Interaction5361
type: MolecularInteraction
interaction type: direct_interaction
name: D(1A) dopamine receptor activates Guanine nucleotide-binding protein gamma-beta (Homo sapiens) + Guanine nucleotide-binding protein alpha (Homo sapiens)
participant: Guanine nucleotide-binding protein gamma-beta (Homo sapiens)_Guanine nucleotide-binding protein alpha (Homo sapiens)
participant: D(1A) dopamine receptor

Gβ
type: ProteinReference
xref: Reference/UniProt P62873
organism: BiologicalState789

Interaction5362
type: MolecularInteraction
interaction type: direct_interaction
name: D(1B) dopamine receptor activates Guanine nucleotide-binding protein gamma-beta (Homo sapiens) + Guanine nucleotide-binding protein alpha (Homo sapiens)
participant: Guanine nucleotide-binding protein gamma-beta (Homo sapiens)_Guanine nucleotide-binding protein alpha (Homo sapiens)
participant: D(1B) dopamine receptor

Reference/PubChem-compound 923
type: UnificationXref
id: 923
db: PubChem-compound

cAMP-dependent protein kinase catalytic subunit beta
type: ProteinReference
xref: Reference/UniProt P22694
organism: BiologicalState789

Interaction5364
type: MolecularInteraction
interaction type: direct_interaction
name: D(1A) dopamine receptor activates Guanosine triphosphate + Guanine nucleotide-binding protein alpha (Homo sapiens) + Adenylate cyclase type 2 (Homo sapiens)
participant: Guanosine triphosphate_Guanine nucleotide-binding protein alpha (Homo sapiens)_Adenylate cyclase type 2 (Homo sapiens)
participant: D(1A) dopamine receptor

BiologicalState789
type: BioSource
cell type: Neuron
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Brain, Neuron
tissue: Brain

cAMP
type: SmallMolecule
cellular location: Cytosol
entity reference: cAMP

Protein kinase A
type: Complex
component stoichiometry: Protein/1315 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/3359 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/3358 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/1990 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/1134 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/3357 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/1262 Cytosol/Stoichiometry/1.0
cellular location: Cytosol
component: cAMP-dependent protein kinase catalytic subunit alpha
component: cAMP-dependent protein kinase type I-alpha regulatory subunit
component: cAMP-dependent protein kinase type II-alpha regulatory subunit
component: cAMP-dependent protein kinase catalytic subunit beta
component: cAMP-dependent protein kinase type II-beta regulatory subunit
component: cAMP-dependent protein kinase catalytic subunit gamma
component: cAMP-dependent protein kinase type I-beta regulatory subunit

direct_interaction
type: InteractionVocabulary

Tyrosine 3-monooxygenase
type: ProteinReference
xref: Reference/UniProt P07101
organism: BiologicalState789

Compound/PW C000103 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Tyrosine
stoichiometric coefficient: 1.0

Reference/GENE ONTOLOGY GO 0070382
type: UnificationXref
id: GO:0070382
db: GENE ONTOLOGY

Protein/1134 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase catalytic subunit gamma
stoichiometric coefficient: 1.0

Compound/PW C000052 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dopamine
stoichiometric coefficient: 1.0

L-Tyrosine
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Tyrosine

1.14.16.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000103 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000117 Cytosol/Stoichiometry/1.0
right: L-Dopa
spontaneous: false
EC number: 1.14.16.2
left: L-Tyrosine
name: L-Tyrosine → L-Dopa
conversion direction: LEFT_TO_RIGHT

Pyrophosphate
type: SmallMolecule
entity reference: Pyrophosphate

Protein/4885 post-synaptic membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: D(1A) dopamine receptor
stoichiometric coefficient: 1.0

Protein/3618 post-synaptic membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Gβ
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein G(T) subunit gamma-T1
type: ProteinReference
xref: Reference/UniProt P63211
organism: BiologicalState789

Guanine nucleotide-binding protein G(i) subunit alpha-1
type: ProteinReference
xref: Reference/UniProt P63096
organism: BiologicalState789

Brain
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000142

Reference/ChemSpider 5833
type: UnificationXref
id: 5833
db: ChemSpider

Reference/UniProt Q01959
type: UnificationXref
id: Q01959
db: UniProt

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

ChemicalStructure/PW C000458
type: ChemicalStructure
structure format: SMILES
structure data: [Na+]

Calcium
type: SmallMolecule
cellular location: Cytosol
entity reference: Calcium

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Neuronal Dopamine Gs Cascade
type: Pathway
pathway order: PathwayTransport/2540398
pathway order: PathwayInteraction/5362
pathway order: PathwayTransport/2540397
pathway order: PathwayInteraction/5361
pathway order: PathwayTransport/2540400
pathway order: PathwayTransport/2540399
pathway order: PathwaySubPathway/121805
pathway order: PathwayInteraction/2835
pathway order: PathwayInteraction/3912
pathway order: PathwayInteraction/5347
pathway order: PathwayEnzymeReaction/2540396
pathway order: PathwayInteraction/3375
pathway order: PathwayEnzymeReaction/2540395
pathway order: PathwayEnzymeReaction/2540394
pathway order: PathwayInteraction/5364
pathway order: PathwayEnzymeReaction/2540393
pathway component: TransportCatalysis4823
pathway component: Interaction5361
pathway component: Interaction5362
pathway component: Interaction5347
pathway component: Transport14128
pathway component: Interaction5364
pathway component: Interaction3375
pathway component: Transport13772
pathway component: TransportCatalysis5082
pathway component: Interaction2835
pathway component: Neuronal modulation and Excitability
pathway component: Transport13773
pathway component: Reaction219552
pathway component: Transport14010
pathway component: Interaction3912
pathway component: TransportCatalysis4991
pathway component: 1.14.16.2
pathway component: 4.1.1.28
pathway component: ReactionCatalysis115
pathway component: ReactionCatalysis214
pathway component: Reaction110775
xref: Reference/SMPDB SMP0126952
xref: Reference/PathWhiz PW128568
organism: Homo sapiens

cAMP
type: SmallMolecule
entity reference: cAMP

Compound/PW C000414/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000103
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CC1=CC=C(O)C=C1)C(O)=O

Aromatic-L-amino-acid decarboxylase
type: ProteinReference
xref: Reference/UniProt P20711
organism: BiologicalState789

Reference/ChemSpider 559142
type: UnificationXref
id: 559142
db: ChemSpider

Reference/UniProt P21728
type: UnificationXref
id: P21728
db: UniProt

Reference/BioCyc L-DOPA
type: UnificationXref
id: L-DOPA
db: BioCyc

cAMP
type: SmallMoleculeReference
xref: Reference/PubChem-compound 6076
xref: Reference/HMDB HMDB0000058
xref: Reference/ChEBI CHEBI 17489
xref: Reference/CAS 60-92-4
xref: Reference/BioCyc CAMP
xref: Reference/ChemSpider 5851
xref: Reference/KEGG Compound C00575
chemical formula: C10H12N5O6P
molecular weight: 329.05252
structure: ChemicalStructure/PW C000041

Reference/UniProt P59768
type: UnificationXref
id: P59768
db: UniProt

Reference/UniProt Q08462
type: UnificationXref
id: Q08462
db: UniProt

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: Protein
cellular location: post-synaptic membrane
entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Reference/PubChem-compound 6047
type: UnificationXref
id: 6047
db: PubChem-compound

Reference/KEGG Compound C00575
type: UnificationXref
id: C00575
db: KEGG Compound

Transport13772
type: Transport
participant stoichiometry: Compound/PW C000052 Exocytic Vesicle/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000052 Synapse/Stoichiometry/1.0
right: Dopamine
spontaneous: true
left: Dopamine
name: Dopamine (→) Transport: Homo sapiens, Brain, Neuron, Exocytic Vesicle to Homo sapiens, Brain, Neuron, Synapse
conversion direction: REVERSIBLE

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Transport13773
type: Transport
participant stoichiometry: Compound/PW C000052 Exocytic Vesicle/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000052 Cytosol/Stoichiometry/1.0
right: Dopamine
spontaneous: false
left: Dopamine
name: Dopamine (→) Transport: Homo sapiens, Brain, Neuron, Cytosol to Homo sapiens, Brain, Neuron, Exocytic Vesicle
conversion direction: LEFT_TO_RIGHT

Reference/ChemSpider 274
type: UnificationXref
id: 274
db: ChemSpider

Protein/864 post-synaptic membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenylate cyclase type 2
stoichiometric coefficient: 1.0

Reference/BioCyc TYR
type: UnificationXref
id: TYR
db: BioCyc

G protein complex
type: Complex
cellular location: post-synaptic membrane
component: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
component: Guanine nucleotide-binding protein G(i) subunit alpha-1
component: Gγ

Presynaptic membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0042734

Synaptic vesicular amine transporter
type: Protein
entity reference: Synaptic vesicular amine transporter

cAMP-dependent protein kinase type II-alpha regulatory subunit
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase type II-alpha regulatory subunit

Reference/ChemSpider 5851
type: UnificationXref
id: 5851
db: ChemSpider

Reference/PubChem-compound 6830
type: UnificationXref
id: 6830
db: PubChem-compound

Reference/ChemSpider 266
type: UnificationXref
id: 266
db: ChemSpider

Reference/BioCyc PPI
type: UnificationXref
id: PPI
db: BioCyc

Guanosine triphosphate
type: SmallMolecule
cellular location: post-synaptic membrane
entity reference: Guanosine triphosphate

Dopamine
type: SmallMolecule
cellular location: Cytosol
entity reference: Dopamine

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: Reference/UniProt P62873
organism: BiologicalState789

Protein/3359 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase type II-beta regulatory subunit
stoichiometric coefficient: 1.0

Guanosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15996
xref: Reference/ChemSpider 6569
xref: Reference/KEGG Compound C00044
xref: Reference/PubChem-compound 6830
xref: Reference/HMDB HMDB0001273
xref: Reference/CAS 86-01-1
xref: Reference/BioCyc GTP
chemical formula: C10H16N5O14P3
molecular weight: 522.99066
structure: ChemicalStructure/PW C000986

Reference/ChEBI CHEBI 15765
type: UnificationXref
id: CHEBI:15765
db: ChEBI

Carbon dioxide
type: SmallMolecule
cellular location: Cytosol
entity reference: Carbon dioxide

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Gγ
type: ProteinReference
xref: Reference/UniProt P59768
organism: BiologicalState789

Reference/KEGG Compound C00355
type: UnificationXref
id: C00355
db: KEGG Compound

Reference/PubChem-compound 681
type: UnificationXref
id: 681
db: PubChem-compound

D(1A) dopamine receptor
type: Protein
cellular location: post-synaptic membrane
entity reference: D(1A) dopamine receptor

Adenosine triphosphate
type: SmallMolecule
entity reference: Adenosine triphosphate

SubPathwayInteraction121805
type: Interaction
name: SubPathwayReaction
name: SubPathway121805Reaction

Reference/UniProt P13861
type: UnificationXref
id: P13861
db: UniProt

Reference/CAS 124-38-9
type: UnificationXref
id: 124-38-9
db: CAS

Voltage-dependent calcium channel subunit alpha-2/delta-1
type: Protein
entity reference: Voltage-dependent calcium channel subunit alpha-2/delta-1

Voltage-dependent calcium channel subunit alpha-2/delta-2
type: Protein
entity reference: Voltage-dependent calcium channel subunit alpha-2/delta-2

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase type I-alpha regulatory subunit

Compound/PW C000052 Exocytic Vesicle/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dopamine
stoichiometric coefficient: 1.0

Protein/1315 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase catalytic subunit beta
stoichiometric coefficient: 1.0

Reference/KEGG Compound C03758
type: UnificationXref
id: C03758
db: KEGG Compound

Protein/3357 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase type I-beta regulatory subunit
stoichiometric coefficient: 1.0

Reference/UniProt P22694
type: UnificationXref
id: P22694
db: UniProt

Reference/KEGG Compound C01330
type: UnificationXref
id: C01330
db: KEGG Compound

Reference/ChEBI CHEBI 18361
type: UnificationXref
id: CHEBI:18361
db: ChEBI

D(1B) dopamine receptor
type: ProteinReference
xref: Reference/UniProt P21918
organism: BiologicalState789

Reference/UniProt P63211
type: UnificationXref
id: P63211
db: UniProt

Reference/ChEBI CHEBI 18243
type: UnificationXref
id: CHEBI:18243
db: ChEBI

Reference/UniProt Q9NY47
type: UnificationXref
id: Q9NY47
db: UniProt

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Reference/HMDB HMDB0000464
type: UnificationXref
id: HMDB0000464
db: HMDB

Reference/UniProt P20711
type: UnificationXref
id: P20711
db: UniProt

Reference/HMDB HMDB0000588
type: UnificationXref
id: HMDB0000588
db: HMDB

Reference/ChEBI CHEBI 17489
type: UnificationXref
id: CHEBI:17489
db: ChEBI

Reference/BioCyc CAMP
type: UnificationXref
id: CAMP
db: BioCyc

Reference/CELL TYPE ONTOLOGY CL 0000540
type: UnificationXref
id: CL:0000540
db: CELL TYPE ONTOLOGY

D(1A) dopamine receptor
type: ProteinReference
xref: Reference/UniProt P21728
organism: BiologicalState789

Neuron
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000540

Reference/KEGG Compound C00011
type: UnificationXref
id: C00011
db: KEGG Compound

ChemicalStructure/PW C001316
type: ChemicalStructure
structure format: SMILES
structure data: O=C=O

Sodium-dependent dopamine transporter
type: Protein
entity reference: Sodium-dependent dopamine transporter

cAMP-dependent protein kinase catalytic subunit gamma
type: ProteinReference
xref: Reference/UniProt P22612
organism: BiologicalState789

Voltage-dependent N-type calcium channel subunit alpha-1B
type: Protein
entity reference: Voltage-dependent N-type calcium channel subunit alpha-1B

Reference/KEGG Compound C00013
type: UnificationXref
id: C00013
db: KEGG Compound

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Pyrophosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 644102
xref: Reference/BioCyc PPI
xref: Reference/ChemSpider 559142
xref: Reference/ChEBI CHEBI 18361
xref: Reference/HMDB HMDB0000250
xref: Reference/CAS 14000-31-8
xref: Reference/KEGG Compound C00013
chemical formula: H4O7P2
molecular weight: 177.94322
structure: ChemicalStructure/PW C000170

Reaction219552
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000458 Presynaptic membrane/Stoichiometry/1.0
right: Sodium
spontaneous: false
left: Sodium
name: Sodium ↔ Sodium
conversion direction: REVERSIBLE

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Reference/CAS 14127-61-8
type: UnificationXref
id: 14127-61-8
db: CAS

ChemicalStructure/PW C000353
type: ChemicalStructure
structure format: SMILES
structure data: [Ca++]

D(1A) dopamine receptor (Homo sapiens)_G protein complex (Homo sapiens)
type: Complex
component stoichiometry: ProteinComplex/14553 post-synaptic membrane/Stoichiometry/1.0
component stoichiometry: Protein/4885 post-synaptic membrane/Stoichiometry/1.0
cellular location: post-synaptic membrane
component: D(1A) dopamine receptor
component: G protein complex

Protein/3627 post-synaptic membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanine nucleotide-binding protein G(T) subunit gamma-T1
stoichiometric coefficient: 1.0

Dopamine
type: SmallMoleculeReference
xref: Reference/CAS 51-61-6
xref: Reference/KEGG Compound C03758
xref: Reference/ChemSpider 661
xref: Reference/BioCyc DOPAMINE
xref: Reference/HMDB HMDB0000073
xref: Reference/PubChem-compound 681
xref: Reference/ChEBI CHEBI 18243
chemical formula: C8H11NO2
molecular weight: 153.07898
structure: ChemicalStructure/PW C000052

TransportCatalysis4823
type: Catalysis
controller: Synaptic vesicular amine transporter
controlled: Transport13773
control type: ACTIVATION

Reference/UniProt P54289
type: UnificationXref
id: P54289
db: UniProt

Calcium
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Calcium

Reference/ChEBI CHEBI 15996
type: UnificationXref
id: CHEBI:15996
db: ChEBI

Tyrosine 3-monooxygenase
type: Protein
cellular location: Cytosol
entity reference: Tyrosine 3-monooxygenase

Compound/PW C000458 Presynaptic membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000117
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CC1=CC=C(O)C(O)=C1)C(O)=O

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Guanine nucleotide-binding protein gamma-beta (Homo sapiens)_Guanine nucleotide-binding protein alpha (Homo sapiens)
type: Complex
component stoichiometry: ProteinComplex/120 post-synaptic membrane/Stoichiometry/1.0
component stoichiometry: Protein/1601 post-synaptic membrane/Stoichiometry/1.0
cellular location: post-synaptic membrane
component: Guanine nucleotide-binding protein gamma-beta
component: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: Reference/UniProt P17612
organism: BiologicalState789

post-synaptic membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0045211

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Transport14010
type: Transport
participant stoichiometry: Compound/PW C000052 Synapse/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000052 Cytosol/Stoichiometry/1.0
right: Dopamine
spontaneous: false
left: Dopamine
name: Dopamine (→) Transport: Homo sapiens, Brain, Neuron, Cytosol to Homo sapiens, Brain, Neuron, Synapse
conversion direction: LEFT_TO_RIGHT

Reference/ChEBI CHEBI 29108
type: UnificationXref
id: CHEBI:29108
db: ChEBI

Reference/CAS 60-92-4
type: UnificationXref
id: 60-92-4
db: CAS

Reference/ChEBI CHEBI 29101
type: UnificationXref
id: CHEBI:29101
db: ChEBI

D(1B) dopamine receptor
type: Protein
cellular location: post-synaptic membrane
entity reference: D(1B) dopamine receptor

Reaction110775
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000041/Stoichiometry/1.0
right: cAMP
right: Pyrophosphate
spontaneous: false
left: Adenosine triphosphate
name: Adenosine triphosphate → Pyrophosphate + cAMP
conversion direction: LEFT_TO_RIGHT

Synaptic vesicular amine transporter
type: ProteinReference
xref: Reference/UniProt Q05940

Compound/PW C000052 Synapse/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dopamine
stoichiometric coefficient: 1.0

Protein/1990 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase type I-alpha regulatory subunit
stoichiometric coefficient: 1.0

Dopamine
type: SmallMolecule
cellular location: Exocytic Vesicle
entity reference: Dopamine

Transport14128
type: Transport
participant stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
right: Calcium
spontaneous: false
left: Calcium
name: Calcium (→) Transport: Homo sapiens, Brain, Neuron, Extracellular Space to Homo sapiens, Brain, Neuron, Cytosol
conversion direction: LEFT_TO_RIGHT

Reference/ChemSpider 899
type: UnificationXref
id: 899
db: ChemSpider

TransportCatalysis5082
type: Catalysis
controller: Calcium channel
controlled: Transport14128
control type: ACTIVATION

Reference/BRENDA TISSUE ONTOLOGY BTO 0000142
type: UnificationXref
id: BTO:0000142
db: BRENDA TISSUE ONTOLOGY

ChemicalStructure/PW C000052
type: ChemicalStructure
structure format: SMILES
structure data: NCCC1=CC(O)=C(O)C=C1

Compound/PW C000986 post-synaptic membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanosine triphosphate
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000250
type: UnificationXref
id: HMDB0000250
db: HMDB

ChemicalStructure/PW C000170
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(=O)OP(O)(O)=O

Reference/CAS 14000-31-8
type: UnificationXref
id: 14000-31-8
db: CAS

Calcium channel
type: Complex
component: Voltage-dependent calcium channel subunit alpha-2/delta-1
component: Voltage-dependent calcium channel subunit alpha-2/delta-2
component: Voltage-dependent N-type calcium channel subunit alpha-1B

Compound/PW C000353 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
type: ProteinReference
xref: Reference/UniProt P63092
organism: BiologicalState789

Reference/KEGG Compound C00044
type: UnificationXref
id: C00044
db: KEGG Compound

cAMP-dependent protein kinase type II-beta regulatory subunit
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase type II-beta regulatory subunit

Dopamine
type: SmallMolecule
cellular location: post-synaptic membrane
entity reference: Dopamine

Reference/UniProt Q05940
type: UnificationXref
id: Q05940
db: UniProt

Reference/GENE ONTOLOGY GO 0045211
type: UnificationXref
id: GO:0045211
db: GENE ONTOLOGY

Reference/UniProt P63096
type: UnificationXref
id: P63096
db: UniProt

Neuronal modulation and Excitability
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway121805
pathway component: SubPathwayInteraction121805
name: SubPathway

Compound/PW C000170/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

Reference/UniProt P63092
type: UnificationXref
id: P63092
db: UniProt

Reference/CAS 59-92-7
type: UnificationXref
id: 59-92-7
db: CAS

Protein/3358 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase type II-alpha regulatory subunit
stoichiometric coefficient: 1.0

Reference/CAS 17341-25-2
type: UnificationXref
id: 17341-25-2
db: CAS

Voltage-dependent calcium channel subunit alpha-2/delta-1
type: ProteinReference
xref: Reference/UniProt P54289

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Guanine nucleotide-binding protein gamma-beta
type: Complex
component stoichiometry: Protein/3627 post-synaptic membrane/Stoichiometry/1.0
component stoichiometry: Protein/3618 post-synaptic membrane/Stoichiometry/1.0
cellular location: post-synaptic membrane
component: Guanine nucleotide-binding protein G(T) subunit gamma-T1
component: Gβ

Reference/CAS 51-61-6
type: UnificationXref
id: 51-61-6
db: CAS

cAMP-dependent protein kinase type II-beta regulatory subunit
type: ProteinReference
xref: Reference/UniProt P31323
organism: BiologicalState789

cAMP-dependent protein kinase type II-alpha regulatory subunit
type: ProteinReference
xref: Reference/UniProt P13861
organism: BiologicalState789

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

cAMP-dependent protein kinase type I-beta regulatory subunit
type: ProteinReference
xref: Reference/UniProt P31321
organism: BiologicalState789

Interaction2835
type: MolecularInteraction
interaction type: direct_interaction
name: cAMP activates Protein kinase A
participant: Protein kinase A
participant: cAMP

Reference/HMDB HMDB0000158
type: UnificationXref
id: HMDB0000158
db: HMDB

Exocytic Vesicle
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0070382

Guanine nucleotide-binding protein G(i) subunit alpha-1
type: Protein
cellular location: post-synaptic membrane
entity reference: Guanine nucleotide-binding protein G(i) subunit alpha-1

Reference/UniProt P21918
type: UnificationXref
id: P21918
db: UniProt

Voltage-dependent calcium channel subunit alpha-2/delta-2
type: ProteinReference
xref: Reference/UniProt Q9NY47

Reference/CAS 60-18-4
type: UnificationXref
id: 60-18-4
db: CAS

Voltage-dependent N-type calcium channel subunit alpha-1B
type: ProteinReference
xref: Reference/UniProt Q00975

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Sodium-dependent dopamine transporter
type: ProteinReference
xref: Reference/UniProt Q01959

Reference/BioCyc DOPAMINE
type: UnificationXref
id: DOPAMINE
db: BioCyc

Reference/ChEBI CHEBI 16526
type: UnificationXref
id: CHEBI:16526
db: ChEBI

Dopamine
type: SmallMolecule
cellular location: Synapse
entity reference: Dopamine

cAMP-dependent protein kinase catalytic subunit alpha
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase catalytic subunit alpha

ChemicalStructure/PW C000041
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 661
type: UnificationXref
id: 661
db: ChemSpider

Interaction3912
type: MolecularInteraction
interaction type: direct_interaction
name: Calcium activates Dopamine
participant: Dopamine
participant: Calcium

Protein/1601 post-synaptic membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
stoichiometric coefficient: 1.0

Calcium
type: SmallMolecule
cellular location: Exocytic Vesicle
entity reference: Calcium

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Reference/UniProt P07101
type: UnificationXref
id: P07101
db: UniProt

L-Tyrosine
type: SmallMoleculeReference
xref: Reference/CAS 60-18-4
xref: Reference/PubChem-compound 6057
xref: Reference/HMDB HMDB0000158
xref: Reference/ChEBI CHEBI 17895
xref: Reference/KEGG Compound C00082
xref: Reference/ChemSpider 5833
xref: Reference/BioCyc TYR
chemical formula: C9H11NO3
molecular weight: 181.0739
structure: ChemicalStructure/PW C000103

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: ProteinReference
xref: Reference/UniProt P10644
organism: BiologicalState789

Reference/UniProt P62873
type: UnificationXref
id: P62873
db: UniProt

Reference/PathWhiz PW128568
type: UnificationXref
id: PW128568
db: PathWhiz

ProteinComplex/14553 post-synaptic membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: G protein complex
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00076
type: UnificationXref
id: C00076
db: KEGG Compound

Gβ
type: Protein
cellular location: post-synaptic membrane
entity reference: Gβ

Carbon dioxide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 280
xref: Reference/ChEBI CHEBI 16526
xref: Reference/ChemSpider 274
xref: Reference/HMDB HMDB0001967
xref: Reference/CAS 124-38-9
xref: Reference/KEGG Compound C00011
chemical formula: CO2
molecular weight: 43.98983
structure: ChemicalStructure/PW C001316

Adenylate cyclase type 2
type: ProteinReference
xref: Reference/UniProt Q08462
organism: BiologicalState789

Adenylate cyclase type 2
type: Protein
cellular location: post-synaptic membrane
entity reference: Adenylate cyclase type 2

Reference/BioCyc CA+2
type: UnificationXref
id: CA%2b2
db: BioCyc

Reference/HMDB HMDB0000058
type: UnificationXref
id: HMDB0000058
db: HMDB

Reference/KEGG Compound C00082
type: UnificationXref
id: C00082
db: KEGG Compound

TransportCatalysis4991
type: Catalysis
controller: Sodium-dependent dopamine transporter
controlled: Transport14010
control type: ACTIVATION

Calcium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000464
xref: Reference/BioCyc CA+2
xref: Reference/ChemSpider 266
xref: Reference/ChEBI CHEBI 29108
xref: Reference/CAS 14127-61-8
xref: Reference/KEGG Compound C00076
xref: Reference/PubChem-compound 271
chemical formula: Ca
molecular weight: 39.96259
structure: ChemicalStructure/PW C000353

Reference/PubChem-compound 6057
type: UnificationXref
id: 6057
db: PubChem-compound

Reference/UniProt P31321
type: UnificationXref
id: P31321
db: UniProt

Reference/UniProt P10644
type: UnificationXref
id: P10644
db: UniProt

L-Dopa
type: SmallMoleculeReference
xref: Reference/ChemSpider 5824
xref: Reference/CAS 59-92-7
xref: Reference/ChEBI CHEBI 15765
xref: Reference/HMDB HMDB0000181
xref: Reference/BioCyc L-DOPA
xref: Reference/KEGG Compound C00355
xref: Reference/PubChem-compound 6047
chemical formula: C9H11NO4
molecular weight: 197.0688
structure: ChemicalStructure/PW C000117

Reference/SMPDB SMP0126952
type: UnificationXref
id: SMP0126952
db: SMPDB

Reference/UniProt P31323
type: UnificationXref
id: P31323
db: UniProt

Reference/ChemSpider 6569
type: UnificationXref
id: 6569
db: ChemSpider

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 271
type: UnificationXref
id: 271
db: PubChem-compound

cAMP-dependent protein kinase catalytic subunit gamma
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase catalytic subunit gamma

Reference/BioCyc GTP
type: UnificationXref
id: GTP
db: BioCyc

Interaction3375
type: MolecularInteraction
interaction type: direct_interaction
name: Dopamine activates D(1B) dopamine receptor
participant: Dopamine
participant: D(1B) dopamine receptor

ProteinComplex/120 post-synaptic membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanine nucleotide-binding protein gamma-beta
stoichiometric coefficient: 1.0

Reference/UniProt P22612
type: UnificationXref
id: P22612
db: UniProt

Reference/PubChem-compound 280
type: UnificationXref
id: 280
db: PubChem-compound

Sodium
type: SmallMolecule
cellular location: Presynaptic membrane
entity reference: Sodium

Reference/HMDB HMDB0000181
type: UnificationXref
id: HMDB0000181
db: HMDB

Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
type: Protein
cellular location: post-synaptic membrane
entity reference: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

Reference/HMDB HMDB0001273
type: UnificationXref
id: HMDB0001273
db: HMDB

ReactionCatalysis214
type: Catalysis
controller: Aromatic-L-amino-acid decarboxylase
controlled: 4.1.1.28
control type: ACTIVATION

cAMP-dependent protein kinase type I-beta regulatory subunit
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase type I-beta regulatory subunit

Reference/ChemSpider 5824
type: UnificationXref
id: 5824
db: ChemSpider

Compound/PW C000117 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Dopa
stoichiometric coefficient: 1.0

Reference/PubChem-compound 644102
type: UnificationXref
id: 644102
db: PubChem-compound

Interaction5347
type: MolecularInteraction
interaction type: direct_interaction
name: Dopamine activates D(1A) dopamine receptor (Homo sapiens) + G protein complex (Homo sapiens)
participant: D(1A) dopamine receptor (Homo sapiens)_G protein complex (Homo sapiens)
participant: Dopamine

Reference/UniProt Q00975
type: UnificationXref
id: Q00975
db: UniProt

cAMP-dependent protein kinase catalytic subunit beta
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase catalytic subunit beta

ChemicalStructure/PW C000986
type: ChemicalStructure
structure format: SMILES

L-Dopa
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Dopa

Reference/HMDB HMDB0000073
type: UnificationXref
id: HMDB0000073
db: HMDB

Reference/GENE ONTOLOGY GO 0042734
type: UnificationXref
id: GO:0042734
db: GENE ONTOLOGY

Reference/CAS 86-01-1
type: UnificationXref
id: 86-01-1
db: CAS

Reference/GENE ONTOLOGY GO 0045202
type: UnificationXref
id: GO:0045202
db: GENE ONTOLOGY

Reference/ChEBI CHEBI 17895
type: UnificationXref
id: CHEBI:17895
db: ChEBI

Reference/PubChem-compound 6076
type: UnificationXref
id: 6076
db: PubChem-compound

Sodium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000588
xref: Reference/PubChem-compound 923
xref: Reference/KEGG Compound C01330
xref: Reference/ChEBI CHEBI 29101
xref: Reference/ChemSpider 899
xref: Reference/CAS 17341-25-2
chemical formula: Na
molecular weight: 22.989769
structure: ChemicalStructure/PW C000458

Compound/PW C001316 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001967
type: UnificationXref
id: HMDB0001967
db: HMDB

Compound/PW C000041/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP
stoichiometric coefficient: 1.0

Protein/1262 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase catalytic subunit alpha
stoichiometric coefficient: 1.0

Reference/UniProt P17612
type: UnificationXref
id: P17612
db: UniProt

Gγ
type: Protein
cellular location: post-synaptic membrane
entity reference: Gγ

Guanine nucleotide-binding protein G(T) subunit gamma-T1
type: Protein
cellular location: post-synaptic membrane
entity reference: Guanine nucleotide-binding protein G(T) subunit gamma-T1

4.1.1.28
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000117 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000052 Cytosol/Stoichiometry/1.0
right: Carbon dioxide
right: Dopamine
spontaneous: false
EC number: 4.1.1.28
left: L-Dopa
name: L-Dopa → Carbon dioxide + Dopamine
conversion direction: LEFT_TO_RIGHT

Guanosine triphosphate_Guanine nucleotide-binding protein alpha (Homo sapiens)_Adenylate cyclase type 2 (Homo sapiens)
type: Complex
component stoichiometry: Protein/864 post-synaptic membrane/Stoichiometry/1.0
component stoichiometry: Compound/PW C000986 post-synaptic membrane/Stoichiometry/1.0
component stoichiometry: Protein/1601 post-synaptic membrane/Stoichiometry/1.0
cellular location: post-synaptic membrane
component: Guanosine triphosphate
component: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
component: Adenylate cyclase type 2

ReactionCatalysis115
type: Catalysis
controller: Tyrosine 3-monooxygenase
controlled: 1.14.16.2
control type: ACTIVATION

Aromatic-L-amino-acid decarboxylase
type: Protein
cellular location: Cytosol
entity reference: Aromatic-L-amino-acid decarboxylase

Synapse
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0045202