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Cytochrome P450 3A4 Alclofenac Alclofenac Alclofenac PIS1M1 Alclofenac PIS1M1 Urinary Excretion and/or Bile duct Excretion Heme Hepatocytes Kidney Liver Cytosol Alclofenac undergoes metabolism to give Alclofenac PIS1M1. Endoplasmic Reticulum Bile Ducts Blood Vessel Blood Vessel
Endoplasmic Reticulum CYP3A4 Alclofenac Alclofenac Alclofenac PIS1M1 Alclofenac PIS1M1 Urinary Excretion and/or Bile duct Excretion
CYP3A4 Alclo Alclo Alc PIS Alc PIS U E a B Heme Hepatocytes Kidney Liver Cytosol Alclofenac undergoes metabolism to give Alclofenac PIS1M1. Endoplasmic Reticulum Bile Ducts Blood Vessel Blood Vessel