Phentermine is an amine anorectic agent used in weight reduction in cases of exogenous obesity as an adjunct or alone. It is chemically related to amphetamine. It is thought that the primary way phentermine works is by inducing a reduction in appetite, potentially through the elevation of leptin levels. However, it's believed that there are likely additional mechanisms to help reduce the weight. This molecule also acts by releasing more noradrenaline from the presynaptic vesicles situated in the lateral hypothalamus. This elevation in this hormone's concentration within the synaptic cleft triggers the activation of beta2-adrenergic receptors. This drug also impacts dopamine levels, along with its consequential influence on serotonin. These combined effects lead to a continuous fight-or-flight response within the body, diminishing hunger signals. Phentermine inhibits the sodium-dependent noradrenaline transporter, the sodium-dependent serotonin transporter, and the sodium-dependent dopamine transporter. This drug is administered as an oral capsule.

Phentermine Serotonin Reuptake transporter Satiety Pathway References