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Pathway Description
Moroctocog Alfa Action Pathway
Homo sapiens
Drug Action Pathway
Moroctocog alfa also known as Refacto AF and Xyntha, is a B-domain deleted recombinant factor VIII similar to the endogenous coagulation factor VIII. Moroctocog alfa is administered intravenously used to treat hemophilia A to control bleeding. It acts by replacing coagulation factor VIII which is deficient in those with hemophilia, this allows coagulation factor IX and X to be activated and facilitate the clotting cascade.
References
Moroctocog Alfa Pathway References
Titheradge MA, Coore HG: Initial rates of pyruvate transport in mitochondria determined by an "inhibitor-stop" technique. Biochem J. 1975 Sep;150(3):553-6. doi: 10.1042/bj1500553.
Pubmed: 2157
Frampton JE: Efmoroctocog Alfa: A Review in Haemophilia A. Drugs. 2016 Sep;76(13):1281-1291. doi: 10.1007/s40265-016-0622-z.
Pubmed: 27487799
Santagostino E: A new recombinant factor VIII: from genetics to clinical use. Drug Des Devel Ther. 2014 Dec 12;8:2507-15. doi: 10.2147/DDDT.S73241. eCollection 2014.
Pubmed: 25548513
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