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Pathway Description
Lonoctocog Alfa Action Pathway
Homo sapiens
Drug Action Pathway
Lonoctocog alfa also known as Afstyla is a recombinant coagulation factor VIII that is used in the treatment of hemophilia A. Once administered intravenously it binds to the coagulation factor IXa to convert coagulation factor X to its active form Xa to carry on the reactions of the clotting cascade.
References
Lonoctocog Alfa Pathway References
Al-Salama ZT, Scott LJ: Lonoctocog Alfa: A Review in Haemophilia A. Drugs. 2017 Oct;77(15):1677-1686. doi: 10.1007/s40265-017-0815-0.
Pubmed: 28900904
Raso S, Hermans C: Lonoctocog alfa (rVIII-SingleChain) for the treatment of haemophilia A. Expert Opin Biol Ther. 2018 Jan;18(1):87-94. doi: 10.1080/14712598.2018.1416088.
Pubmed: 29256333
Al-Salama ZT, Scott LJ: Correction to: Lonoctocog Alfa: A Review in Haemophilia A. Drugs. 2018 Mar;78(4):521. doi: 10.1007/s40265-018-0886-6.
Pubmed: 29500556
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