Reference/PubChem-compound 6021
type: UnificationXref
id: 6021
db: PubChem-compound

Reference/CAS 7722-84-1
type: UnificationXref
id: 7722-84-1
db: CAS

Guanine deaminase
type: Complex
component stoichiometry: Protein/7725 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Unknown

Reference/UniProt Q00519
type: UnificationXref
id: Q00519
db: UniProt

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Reference/BioCyc RIBOSE-1P
type: UnificationXref
id: RIBOSE-1P
db: BioCyc

Reference/ChEBI CHEBI 16134
type: UnificationXref
id: CHEBI:16134
db: ChEBI

Reference/HMDB HMDB0003125
type: UnificationXref
id: HMDB0003125
db: HMDB

Reference/PubChem-compound 439153
type: UnificationXref
id: 439153
db: PubChem-compound

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

ChemicalStructure/PW C001783
type: ChemicalStructure
structure format: SMILES
structure data: OO

Ammonia
type: SmallMoleculeReference
xref: Reference/BioCyc AMMONIA
xref: Reference/CAS 7664-41-7
xref: Reference/HMDB HMDB0000051
xref: Reference/PubChem-compound 222
xref: Reference/KEGG Compound C00014
xref: Reference/ChEBI CHEBI 16134
xref: Reference/ChemSpider 217
chemical formula: H3N
molecular weight: 17.026548
structure: ChemicalStructure/PW C000035

Adenosine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 60961
xref: Reference/ChEBI CHEBI 16335
xref: Reference/ChemSpider 54923
xref: Reference/HMDB HMDB0000050
xref: Reference/CAS 58-61-7
xref: Reference/KEGG Compound C00212
xref: Reference/BioCyc ADENOSINE
chemical formula: C10H13N5O4
molecular weight: 267.09674
structure: ChemicalStructure/PW C000034

Purine nucleoside phosphorylase
type: Complex
component stoichiometry: Protein/7725 Cytosol/Stoichiometry/3.0
cellular location: Cytosol
component: Unknown

Compound/PW C001065 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 17596
type: UnificationXref
id: CHEBI:17596
db: ChEBI

Reference/ChemSpider 219288
type: UnificationXref
id: 219288
db: ChemSpider

ChemicalStructure/PW C000102
type: ChemicalStructure
structure format: SMILES
structure data: OC1=NC=NC2=C1NC=N2

Reference/ChEBI CHEBI 15846
type: UnificationXref
id: CHEBI:15846
db: ChEBI

Reference/ChEBI CHEBI 16235
type: UnificationXref
id: CHEBI:16235
db: ChEBI

Reference/CELL TYPE ONTOLOGY CL 0000182
type: UnificationXref
id: CL:0000182
db: CELL TYPE ONTOLOGY

Reference/TAXONOMY 10090
type: UnificationXref
id: 10090
db: TAXONOMY

Reference/BRENDA TISSUE ONTOLOGY BTO 0000759
type: UnificationXref
id: BTO:0000759
db: BRENDA TISSUE ONTOLOGY

Inosine
type: SmallMoleculeReference
xref: Reference/CAS 58-63-9
xref: Reference/PubChem-compound 6021
xref: Reference/KEGG Compound C00294
xref: Reference/BioCyc INOSINE
xref: Reference/ChemSpider 5799
xref: Reference/ChEBI CHEBI 17596
xref: Reference/HMDB HMDB0000195
chemical formula: C10H12N4O5
molecular weight: 268.08078
structure: ChemicalStructure/PW C000127

Metabolism and Physiological Effects of Allantoin
type: Pathway
pathway order: PathwayEnzymeReaction/2552914
pathway order: PathwayEnzymeReaction/2552912
pathway order: PathwayEnzymeReaction/2552899
pathway order: PathwayTransport/2552905
pathway order: PathwayEnzymeReaction/2552900
pathway order: PathwayTransport/2552906
pathway order: PathwayEnzymeReaction/2552897
pathway order: PathwayEnzymeReaction/2552898
pathway order: PathwayEnzymeReaction/2552895
pathway order: PathwayEnzymeReaction/2552896
pathway order: PathwaySubPathway/122677
pathway order: PathwaySubPathway/122676
pathway order: PathwayTransport/2552901
pathway order: PathwayTransport/2552902
pathway order: PathwayTransport/2552903
pathway order: PathwayTransport/2552904
pathway order: PathwayTransport/2552915
pathway component: Reaction110380
pathway component: ReactionCatalysis100674
pathway component: Reaction110381
pathway component: ReactionCatalysis100695
pathway component: ReactionCatalysis100694
pathway component: 3.5.4.4
pathway component: ReactionCatalysis100692
pathway component: Transport17653
pathway component: 2.4.2.1
pathway component: 3.5.4.3
pathway component: Transport17651
pathway component: Transport17650
pathway component: ReactionCatalysis100699
pathway component: ReactionCatalysis100698
pathway component: TransportCatalysis6127
pathway component: TransportCatalysis6126
pathway component: Oxidative Stress
pathway component: Kidney Damage
pathway component: Transport17649
pathway component: Transport17648
pathway component: Transport17647
pathway component: Transport17646
pathway component: Reaction221551
pathway component: 1.7.3.3
pathway component: TransportCatalysis6125
pathway component: TransportCatalysis6124
pathway component: ReactionCatalysis210890
xref: Reference/SMPDB SMP0127696
xref: Reference/PathWhiz PW129315
organism: Mus musculus

Reference/PathWhiz PW129315
type: UnificationXref
id: PW129315
db: PathWhiz

NADH
type: SmallMolecule
cellular location: Cytosol
entity reference: NADH

BiologicalState327
type: BioSource
cell type: Hepatocyte
xref: Reference/TAXONOMY 10090
name: Mus musculus, Liver, Hepatocyte
tissue: Liver

Reference/KEGG Compound C00212
type: UnificationXref
id: C00212
db: KEGG Compound

Reference/ChemSpider 1142
type: UnificationXref
id: 1142
db: ChemSpider

Reference/ChemSpider 952
type: UnificationXref
id: 952
db: ChemSpider

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Compound/PW C000195 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Uric acid
stoichiometric coefficient: 1.0

Reference/ChemSpider 274
type: UnificationXref
id: 274
db: ChemSpider

Uricase
type: ProteinReference
xref: Reference/UniProt P25688
organism: BiologicalState327

ChemicalStructure/PW C011313
type: ChemicalStructure
structure format: SMILES
structure data: OC12NC(=O)N=C1NC(=O)NC2=O

Reference/BioCyc HYPOXANTHINE
type: UnificationXref
id: HYPOXANTHINE
db: BioCyc

Reference/BioCyc XANTHINE
type: UnificationXref
id: XANTHINE
db: BioCyc

Reference/ChEBI CHEBI 16908
type: UnificationXref
id: CHEBI:16908
db: ChEBI

Compound/PW C000198 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Xanthine
stoichiometric coefficient: 1.0

Ammonia
type: SmallMolecule
cellular location: Cytosol
entity reference: Ammonia

Compound/PW C000034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine
stoichiometric coefficient: 1.0

TransportCatalysis6127
type: Catalysis
controller: Unknown
controlled: Transport17651
control type: ACTIVATION

TransportCatalysis6126
type: Catalysis
controller: Unknown
controlled: Transport17650
control type: ACTIVATION

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: H3O4P
molecular weight: 97.9769
structure: ChemicalStructure/PW C001104

Reference/KEGG Compound C01551
type: UnificationXref
id: C01551
db: KEGG Compound

Reference/ChEBI CHEBI 16240
type: UnificationXref
id: CHEBI:16240
db: ChEBI

Reaction221551
type: BiochemicalReaction
participant stoichiometry: Compound/PW C011313 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000352 Cytosol/Stoichiometry/1.0
right: Carbon dioxide
right: Allantoin
spontaneous: true
left: 5-Hydroxyisourate
left: Water
name: 5-Hydroxyisourate + Water → Allantoin + Carbon dioxide
conversion direction: LEFT_TO_RIGHT

1.7.3.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C011313 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001783 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000195 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
right: 5-Hydroxyisourate
right: Hydrogen peroxide
spontaneous: false
EC number: 1.7.3.3
left: Oxygen
left: Uric acid
left: Water
name: Oxygen + Uric acid + Water → 5-Hydroxyisourate + Hydrogen peroxide
conversion direction: LEFT_TO_RIGHT

Adenine
type: SmallMolecule
entity reference: Adenine

TransportCatalysis6125
type: Catalysis
controller: Unknown
controlled: Transport17648
control type: ACTIVATION

Adenine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000034
xref: Reference/BioCyc ADENINE
xref: Reference/PubChem-compound 190
xref: Reference/ChemSpider 185
xref: Reference/KEGG Compound C00147
xref: Reference/ChEBI CHEBI 16708
xref: Reference/CAS 73-24-5
chemical formula: C5H5N5
molecular weight: 135.05449
structure: ChemicalStructure/PW C000024

TransportCatalysis6124
type: Catalysis
controller: Unknown
controlled: Transport17647
control type: ACTIVATION

Mus musculus
type: BioSource
xref: Reference/TAXONOMY 10090

Compound/PW C000086 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanine
stoichiometric coefficient: 1.0

Reference/PubChem-compound 204
type: UnificationXref
id: 204
db: PubChem-compound

Carbon dioxide
type: SmallMolecule
cellular location: Cytosol
entity reference: Carbon dioxide

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

ChemicalStructure/PW C000127
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc CPD-6641
type: UnificationXref
id: CPD-6641
db: BioCyc

Compound/PW C001144 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

Reference/ChemSpider 217
type: UnificationXref
id: 217
db: ChemSpider

Compound/PW C000086/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanine
stoichiometric coefficient: 1.0

Reference/CAS 58-68-4
type: UnificationXref
id: 58-68-4
db: CAS

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=O

Compound/PW C001146 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ribose 1-phosphate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 250388
type: UnificationXref
id: 250388
db: PubChem-compound

Reference/CAS 124-38-9
type: UnificationXref
id: 124-38-9
db: CAS

Xanthine
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 17712
xref: Reference/ChemSpider 1151
xref: Reference/KEGG Compound C00385
xref: Reference/HMDB HMDB0000292
xref: Reference/CAS 69-89-6
xref: Reference/BioCyc XANTHINE
xref: Reference/PubChem-compound 1188
chemical formula: C5H4N4O2
molecular weight: 152.03343
structure: ChemicalStructure/PW C000198

Uric acid
type: SmallMoleculeReference
xref: Reference/BioCyc URATE
xref: Reference/HMDB HMDB0000289
xref: Reference/ChEBI CHEBI 17775
xref: Reference/CAS 69-93-2
xref: Reference/PubChem-compound 1175
xref: Reference/KEGG Compound C00366
xref: Reference/ChemSpider 1142
chemical formula: C5H4N4O3
molecular weight: 168.02834
structure: ChemicalStructure/PW C000195

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Reference/KEGG Compound C00007
type: UnificationXref
id: C00007
db: KEGG Compound

Inosine
type: SmallMolecule
cellular location: Cytosol
entity reference: Inosine

Reference/BioCyc ADENINE
type: UnificationXref
id: ADENINE
db: BioCyc

Reference/ChEBI CHEBI 17712
type: UnificationXref
id: CHEBI:17712
db: ChEBI

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/ChemSpider 1151
type: UnificationXref
id: 1151
db: ChemSpider

Adenosine
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine

Reference/PubChem-compound 790
type: UnificationXref
id: 790
db: PubChem-compound

Reference/KEGG Compound C00242
type: UnificationXref
id: C00242
db: KEGG Compound

Compound/PW C000721 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0030097
type: UnificationXref
id: HMDB0030097
db: HMDB

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

Reference/KEGG Compound C00004
type: UnificationXref
id: C00004
db: KEGG Compound

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

Reference/KEGG Compound C00003
type: UnificationXref
id: C00003
db: KEGG Compound

Reference/KEGG Compound C00366
type: UnificationXref
id: C00366
db: KEGG Compound

Liver
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000759

Guanine
type: SmallMolecule
entity reference: Guanine

ChemicalStructure/PW C000024
type: ChemicalStructure
structure format: SMILES
structure data: NC1=C2NC=NC2=NC=N1

Reference/CAS 7664-41-7
type: UnificationXref
id: 7664-41-7
db: CAS

Reference/BioCyc R--ALLANTOIN
type: UnificationXref
id: R--ALLANTOIN
db: BioCyc

Guanine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 764
xref: Reference/ChEBI CHEBI 16235
xref: Reference/CAS 73-40-5
xref: Reference/BioCyc GUANINE
xref: Reference/KEGG Compound C00242
xref: Reference/HMDB HMDB0000132
xref: Reference/ChemSpider 744
chemical formula: C5H5N5O
molecular weight: 151.04941
structure: ChemicalStructure/PW C000086

Reference/HMDB HMDB0000462
type: UnificationXref
id: HMDB0000462
db: HMDB

Reference/PubChem-compound 60961
type: UnificationXref
id: 60961
db: PubChem-compound

Reference/ChEBI CHEBI 17368
type: UnificationXref
id: CHEBI:17368
db: ChEBI

Reference/BioCyc GUANINE
type: UnificationXref
id: GUANINE
db: BioCyc

NAD
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15846
xref: Reference/HMDB HMDB0000902
xref: Reference/CAS 53-84-9
xref: Reference/KEGG Compound C00003
xref: Reference/PubChem-compound 5893
xref: Reference/BioCyc NAD
xref: Reference/ChemSpider 5682
chemical formula: C21H27N7O14P2
molecular weight: 663.10913
structure: ChemicalStructure/PW C000721

Reference/KEGG Compound C00011
type: UnificationXref
id: C00011
db: KEGG Compound

ChemicalStructure/PW C001316
type: ChemicalStructure
structure format: SMILES
structure data: O=C=O

Reference/HMDB HMDB0000902
type: UnificationXref
id: HMDB0000902
db: HMDB

Reference/PubChem-compound 222
type: UnificationXref
id: 222
db: PubChem-compound

Reference/KEGG Compound C00014
type: UnificationXref
id: C00014
db: KEGG Compound

ChemicalStructure/PW C000352
type: ChemicalStructure
structure format: SMILES
structure data: NC(=O)NC1NC(=O)NC1=O

Compound/PW C011313 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 5-Hydroxyisourate
stoichiometric coefficient: 1.0

Reference/KEGG Compound C11821
type: UnificationXref
id: C11821
db: KEGG Compound

NADH
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001487
xref: Reference/CAS 58-68-4
xref: Reference/PubChem-compound 439153
xref: Reference/BioCyc NADH
xref: Reference/ChemSpider 388299
xref: Reference/KEGG Compound C00004
xref: Reference/ChEBI CHEBI 16908
chemical formula: C21H29N7O14P2
molecular weight: 665.12476
structure: ChemicalStructure/PW C001144

Transport17653
type: Transport
participant stoichiometry: Compound/PW C000352/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000352 Cytosol/Stoichiometry/1.0
right: Allantoin
spontaneous: false
left: Allantoin
name: Allantoin (→) Transport: Mus musculus, Liver, Hepatocyte, Cytosol to Mus musculus, Blood Vessel
conversion direction: LEFT_TO_RIGHT

Ribose 1-phosphate
type: SmallMoleculeReference
xref: Reference/CAS 14075-00-4
xref: Reference/ChEBI CHEBI 16300
xref: Reference/HMDB HMDB0001489
xref: Reference/PubChem-compound 439236
xref: Reference/ChemSpider 388373
xref: Reference/BioCyc RIBOSE-1P
xref: Reference/KEGG Compound C00620
chemical formula: C5H11O8P
molecular weight: 230.01915
structure: ChemicalStructure/PW C001146

Transport17651
type: Transport
participant stoichiometry: Compound/PW C000086 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000086/Stoichiometry/1.0
right: Guanine
spontaneous: false
left: Guanine
name: Guanine (→) Transport: Mus musculus, Blood Vessel to Mus musculus, Liver, Hepatocyte, Cytosol
conversion direction: LEFT_TO_RIGHT

Transport17650
type: Transport
participant stoichiometry: Compound/PW C000086/Stoichiometry/1.0
right: Guanine
spontaneous: false
left: Guanine
name: Guanine (→) Transport: Mus musculus, Intestine to Mus musculus, Blood Vessel
conversion direction: LEFT_TO_RIGHT

Hepatocyte
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000182

Reference/ChEBI CHEBI 16708
type: UnificationXref
id: CHEBI:16708
db: ChEBI

Reference/CAS 68-94-0
type: UnificationXref
id: 68-94-0
db: CAS

Reference/KEGG Compound C00385
type: UnificationXref
id: C00385
db: KEGG Compound

Reference/KEGG Compound C00262
type: UnificationXref
id: C00262
db: KEGG Compound

Reference/CAS 53-84-9
type: UnificationXref
id: 53-84-9
db: CAS

Reference/KEGG Compound C00027
type: UnificationXref
id: C00027
db: KEGG Compound

Reference/KEGG Compound C00147
type: UnificationXref
id: C00147
db: KEGG Compound

Transport17649
type: Transport
participant stoichiometry: Compound/PW C000086/Stoichiometry/1.0
right: Guanine
spontaneous: false
left: Guanine
name: Guanine (→) Transport: Mus musculus to Mus musculus, Intestine
conversion direction: LEFT_TO_RIGHT

Transport17648
type: Transport
participant stoichiometry: Compound/PW C000024 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000024/Stoichiometry/1.0
right: Adenine
spontaneous: false
left: Adenine
name: Adenine (→) Transport: Mus musculus, Blood Vessel to Mus musculus, Liver, Hepatocyte, Cytosol
conversion direction: LEFT_TO_RIGHT

Transport17647
type: Transport
participant stoichiometry: Compound/PW C000024/Stoichiometry/1.0
right: Adenine
spontaneous: false
left: Adenine
name: Adenine (→) Transport: Mus musculus, Intestine to Mus musculus, Blood Vessel
conversion direction: LEFT_TO_RIGHT

Transport17646
type: Transport
participant stoichiometry: Compound/PW C000024/Stoichiometry/1.0
right: Adenine
spontaneous: false
left: Adenine
name: Adenine (→) Transport: Mus musculus to Mus musculus, Intestine
conversion direction: LEFT_TO_RIGHT

Protein/13685 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Xanthine dehydrogenase/oxidase
stoichiometric coefficient: 2.0

Reference/CAS 73-24-5
type: UnificationXref
id: 73-24-5
db: CAS

Reference/PubChem-compound 764
type: UnificationXref
id: 764
db: PubChem-compound

Reference/SMPDB SMP0127696
type: UnificationXref
id: SMP0127696
db: SMPDB

Uric acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Uric acid

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

ChemicalStructure/PW C000721
type: ChemicalStructure
structure format: SMILES

Guanine
type: SmallMolecule
cellular location: Cytosol
entity reference: Guanine

Reference/ChemSpider 5682
type: UnificationXref
id: 5682
db: ChemSpider

ChemicalStructure/PW C001144
type: ChemicalStructure
structure format: SMILES

ReactionCatalysis100695
type: Catalysis
controller: Xanthine dehydrogenase/oxidase
controlled: Reaction110381
control type: ACTIVATION

ReactionCatalysis100694
type: Catalysis
controller: Xanthine dehydrogenase/oxidase
controlled: Reaction110380
control type: ACTIVATION

Compound/PW C000024/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenine
stoichiometric coefficient: 1.0

ReactionCatalysis100692
type: Catalysis
controller: Purine nucleoside phosphorylase
controlled: 2.4.2.1
control type: ACTIVATION

Unknown
type: Protein
entity reference: Unknown

ChemicalStructure/PW C001146
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc HYDROGEN-PEROXIDE
type: UnificationXref
id: HYDROGEN-PEROXIDE
db: BioCyc

Reference/CAS 69-93-2
type: UnificationXref
id: 69-93-2
db: CAS

5-Hydroxyisourate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C11821
xref: Reference/ChEBI CHEBI 18072
xref: Reference/PubChem-compound 250388
xref: Reference/HMDB HMDB0030097
xref: Reference/ChemSpider 219288
chemical formula: C5H4N4O4
molecular weight: 184.02325
structure: ChemicalStructure/PW C011313

Xanthine dehydrogenase/oxidase
type: Complex
component stoichiometry: Protein/13685 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Xanthine dehydrogenase/oxidase

ReactionCatalysis100699
type: Catalysis
controller: Purine nucleoside phosphorylase
controlled: 2.4.2.1
control type: ACTIVATION

ReactionCatalysis100698
type: Catalysis
controller: Unknown
controlled: 3.5.4.4
control type: ACTIVATION

Reference/HMDB HMDB0000132
type: UnificationXref
id: HMDB0000132
db: HMDB

Reference/ChEBI CHEBI 16300
type: UnificationXref
id: CHEBI:16300
db: ChEBI

Xanthine dehydrogenase/oxidase
type: ProteinReference
xref: Reference/UniProt Q00519
organism: BiologicalState327

Reference/ChemSpider 5799
type: UnificationXref
id: 5799
db: ChemSpider

Reference/ChemSpider 768
type: UnificationXref
id: 768
db: ChemSpider

Reference/ChemSpider 763
type: UnificationXref
id: 763
db: ChemSpider

Compound/PW C000127 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Inosine
stoichiometric coefficient: 1.0

Reference/CAS 73-40-5
type: UnificationXref
id: 73-40-5
db: CAS

Reference/KEGG Compound C00294
type: UnificationXref
id: C00294
db: KEGG Compound

ReactionCatalysis210890
type: Catalysis
controller: Uricase
controlled: 1.7.3.3
control type: ACTIVATION

Reference/CAS 14075-00-4
type: UnificationXref
id: 14075-00-4
db: CAS

Reference/PubChem-compound 784
type: UnificationXref
id: 784
db: PubChem-compound

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reference/ChemSpider 388299
type: UnificationXref
id: 388299
db: ChemSpider

Reference/HMDB HMDB0001487
type: UnificationXref
id: HMDB0001487
db: HMDB

Reference/HMDB HMDB0000034
type: UnificationXref
id: HMDB0000034
db: HMDB

Reference/HMDB HMDB0001489
type: UnificationXref
id: HMDB0001489
db: HMDB

Oxygen
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001377
xref: Reference/ChemSpider 952
xref: Reference/KEGG Compound C00007
xref: Reference/ChEBI CHEBI 15379
xref: Reference/PubChem-compound 977
xref: Reference/BioCyc CPD-6641
xref: Reference/CAS 7782-44-7
chemical formula: O2
molecular weight: 31.98983
structure: ChemicalStructure/PW C001065

Reference/HMDB HMDB0000157
type: UnificationXref
id: HMDB0000157
db: HMDB

Reference/BioCyc INOSINE
type: UnificationXref
id: INOSINE
db: BioCyc

Reference/BioCyc AMMONIA
type: UnificationXref
id: AMMONIA
db: BioCyc

ChemicalStructure/PW C000035
type: ChemicalStructure
structure format: SMILES
structure data: N

ChemicalStructure/PW C000034
type: ChemicalStructure
structure format: SMILES

SubPathwayInteraction122676
type: Interaction
name: SubPathwayReaction
name: SubPathway122676Reaction
participant: Allantoin

SubPathwayInteraction122677
type: Interaction
name: SubPathway122677Reaction
name: SubPathwayReaction
participant: Allantoin

Xanthine
type: SmallMolecule
cellular location: Cytosol
entity reference: Xanthine

Water
type: SmallMolecule
cellular location: Cytosol
entity reference: Water

NAD
type: SmallMolecule
cellular location: Cytosol
entity reference: NAD

Reference/ChEBI CHEBI 15676
type: UnificationXref
id: CHEBI:15676
db: ChEBI

Unknown
type: ProteinReference
organism: BiologicalState327

Reference/ChEBI CHEBI 16526
type: UnificationXref
id: CHEBI:16526
db: ChEBI

Reference/CAS 58-61-7
type: UnificationXref
id: 58-61-7
db: CAS

Reference/KEGG Compound C00620
type: UnificationXref
id: C00620
db: KEGG Compound

Allantoin
type: SmallMolecule
cellular location: Cytosol
entity reference: Allantoin

Reference/CAS 7782-44-7
type: UnificationXref
id: 7782-44-7
db: CAS

Reference/HMDB HMDB0001377
type: UnificationXref
id: HMDB0001377
db: HMDB

Reference/HMDB HMDB0000289
type: UnificationXref
id: HMDB0000289
db: HMDB

Compound/PW C000035 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ammonia
stoichiometric coefficient: 1.0

Compound/PW C001420 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/CAS 97-59-6
type: UnificationXref
id: 97-59-6
db: CAS

Compound/PW C000102 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hypoxanthine
stoichiometric coefficient: 1.0

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/ChEBI CHEBI 16335
type: UnificationXref
id: CHEBI:16335
db: ChEBI

Compound/PW C001783 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen peroxide
stoichiometric coefficient: 1.0

Hydrogen peroxide
type: SmallMolecule
cellular location: Cytosol
entity reference: Hydrogen peroxide

Carbon dioxide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 280
xref: Reference/ChEBI CHEBI 16526
xref: Reference/ChemSpider 274
xref: Reference/HMDB HMDB0001967
xref: Reference/CAS 124-38-9
xref: Reference/KEGG Compound C00011
chemical formula: CO2
molecular weight: 43.98983
structure: ChemicalStructure/PW C001316

Reference/PubChem-compound 1175
type: UnificationXref
id: 1175
db: PubChem-compound

Reference/PubChem-compound 5893
type: UnificationXref
id: 5893
db: PubChem-compound

Reaction110380
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000198 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001783 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000102 Cytosol/Stoichiometry/1.0
right: Xanthine
right: Hydrogen peroxide
spontaneous: false
left: Oxygen
left: Hypoxanthine
left: Water
name: Hypoxanthine + Oxygen + Water → Hydrogen peroxide + Xanthine
conversion direction: LEFT_TO_RIGHT

Reaction110381
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000198 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000195 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Cytosol/Stoichiometry/1.0
right: Uric acid
right: NADH
spontaneous: false
left: NAD
left: Xanthine
left: Water
name: NAD + Water + Xanthine → NADH + Uric acid
conversion direction: LEFT_TO_RIGHT

Unknown
type: Protein
cellular location: Cytosol
entity reference: Unknown

ChemicalStructure/PW C001065
type: ChemicalStructure
structure format: SMILES
structure data: O=O

Reference/PubChem-compound 439236
type: UnificationXref
id: 439236
db: PubChem-compound

3.5.4.4
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000127 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000035 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
right: Inosine
right: Ammonia
spontaneous: false
EC number: 3.5.4.4
left: Adenosine
left: Water
name: Adenosine + Water → Ammonia + Inosine
conversion direction: LEFT_TO_RIGHT

Reference/ChEBI CHEBI 18072
type: UnificationXref
id: CHEBI:18072
db: ChEBI

2.4.2.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000024 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001146 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytosol/Stoichiometry/1.0
right: Adenine
right: Ribose 1-phosphate
spontaneous: false
EC number: 2.4.2.1
left: Phosphate
left: Adenosine
name: Adenosine + Phosphate ↔ Adenine + Ribose 1-phosphate
conversion direction: REVERSIBLE

Reference/HMDB HMDB0000051
type: UnificationXref
id: HMDB0000051
db: HMDB

Reference/HMDB HMDB0000050
type: UnificationXref
id: HMDB0000050
db: HMDB

Reference/HMDB HMDB0000292
type: UnificationXref
id: HMDB0000292
db: HMDB

Allantoin
type: SmallMoleculeReference
xref: Reference/PubChem-compound 204
xref: Reference/ChEBI CHEBI 15676
xref: Reference/ChemSpider 199
xref: Reference/KEGG Compound C01551
xref: Reference/BioCyc R--ALLANTOIN
xref: Reference/CAS 97-59-6
xref: Reference/HMDB HMDB0000462
chemical formula: C4H6N4O3
molecular weight: 158.04399
structure: ChemicalStructure/PW C000352

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Reference/BioCyc ADENOSINE
type: UnificationXref
id: ADENOSINE
db: BioCyc

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/ChEBI CHEBI 15379
type: UnificationXref
id: CHEBI:15379
db: ChEBI

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

Protein/7725 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 2.0

Unknown
type: ProteinReference

Phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Phosphate

Adenine
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenine

Oxygen
type: SmallMolecule
cellular location: Cytosol
entity reference: Oxygen

Compound/PW C000024 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenine
stoichiometric coefficient: 1.0

Compound/PW C000352/Stoichiometry/1.0
type: Stoichiometry
physical entity: Allantoin
stoichiometric coefficient: 1.0

Reference/PubChem-compound 280
type: UnificationXref
id: 280
db: PubChem-compound

Reference/UniProt P25688
type: UnificationXref
id: P25688
db: UniProt

5-Hydroxyisourate
type: SmallMolecule
cellular location: Cytosol
entity reference: 5-Hydroxyisourate

Reference/ChemSpider 388373
type: UnificationXref
id: 388373
db: ChemSpider

Reference/CAS 69-89-6
type: UnificationXref
id: 69-89-6
db: CAS

Reference/CAS 58-63-9
type: UnificationXref
id: 58-63-9
db: CAS

ChemicalStructure/PW C000198
type: ChemicalStructure
structure format: SMILES
structure data: O=C1NC2=C(NC=N2)C(=O)N1

ReactionCatalysis100674
type: Catalysis
controller: Guanine deaminase
controlled: 3.5.4.3
control type: ACTIVATION

ChemicalStructure/PW C000195
type: ChemicalStructure
structure format: SMILES
structure data: O=C1NC2=C(N1)C(=O)NC(=O)N2

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Hydrogen peroxide
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0003125
xref: Reference/PubChem-compound 784
xref: Reference/ChemSpider 763
xref: Reference/CAS 7722-84-1
xref: Reference/BioCyc HYDROGEN-PEROXIDE
xref: Reference/ChEBI CHEBI 16240
xref: Reference/KEGG Compound C00027
chemical formula: H2O2
molecular weight: 34.005478
structure: ChemicalStructure/PW C001783

Reference/ChemSpider 199
type: UnificationXref
id: 199
db: ChemSpider

Xanthine dehydrogenase/oxidase
type: Protein
cellular location: Cytosol
entity reference: Xanthine dehydrogenase/oxidase

3.5.4.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000198 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000086 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000035 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
right: Ammonia
right: Xanthine
spontaneous: false
EC number: 3.5.4.3
left: Guanine
left: Water
name: Guanine + Water → Ammonia + Xanthine
conversion direction: LEFT_TO_RIGHT

Allantoin
type: SmallMolecule
entity reference: Allantoin
name: SubPathwayInput

Reference/PubChem-compound 190
type: UnificationXref
id: 190
db: PubChem-compound

Hypoxanthine
type: SmallMolecule
cellular location: Cytosol
entity reference: Hypoxanthine

Reference/ChemSpider 54923
type: UnificationXref
id: 54923
db: ChemSpider

Reference/BioCyc NADH
type: UnificationXref
id: NADH
db: BioCyc

Reference/HMDB HMDB0000195
type: UnificationXref
id: HMDB0000195
db: HMDB

Ribose 1-phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Ribose 1-phosphate

Reference/BioCyc NAD
type: UnificationXref
id: NAD
db: BioCyc

Reference/BioCyc URATE
type: UnificationXref
id: URATE
db: BioCyc

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

Reference/ChEBI CHEBI 17775
type: UnificationXref
id: CHEBI:17775
db: ChEBI

Reference/PubChem-compound 977
type: UnificationXref
id: 977
db: PubChem-compound

Protein/7725 Cytosol/Stoichiometry/3.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 3.0

Compound/PW C001316 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001967
type: UnificationXref
id: HMDB0001967
db: HMDB

Oxidative Stress
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway122677
pathway component: SubPathwayInteraction122677
name: SubPathway

Compound/PW C000352 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Allantoin
stoichiometric coefficient: 1.0

Kidney Damage
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway122676
pathway component: SubPathwayInteraction122676
name: SubPathway

Compound/PW C001104 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 1188
type: UnificationXref
id: 1188
db: PubChem-compound

Reference/ChemSpider 744
type: UnificationXref
id: 744
db: ChemSpider

ChemicalStructure/PW C000086
type: ChemicalStructure
structure format: SMILES
structure data: NC1=NC(=O)C2=C(N1)N=CN2

Reference/ChemSpider 185
type: UnificationXref
id: 185
db: ChemSpider

Hypoxanthine
type: SmallMoleculeReference
xref: Reference/CAS 68-94-0
xref: Reference/HMDB HMDB0000157
xref: Reference/ChEBI CHEBI 17368
xref: Reference/PubChem-compound 790
xref: Reference/KEGG Compound C00262
xref: Reference/BioCyc HYPOXANTHINE
xref: Reference/ChemSpider 768
chemical formula: C5H4N4O
molecular weight: 136.03851
structure: ChemicalStructure/PW C000102

2.4.2.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000127 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001146 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000102 Cytosol/Stoichiometry/1.0
right: Hypoxanthine
right: Ribose 1-phosphate
spontaneous: false
EC number: 2.4.2.1
left: Phosphate
left: Inosine
name: Inosine + Phosphate ↔ Hypoxanthine + Ribose 1-phosphate
conversion direction: REVERSIBLE

Uricase
type: Protein
cellular location: Cytosol
entity reference: Uricase