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Pathway Description

Metacycline Action Pathway

Homo sapiens

Drug Action Pathway

Metacycline is a broad-spectrum antibiotic from the tetracycline family that differs as it is excreted more slowly and maintains a more effective concentration within the blood for an extended period of time. It binds to the 16S unit of the 30S ribosomal subunit which prevents tRNA from binding to the A site of the ribosome, preventing cell growth and translation from occurring.

References

Metacycline Pathway References

Bodunkova LE, Berezina EK, Koroleva VG, Samoilova LN, Navashin SM: [Metacycline, its chemotherapeutic activity and pharmacokinetic characteristics]. Antibiotiki. 1975 Nov;20(11):1014-8.

Pubmed: 817646

Navashin SM, Koroleva VG, Samoilova LN, Petrakovich GN, Klienashvili AD: [Doxycycline and methacycline, some peculiarities of chemotherapeutic effect and pharmacokinetics]. Antibiotiki. 1971 Sep;16(9):789-93.

Pubmed: 4945155

Kanazawa Y, Kuramata T: [Laboratory and clinical studies on methacycline. 2. Sensitivity test by a disc method]. Jpn J Antibiot. 1968 Apr;21(2):63-7.

Pubmed: 4970420

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	Methacycline
	Tetracycline

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