Reference/PubChem-compound 923
type: UnificationXref
id: 923
db: PubChem-compound

Tropomyosin
type: Complex
component stoichiometry: Protein/20668 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/20652 Cytoplasm/Stoichiometry/1.0
cellular location: Cytoplasm
component: Tropomyosin beta chain
component: Tropomyosin alpha-1 chain

Sodium/calcium exchanger 1
type: ProteinReference
xref: Reference/UniProt Q9WU30

Inositol 1,4,5-trisphosphate receptor type 1
type: Complex
component stoichiometry: Protein/19708/Stoichiometry/4.0
component: Inositol 1,4,5-trisphosphate receptor type 1

cAMP
type: SmallMolecule
cellular location: Cytosol
entity reference: cAMP

direct_interaction
type: InteractionVocabulary

ProteinComplex/16634 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: G protein complex
stoichiometric coefficient: 1.0

Compound/PW C000041 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP
stoichiometric coefficient: 1.0

Reaction179579
type: BiochemicalReaction
participant stoichiometry: Protein/Generic536 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: BoundComplex/507 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353 Cytoplasm/Stoichiometry/1.0
right: Calcium_Troponin
spontaneous: false
left: Troponin
left: Calcium
name: Calcium + Troponin → Calcium + Troponin
conversion direction: LEFT_TO_RIGHT

Inositol 1,4,5-trisphosphate receptor type 1
type: ProteinReference
xref: Reference/UniProt Q62869

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
type: ProteinReference
xref: Reference/UniProt Q9UBI6
organism: BiologicalState1537

Gi Muscarinic Cardiac Muscle Contraction
type: Pathway
pathway order: PathwayTransport/2540510
pathway order: PathwayTransport/2540507
pathway order: PathwaySubPathway/121802
pathway order: PathwayEnzymeReaction/2540506
pathway order: PathwayEnzymeReaction/2540505
pathway order: PathwayEnzymeReaction/2540504
pathway order: PathwayEnzymeReaction/2540503
pathway order: PathwayTransport/2540509
pathway order: PathwayEnzymeReaction/2540502
pathway order: PathwayTransport/2540508
pathway order: PathwayInteraction/5357
pathway order: PathwayInteraction/5356
pathway order: PathwayInteraction/5321
pathway order: PathwayInteraction/5341
pathway component: Reaction179579
pathway component: TransportCatalysis1359
pathway component: Interaction5341
pathway component: TransportCatalysis1358
pathway component: TransportCatalysis6029
pathway component: TransportCatalysis6028
pathway component: Reaction219632
pathway component: Interaction5357
pathway component: Transport16307
pathway component: Interaction5321
pathway component: Reaction219306
pathway component: Reaction219658
pathway component: Transport16308
pathway component: Interaction5356
pathway component: Transport10141
pathway component: Reaction219650
pathway component: Transport10140
pathway component: SubPathwayControl121802
xref: Reference/PathWhiz PW128573
xref: Reference/SMPDB SMP0126957
organism: Rattus norvegicus

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

ChemicalStructure/PW C000458
type: ChemicalStructure
structure format: SMILES
structure data: [Na+]

Interaction5357
type: MolecularInteraction
interaction type: direct_interaction
name: cAMP activates Funny channel (If)
participant: cAMP
participant: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4

Calcium
type: SmallMolecule
cellular location: Cytosol
entity reference: Calcium

ChemicalStructure/PW C000457
type: ChemicalStructure
structure format: SMILES
structure data: [K+]

Guanine nucleotide-binding protein G(i) subunit alpha-1
type: ProteinReference
xref: Reference/UniProt Q45QN2
organism: BiologicalState1537

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Interaction5356
type: MolecularInteraction
interaction type: direct_interaction
name: Calcium + Troponin activates Tropomyosin
participant: Calcium_Troponin
participant: Tropomyosin

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
type: ProteinReference
xref: Reference/UniProt Q9QZW4

Compound/PW C000457 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Potassium
stoichiometric coefficient: 1.0

cAMP
type: SmallMoleculeReference
xref: Reference/PubChem-compound 6076
xref: Reference/HMDB HMDB0000058
xref: Reference/ChEBI CHEBI 17489
xref: Reference/CAS 60-92-4
xref: Reference/BioCyc CAMP
xref: Reference/ChemSpider 5851
xref: Reference/KEGG Compound C00575
chemical formula: C10H12N5O6P
molecular weight: 329.05252
structure: ChemicalStructure/PW C000041

Reference/UniProt P59768
type: UnificationXref
id: P59768
db: UniProt

Reference/GENE ONTOLOGY GO 0016529
type: UnificationXref
id: GO:0016529
db: GENE ONTOLOGY

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: Protein
cellular location: Cell Membrane
entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Reference/CELL TYPE ONTOLOGY CL 0000187
type: UnificationXref
id: CL:0000187
db: CELL TYPE ONTOLOGY

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Gγ
type: Protein
cellular location: Cell Membrane
entity reference: Gγ

Reference/KEGG Compound C00575
type: UnificationXref
id: C00575
db: KEGG Compound

Calcium_Troponin
type: Complex
component stoichiometry: Protein/Generic536 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Compound/PW C000353 Cytoplasm/Stoichiometry/1.0
cellular location: Cytoplasm
component: Troponin
component: Calcium

Transport10141
type: Transport
participant stoichiometry: Compound/PW C000458 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000457 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000457 Cytosol/Stoichiometry/1.0
right: Sodium
right: Potassium
spontaneous: false
left: Sodium
left: Potassium
name: Sodium (→), Potassium (←) Transport: Rattus norvegicus, Extracellular Space to Rattus norvegicus, Cardiomyocyte, Cytosol
conversion direction: LEFT_TO_RIGHT

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Sarcoplasmic Reticulum
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0016529

Voltage-dependent T-type calcium channel subunit alpha-1G
type: Protein
entity reference: Voltage-dependent T-type calcium channel subunit alpha-1G

Transport10140
type: Transport
participant stoichiometry: Compound/PW C000458 Cytosol/Stoichiometry/3.0
participant stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Extracellular Space/Stoichiometry/3.0
participant stoichiometry: Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
right: Calcium
right: Sodium
spontaneous: false
left: Sodium
left: Calcium
name: Calcium (→), Sodium (←) Transport: Rattus norvegicus, Cardiomyocyte, Cytosol to Rattus norvegicus, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Reference/BRENDA TISSUE ONTOLOGY BTO 0000887
type: UnificationXref
id: BTO:0000887
db: BRENDA TISSUE ONTOLOGY

Unknown
type: Protein
cellular location: Cytosol
entity reference: Unknown

Protein/3625 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
stoichiometric coefficient: 1.0

Reference/UniProt Q9WU30
type: UnificationXref
id: Q9WU30
db: UniProt

Voltage-dependent T-type calcium channel subunit alpha-1H
type: Protein
entity reference: Voltage-dependent T-type calcium channel subunit alpha-1H

TransportCatalysis1359
type: Catalysis
controller: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
controlled: Transport10141
control type: ACTIVATION

TransportCatalysis1358
type: Catalysis
controller: Sodium/calcium exchanger 1
controlled: Transport10140
control type: ACTIVATION

Reference/PubChem-compound 813
type: UnificationXref
id: 813
db: PubChem-compound

Reference/ChemSpider 5851
type: UnificationXref
id: 5851
db: ChemSpider

Reference/PubChem-compound 6830
type: UnificationXref
id: 6830
db: PubChem-compound

BiologicalState458
type: BioSource
cell type: Myocyte
xref: Reference/TAXONOMY 10116
name: Rattus norvegicus, Muscle, Myocyte
tissue: Muscle

Guanosine diphosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001201
xref: Reference/BioCyc GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
xref: Reference/CAS 146-91-8
xref: Reference/PubChem-compound 8977
xref: Reference/ChEBI CHEBI 17552
xref: Reference/ChemSpider 8630
xref: Reference/KEGG Compound C00035
chemical formula: C10H15N5O11P2
molecular weight: 443.02432
structure: ChemicalStructure/PW C000936

Reference/CELL TYPE ONTOLOGY CL 0000746
type: UnificationXref
id: CL:0000746
db: CELL TYPE ONTOLOGY

Reference/ChemSpider 266
type: UnificationXref
id: 266
db: ChemSpider

Rattus norvegicus
type: BioSource
xref: Reference/TAXONOMY 10116

Protein/21587 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanine nucleotide-binding protein G(i) subunit alpha-1
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: Reference/UniProt P62873
organism: BiologicalState1537

Reference/UniProt Q9QWG8
type: UnificationXref
id: Q9QWG8
db: UniProt

Reference/KEGG Compound C00238
type: UnificationXref
id: C00238
db: KEGG Compound

Guanosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15996
xref: Reference/ChemSpider 6569
xref: Reference/KEGG Compound C00044
xref: Reference/PubChem-compound 6830
xref: Reference/HMDB HMDB0001273
xref: Reference/CAS 86-01-1
xref: Reference/BioCyc GTP
chemical formula: C10H16N5O14P3
molecular weight: 522.99066
structure: ChemicalStructure/PW C000986

Compound/PW C000414 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Guanosine triphosphate
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Guanosine triphosphate

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Gγ
type: ProteinReference
xref: Reference/UniProt P59768
organism: BiologicalState1537

Troponin
type: ProteinReference
organism: BiologicalState458

Protein/20668 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Tropomyosin beta chain
stoichiometric coefficient: 1.0

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
type: Protein
cellular location: Cell Membrane
entity reference: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4

Reaction219650
type: BiochemicalReaction
participant stoichiometry: ProteinComplex/16634 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Protein/21587 Cell Membrane/Stoichiometry/1.0
right: Guanine nucleotide-binding protein G(i) subunit alpha-1
spontaneous: false
left: G protein complex
name: G protein complex → Guanine nucleotide-binding protein G(i) subunit alpha-1
conversion direction: LEFT_TO_RIGHT

Muscarinic Receptor
type: ProteinReference
organism: BiologicalState1537

Reference/GENE ONTOLOGY GO 0005886
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

Compound/PW C000353 Sarcoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

SubPathwayControl121802
type: Interaction
name: SubPathway121802Control
name: InhibitorySubPathwayControl
participant: Muscle Contraction

Compound/PW C000458 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 1.0

Reference/CAS 24203-36-9
type: UnificationXref
id: 24203-36-9
db: CAS

Reference/KEGG Compound C01330
type: UnificationXref
id: C01330
db: KEGG Compound

ChemicalStructure/PW C000936
type: ChemicalStructure
structure format: SMILES

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: Protein
cellular location: Cell Membrane
entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

Reaction219658
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000041 Cytosol/Stoichiometry/1.0
right: cAMP
spontaneous: false
left: Adenosine triphosphate
name: Adenosine triphosphate → cAMP
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Reference/HMDB HMDB0000464
type: UnificationXref
id: HMDB0000464
db: HMDB

Myocyte
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000187

Cardiomyocyte
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000746

Reference/HMDB HMDB0000586
type: UnificationXref
id: HMDB0000586
db: HMDB

Reference/BioCyc GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
type: UnificationXref
id: GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
db: BioCyc

Reference/HMDB HMDB0000588
type: UnificationXref
id: HMDB0000588
db: HMDB

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: Reference/UniProt Q9QWG8
organism: BiologicalState1537

Muscle
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000887

Reference/ChEBI CHEBI 17489
type: UnificationXref
id: CHEBI:17489
db: ChEBI

Voltage-gated T-type calcium channel (ICaT)
type: Complex
component: Voltage-dependent T-type calcium channel subunit alpha-1G
component: Voltage-dependent T-type calcium channel subunit alpha-1H

Reference/BioCyc CAMP
type: UnificationXref
id: CAMP
db: BioCyc

Tropomyosin alpha-1 chain
type: Protein
cellular location: Cytoplasm
entity reference: Tropomyosin alpha-1 chain

Reference/UniProt Q45QN2
type: UnificationXref
id: Q45QN2
db: UniProt

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
type: Protein
cellular location: Cell Membrane
entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12

BoundComplex/650 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (Rattus norvegicus)_Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 (Rattus norvegicus)
stoichiometric coefficient: 1.0

Reaction219306
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000936 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000986 Cell Membrane/Stoichiometry/1.0
right: Guanosine triphosphate
spontaneous: false
left: Guanosine diphosphate
name: Guanosine diphosphate → Guanosine triphosphate
conversion direction: LEFT_TO_RIGHT

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Reference/HMDB HMDB0001201
type: UnificationXref
id: HMDB0001201
db: HMDB

Reference/CAS 14127-61-8
type: UnificationXref
id: 14127-61-8
db: CAS

ChemicalStructure/PW C000353
type: ChemicalStructure
structure format: SMILES
structure data: [Ca++]

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Reference/ChEBI CHEBI 15996
type: UnificationXref
id: CHEBI:15996
db: ChEBI

Calcium
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Calcium

Compound/PW C000457 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Potassium
stoichiometric coefficient: 1.0

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Muscarinic Receptor
type: Protein
cellular location: Cell Membrane
entity reference: Muscarinic Receptor

Sodium
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Sodium

Adenosine triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine triphosphate

Reference/UniProt Q548R1
type: UnificationXref
id: Q548R1
db: UniProt

Protein/19348 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
stoichiometric coefficient: 1.0

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Reference/ChEBI CHEBI 29108
type: UnificationXref
id: CHEBI:29108
db: ChEBI

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

Troponin
type: Protein
cellular location: Cytoplasm
entity reference: Troponin

Reference/CAS 60-92-4
type: UnificationXref
id: 60-92-4
db: CAS

Reference/ChEBI CHEBI 29101
type: UnificationXref
id: CHEBI:29101
db: ChEBI

Reference/ChEBI CHEBI 29103
type: UnificationXref
id: CHEBI:29103
db: ChEBI

Guanosine diphosphate
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Guanosine diphosphate

Compound/PW C000458 Cytosol/Stoichiometry/3.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 3.0

Reference/TAXONOMY 10116
type: UnificationXref
id: 10116
db: TAXONOMY

Transport16307
type: Transport
participant stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353 Sarcoplasmic Reticulum/Stoichiometry/1.0
right: Calcium
spontaneous: false
left: Calcium
name: Calcium (→) Transport: Rattus norvegicus, Heart, Cardiomyocyte, Sarcoplasmic Reticulum to Rattus norvegicus, Heart, Cardiomyocyte, Cytosol
conversion direction: LEFT_TO_RIGHT

Transport16308
type: Transport
participant stoichiometry: Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353 Cytoplasm/Stoichiometry/1.0
right: Calcium
spontaneous: false
left: Calcium
name: Calcium (→) Transport: Rattus norvegicus, Extracellular Space to Rattus norvegicus, Cell, Cytoplasm
conversion direction: LEFT_TO_RIGHT

Reference/ChemSpider 899
type: UnificationXref
id: 899
db: ChemSpider

Reference/KEGG Compound C00035
type: UnificationXref
id: C00035
db: KEGG Compound

Calcium
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Calcium

Potassium
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Potassium

Heart
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000562

Compound/PW C000353 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Compound/PW C000458 Extracellular Space/Stoichiometry/3.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 3.0

Reference/KEGG Compound C00044
type: UnificationXref
id: C00044
db: KEGG Compound

Reference/BioCyc K+
type: UnificationXref
id: K%2b
db: BioCyc

Tropomyosin alpha-1 chain
type: ProteinReference
xref: Reference/UniProt Q63609
organism: BiologicalState458

Protein/19708/Stoichiometry/4.0
type: Stoichiometry
physical entity: Inositol 1,4,5-trisphosphate receptor type 1
stoichiometric coefficient: 4.0

Muscle Contraction
type: Pathway
name: InhibitorySubPathway

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

Compound/PW C000986 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanosine triphosphate
stoichiometric coefficient: 1.0

Reference/CAS 17341-25-2
type: UnificationXref
id: 17341-25-2
db: CAS

Guanine nucleotide-binding protein G(i) subunit alpha-1
type: Protein
cellular location: Cell Membrane
entity reference: Guanine nucleotide-binding protein G(i) subunit alpha-1

cAMP
type: SmallMolecule
cellular location: Cell Membrane
entity reference: cAMP

G protein complex
type: Complex
cellular location: Cell Membrane
component: Guanine nucleotide-binding protein G(i) subunit alpha-1
component: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
component: Gγ

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Protein/Generic536 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Troponin
stoichiometric coefficient: 1.0

Potassium
type: SmallMolecule
cellular location: Cytosol
entity reference: Potassium

Tropomyosin beta chain
type: ProteinReference
xref: Reference/UniProt P06395
organism: BiologicalState458

Reference/UniProt Q62869
type: UnificationXref
id: Q62869
db: UniProt

Reference/ChemSpider 791
type: UnificationXref
id: 791
db: ChemSpider

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Reaction219632
type: BiochemicalReaction
participant stoichiometry: ProteinComplex/16634 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: BoundComplex/650 Cell Membrane/Stoichiometry/1.0
right: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (Rattus norvegicus)_Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 (Rattus norvegicus)
spontaneous: false
left: G protein complex
name: G protein complex → Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (Rattus norvegicus) + Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 (Rattus norvegicus)
conversion direction: LEFT_TO_RIGHT

Voltage-dependent T-type calcium channel subunit alpha-1G
type: ProteinReference
xref: Reference/UniProt Q548R1

Reference/PubChem-compound 8977
type: UnificationXref
id: 8977
db: PubChem-compound

Reference/UniProt Q63609
type: UnificationXref
id: Q63609
db: UniProt

ChemicalStructure/PW C000041
type: ChemicalStructure
structure format: SMILES

Voltage-dependent T-type calcium channel subunit alpha-1H
type: ProteinReference
xref: Reference/UniProt Q9EQ60

Reference/UniProt P62873
type: UnificationXref
id: P62873
db: UniProt

Reference/KEGG Compound C00076
type: UnificationXref
id: C00076
db: KEGG Compound

Sodium
type: SmallMolecule
cellular location: Cytosol
entity reference: Sodium

Compound/PW C000458 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 1.0

Interaction5321
type: MolecularInteraction
interaction type: direct_interaction
name: Guanine nucleotide-binding protein G(i) subunit alpha-1 inhibits Adenylyl Cyclase
participant: Unknown
participant: Guanine nucleotide-binding protein G(i) subunit alpha-1

Reference/ChemSpider 8630
type: UnificationXref
id: 8630
db: ChemSpider

Reference/BioCyc CA+2
type: UnificationXref
id: CA%2b2
db: BioCyc

Reference/HMDB HMDB0000058
type: UnificationXref
id: HMDB0000058
db: HMDB

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
type: Protein
entity reference: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4

Inositol 1,4,5-trisphosphate receptor type 1
type: Protein
entity reference: Inositol 1,4,5-trisphosphate receptor type 1

Calcium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000464
xref: Reference/BioCyc CA+2
xref: Reference/ChemSpider 266
xref: Reference/ChEBI CHEBI 29108
xref: Reference/CAS 14127-61-8
xref: Reference/KEGG Compound C00076
xref: Reference/PubChem-compound 271
chemical formula: Ca
molecular weight: 39.96259
structure: ChemicalStructure/PW C000353

Guanine nucleotide-binding protein G(i) subunit alpha-1
type: Protein
cellular location: Cytosol
entity reference: Guanine nucleotide-binding protein G(i) subunit alpha-1

Protein/20652 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Tropomyosin alpha-1 chain
stoichiometric coefficient: 1.0

Cell Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005886

Reference/PathWhiz PW128573
type: UnificationXref
id: PW128573
db: PathWhiz

TransportCatalysis6029
type: Catalysis
controller: Voltage-gated T-type calcium channel (ICaT)
controlled: Transport16308
control type: ACTIVATION

TransportCatalysis6028
type: Catalysis
controller: Inositol 1,4,5-trisphosphate receptor type 1
controlled: Transport16307
control type: ACTIVATION

Reference/ChemSpider 6569
type: UnificationXref
id: 6569
db: ChemSpider

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 271
type: UnificationXref
id: 271
db: PubChem-compound

Reference/ChEBI CHEBI 17552
type: UnificationXref
id: CHEBI:17552
db: ChEBI

Reference/BioCyc GTP
type: UnificationXref
id: GTP
db: BioCyc

Reference/UniProt Q9QZW4
type: UnificationXref
id: Q9QZW4
db: UniProt

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (Rattus norvegicus)_Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 (Rattus norvegicus)
type: Complex
component stoichiometry: Protein/19348 Cell Membrane/Stoichiometry/1.0
component stoichiometry: Protein/3625 Cell Membrane/Stoichiometry/1.0
cellular location: Cell Membrane
component: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
component: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

Sodium/calcium exchanger 1
type: Protein
entity reference: Sodium/calcium exchanger 1

Reference/SMPDB SMP0126957
type: UnificationXref
id: SMP0126957
db: SMPDB

Reference/HMDB HMDB0001273
type: UnificationXref
id: HMDB0001273
db: HMDB

Interaction5341
type: MolecularInteraction
interaction type: direct_interaction
name: Muscarinic Receptor activates G protein complex
participant: Muscarinic Receptor
participant: G protein complex

Unknown
type: ProteinReference
organism: BiologicalState1537

ChemicalStructure/PW C000986
type: ChemicalStructure
structure format: SMILES

Reference/UniProt P06395
type: UnificationXref
id: P06395
db: UniProt

BiologicalState1537
type: BioSource
cell type: Cardiomyocyte
xref: Reference/TAXONOMY 10116
name: Rattus norvegicus, Heart, Cardiomyocyte
tissue: Heart

Reference/BRENDA TISSUE ONTOLOGY BTO 0000562
type: UnificationXref
id: BTO:0000562
db: BRENDA TISSUE ONTOLOGY

BoundComplex/507 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium_Troponin
stoichiometric coefficient: 1.0

Reference/CAS 86-01-1
type: UnificationXref
id: 86-01-1
db: CAS

Reference/PubChem-compound 6076
type: UnificationXref
id: 6076
db: PubChem-compound

Sodium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000588
xref: Reference/PubChem-compound 923
xref: Reference/KEGG Compound C01330
xref: Reference/ChEBI CHEBI 29101
xref: Reference/ChemSpider 899
xref: Reference/CAS 17341-25-2
chemical formula: Na
molecular weight: 22.989769
structure: ChemicalStructure/PW C000458

Tropomyosin beta chain
type: Protein
cellular location: Cytoplasm
entity reference: Tropomyosin beta chain

Potassium
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00238
xref: Reference/HMDB HMDB0000586
xref: Reference/PubChem-compound 813
xref: Reference/ChemSpider 791
xref: Reference/CAS 24203-36-9
xref: Reference/BioCyc K+
xref: Reference/ChEBI CHEBI 29103
chemical formula: K
molecular weight: 38.963707
structure: ChemicalStructure/PW C000457

Compound/PW C000936 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanosine diphosphate
stoichiometric coefficient: 1.0

Reference/CAS 146-91-8
type: UnificationXref
id: 146-91-8
db: CAS

Calcium
type: SmallMolecule
cellular location: Sarcoplasmic Reticulum
entity reference: Calcium

Compound/PW C000353 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Reference/UniProt Q9EQ60
type: UnificationXref
id: Q9EQ60
db: UniProt

Reference/UniProt Q9UBI6
type: UnificationXref
id: Q9UBI6
db: UniProt