PathWhiz

Pathway Description

Moricizine Action Pathway

Homo sapiens

Drug Action Pathway

Moricizine is an antiarrhythmic used to treat arrhythmias (irregular heartbeats) and to maintain normal heart rate. it acts on heart muscles by inhibiting inward sodium channels. This results in a slowed atrioventricular nodal and His-Purkinje conduction, which decreases excitability conduction velocity, and automaticity. It decreases the maximum rate of phase 0 depolarization, but it does not affect action potential amplitude, sinoatrial (SA) nodal or intra-atrial conduction, or maximum diastolic potential. It minimally effects sinus cycle length and sinus node recovery time.

References

Moricizine Pathway References

Sherman ME, Schiffman MH, Lorincz AT, Herrero R, Hutchinson ML, Bratti C, Zahniser D, Morales J, Hildesheim A, Helgesen K, Kelly D, Alfaro M, Mena F, Balmaceda I, Mango L, Greenberg M: Cervical specimens collected in liquid buffer are suitable for both cytologic screening and ancillary human papillomavirus testing. Cancer. 1997 Apr 25;81(2):89-97.

Pubmed: 9126136

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. doi: 10.1038/nrd2199.

Pubmed: 17139284

Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. doi: 10.1038/nrd2132.

Pubmed: 17016423

Ahmmed GU, Hisatome I, Kurata Y, Makita N, Tanaka Y, Tanaka H, Okamura T, Sonoyama K, Furuse Y, Kato M, Yamamoto Y, Ogura K, Shimoyama M, Miake J, Sasaki N, Ogino K, Igawa O, Yoshida A, Shigemasa C: Analysis of moricizine block of sodium current in isolated guinea-pig atrial myocytes. Atrioventricular difference of moricizine block. Vascul Pharmacol. 2002 Mar;38(3):131-41. doi: 10.1016/s1537-1891(02)00213-6.

Pubmed: 12402511

Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. doi: 10.1093/nar/30.1.412.

Pubmed: 11752352

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Visualize Compound Data

		Calcium
		cAMP
		Moricizine
		Potassium
		Sodium

Visualize Protein Data

		ATP-binding cassette sub-family C member 8
		ATP-binding cassette sub-family C member 9
		ATP-sensitive inward rectifier potassium channel 11
		ATP-sensitive inward rectifier potassium channel 8
		cAMP-dependent protein kinase catalytic subunit alpha
		cAMP-dependent protein kinase type I-alpha regulatory subunit
		Disks large homolog 1
		G protein-activated inward rectifier potassium channel 1
		G protein-activated inward rectifier potassium channel 4
		Inward rectifier potassium channel 2
		Inward rectifier potassium channel 4
		Kv channel-interacting protein 2
		Potassium channel subfamily K member 1
		Potassium voltage-gated channel subfamily A member 5
		Potassium voltage-gated channel subfamily D member 3
		Potassium voltage-gated channel subfamily E member 1
		Potassium voltage-gated channel subfamily E member 2
		Potassium voltage-gated channel subfamily H member 2
		Potassium voltage-gated channel subfamily KQT member 1
		Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
		Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase
		Ryanodine receptor 2
		Sodium channel protein type 5 subunit alpha
		Tropomyosin alpha-1 chain
		Tropomyosin beta chain
		Voltage-dependent calcium channel subunit alpha-2/delta-2
		Voltage-dependent L-type calcium channel subunit beta-1
		Voltage-dependent P/Q-type calcium channel subunit alpha-1A
		Voltage-dependent T-type calcium channel subunit alpha-1G
		Voltage-dependent T-type calcium channel subunit alpha-1H

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