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Alpha-1A adrenergic receptor Beta-1 adrenergic receptor Beta-2 adrenergic receptor Sodium- dependent noradrenaline transporter Synaptic vesicular amine transporter Sodium- dependent noradrenaline transporter Synaptic vesicular amine transporter Aromatic-L- amino-acid decarboxylase Dopamine beta- hydroxylase Amine oxidase [flavin- containing] A Tyrosine 3-monooxygenase Aldehyde dehydrogenase, dimeric NADP-preferring Catechol O- methyltransferase Norepinephrine Phentermine Norepinephrine Norepinephrine Norepinephrine Phentermine Phentermine L-Dopa Dopamine CO2 Ascorbic acid O2 Dehydroascorbic acid H2O H2O O2 3,4-Dihydroxymandelaldehyde H2O2 NH3 L-Tyrosine Tetrahydrobiopterin O2 Dihydrobiopterin H2O NAD H2O 3,4-Dihydroxymandelic acid NADH H+ S-Adenosylmethionine Vanillylmandelic acid S-Adenosylhomocysteine Magnesium Gq signaling cascade Gs signaling cascade FAD Pyridoxal 5'-phosphate Fe2+ Pyrroloquinoline quinone Copper Post synaptic neuron Norepinephrine is synthesized from tyrosine and stored in presynaptic vesicles. Synapse Cytosol Presynaptic Neuron Cytosol Postsynaptic Neuron Diffusion Blood-Brain Barrier Suppression of Appetite Phentermine is a sodium-dependent noradrenaline transporter inhibitor. This activity results in higher concentrations of noradrenaline in the synapse. Norepinephrine activates the postsynaptic adrenergic receptors (alpha and beta). This provokes the satiety feeling. Lateral Hypothalamus
ADRA1A ADRB1 ADRB2 SLC6A2 SLC18A2 SLC6A2 SLC18A2 DDC DBH MAOA TH ALDH3A1 COMT Norepinephrine Phentermine Norepinephrine Norepinephrine Norepinephrine Phentermine Phentermine L-Dopa Dopamine Carbon dioxide Ascorbic acid Oxygen Dehydroascorbic acid Water Water Oxygen 3,4- Dihydroxymandelaldehyde Hydrogen peroxide Ammonia L-Tyrosine Tetrahydrobiopterin Oxygen Dihydrobiopterin Water NAD Water 3,4- Dihydroxymandelic acid NADH Hydrogen Ion S- Adenosylmethionine Vanillylmandelic acid S- Adenosylhomocysteine Gq signaling cascade Gs signaling cascade
ADRA1A ADRB1 ADRB2 SLC6A2 SLC18A2 SLC6A2 SLC18A2 DDC DBH MAOA TH ALDH3A1 COMT Norpp Fenterm Norpp Norpp Norpp Fenterm Fenterm L-Dopa LDP CO2 VitC O2 DHAA H2O H2O O2 34DIHY H2O2 NH3 Tyr BH4 O2 BH3 H2O NAD H2O 34-DHMA NADH H+ SAMe VMA SAH Mg2+ Gq si c G s c FAD Pyr-5'P Fe2+ Pqq Cu Post synaptic neuron Norepinephrine is synthesized from tyrosine and stored in presynaptic vesicles. Synapse Cytosol Presynaptic Neuron Cytosol Postsynaptic Neuron Diffusion Blood-Brain Barrier Suppression of Appetite Phentermine is a sodium-dependent noradrenaline transporter inhibitor. This activity results in higher concentrations of noradrenaline in the synapse. Norepinephrine activates the postsynaptic adrenergic receptors (alpha and beta). This provokes the satiety feeling. Lateral Hypothalamus
ADRA1A ADRB1 ADRB2 SLC6A2 SLC18A2 SLC6A2 SLC18A2 DDC DBH MAOA TH ALDH3A1 COMT Norpp Fenterm Norpp Norpp Norpp Fenterm Fenterm L-Dopa LDP CO2 VitC O2 DHAA H2O H2O O2 34DIHY H2O2 NH3 Tyr BH4 O2 BH3 H2O NAD H2O 34-DHMA NADH H+ SAMe VMA SAH Gq si c G s c