Methylphosphinic acid is an experimental drug being tested to be a possible cholinesterase inhibitor, as it appears to inhibit the breakdown of acetylcholine. Further research needs to be conducted in order to confirm results, safety and confirm the mechanism of action.
References
Methylphosphinic Acid Pathway References
Worek F, Elsinghorst P, Koller M, Thiermann H: Reactions of methylphosphonic difluoride with human acetylcholinesterase and oximes--Possible therapeutic implications. Toxicol Lett. 2014 Nov 18;231(1):92-8. doi: 10.1016/j.toxlet.2014.09.012. Epub 2014 Sep 18.
Dahl AR, Hobbs CH, Marshall TC: The inhibition of rat and guinea pig cholinesterases by anionic hydrolysis products of methylphosphonic difluoride (difluoro). Toxicol Appl Pharmacol. 1986 Jul;84(3):561-6. doi: 10.1016/0041-008x(86)90261-9.
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