1
type: ProteinReference
xref: Reference/UniProt Q14974

Reference/KEGG Compound C00024
type: UnificationXref
id: C00024
db: KEGG Compound

Sterol regulatory element-binding protein cleavage-activating protein
type: Protein
cellular location: Golgi Apparatus Membrane
entity reference: Sterol regulatory element-binding protein cleavage-activating protein

Nucleoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005654

2.3.1.9
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000940 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001142 Cytosol/Stoichiometry/1.0
right: Acetyl-CoA
spontaneous: false
EC number: 2.3.1.9
left: Acetoacetyl-CoA
name: Acetoacetyl-CoA ↔ Acetyl-CoA
conversion direction: REVERSIBLE

3.4.21.112
type: BiochemicalReaction
participant stoichiometry: ProteinComplex/14189 Golgi Apparatus/Stoichiometry/1.0
participant stoichiometry: Protein/3794 Golgi Apparatus/Stoichiometry/1.0
participant stoichiometry: Protein/23389 Golgi Apparatus/Stoichiometry/1.0
right: Sterol regulatory element-binding protein 1
right: Sterol regulatory element-binding protein cleavage-activating protein
spontaneous: false
EC number: 3.4.21.112
left: SCAP/SREBF
name: SCAP/SREBF → Sterol regulatory element-binding protein 1 + Sterol regulatory element-binding protein cleavage-activating protein
conversion direction: LEFT_TO_RIGHT

Golgi Apparatus Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0000139

Reference/KEGG Compound C13334
type: UnificationXref
id: C13334
db: KEGG Compound

ProteinComplex/14189 Golgi Apparatus/Stoichiometry/1.0
type: Stoichiometry
physical entity: SCAP/SREBF
stoichiometric coefficient: 1.0

Protein/3794 Golgi Apparatus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sterol regulatory element-binding protein cleavage-activating protein
stoichiometric coefficient: 1.0

Endoplasmic Reticulum
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005783

Endoplasmic Reticulum Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005789

Compound/PW C001063 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-Hydroxy-3-methylglutaryl-CoA
stoichiometric coefficient: 1.0

Low-density lipoprotein receptor
type: Protein
entity reference: Low-density lipoprotein receptor

Membrane-bound transcription factor site-2 protease
type: Protein
cellular location: Golgi Apparatus
entity reference: Membrane-bound transcription factor site-2 protease

Pitavastatin Action Pathway
type: Pathway
pathway order: PathwayInteraction/5032
pathway order: PathwaySubPathway/121325
pathway order: PathwaySubPathway/121324
pathway order: PathwayEnzymeReaction/2535732
pathway order: PathwayTransport/2535738
pathway order: PathwayEnzymeReaction/2535731
pathway order: PathwayTransport/2535737
pathway order: PathwayEnzymeReaction/2535730
pathway order: PathwayTransport/2535739
pathway order: PathwayEnzymeReaction/2535735
pathway order: PathwayEnzymeReaction/2535734
pathway order: PathwayEnzymeReaction/2535733
pathway order: PathwayEnzymeReaction/2535729
pathway order: PathwayEnzymeReaction/2535728
pathway order: PathwayTransport/2535743
pathway order: PathwayTransport/2535744
pathway order: PathwayTransport/2535736
pathway component: ReactionCatalysis587
pathway component: TransportCatalysis4766
pathway component: Interaction5032
pathway component: Reaction212802
pathway component: TransportCatalysis4762
pathway component: Reaction212814
pathway component: ReactionCatalysis202444
pathway component: ReactionCatalysis202795
pathway component: Cholesterol Biosynthesis
pathway component: ReactionCatalysis202445
pathway component: Transport10772
pathway component: TransportCatalysis5905
pathway component: Transport10764
pathway component: Transport15885
pathway component: Transport13685
pathway component: Transport15884
pathway component: Transport13690
pathway component: Glycolysis
pathway component: 4.1.3.4
pathway component: 2.3.1.9
pathway component: Reaction212815
pathway component: 2.3.3.10
pathway component: 3.4.21.112
pathway component: ReactionCatalysis247
xref: Reference/SMPDB SMP0126665
xref: Reference/PathWhiz PW128268
organism: Homo sapiens

Reference/ChEBI CHEBI 1146900
type: UnificationXref
id: CHEBI:1146900
db: ChEBI

ChemicalStructure/PW C001142
type: ChemicalStructure
structure format: SMILES

Sterol regulatory element-binding protein 1
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: Sterol regulatory element-binding protein 1

SubPathwayInteraction121325
type: Interaction
name: SubPathway121325Reaction
name: SubPathwayReaction
participant: Mevalonate
participant: Cholesterol

SubPathwayInteraction121324
type: Interaction
name: SubPathwayReaction
name: SubPathway121324Reaction
participant: Acetyl-CoA

Reference/BioCyc CO-A
type: UnificationXref
id: CO-A
db: BioCyc

Reference/ChemSpider 5675
type: UnificationXref
id: 5675
db: ChemSpider

Reference/CAS 72-89-9
type: UnificationXref
id: 72-89-9
db: CAS

Reference/UniProt Q9Y6L6
type: UnificationXref
id: Q9Y6L6
db: UniProt

Coenzyme A
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 1146900
xref: Reference/HMDB HMDB0001423
xref: Reference/PubChem-compound 6816
xref: Reference/BioCyc CO-A
xref: Reference/ChemSpider 6557
xref: Reference/CAS 85-61-0
xref: Reference/KEGG Compound C00010
chemical formula: C21H36N7O16P3S
molecular weight: 767.11523
structure: ChemicalStructure/PW C001099

Golgi Apparatus
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005794

3-Hydroxy-3-methylglutaryl-CoA
type: SmallMolecule
cellular location: Cytosol
entity reference: 3-Hydroxy-3-methylglutaryl-CoA

Reference/GENE ONTOLOGY GO 0005794
type: UnificationXref
id: GO:0005794
db: GENE ONTOLOGY

Reference/INSDC AH002776
type: UnificationXref
id: AH002776
db: INSDC

Reference/BioCyc ACETOACETYL-COA
type: UnificationXref
id: ACETOACETYL-COA
db: BioCyc

Compound/PW C001142/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetoacetyl-CoA
stoichiometric coefficient: 1.0

Reference/ChemSpider 6557
type: UnificationXref
id: 6557
db: ChemSpider

Protein/23389/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sterol regulatory element-binding protein 1
stoichiometric coefficient: 1.0

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

ChemicalStructure/PW C000940
type: ChemicalStructure
structure format: SMILES

Protein/1764 Nucleoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Low-density lipoprotein receptor
stoichiometric coefficient: 1.0

Protein/51/Stoichiometry/2.0
type: Stoichiometry
physical entity: Hydroxymethylglutaryl-CoA synthase, cytoplasmic
stoichiometric coefficient: 2.0

3-Hydroxy-3-methylglutaryl-CoA
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15467
xref: Reference/ChemSpider 388357
xref: Reference/CAS 1553-55-5
xref: Reference/BioCyc 3-HYDROXY-3-METHYL-GLUTARYL-COA
xref: Reference/KEGG Compound C00356
xref: Reference/HMDB HMDB0001375
xref: Reference/PubChem-compound 439218
chemical formula: C27H44N7O20P3S
molecular weight: 911.1575
structure: ChemicalStructure/PW C001063

Reference/PubChem-compound 439214
type: UnificationXref
id: 439214
db: PubChem-compound

Reference/UniProt Q01581
type: UnificationXref
id: Q01581
db: UniProt

Reference/GENE ONTOLOGY GO 0005789
type: UnificationXref
id: GO:0005789
db: GENE ONTOLOGY

Solute carrier organic anion transporter family member 1B1
type: ProteinReference
xref: Reference/UniProt Q9Y6L6

Reference/GENE ONTOLOGY GO 0005783
type: UnificationXref
id: GO:0005783
db: GENE ONTOLOGY

Reference/HMDB HMDB0001484
type: UnificationXref
id: HMDB0001484
db: HMDB

Reference/PubChem-compound 439218
type: UnificationXref
id: 439218
db: PubChem-compound

Reference/UniProt P36956
type: UnificationXref
id: P36956
db: UniProt

Compound/PW C000143 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

Hydroxymethylglutaryl-CoA synthase, cytoplasmic
type: ProteinReference
xref: Reference/UniProt Q01581

Reference/KEGG Compound C00187
type: UnificationXref
id: C00187
db: KEGG Compound

Transport10772
type: Transport
participant stoichiometry: Protein/1764 Nucleoplasm/Stoichiometry/1.0
participant stoichiometry: Protein/1764 Cell Membrane/Stoichiometry/1.0
right: Low-density lipoprotein receptor
spontaneous: false
left: Low-density lipoprotein receptor
name: Low-density lipoprotein receptor (→) Transport: Homo sapiens, Cell, Nucleoplasm to Homo sapiens, Cell, Cell Membrane
conversion direction: LEFT_TO_RIGHT

ChemicalStructure/PW C022726
type: ChemicalStructure
structure format: SMILES

Membrane-bound transcription factor site-1 protease
type: Protein
cellular location: Golgi Apparatus
entity reference: Membrane-bound transcription factor site-1 protease

Sterol regulatory element-binding protein 1
type: ProteinReference
xref: Reference/UniProt P36956

ChemicalStructure/PW C000047
type: ChemicalStructure
structure format: SMILES

Acetyl-CoA acetyltransferase, mitochondrial
type: Protein
cellular location: Cytosol
entity reference: Acetyl-CoA acetyltransferase, mitochondrial

Reference/GENE ONTOLOGY GO 0005654
type: UnificationXref
id: GO:0005654
db: GENE ONTOLOGY

Reference/HMDB HMDB0001375
type: UnificationXref
id: HMDB0001375
db: HMDB

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Reference/ChemSpider 392413
type: UnificationXref
id: 392413
db: ChemSpider

Compound/PW C000146 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

Reference/PathWhiz PW000146
type: UnificationXref
id: PW000146
db: PathWhiz

Reference/ChEBI CHEBI 32020
type: UnificationXref
id: CHEBI:32020
db: ChEBI

Coenzyme A
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: Coenzyme A

Transport10764
type: Transport
participant stoichiometry: ProteinComplex/14189 Golgi Apparatus Membrane/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/14189 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: SCAP/SREBF
spontaneous: false
left: SCAP/SREBF
name: SCAP/SREBF (→) Transport: Homo sapiens, Cell, Endoplasmic Reticulum Membrane to Homo sapiens, Cell, Golgi Apparatus Membrane
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

Mevalonate
type: SmallMolecule
entity reference: Mevalonate
name: SubPathwayInput

3-Hydroxy-3-methylglutaryl-CoA
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: 3-Hydroxy-3-methylglutaryl-CoA

Reference/CAS 1420-36-6
type: UnificationXref
id: 1420-36-6
db: CAS

ChemicalStructure/PW C001063
type: ChemicalStructure
structure format: SMILES

Reference/CAS 147511-69-1
type: UnificationXref
id: 147511-69-1
db: CAS

Cell Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005886

Unknown
type: Protein
entity reference: Unknown

ReactionCatalysis587
type: Catalysis
controller: Acetyl-CoA acetyltransferase, mitochondrial
controlled: 2.3.1.9
control type: ACTIVATION

Low-density lipoprotein receptor
type: DnaReference
xref: Reference/INSDC AH002776

Reference/UniProt P01130
type: UnificationXref
id: P01130
db: UniProt

Compound/PW C109113 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Mevalonate
stoichiometric coefficient: 1.0

TransportCatalysis4766
type: Catalysis
controller: Unknown
controlled: Transport13690
control type: ACTIVATION

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Protein/1764/Stoichiometry/1.0
type: Stoichiometry
physical entity: Low-density lipoprotein receptor
stoichiometric coefficient: 1.0

Low-density lipoprotein receptor
type: ProteinReference
xref: Reference/UniProt P01130

SCAP/SREBF
type: Complex
cellular location: Golgi Apparatus Membrane
component: Sterol regulatory element-binding protein cleavage-activating protein
component: Sterol regulatory element-binding protein 1

TransportCatalysis4762
type: Catalysis
controller: Importin subunit beta-1
controlled: Transport13685
control type: ACTIVATION

Reference/PubChem-compound 5282452
type: UnificationXref
id: 5282452
db: PubChem-compound

Cholesterol Biosynthesis
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway121325
pathway component: SubPathwayInteraction121325
name: SubPathway

Reference/PubChem-compound 5886
type: UnificationXref
id: 5886
db: PubChem-compound

ProteinComplex/14189/Stoichiometry/1.0
type: Stoichiometry
physical entity: SCAP/SREBF
stoichiometric coefficient: 1.0

BoundComplex/517/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sterol regulatory element-binding protein 1 (Homo sapiens)_Promoter
stoichiometric coefficient: 1.0

Transport15885
type: Transport
participant stoichiometry: Compound/PW C022726 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C022726/Stoichiometry/1.0
right: Pitavastatin
spontaneous: false
left: Pitavastatin
name: Pitavastatin (→) Transport: Homo sapiens, Blood Vessel to Homo sapiens, Cell, Endoplasmic Reticulum
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0000067
type: UnificationXref
id: HMDB0000067
db: HMDB

Transport15884
type: Transport
participant stoichiometry: Compound/PW C022726/Stoichiometry/1.0
right: Pitavastatin
spontaneous: false
left: Pitavastatin
name: Pitavastatin (→) Transport: Homo sapiens, Intestine to Homo sapiens, Blood Vessel
conversion direction: LEFT_TO_RIGHT

Compound/PW C022726 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pitavastatin
stoichiometric coefficient: 1.0

SCAP/SREBF
type: Complex
component: Sterol regulatory element-binding protein cleavage-activating protein
component: Sterol regulatory element-binding protein 1

Reference/ChEBI CHEBI 15467
type: UnificationXref
id: CHEBI:15467
db: ChEBI

Sterol regulatory element-binding protein 1
type: Protein
cellular location: Nucleus
entity reference: Sterol regulatory element-binding protein 1

Reference/ChEBI CHEBI 15345
type: UnificationXref
id: CHEBI:15345
db: ChEBI

Low-density lipoprotein receptor
type: Protein
cellular location: Cell Membrane
entity reference: Low-density lipoprotein receptor

Reference/PubChem-compound 444493
type: UnificationXref
id: 444493
db: PubChem-compound

Promoter
type: Dna
entity reference: Promoter

INSIG/SCAP/SREBF
type: Complex
component: Insulin-induced gene 1 protein
component: Sterol regulatory element-binding protein cleavage-activating protein
component: Sterol regulatory element-binding protein 1

Reference/PubChem-compound 22833512
type: UnificationXref
id: 22833512
db: PubChem-compound

Reference/BioCyc ACETYL-COA
type: UnificationXref
id: ACETYL-COA
db: BioCyc

Compound/PW C001099 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coenzyme A
stoichiometric coefficient: 1.0

Mevalonate
type: SmallMoleculeReference
chemical formula: C6H12O4
molecular weight: 148.07356
structure: ChemicalStructure/PW C109113

Transport13690
type: Transport
participant stoichiometry: Compound/PW C001063 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001063 Cytosol/Stoichiometry/1.0
right: 3-Hydroxy-3-methylglutaryl-CoA
spontaneous: true
left: 3-Hydroxy-3-methylglutaryl-CoA
name: 3-Hydroxy-3-methylglutaryl-CoA (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Cell, Endoplasmic Reticulum
conversion direction: REVERSIBLE

Protein/23390/Stoichiometry/1.0
type: Stoichiometry
physical entity: Insulin-induced gene 1 protein
stoichiometric coefficient: 1.0

ReactionCatalysis247
type: Catalysis
controller: Hydroxymethylglutaryl-CoA synthase, cytoplasmic
controlled: 2.3.3.10
control type: ACTIVATION

Nucleus
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005634

Protein/1764 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Low-density lipoprotein receptor
stoichiometric coefficient: 1.0

Reference/UniProt Q8TB92
type: UnificationXref
id: Q8TB92
db: UniProt

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Sterol regulatory element-binding protein 1
type: Protein
cellular location: Golgi Apparatus Membrane
entity reference: Sterol regulatory element-binding protein 1

Reference/ChEBI CHEBI 15351
type: UnificationXref
id: CHEBI:15351
db: ChEBI

Compound/PW C001063/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-Hydroxy-3-methylglutaryl-CoA
stoichiometric coefficient: 1.0

Transport13685
type: Transport
participant stoichiometry: Protein/23389 Golgi Apparatus/Stoichiometry/1.0
participant stoichiometry: Protein/23389 Nucleus/Stoichiometry/1.0
right: Sterol regulatory element-binding protein 1
spontaneous: true
left: Sterol regulatory element-binding protein 1
name: Sterol regulatory element-binding protein 1 (→) Transport: Homo sapiens, Cell, Golgi Apparatus to Homo sapiens, Cell, Nucleus
conversion direction: REVERSIBLE

4.1.3.4
type: BiochemicalReaction
participant stoichiometry: Compound/PW C109113 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001063 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Endoplasmic Reticulum/Stoichiometry/1.0
right: NADP
right: Coenzyme A
right: Mevalonate
spontaneous: false
EC number: 4.1.3.4
left: Hydrogen Ion
left: 3-Hydroxy-3-methylglutaryl-CoA
left: NADPH
name: 3-Hydroxy-3-methylglutaryl-CoA + Hydrogen Ion + NADPH → Coenzyme A + Mevalonate + NADP
conversion direction: LEFT_TO_RIGHT

Reference/CAS 85-61-0
type: UnificationXref
id: 85-61-0
db: CAS

Reference/UniProt O43462
type: UnificationXref
id: O43462
db: UniProt