Thrombin alfa also known under the brand name Recothrom, is a platelet-activating factor to treat minor bleeding. It is administered topically, it is a recombinant thrombin identical to that of the endogenous human thrombin. Thrombin alfa is a human serine protease that cleaves fibrinogen to fibrin which leads to clot formation. Once thrombin alfa has performed its function it is rapidly inactivated by circulating endogenous plasma inhibitors.
References
Thrombin Alfa Pathway (didnt work) References
Crawley JT, Zanardelli S, Chion CK, Lane DA: The central role of thrombin in hemostasis. J Thromb Haemost. 2007 Jul;5 Suppl 1:95-101. doi: 10.1111/j.1538-7836.2007.02500.x.
Slezak P, Keibl C, Labahn D, Schmidbauer A, Genyk Y, Gulle H: A Comparative Efficacy Evaluation of Recombinant Topical Thrombin (RECOTHROM((R))) With A Gelatin Sponge Carrier Versus Topical Oxidized Regenerated Cellulose (TABOTAMP((R))/SURGICEL((R))) In A Porcine Liver Bleeding Model. J Invest Surg. 2021 Aug;34(8):862-868. doi: 10.1080/08941939.2019.1705444. Epub 2020 Jan 20.
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