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Pathway Description
Bimatoprost Action Pathway
Homo sapiens
Drug Action Pathway
Bimatoprost is a prostaglandin analog with multiple medical applications. It belongs to the prostamide group of drugs and is available in both ophthalmic solution and implant forms. Primarily, bimatoprost is used to manage elevated intraocular pressure in conditions such as open-angle glaucoma and ocular hypertension. It achieves this by mimicking the effects of prostamides, particularly prostaglandin F2α, to stimulate aqueous humor outflow. This reduction in intraocular pressure helps prevent optic nerve damage.
Additionally, bimatoprost is utilized for a cosmetic purpose – to treat eyelash hypotrichosis, a condition characterized by sparse eyelash growth. This application arose as an unintended but desirable side effect for patients using the drug. Bimatoprost has been approved for these purposes and is available under brand names like Latisse and Lumigan, marketed by Allergan. This versatile medication underscores the importance of understanding its pharmacological actions in different medical contexts.
References
Bimatoprost Pathway References
Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M: DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037.
Pubmed: 29126136
Jiang Xing Chen, "Process for the production of intermediates for making prostaglandin derivatives such as latanaprost, travaprost, and bimatoprost." U.S. Patent US20090287003, issued November 19, 2009
Chen MJ, Cheng CY, Chen YC, Chou CK, Hsu WM: Effects of bimatoprost 0.03% on ocular hemodynamics in normal tension glaucoma. J Ocul Pharmacol Ther. 2006 Jun;22(3):188-93
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