PathWhiz

Pathway Description

Nalidixic acid Action Pathway

Escherichia coli

Drug Action Pathway

Nalidixic acid is a quinolone antibacterial used to treat urinary tract infections, taken orally. Nalidixic acid acts on gram-negative bacteria including the majority of E. Coli, Enterobacter species, Klebsiella species, and Proteus species. It is an inhibitor of the A subunit of bacterial DNA gyrase. The inhibition of DNA gyrase (topoisomerase II) and causes supercoiling of the bacterial DNA. This prevents DNA replication.

References

Nalidixic acid Pathway References

Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M: DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037.

Pubmed: 29126136

Highlighted elements will appear in red.

Highlight Compounds

	Magnesium
	Nalidixic Acid

Highlight Proteins

	DNA gyrase subunit A
	DNA gyrase subunit B

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