Reference/ChEBI CHEBI 16015
type: UnificationXref
id: CHEBI:16015
db: ChEBI

Reference/PubChem-compound 127
type: UnificationXref
id: 127
db: PubChem-compound

Reference/ChemSpider 30572
type: UnificationXref
id: 30572
db: ChemSpider

Reference/HMDB HMDB0001858
type: UnificationXref
id: HMDB0001858
db: HMDB

Reference/UniProt P0DMN0
type: UnificationXref
id: P0DMN0
db: UniProt

Reference/BioCyc P-HYDROXY-PHENYLPYRUVATE
type: UnificationXref
id: P-HYDROXY-PHENYLPYRUVATE
db: BioCyc

Tyrosine aminotransferase
type: Complex
component stoichiometry: Protein/271 Inner Membrane/Stoichiometry/2.0
cellular location: Inner Membrane
component: Tyrosine aminotransferase

Compound/PW C000103 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Tyrosine
stoichiometric coefficient: 1.0

Unknown
type: ProteinReference

L-Tyrosine
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Tyrosine

p-Cresol sulfate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 82914
xref: Reference/PubChem-compound 4615423
xref: Reference/HMDB HMDB0011635
xref: Reference/ChemSpider 3806481
xref: Reference/CAS 3233-58-7
chemical formula: C7H8O4S
molecular weight: 188.01433
structure: ChemicalStructure/PW C007222

Reference/ChemSpider 50
type: UnificationXref
id: 50
db: ChemSpider

Reference/PubChem-compound 58838673
type: UnificationXref
id: 58838673
db: PubChem-compound

Reference/ChemSpider 5833
type: UnificationXref
id: 5833
db: ChemSpider

BiologicalState311
type: BioSource
xref: Reference/TAXONOMY 2
name: Bacteria

ReactionCatalysis208987
type: Catalysis
controller: Sulfotransferase 1A4
controlled: Reaction219608
control type: ACTIVATION

ReactionCatalysis208986
type: Catalysis
controller: 4-hydroxyphenylacetate decarboxylase glycyl radical subunit
controlled: Reaction219607
control type: ACTIVATION

ReactionCatalysis208985
type: Catalysis
controller: 4-hydroxyphenylpyruvate dioxygenase
controlled: 1.13.11.27
control type: ACTIVATION

ReactionCatalysis208984
type: Catalysis
controller: Tyrosine aminotransferase
controlled: Reaction219605
control type: ACTIVATION

Reference/ChemSpider 124
type: UnificationXref
id: 124
db: ChemSpider

ChemicalStructure/PW C000103
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CC1=CC=C(O)C=C1)C(O)=O

Reference/PubChem-compound 51
type: UnificationXref
id: 51
db: PubChem-compound

Compound/PW C001065 Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 1.0

Tyrosine aminotransferase
type: ProteinReference
xref: Reference/UniProt P17735
organism: BiologicalState311

Adenosine 3',5'-diphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 17985
xref: Reference/CAS 1053-73-2
xref: Reference/PubChem-compound 159296
xref: Reference/ChemSpider 140102
xref: Reference/BioCyc 3-5-ADP
xref: Reference/KEGG Compound C00054
xref: Reference/HMDB HMDB0000061
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C000043

Reference/CELL TYPE ONTOLOGY CL 0000182
type: UnificationXref
id: CL:0000182
db: CELL TYPE ONTOLOGY

Reference/BRENDA TISSUE ONTOLOGY BTO 0000759
type: UnificationXref
id: BTO:0000759
db: BRENDA TISSUE ONTOLOGY

Reference/ChemSpider 954
type: UnificationXref
id: 954
db: ChemSpider

4-hydroxyphenylacetate decarboxylase glycyl radical subunit
type: ProteinReference
xref: Reference/UniProt Q84F16
organism: BiologicalState311

Reference/ChemSpider 952
type: UnificationXref
id: 952
db: ChemSpider

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Reference/BioCyc ALPHA-GLUCOSE-16-BISPHOSPHATE
type: UnificationXref
id: ALPHA-GLUCOSE-16-BISPHOSPHATE
db: BioCyc

p-Cresol sulfate
type: SmallMolecule
entity reference: p-Cresol sulfate
name: SubPathwayInput

Reference/ChemSpider 274
type: UnificationXref
id: 274
db: ChemSpider

Oxoglutaric acid
type: SmallMoleculeReference
xref: Reference/CAS 328-50-7
xref: Reference/PubChem-compound 51
xref: Reference/BioCyc 2-KETOGLUTARATE
xref: Reference/HMDB HMDB0000208
xref: Reference/ChEBI CHEBI 30915
xref: Reference/KEGG Compound C00026
xref: Reference/ChemSpider 50
chemical formula: C5H6O5
molecular weight: 146.02153
structure: ChemicalStructure/PW C000134

p-Hydroxyphenylacetic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 127
xref: Reference/ChemSpider 124
xref: Reference/CAS 156-38-7
xref: Reference/HMDB HMDB0000020
xref: Reference/BioCyc 4-HYDROXYPHENYLACETATE
xref: Reference/KEGG Compound C00642
xref: Reference/ChEBI CHEBI 18101
chemical formula: C8H8O3
molecular weight: 152.04735
structure: ChemicalStructure/PW C000013

Compound/PW C000134 Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxoglutaric acid
stoichiometric coefficient: 1.0

Carbon dioxide
type: SmallMolecule
cellular location: Inner Membrane
entity reference: Carbon dioxide

Reference/BioCyc TYR
type: UnificationXref
id: TYR
db: BioCyc

Reference/UniProt P32754
type: UnificationXref
id: P32754
db: UniProt

3'-Phosphoadenylyl sulfate
type: SmallMolecule
cellular location: Cytosol
entity reference: 3'-Phosphoadenylyl sulfate

Reference/SMPDB SMP0126850
type: UnificationXref
id: SMP0126850
db: SMPDB

ChemicalStructure/PW C000558
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)C(=O)CC1=CC=C(O)C=C1

Reference/GENE ONTOLOGY GO 0070258
type: UnificationXref
id: GO:0070258
db: GENE ONTOLOGY

p-Cresol
type: SmallMolecule
entity reference: p-Cresol

p-Cresol
type: SmallMoleculeReference
xref: Reference/BioCyc CPD-108
xref: Reference/ChEBI CHEBI 17847
xref: Reference/PubChem-compound 2879
xref: Reference/ChemSpider 13839082
xref: Reference/HMDB HMDB0001858
xref: Reference/KEGG Compound C01468
xref: Reference/CAS 106-44-5
chemical formula: C7H8O
molecular weight: 108.05752
structure: ChemicalStructure/PW C001232

Protein/271 Inner Membrane/Stoichiometry/2.0
type: Stoichiometry
physical entity: Tyrosine aminotransferase
stoichiometric coefficient: 2.0

Oxygen
type: SmallMolecule
cellular location: Inner Membrane
entity reference: Oxygen

p-Cresol
type: SmallMolecule
cellular location: Inner Membrane
entity reference: p-Cresol

Reference/BioCyc 3-5-ADP
type: UnificationXref
id: 3-5-ADP
db: BioCyc

Adenosine 3',5'-diphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine 3',5'-diphosphate

Reference/CAS 1053-73-2
type: UnificationXref
id: 1053-73-2
db: CAS

Reference/HMDB HMDB0000208
type: UnificationXref
id: HMDB0000208
db: HMDB

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Reference/BioCyc CPD-6641
type: UnificationXref
id: CPD-6641
db: BioCyc

ChemicalStructure/PW C000134
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CCC(=O)C(O)=O

ChemicalStructure/PW C000013
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CC1=CC=C(O)C=C1

Reference/ChEBI CHEBI 30915
type: UnificationXref
id: CHEBI:30915
db: ChEBI

Reference/CAS 124-38-9
type: UnificationXref
id: 124-38-9
db: CAS

Compound/PW C001051 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen
stoichiometric coefficient: 1.0

Reference/BioCyc CPD-108
type: UnificationXref
id: CPD-108
db: BioCyc

Reference/KEGG Compound C00007
type: UnificationXref
id: C00007
db: KEGG Compound

Compound/PW C000558 Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: 4-Hydroxyphenylpyruvic acid
stoichiometric coefficient: 1.0

Compound/PW C001232/Stoichiometry/1.0
type: Stoichiometry
physical entity: p-Cresol
stoichiometric coefficient: 1.0

Inner Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0070258

Liver
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000759

ChemicalStructure/PW C001232
type: ChemicalStructure
structure format: SMILES
structure data: CC1=CC=C(O)C=C1

Transport16211
type: Transport
participant stoichiometry: Compound/PW C001232 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001232/Stoichiometry/1.0
right: p-Cresol
spontaneous: false
left: p-Cresol
name: p-Cresol (→) Transport: Homo sapiens, Intestine, Epithelial Cell, Cytosol to Homo sapiens, Blood Vessel
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 159296
type: UnificationXref
id: 159296
db: PubChem-compound

Reference/PubChem-compound 4615423
type: UnificationXref
id: 4615423
db: PubChem-compound

Hydrogen
type: SmallMolecule
cellular location: Cytosol
entity reference: Hydrogen

Reference/BioCyc GLT
type: UnificationXref
id: GLT
db: BioCyc

Hydrogen
type: SmallMoleculeReference
xref: Reference/PubChem-compound 58838673
xref: Reference/CAS 1333-74-0
xref: Reference/ChemSpider 762
xref: Reference/BioCyc ALPHA-GLUCOSE-16-BISPHOSPHATE
xref: Reference/KEGG Compound C00282
xref: Reference/HMDB HMDB0001362
xref: Reference/ChEBI CHEBI 18276
chemical formula: H2
molecular weight: 2.01565
structure: ChemicalStructure/PW C001051

Reference/KEGG Compound C00011
type: UnificationXref
id: C00011
db: KEGG Compound

ChemicalStructure/PW C001316
type: ChemicalStructure
structure format: SMILES
structure data: O=C=O

Reference/KEGG Compound C01468
type: UnificationXref
id: C01468
db: KEGG Compound

SubPathwayInteraction121700
type: Interaction
name: SubPathway121700Reaction
name: SubPathwayReaction
participant: p-Cresol sulfate

SubPathwayInteraction121701
type: Interaction
name: SubPathwayReaction
name: SubPathway121701Reaction
participant: p-Cresol sulfate

Hepatocyte
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000182

Compound/PW C000095 Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamic acid
stoichiometric coefficient: 1.0

p-Cresol
type: SmallMolecule
cellular location: Cytoplasm
entity reference: p-Cresol

Reference/ChEBI CHEBI 15999
type: UnificationXref
id: CHEBI:15999
db: ChEBI

Hydrogen
type: SmallMolecule
cellular location: Inner Membrane
entity reference: Hydrogen

Reference/KEGG Compound C00026
type: UnificationXref
id: C00026
db: KEGG Compound

Reference/KEGG Compound C00025
type: UnificationXref
id: C00025
db: KEGG Compound

4-hydroxyphenylpyruvate dioxygenase
type: Protein
cellular location: Inner Membrane
entity reference: 4-hydroxyphenylpyruvate dioxygenase

Metabolism and Physiological Effects of p-Cresol sulphate
type: Pathway
pathway order: PathwayTransport/2539221
pathway order: PathwayTransport/2539222
pathway order: PathwayEnzymeReaction/2539196
pathway order: PathwayEnzymeReaction/2539217
pathway order: PathwayTransport/2539179
pathway order: PathwayTransport/2539224
pathway order: PathwaySubPathway/121701
pathway order: PathwayEnzymeReaction/2539223
pathway order: PathwaySubPathway/121700
pathway order: PathwayEnzymeReaction/2539215
pathway order: PathwayEnzymeReaction/2539220
pathway order: PathwaySubPathway/121699
pathway component: Reaction219608
pathway component: Reaction219607
pathway component: TransportCatalysis2335
pathway component: 1.13.11.27
pathway component: Reaction219605
pathway component: Reaction213955
pathway component: TransportCatalysis2333
pathway component: Kidney Damage
pathway component: Cardiovascular Disease
pathway component: ReactionCatalysis208987
pathway component: ReactionCatalysis208986
pathway component: ReactionCatalysis208985
pathway component: ReactionCatalysis208984
pathway component: Transport11197
pathway component: Transport11199
pathway component: Transport16211
pathway component: Transport11195
pathway component: Oxidative Stress
xref: Reference/SMPDB SMP0126850
xref: Reference/PathWhiz PW128455
organism: Homo sapiens

Reference/ChEBI CHEBI 18101
type: UnificationXref
id: CHEBI:18101
db: ChEBI

Sulfotransferase 1A4
type: ProteinReference
xref: Reference/UniProt P0DMN0
organism: BiologicalState26

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

p-Cresol
type: SmallMolecule
cellular location: Cytosol
entity reference: p-Cresol

Compound/PW C113709 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3'-Phosphoadenylyl sulfate
stoichiometric coefficient: 1.0

Compound/PW C000103/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Tyrosine
stoichiometric coefficient: 1.0

Protein/24158 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Sulfotransferase 1A4
stoichiometric coefficient: 2.0

Reaction219608
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001232 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C007222 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C113709 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001051 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000043 Cytosol/Stoichiometry/1.0
right: Adenosine 3',5'-diphosphate
right: p-Cresol sulfate
right: Hydrogen
spontaneous: false
left: 3'-Phosphoadenylyl sulfate
left: p-Cresol
name: 3'-Phosphoadenylyl sulfate + p-Cresol → Adenosine 3',5'-diphosphate + Hydrogen + p-Cresol sulfate
conversion direction: LEFT_TO_RIGHT

Reference/ChEBI CHEBI 17985
type: UnificationXref
id: CHEBI:17985
db: ChEBI

Reaction219607
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001316 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000013 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001051 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001232 Inner Membrane/Stoichiometry/1.0
right: p-Cresol
right: Carbon dioxide
spontaneous: false
left: Hydrogen
left: p-Hydroxyphenylacetic acid
name: Hydrogen + p-Hydroxyphenylacetic acid → Carbon dioxide + p-Cresol
conversion direction: LEFT_TO_RIGHT

1.13.11.27
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001316 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000558 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000013 Inner Membrane/Stoichiometry/1.0
right: Carbon dioxide
right: p-Hydroxyphenylacetic acid
spontaneous: false
EC number: 1.13.11.27
left: 4-Hydroxyphenylpyruvic acid
left: Oxygen
name: 4-Hydroxyphenylpyruvic acid + Oxygen → Carbon dioxide + p-Hydroxyphenylacetic acid
conversion direction: LEFT_TO_RIGHT

BiologicalState26
type: BioSource
cell type: Hepatocyte
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Liver, Hepatocyte
tissue: Liver

Reaction219605
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000103 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000558 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000134 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095 Inner Membrane/Stoichiometry/1.0
right: 4-Hydroxyphenylpyruvic acid
right: L-Glutamic acid
spontaneous: false
left: Oxoglutaric acid
left: L-Tyrosine
name: L-Tyrosine + Oxoglutaric acid ↔ 4-Hydroxyphenylpyruvic acid + L-Glutamic acid
conversion direction: REVERSIBLE

Reference/BioCyc 4-HYDROXYPHENYLACETATE
type: UnificationXref
id: 4-HYDROXYPHENYLACETATE
db: BioCyc

4-hydroxyphenylpyruvate dioxygenase
type: ProteinReference
xref: Reference/UniProt P32754
organism: BiologicalState311

Reference/ChEBI CHEBI 18276
type: UnificationXref
id: CHEBI:18276
db: ChEBI

Reference/CAS 106-44-5
type: UnificationXref
id: 106-44-5
db: CAS

Reference/CAS 328-50-7
type: UnificationXref
id: 328-50-7
db: CAS

Reference/KEGG Compound C00282
type: UnificationXref
id: C00282
db: KEGG Compound

Compound/PW C001051 Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen
stoichiometric coefficient: 1.0

4-Hydroxyphenylpyruvic acid
type: SmallMoleculeReference
xref: Reference/BioCyc P-HYDROXY-PHENYLPYRUVATE
xref: Reference/CAS 156-39-8
xref: Reference/ChEBI CHEBI 15999
xref: Reference/PubChem-compound 979
xref: Reference/HMDB HMDB0000707
xref: Reference/ChemSpider 954
xref: Reference/KEGG Compound C01179
chemical formula: C9H8O4
molecular weight: 180.04225
structure: ChemicalStructure/PW C000558

4-Hydroxyphenylpyruvic acid
type: SmallMolecule
cellular location: Inner Membrane
entity reference: 4-Hydroxyphenylpyruvic acid

Reference/PubChem-compound 990
type: UnificationXref
id: 990
db: PubChem-compound

Oxoglutaric acid
type: SmallMolecule
cellular location: Inner Membrane
entity reference: Oxoglutaric acid

Reference/ChemSpider 762
type: UnificationXref
id: 762
db: ChemSpider

Reference/HMDB HMDB0000148
type: UnificationXref
id: HMDB0000148
db: HMDB

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

Reference/HMDB HMDB0000020
type: UnificationXref
id: HMDB0000020
db: HMDB

Reference/UniProt Q84F16
type: UnificationXref
id: Q84F16
db: UniProt

Reference/ChEBI CHEBI 17847
type: UnificationXref
id: CHEBI:17847
db: ChEBI

Sulfotransferase 1A4
type: Protein
cellular location: Cytosol
entity reference: Sulfotransferase 1A4

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

4-hydroxyphenylacetate decarboxylase glycyl radical subunit
type: Protein
cellular location: Inner Membrane
entity reference: 4-hydroxyphenylacetate decarboxylase glycyl radical subunit

Reference/ChemSpider 140102
type: UnificationXref
id: 140102
db: ChemSpider

Reference/KEGG Compound C00054
type: UnificationXref
id: C00054
db: KEGG Compound

Reference/CAS 3233-58-7
type: UnificationXref
id: 3233-58-7
db: CAS

Reference/HMDB HMDB0000707
type: UnificationXref
id: HMDB0000707
db: HMDB

Compound/PW C007222/Stoichiometry/1.0
type: Stoichiometry
physical entity: p-Cresol sulfate
stoichiometric coefficient: 1.0

Transport11197
type: Transport
participant stoichiometry: Compound/PW C001232/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001232 Cytoplasm/Stoichiometry/1.0
right: p-Cresol
spontaneous: false
left: p-Cresol
name: p-Cresol (→) Transport: Homo sapiens, Blood Vessel to Homo sapiens, Liver, Cell, Cytoplasm
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0000158
type: UnificationXref
id: HMDB0000158
db: HMDB

Oxygen
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001377
xref: Reference/ChemSpider 952
xref: Reference/KEGG Compound C00007
xref: Reference/ChEBI CHEBI 15379
xref: Reference/PubChem-compound 977
xref: Reference/BioCyc CPD-6641
xref: Reference/CAS 7782-44-7
chemical formula: O2
molecular weight: 31.98983
structure: ChemicalStructure/PW C001065

Transport11199
type: Transport
participant stoichiometry: Compound/PW C007222 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C007222/Stoichiometry/1.0
right: p-Cresol sulfate
spontaneous: false
left: p-Cresol sulfate
name: p-Cresol sulfate (→) Transport: Homo sapiens, Liver, Hepatocyte, Cytosol to Homo sapiens, Blood Vessel
conversion direction: LEFT_TO_RIGHT

Transport11195
type: Transport
participant stoichiometry: Compound/PW C000103/Stoichiometry/1.0
right: L-Tyrosine
spontaneous: false
left: L-Tyrosine
name: L-Tyrosine (→) Transport: Homo sapiens to Homo sapiens, Intestine
conversion direction: LEFT_TO_RIGHT

Reference/CAS 56-86-0
type: UnificationXref
id: 56-86-0
db: CAS

ChemicalStructure/PW C007222
type: ChemicalStructure
structure format: SMILES
structure data: CC1=CC=C(OS(O)(=O)=O)C=C1

Reference/HMDB HMDB0001362
type: UnificationXref
id: HMDB0001362
db: HMDB

Sulfotransferase 1A4
type: Complex
component stoichiometry: Protein/24158 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Sulfotransferase 1A4

L-Glutamic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 33032
xref: Reference/ChEBI CHEBI 16015
xref: Reference/ChemSpider 30572
xref: Reference/HMDB HMDB0000148
xref: Reference/CAS 56-86-0
xref: Reference/BioCyc GLT
xref: Reference/KEGG Compound C00025
chemical formula: C5H9NO4
molecular weight: 147.05316
structure: ChemicalStructure/PW C000095

Reference/PubChem-compound 33032
type: UnificationXref
id: 33032
db: PubChem-compound

Reference/CAS 60-18-4
type: UnificationXref
id: 60-18-4
db: CAS

Compound/PW C000103 Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Tyrosine
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16526
type: UnificationXref
id: CHEBI:16526
db: ChEBI

Kidney Damage
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway121700
pathway component: SubPathwayInteraction121700
name: SubPathway

Compound/PW C000013 Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: p-Hydroxyphenylacetic acid
stoichiometric coefficient: 1.0

Reference/CAS 7782-44-7
type: UnificationXref
id: 7782-44-7
db: CAS

Reference/HMDB HMDB0001377
type: UnificationXref
id: HMDB0001377
db: HMDB

ChemicalStructure/PW C000043
type: ChemicalStructure
structure format: SMILES

SubPathwayInteraction121699
type: Interaction
name: SubPathway121699Reaction
name: SubPathwayReaction
participant: p-Cresol sulfate

Reference/PubChem-compound 2879
type: UnificationXref
id: 2879
db: PubChem-compound

Oxidative Stress
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway121701
pathway component: SubPathwayInteraction121701
name: SubPathway

Compound/PW C001232 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: p-Cresol
stoichiometric coefficient: 1.0

Compound/PW C000043 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine 3',5'-diphosphate
stoichiometric coefficient: 1.0

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Tyrosine aminotransferase
type: Protein
cellular location: Inner Membrane
entity reference: Tyrosine aminotransferase

Reference/CAS 1333-74-0
type: UnificationXref
id: 1333-74-0
db: CAS

TransportCatalysis2335
type: Catalysis
controller: Unknown
controlled: Transport11199
control type: ACTIVATION

Reference/CAS 156-38-7
type: UnificationXref
id: 156-38-7
db: CAS

3'-Phosphoadenylyl sulfate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0062646
xref: Reference/PubChem-compound 990
chemical formula: C10H15N5O13P2S
molecular weight: 506.98624

Reference/BioCyc 2-KETOGLUTARATE
type: UnificationXref
id: 2-KETOGLUTARATE
db: BioCyc

L-Tyrosine
type: SmallMoleculeReference
xref: Reference/CAS 60-18-4
xref: Reference/PubChem-compound 6057
xref: Reference/HMDB HMDB0000158
xref: Reference/ChEBI CHEBI 17895
xref: Reference/KEGG Compound C00082
xref: Reference/ChemSpider 5833
xref: Reference/BioCyc TYR
chemical formula: C9H11NO3
molecular weight: 181.0739
structure: ChemicalStructure/PW C000103

TransportCatalysis2333
type: Catalysis
controller: Unknown
controlled: Transport11197
control type: ACTIVATION

Cardiovascular Disease
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway121699
pathway component: SubPathwayInteraction121699
name: SubPathway

p-Hydroxyphenylacetic acid
type: SmallMolecule
cellular location: Inner Membrane
entity reference: p-Hydroxyphenylacetic acid

Carbon dioxide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 280
xref: Reference/ChEBI CHEBI 16526
xref: Reference/ChemSpider 274
xref: Reference/HMDB HMDB0001967
xref: Reference/CAS 124-38-9
xref: Reference/KEGG Compound C00011
chemical formula: CO2
molecular weight: 43.98983
structure: ChemicalStructure/PW C001316

ChemicalStructure/PW C001065
type: ChemicalStructure
structure format: SMILES
structure data: O=O

Reference/ChEBI CHEBI 82914
type: UnificationXref
id: CHEBI:82914
db: ChEBI

Reference/KEGG Compound C00082
type: UnificationXref
id: C00082
db: KEGG Compound

ChemicalStructure/PW C000095
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCC(O)=O)C(O)=O

Reference/HMDB HMDB0062646
type: UnificationXref
id: HMDB0062646
db: HMDB

Unknown
type: Protein
entity reference: Unknown

Reference/PubChem-compound 6057
type: UnificationXref
id: 6057
db: PubChem-compound

Compound/PW C001316 Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15379
type: UnificationXref
id: CHEBI:15379
db: ChEBI

Reaction213955
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001232 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000103 Cytosol/Stoichiometry/1.0
right: p-Cresol
spontaneous: false
left: L-Tyrosine
name: L-Tyrosine → p-Cresol
conversion direction: LEFT_TO_RIGHT

Reference/PathWhiz PW128455
type: UnificationXref
id: PW128455
db: PathWhiz

Reference/HMDB HMDB0011635
type: UnificationXref
id: HMDB0011635
db: HMDB

Reference/KEGG Compound C00642
type: UnificationXref
id: C00642
db: KEGG Compound

Reference/KEGG Compound C01179
type: UnificationXref
id: C01179
db: KEGG Compound

Compound/PW C007222 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: p-Cresol sulfate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 280
type: UnificationXref
id: 280
db: PubChem-compound

Reference/HMDB HMDB0000061
type: UnificationXref
id: HMDB0000061
db: HMDB

Reference/TAXONOMY 2
type: UnificationXref
id: 2
db: TAXONOMY

Reference/CAS 156-39-8
type: UnificationXref
id: 156-39-8
db: CAS

L-Tyrosine
type: SmallMolecule
cellular location: Inner Membrane
entity reference: L-Tyrosine

Compound/PW C001232 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: p-Cresol
stoichiometric coefficient: 1.0

Reference/ChemSpider 3806481
type: UnificationXref
id: 3806481
db: ChemSpider

Reference/ChEBI CHEBI 17895
type: UnificationXref
id: CHEBI:17895
db: ChEBI

Reference/PubChem-compound 977
type: UnificationXref
id: 977
db: PubChem-compound

Reference/ChemSpider 13839082
type: UnificationXref
id: 13839082
db: ChemSpider

L-Glutamic acid
type: SmallMolecule
cellular location: Inner Membrane
entity reference: L-Glutamic acid

Reference/HMDB HMDB0001967
type: UnificationXref
id: HMDB0001967
db: HMDB

L-Tyrosine
type: SmallMolecule
entity reference: L-Tyrosine

Reference/UniProt P17735
type: UnificationXref
id: P17735
db: UniProt

Compound/PW C001232 Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: p-Cresol
stoichiometric coefficient: 1.0

p-Cresol sulfate
type: SmallMolecule
cellular location: Cytosol
entity reference: p-Cresol sulfate

Reference/PubChem-compound 979
type: UnificationXref
id: 979
db: PubChem-compound

ChemicalStructure/PW C001051
type: ChemicalStructure
structure format: SMILES
structure data: [H][H]