Dinoprostone is a naturally occurring prostaglandin E2 (PGE2) with significant roles in various physiological processes, most notably in labor. This medication, available as a vaginal suppository, is used for several medical purposes. Firstly, it is employed to prepare the cervix for labor and induce labor itself. Dinoprostone's ability to stimulate the uterine muscles helps facilitate childbirth. Moreover, dinoprostone is utilized for pregnancy termination during the second trimester (from the 12th through the 20th gestational week) and for managing missed abortion or intrauterine fetal death up to 28 weeks of gestational age. Additionally, it plays a crucial role in the management of nonmetastatic gestational trophoblastic disease, specifically benign hydatidiform mole. Dinoprostone's versatility in various reproductive and obstetric contexts highlights its importance in women's health. Its mechanisms of action include direct stimulation of the myometrium and potential effects on cervical softening, effacement, and dilation, although the precise mechanisms are not fully understood.

Dinoprostone Pathway References