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Pathway Description
Secobarbital Action Pathway
Homo sapiens
Drug Action Pathway
Secobarbital is a barbiturate derivative that serves as a short-term treatment for insomnia, offering an array of properties including anesthesia induction, anticonvulsant effects, and sedative-hypnotic capabilities. It finds use in inducing anesthesia before other general anesthetic agents and for brief surgical, diagnostic, or therapeutic procedures with limited painful stimuli. While barbiturates like secobarbital don't provide significant analgesia and might even incite excitation in the presence of pain, their metabolization primarily occurs through the hepatic microsomal enzyme system, with resultant metabolites being excreted mainly through urine, and occasionally through feces. Overdose manifestations encompass lethargy, lack of coordination, cognitive impairment, slowed speech, impaired judgment, drowsiness, shallow breathing, instability, and, in severe instances, potential progression to coma and fatality.
References
Secobarbital Pathway References
Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M: DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037.
Pubmed: 29126136
Visser LE, van Schaik RH, Jan Danser AH, Hofman A, Witteman JC, van Duijn CM, Uitterlinden AG, Pols HA, Stricker BH: The risk of myocardial infarction in patients with reduced activity of cytochrome P450 2C9. Pharmacogenet Genomics. 2007 Jul;17(7):473-9
Chen Y, Ferguson SS, Negishi M, Goldstein JA: Induction of human CYP2C9 by rifampicin, hyperforin, and phenobarbital is mediated by the pregnane X receptor. J Pharmacol Exp Ther. 2004 Feb;308(2):495-501. Epub 2003 Nov 4
Gerbal-Chaloin S, Pascussi JM, Pichard-Garcia L, Daujat M, Waechter F, Fabre JM, Carrere N, Maurel P: Induction of CYP2C genes in human hepatocytes in primary culture. Drug Metab Dispos. 2001 Mar;29(3):242-51
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