Protein kinase C alpha type
type: Protein
cellular location: Cell Membrane
entity reference: Protein kinase C alpha type

cAMP-dependent protein kinase catalytic subunit beta
type: ProteinReference
xref: Reference/UniProt P22694
organism: BiologicalState1505

Reference/UniProt Q9JID0
type: UnificationXref
id: Q9JID0
db: UniProt

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: Protein
cellular location: Cell Membrane
entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

G protein-coupled receptor
type: ProteinReference
organism: BiologicalState1505

cAMP
type: SmallMolecule
cellular location: Cytosol
entity reference: cAMP

direct_interaction
type: InteractionVocabulary

Reference/UniProt P0DP28
type: UnificationXref
id: P0DP28
db: UniProt

Transport16263
type: Transport
participant stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353 Sarcoplasmic Reticulum/Stoichiometry/1.0
right: Calcium
spontaneous: false
left: Calcium
name: Calcium (→) Transport: Mus musculus, Cell, Sarcoplasmic Reticulum to Mus musculus, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Compound/PW C000041 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP
stoichiometric coefficient: 1.0

Inositol 1,4,5-trisphosphate receptor type 1
type: ProteinReference
xref: Reference/UniProt Q99LG5
organism: BiologicalState1505

Reaction179579
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/Generic536 Cytosol/Stoichiometry/1.0
participant stoichiometry: BoundComplex/507 Cytosol/Stoichiometry/1.0
right: Calcium_Troponin
spontaneous: false
left: Calcium
left: Troponin
name: Calcium + Troponin → Calcium + Troponin
conversion direction: LEFT_TO_RIGHT

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
type: ProteinReference
xref: Reference/UniProt Q9Z2T5
organism: BiologicalState1505

Guanine nucleotide-binding protein G(i) subunit alpha-1
type: ProteinReference
xref: Reference/UniProt P63096
organism: BiologicalState1505

Phosphatidylinositol-4,5-bisphosphate
type: SmallMoleculeReference

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
type: ProteinReference
xref: Reference/UniProt Q9UBI6
organism: BiologicalState1505

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Inositol 1,4,5-trisphosphate receptor type 1
type: Protein
cellular location: Cytosol
entity reference: Inositol 1,4,5-trisphosphate receptor type 1

Calcium
type: SmallMolecule
cellular location: Cytosol
entity reference: Calcium

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Protein/19763 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase type I-beta regulatory subunit
stoichiometric coefficient: 1.0

ChemicalStructure/PW C097005
type: ChemicalStructure
structure format: SMILES

Protein/19770 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase type II-alpha regulatory subunit
stoichiometric coefficient: 1.0

cAMP-dependent protein kinase catalytic subunit gamma
type: Protein
entity reference: cAMP-dependent protein kinase catalytic subunit gamma

Calcium_Troponin
type: Complex
component stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/Generic536 Cytosol/Stoichiometry/1.0
cellular location: Cytosol
component: Calcium
component: Troponin

cAMP
type: SmallMoleculeReference
xref: Reference/PubChem-compound 6076
xref: Reference/HMDB HMDB0000058
xref: Reference/ChEBI CHEBI 17489
xref: Reference/CAS 60-92-4
xref: Reference/BioCyc CAMP
xref: Reference/ChemSpider 5851
xref: Reference/KEGG Compound C00575
chemical formula: C10H12N5O6P
molecular weight: 329.05252
structure: ChemicalStructure/PW C000041

ProteinComplex/11049 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Protein kinase A
stoichiometric coefficient: 1.0

Protein/19865 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calmodulin-3
stoichiometric coefficient: 1.0

Reference/UniProt P59768
type: UnificationXref
id: P59768
db: UniProt

Reference/GENE ONTOLOGY GO 0016529
type: UnificationXref
id: GO:0016529
db: GENE ONTOLOGY

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase type I-alpha regulatory subunit

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: Protein
cellular location: Cell Membrane
entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

Protein/19707 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Inositol 1,4,5-trisphosphate receptor type 1
stoichiometric coefficient: 1.0

Reference/TAXONOMY 10090
type: UnificationXref
id: 10090
db: TAXONOMY

Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Reference/CELL TYPE ONTOLOGY CL 0000187
type: UnificationXref
id: CL:0000187
db: CELL TYPE ONTOLOGY

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Gγ
type: Protein
cellular location: Cell Membrane
entity reference: Gγ

Reference/KEGG Compound C00575
type: UnificationXref
id: C00575
db: KEGG Compound

Reference/ChEBI CHEBI 16595
type: UnificationXref
id: CHEBI:16595
db: ChEBI

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Sarcoplasmic Reticulum
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0016529

ProteinComplex/16629 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: G protein complex
stoichiometric coefficient: 1.0

Reference/BRENDA TISSUE ONTOLOGY BTO 0000887
type: UnificationXref
id: BTO:0000887
db: BRENDA TISSUE ONTOLOGY

Reference/CAS 85166-31-0
type: UnificationXref
id: 85166-31-0
db: CAS

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
type: Protein
cellular location: Cytosol
entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1

Protein/3625 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
stoichiometric coefficient: 1.0

Reference/SMPDB SMP0126973
type: UnificationXref
id: SMP0126973
db: SMPDB

Protein kinase C alpha type
type: ProteinReference
xref: Reference/UniProt P20444
organism: BiologicalState1505

Interaction5374
type: MolecularInteraction
interaction type: direct_interaction
name: Protein kinase C complex activates Ion Channel
participant: Ion Channel
participant: Protein kinase C complex

ChemicalStructure/PW C097908
type: ChemicalStructure
structure format: SMILES

Interaction5373
type: MolecularInteraction
interaction type: direct_interaction
name: G protein-coupled receptor activates G protein complex
participant: G protein complex
participant: G protein-coupled receptor

TransportCatalysis6008
type: Catalysis
controller: Inositol 1,4,5-trisphosphate receptor type 1
controlled: Transport16263
control type: ACTIVATION

cAMP-dependent protein kinase type II-alpha regulatory subunit
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase type II-alpha regulatory subunit

Reference/UniProt P12367
type: UnificationXref
id: P12367
db: UniProt

Ion Channel
type: ProteinReference
organism: BiologicalState1505

Reference/ChemSpider 5851
type: UnificationXref
id: 5851
db: ChemSpider

Protein/19767 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase type II-beta regulatory subunit
stoichiometric coefficient: 1.0

Reference/PubChem-compound 6830
type: UnificationXref
id: 6830
db: PubChem-compound

Compound/Generic402 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphatidylinositol-4,5-bisphosphate
stoichiometric coefficient: 1.0

Compound/PW C097005 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphatidylinositol 4,5-bisphosphate
stoichiometric coefficient: 1.0

Interaction5375
type: MolecularInteraction
interaction type: direct_interaction
name: PKA complex activates Ion Channel
participant: Ion Channel
participant: PKA complex

Guanosine diphosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001201
xref: Reference/BioCyc GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
xref: Reference/CAS 146-91-8
xref: Reference/PubChem-compound 8977
xref: Reference/ChEBI CHEBI 17552
xref: Reference/ChemSpider 8630
xref: Reference/KEGG Compound C00035
chemical formula: C10H15N5O11P2
molecular weight: 443.02432
structure: ChemicalStructure/PW C000936

Reference/UniProt Q9JHR6
type: UnificationXref
id: Q9JHR6
db: UniProt

Reference/ChemSpider 266
type: UnificationXref
id: 266
db: ChemSpider

Reference/UniProt Q8BRZ7
type: UnificationXref
id: Q8BRZ7
db: UniProt

Protein kinase C beta type
type: ProteinReference
xref: Reference/UniProt F2Z441
organism: BiologicalState1505

cAMP-dependent protein kinase type I-beta regulatory subunit
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase type I-beta regulatory subunit

Mus musculus
type: BioSource
xref: Reference/TAXONOMY 10090

Protein/17408 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
stoichiometric coefficient: 1.0

Protein kinase C alpha type
type: Protein
cellular location: Cytosol
entity reference: Protein kinase C alpha type

Reference/PathWhiz PW128590
type: UnificationXref
id: PW128590
db: PathWhiz

Diacylglycerol
type: SmallMolecule
cellular location: Cytosol
entity reference: Diacylglycerol

Reference/UniProt Q9Z2T5
type: UnificationXref
id: Q9Z2T5
db: UniProt

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: Reference/UniProt P62873
organism: BiologicalState1505

Guanosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15996
xref: Reference/ChemSpider 6569
xref: Reference/KEGG Compound C00044
xref: Reference/PubChem-compound 6830
xref: Reference/HMDB HMDB0001273
xref: Reference/CAS 86-01-1
xref: Reference/BioCyc GTP
chemical formula: C10H16N5O14P3
molecular weight: 522.99066
structure: ChemicalStructure/PW C000986

Compound/PW C000414 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Ion Channel
type: Protein
cellular location: Cell Membrane
entity reference: Ion Channel

Guanosine triphosphate
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Guanosine triphosphate

Reaction219644
type: BiochemicalReaction
participant stoichiometry: Protein/17408 Cytosol/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/11049 Cytosol/Stoichiometry/1.0
right: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
spontaneous: false
left: Protein kinase A
name: Protein kinase A → Phospholipase C
conversion direction: LEFT_TO_RIGHT

Reaction219643
type: BiochemicalReaction
participant stoichiometry: Protein/19707 Cytosol/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/11049 Cytosol/Stoichiometry/1.0
right: Inositol 1,4,5-trisphosphate receptor type 1
spontaneous: false
left: Protein kinase A
name: Protein kinase A → Inositol 1,4,5-trisphosphate receptor
conversion direction: LEFT_TO_RIGHT

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Reaction219641
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000041 Cytosol/Stoichiometry/1.0
right: cAMP
spontaneous: false
left: Adenosine triphosphate
name: Adenosine triphosphate → cAMP
conversion direction: LEFT_TO_RIGHT

Compound/PW C001155 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Inositol 1,4,5-trisphosphate
stoichiometric coefficient: 1.0

Gγ
type: ProteinReference
xref: Reference/UniProt P59768
organism: BiologicalState1505

Troponin
type: ProteinReference
organism: BiologicalState1505

Reaction219645
type: BiochemicalReaction
participant stoichiometry: ProteinComplex/16629 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Protein/4836 Cell Membrane/Stoichiometry/1.0
right: Guanine nucleotide-binding protein G(i) subunit alpha-1
spontaneous: false
left: G protein complex
name: G protein complex → Guanine nucleotide-binding protein G(i) subunit alpha-1
conversion direction: LEFT_TO_RIGHT

G protein complex
type: Complex
cellular location: Cell Membrane
component: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
component: Guanine nucleotide-binding protein G(i) subunit alpha-1
component: Gγ

Transport10243
type: Transport
participant stoichiometry: Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353 Cytoplasm/Stoichiometry/1.0
right: Calcium
spontaneous: false
left: Calcium
name: Calcium (→) Transport: Mus musculus, Extracellular Space to Mus musculus, Cell, Cytoplasm
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 6026790
type: UnificationXref
id: 6026790
db: PubChem-compound

Reference/UniProt P13861
type: UnificationXref
id: P13861
db: UniProt

Reference/GENE ONTOLOGY GO 0005886
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

Compound/PW C000353 Sarcoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Reference/BioCyc inositol 1,4,5-trisphosphate
type: UnificationXref
id: inositol_1,4,5-trisphosphate
db: BioCyc

PKA complex
type: Complex
cellular location: Cytosol
component: cAMP-dependent protein kinase type I-alpha regulatory subunit
component: cAMP-dependent protein kinase type II-alpha regulatory subunit
component: cAMP-dependent protein kinase catalytic subunit beta
component: cAMP-dependent protein kinase type II-beta regulatory subunit
component: cAMP-dependent protein kinase catalytic subunit gamma
component: cAMP-dependent protein kinase type I-beta regulatory subunit

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase type I-alpha regulatory subunit

cAMP-dependent protein kinase type II-alpha regulatory subunit
type: Protein
entity reference: cAMP-dependent protein kinase type II-alpha regulatory subunit

Reference/UniProt P22694
type: UnificationXref
id: P22694
db: UniProt

cAMP-dependent protein kinase type I-beta regulatory subunit
type: Protein
entity reference: cAMP-dependent protein kinase type I-beta regulatory subunit

Protein/Generic536 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Troponin
stoichiometric coefficient: 1.0

cAMP-dependent protein kinase type II-beta regulatory subunit
type: Protein
entity reference: cAMP-dependent protein kinase type II-beta regulatory subunit

ChemicalStructure/PW C000936
type: ChemicalStructure
structure format: SMILES

Troponin
type: Protein
cellular location: Cytosol
entity reference: Troponin

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Reference/ChemSpider 388562
type: UnificationXref
id: 388562
db: ChemSpider

Reference/HMDB HMDB0000464
type: UnificationXref
id: HMDB0000464
db: HMDB

Myocyte
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000187

Calmodulin-3
type: Protein
cellular location: Cytosol
entity reference: Calmodulin-3

Reference/BioCyc GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
type: UnificationXref
id: GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
db: BioCyc

Reference/PubChem-compound 24742074
type: UnificationXref
id: 24742074
db: PubChem-compound

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: Reference/UniProt P62874
organism: BiologicalState1505

Muscle
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000887

Ion Channel
type: Protein
entity reference: Ion Channel

Protein/19360 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase catalytic subunit beta
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 17489
type: UnificationXref
id: CHEBI:17489
db: ChEBI

Inositol 1,4,5-trisphosphate receptor type 1
type: Complex
component stoichiometry: Protein/19707/Stoichiometry/4.0
component: Inositol 1,4,5-trisphosphate receptor type 1

Reference/BioCyc CAMP
type: UnificationXref
id: CAMP
db: BioCyc

cAMP-dependent protein kinase catalytic subunit gamma
type: ProteinReference
xref: Reference/UniProt P22612
organism: BiologicalState1505

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
type: Protein
cellular location: Cell Membrane
entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12

Reaction219306
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000936 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000986 Cell Membrane/Stoichiometry/1.0
right: Guanosine triphosphate
spontaneous: false
left: Guanosine diphosphate
name: Guanosine diphosphate → Guanosine triphosphate
conversion direction: LEFT_TO_RIGHT

Protein/19349 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
stoichiometric coefficient: 1.0

Protein kinase C complex
type: Complex
cellular location: Cell Membrane
component: Protein kinase C alpha type
component: Protein kinase C beta type

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Reference/HMDB HMDB0001201
type: UnificationXref
id: HMDB0001201
db: HMDB

Phosphatidylinositol 4,5-bisphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Phosphatidylinositol 4,5-bisphosphate

Interaction1705
type: MolecularInteraction
interaction type: direct_interaction
name: Diacylglycerol activates Protein kinase C
participant: Diacylglycerol
participant: Protein kinase C alpha type

Reference/UniProt Q99LG5
type: UnificationXref
id: Q99LG5
db: UniProt

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Reference/CAS 14127-61-8
type: UnificationXref
id: 14127-61-8
db: CAS

ChemicalStructure/PW C000353
type: ChemicalStructure
structure format: SMILES
structure data: [Ca++]

PKA complex
type: Complex
component: cAMP-dependent protein kinase type I-alpha regulatory subunit
component: cAMP-dependent protein kinase catalytic subunit gamma
component: cAMP-dependent protein kinase type II-alpha regulatory subunit
component: cAMP-dependent protein kinase type I-beta regulatory subunit
component: cAMP-dependent protein kinase type II-beta regulatory subunit
component: cAMP-dependent protein kinase catalytic subunit beta

Reference/ChEBI CHEBI 15996
type: UnificationXref
id: CHEBI:15996
db: ChEBI

Calcium
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Calcium

cAMP-dependent protein kinase catalytic subunit alpha
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase catalytic subunit alpha

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Phosphatidylinositol 4,5-bisphosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 24742074
chemical formula: C47H80O19P3
molecular weight: 1041.4507
structure: ChemicalStructure/PW C097005

BoundComplex/647 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium_Calmodulin (Mus musculus)
stoichiometric coefficient: 1.0

Muscular Gi Protein Cascade
type: Pathway
pathway order: PathwayInteraction/5373
pathway order: PathwayTransport/2540897
pathway order: PathwayInteraction/1705
pathway order: PathwayTransport/2540898
pathway order: PathwayEnzymeReaction/2540889
pathway order: PathwayEnzymeReaction/2540888
pathway order: PathwayEnzymeReaction/2540887
pathway order: PathwayInteraction/5318
pathway order: PathwayInteraction/5317
pathway order: PathwayEnzymeReaction/2540896
pathway order: PathwayEnzymeReaction/2540895
pathway order: PathwayEnzymeReaction/2540894
pathway order: PathwayEnzymeReaction/2540893
pathway order: PathwayEnzymeReaction/2540892
pathway order: PathwayEnzymeReaction/2540891
pathway order: PathwayEnzymeReaction/2540890
pathway order: PathwayInteraction/5375
pathway order: PathwayInteraction/1041
pathway order: PathwayInteraction/5374
pathway component: Reaction179579
pathway component: Interaction5374
pathway component: Interaction5373
pathway component: TransportCatalysis6008
pathway component: Reaction219644
pathway component: Reaction219643
pathway component: Reaction219641
pathway component: Interaction1041
pathway component: Reaction219626
pathway component: Reaction219306
pathway component: Reaction219625
pathway component: Interaction5375
pathway component: Reaction219624
pathway component: Reaction219645
pathway component: Transport10243
pathway component: Interaction1705
pathway component: Interaction5318
pathway component: Interaction5317
pathway component: Reaction115846
pathway component: Transport16263
xref: Reference/SMPDB SMP0126973
xref: Reference/PathWhiz PW128590
organism: Mus musculus

cAMP-dependent protein kinase catalytic subunit beta
type: ProteinReference
xref: Reference/UniProt Q3UTH5
organism: BiologicalState1505

Adenosine triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine triphosphate

Inositol 1,4,5-trisphosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001498
xref: Reference/PubChem-compound 439456
xref: Reference/CAS 85166-31-0
xref: Reference/BioCyc inositol 1,4,5-trisphosphate
xref: Reference/KEGG Compound C01245
xref: Reference/ChEBI CHEBI 16595
xref: Reference/ChemSpider 388562
chemical formula: C6H15O15P3
molecular weight: 419.96237
structure: ChemicalStructure/PW C001155

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Reference/ChEBI CHEBI 29108
type: UnificationXref
id: CHEBI:29108
db: ChEBI

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: Protein
entity reference: cAMP-dependent protein kinase type I-alpha regulatory subunit

Reference/CAS 60-92-4
type: UnificationXref
id: 60-92-4
db: CAS

Compound/PW C097908 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Diacylglycerol
stoichiometric coefficient: 1.0

Guanosine diphosphate
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Guanosine diphosphate

Interaction1041
type: MolecularInteraction
interaction type: direct_interaction
name: Inositol 1,4,5-trisphosphate activates Inositol 1,4,5-trisphosphate receptor
participant: Inositol 1,4,5-trisphosphate
participant: Inositol 1,4,5-trisphosphate receptor type 1

Reference/KEGG Compound C00035
type: UnificationXref
id: C00035
db: KEGG Compound

Reference/KEGG Compound C01245
type: UnificationXref
id: C01245
db: KEGG Compound

cAMP-dependent protein kinase type II-alpha regulatory subunit
type: ProteinReference
xref: Reference/UniProt P12367
organism: BiologicalState1505

Calcium
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Calcium

cAMP-dependent protein kinase type II-beta regulatory subunit
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase type II-beta regulatory subunit

Protein/19707/Stoichiometry/4.0
type: Stoichiometry
physical entity: Inositol 1,4,5-trisphosphate receptor type 1
stoichiometric coefficient: 4.0

Diacylglycerol
type: SmallMolecule
cellular location: Cytosol
entity reference: Diacylglycerol

Compound/PW C000353 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Diacylglycerol
type: SmallMoleculeReference
xref: Reference/PubChem-compound 6026790
chemical formula: C37H70O5
molecular weight: 594.52234
structure: ChemicalStructure/PW C097908

Diacylglycerol
type: SmallMoleculeReference

Guanine nucleotide-binding protein G(i) subunit alpha-1
type: Protein
cellular location: Cell Membrane
entity reference: Guanine nucleotide-binding protein G(i) subunit alpha-1

Reference/KEGG Compound C00044
type: UnificationXref
id: C00044
db: KEGG Compound

cAMP-dependent protein kinase type II-beta regulatory subunit
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase type II-beta regulatory subunit

ChemicalStructure/PW C001155
type: ChemicalStructure
structure format: SMILES

Reference/UniProt P63096
type: UnificationXref
id: P63096
db: UniProt

Reference/UniProt F2Z441
type: UnificationXref
id: F2Z441
db: UniProt

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

Compound/PW C000986 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanosine triphosphate
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

cAMP-dependent protein kinase type II-beta regulatory subunit
type: ProteinReference
xref: Reference/UniProt P31323
organism: BiologicalState1505

cAMP-dependent protein kinase type II-alpha regulatory subunit
type: ProteinReference
xref: Reference/UniProt P13861
organism: BiologicalState1505

cAMP-dependent protein kinase type I-beta regulatory subunit
type: ProteinReference
xref: Reference/UniProt P31321
organism: BiologicalState1505

Reaction219626
type: BiochemicalReaction
participant stoichiometry: BoundComplex/648 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/16629 Cell Membrane/Stoichiometry/1.0
right: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (Mus musculus)_Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 (Mus musculus)
spontaneous: false
left: G protein complex
name: G protein complex → Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (Mus musculus) + Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 (Mus musculus)
conversion direction: LEFT_TO_RIGHT

Reaction219625
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001155 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/Generic402 Cytosol/Stoichiometry/1.0
right: Inositol 1,4,5-trisphosphate
spontaneous: false
left: Phosphatidylinositol-4,5-bisphosphate
name: Phosphatidylinositol-4,5-bisphosphate → Inositol 1,4,5-trisphosphate
conversion direction: LEFT_TO_RIGHT

Reaction219624
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
participant stoichiometry: BoundComplex/647 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/19865 Cytosol/Stoichiometry/1.0
right: Calcium_Calmodulin (Mus musculus)
spontaneous: false
left: Calmodulin-3
left: Calcium
name: Calcium + Calmodulin → Calcium + Calmodulin (Mus musculus)
conversion direction: LEFT_TO_RIGHT

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (Mus musculus)_Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 (Mus musculus)
type: Complex
component stoichiometry: Protein/19349 Cell Membrane/Stoichiometry/1.0
component stoichiometry: Protein/3625 Cell Membrane/Stoichiometry/1.0
cellular location: Cell Membrane
component: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
component: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12

Reference/PubChem-compound 439456
type: UnificationXref
id: 439456
db: PubChem-compound

Protein kinase A
type: Complex
component stoichiometry: Protein/19360 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/19760 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/19770 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/19756 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/19763 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/19767 Cytosol/Stoichiometry/1.0
cellular location: Cytosol
component: cAMP-dependent protein kinase catalytic subunit beta
component: cAMP-dependent protein kinase type I-alpha regulatory subunit
component: cAMP-dependent protein kinase catalytic subunit alpha
component: cAMP-dependent protein kinase type I-beta regulatory subunit
component: cAMP-dependent protein kinase type II-beta regulatory subunit
component: cAMP-dependent protein kinase type II-alpha regulatory subunit

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Protein/4836 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanine nucleotide-binding protein G(i) subunit alpha-1
stoichiometric coefficient: 1.0

Reference/PubChem-compound 8977
type: UnificationXref
id: 8977
db: PubChem-compound

cAMP-dependent protein kinase catalytic subunit beta
type: Protein
entity reference: cAMP-dependent protein kinase catalytic subunit beta

Reference/HMDB HMDB0001498
type: UnificationXref
id: HMDB0001498
db: HMDB

BiologicalState1505
type: BioSource
cell type: Myocyte
xref: Reference/TAXONOMY 10090
name: Mus musculus, Muscle, Myocyte
tissue: Muscle

BoundComplex/648 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (Mus musculus)_Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 (Mus musculus)
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000041
type: ChemicalStructure
structure format: SMILES

Calcium_Calmodulin (Mus musculus)
type: Complex
component stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/19865 Cytosol/Stoichiometry/1.0
cellular location: Cytosol
component: Calmodulin-3
component: Calcium

BoundComplex/507 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium_Troponin
stoichiometric coefficient: 1.0

Protein/19760 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase type I-alpha regulatory subunit
stoichiometric coefficient: 1.0

Unknown
type: ProteinReference
organism: BiologicalState1505

Reference/UniProt P62873
type: UnificationXref
id: P62873
db: UniProt

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: ProteinReference
xref: Reference/UniProt P10644
organism: BiologicalState1505

Reference/UniProt P62874
type: UnificationXref
id: P62874
db: UniProt

Reference/KEGG Compound C00076
type: UnificationXref
id: C00076
db: KEGG Compound

Reference/ChemSpider 8630
type: UnificationXref
id: 8630
db: ChemSpider

Unknown
type: Protein
cellular location: Cell Membrane
entity reference: Unknown

Reference/UniProt P20444
type: UnificationXref
id: P20444
db: UniProt

Reference/BioCyc CA+2
type: UnificationXref
id: CA%2b2
db: BioCyc

Reference/HMDB HMDB0000058
type: UnificationXref
id: HMDB0000058
db: HMDB

Protein kinase C beta type
type: Protein
cellular location: Cell Membrane
entity reference: Protein kinase C beta type

Inositol 1,4,5-trisphosphate receptor type 1
type: Protein
entity reference: Inositol 1,4,5-trisphosphate receptor type 1

Calcium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000464
xref: Reference/BioCyc CA+2
xref: Reference/ChemSpider 266
xref: Reference/ChEBI CHEBI 29108
xref: Reference/CAS 14127-61-8
xref: Reference/KEGG Compound C00076
xref: Reference/PubChem-compound 271
chemical formula: Ca
molecular weight: 39.96259
structure: ChemicalStructure/PW C000353

cAMP-dependent protein kinase type II-alpha regulatory subunit
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase type II-alpha regulatory subunit

Cell Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005886

Reference/UniProt P31321
type: UnificationXref
id: P31321
db: UniProt

Reference/UniProt P10644
type: UnificationXref
id: P10644
db: UniProt

Reference/ChemSpider 6569
type: UnificationXref
id: 6569
db: ChemSpider

Reference/UniProt P31323
type: UnificationXref
id: P31323
db: UniProt

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Protein/19756 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase catalytic subunit alpha
stoichiometric coefficient: 1.0

Reference/PubChem-compound 271
type: UnificationXref
id: 271
db: PubChem-compound

Reference/ChEBI CHEBI 17552
type: UnificationXref
id: CHEBI:17552
db: ChEBI

Reference/BioCyc GTP
type: UnificationXref
id: GTP
db: BioCyc

cAMP-dependent protein kinase catalytic subunit gamma
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase catalytic subunit gamma

G protein-coupled receptor
type: Protein
cellular location: Cell Membrane
entity reference: G protein-coupled receptor

Reference/UniProt P22612
type: UnificationXref
id: P22612
db: UniProt

Interaction5318
type: MolecularInteraction
interaction type: direct_interaction
name: Guanine nucleotide-binding protein G(i) subunit alpha-1 inhibits Adenylyl Cyclase
participant: Guanine nucleotide-binding protein G(i) subunit alpha-1
participant: Unknown

Interaction5317
type: MolecularInteraction
interaction type: direct_interaction
name: cAMP activates PKA complex
participant: PKA complex
participant: cAMP

Reaction115846
type: BiochemicalReaction
participant stoichiometry: Compound/PW C097005 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C097908 Cytosol/Stoichiometry/1.0
right: Diacylglycerol
spontaneous: false
left: Phosphatidylinositol 4,5-bisphosphate
name: Phosphatidylinositol 4,5-bisphosphate → Diacylglycerol
conversion direction: LEFT_TO_RIGHT

Calmodulin-3
type: ProteinReference
xref: Reference/UniProt P0DP28
organism: BiologicalState1505

Reference/HMDB HMDB0001273
type: UnificationXref
id: HMDB0001273
db: HMDB

cAMP-dependent protein kinase type I-beta regulatory subunit
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase type I-beta regulatory subunit

ChemicalStructure/PW C000986
type: ChemicalStructure
structure format: SMILES

cAMP-dependent protein kinase catalytic subunit beta
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase catalytic subunit beta

cAMP-dependent protein kinase catalytic subunit beta
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase catalytic subunit beta

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: Reference/UniProt Q9JID0
organism: BiologicalState1505

Reference/CAS 86-01-1
type: UnificationXref
id: 86-01-1
db: CAS

Reference/PubChem-compound 6076
type: UnificationXref
id: 6076
db: PubChem-compound

Reference/UniProt Q3UTH5
type: UnificationXref
id: Q3UTH5
db: UniProt

Phosphatidylinositol-4,5-bisphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Phosphatidylinositol-4,5-bisphosphate

Reference/UniProt P12849
type: UnificationXref
id: P12849
db: UniProt

Compound/PW C000936 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanosine diphosphate
stoichiometric coefficient: 1.0

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: ProteinReference
xref: Reference/UniProt Q9JHR6
organism: BiologicalState1505

Reference/CAS 146-91-8
type: UnificationXref
id: 146-91-8
db: CAS

cAMP-dependent protein kinase type I-beta regulatory subunit
type: ProteinReference
xref: Reference/UniProt P12849
organism: BiologicalState1505

Calcium
type: SmallMolecule
cellular location: Sarcoplasmic Reticulum
entity reference: Calcium

Inositol 1,4,5-trisphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Inositol 1,4,5-trisphosphate

cAMP-dependent protein kinase type II-beta regulatory subunit
type: ProteinReference
xref: Reference/UniProt Q8BRZ7
organism: BiologicalState1505

Compound/PW C000353 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Reference/UniProt Q9UBI6
type: UnificationXref
id: Q9UBI6
db: UniProt