Bovine thrombin is a coagulation factor also known under the brand name Thrombin-jmi, used to prevent bleeding during surgery. It is bovine thrombin that behaves like endogenous thrombin, converting fibrinogen to fibrin necessary for clot formation. The speed at which the clotting takes place is dependent on the concentration of bovine thrombin and fibrinogen present. It is metabolized in the same way as endogenous thrombin, it is inactivated by endogenous plasma inhibitors. It is administered as a topical and then cleared via thrombin inhibitor complexes and or through internalization and degradation by the endothelium.

Bovine Thrombin Pathway References